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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/29373| 標題: | 製備鄰苯二胺類分子用以連接酮酸醣及胜肽 Preparation of Phenylenediamine Compounds for Conjugation with Ketoacid Saccharides and Peptides |
| 作者: | Chun-Hao Tseng 曾俊豪 |
| 指導教授: | 方俊民(Jim-Min Fang) |
| 關鍵字: | 唾液酸,連接試劑,喹,喔啉,酮,疊氮苯,胜肽, sialic acid,crosslinker,quinoxalinone,photoligation,peptide, |
| 出版年 : | 2007 |
| 學位: | 碩士 |
| 摘要: | In this thesis, we plan to use a simple linker which can directly conjugate with sugar and peptide without any modification on the peptide and saccharide.
Compound 1 is the crosslinker designed for conjugation with unmodified sialic acid and peptide. Compound 1 reacted with sialic acid to give quinoxalinone derivatives 22. Compound 26 underwent photoligation with n-butylamine to give 3H-azepine derivatives 27, and the gradual disappearance of the azido phenyl group was shown by the UV-Vis spectrum. |
| URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/29373 |
| 全文授權: | 有償授權 |
| 顯示於系所單位： | 化學系 |
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| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-96-1.pdf 目前未授權公開取用 | 3.54 MB | Adobe PDF |
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