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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈立言 | |
| dc.contributor.author | Chih-Tai Yen | en |
| dc.contributor.author | 顏志泰 | zh_TW |
| dc.date.accessioned | 2021-06-13T00:23:55Z | - |
| dc.date.available | 2008-07-30 | |
| dc.date.copyright | 2007-07-30 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-25 | |
| dc.identifier.citation | 王立新、韓哲武。1992。黃耆多醣對內毒素致小鼠毒性損傷的作用。藥學學報。27: 5-9。
王者悅 主編。1992。中國藥膳大辭典。大連出版社。大連。 王浴生、鄧文龍、薛春生。1998。中藥藥理與應用。人民衛生出版社。北京。P. 982-1004。 王勤、李愛媛、黃榮奇、林漓、許學健。1998。羅漢果保肝活性部位之研究。中藥藥理與臨床。14(6): 31-32。 行政院衛生署統計室。2007。台灣地區死因統計結果摘要（民國九十五年）。 宋瑞樓、陳定信、廖運範。2006。肝炎肝硬化與肝癌。橘井文化事業股份有限公司。 東丈夫、賴榮祥。1993。枸杞之知識。生藥資訊1:1-7。 施杞、夏翔 主編。1995。中國食療大全。上海科學技術出版社。上海。P. 266-267。 施新獻。2000。現代醫學動物實驗學P. 335。北京人民軍醫出版社。 苗明三。2003。實驗動物和實驗動物技術 P. 144-145。中國中醫藥出版社。 苗明三。2004。大棗多醣對免疫抑制小鼠腹腔巨噬細胞產生IL-1α及脾細胞體外增殖的影響。中藥藥理與臨床。20(4): 21-22。 袁葉飛、周彥園、馬家驊、梁臣豔。2005。大棗抑制亞硝胺合成的體外實驗研究。廣西中醫藥。28(4): 52-54。 巢佳莉。2002。肝病相關醫藥與診斷最新進展。工業技術研究院產業經濟與資訊服務中心。 張俐勤、戚向陽。2006。羅漢果皂苷提取物的分離、純化及對體外自由基的清除作用。食品研究與開發。27(3): 16-18。 張冠群、李伯鵬、劉付傳雄、朱莉芬、李美珠、鐘傳新。1996。肝炎1號對大白鼠慢性肝損傷的作用。中草藥。27(9)： 549-551。 張敬芳、王光浩、曹平、王錦軍、楊成雄、張華。2007。黃耆注射液對早期糖尿病腎病大鼠血液一氧化氮和內皮素的影響。時珍國醫國藥。18(4): 831-832。 張銀娣、沈健平、朱樹華。1992。黃耆皂苷抗實驗性肝損傷作用。藥學學報。27(6): 401-406。 張慶、雷林生、張莉莎、楊淑琴。2000。大棗中性多醣的抗小鼠腹腔巨噬細胞內活性氧作用。中藥藥理與臨床。16(6): 14-16。 許杜鵑、陳敏珠。2006。黃耆總提物抗腫瘤作用及其機制研究。中華中醫葯雜誌。21(12): 771-772。 陳啟禎。1999。菇類二次代謝物質及其利用。食品工業。31: 1-11。 陸德澄、蘇子杰、芮濤、戴玉瑛、隋鳳、湯永祥、張敬銘、湯國良、呂聖榮、彭國民、閻荷珍。1994。健延齡對血清脂質和載脂蛋白及脂蛋白(a)水平的影響。中國中西醫結合雜誌。14: 142-144。 黃仕政。2005。蛹蟲草之培養和其呈味性質及經γ-照射之巴西蘑菇子實體和樟芝菌絲體之抗氧化性質。國立中興大學食品科學系博士論文。台灣。 黃惠君。2004。食藥用菇的營養與藥用價值。食品工業。36:25-32。 黃雅惠。1999。巴西洋菇分子鑑定系統之研究。國立台灣大學農業化學研究所碩士論文。台灣。 黃鈴娟。2000。樟芝與姬松茸之抗氧化性質及其多醣組成分析。國立中興大學食品科學系碩士論文。台灣。 蔡哲雄、陳昭姿。2001。對抗癌症系列(三)肝病三部曲。天下生活出版股份有限公司。 顧有方、李衛民、李升和、陳會良、董策龍、趙芝剛。2006。大棗多醣對小鼠四氯化碳誘發肝損傷防護作用的實驗研究。中國中醫藥科技。13(2): 105-107。 Aebi H. 1984. Catalase in vitro. Methods Enzymol 105: 121-126. Atanasiu RL, Stea D, Mateescu MA, Vergely C, Dalloz F, Briot F, Maupoil V, Nadeau R, Rochette L. 1998. Direct evidence of caeruloplasmin antioxidant properties. Mol Cell Biochem 189(1-2): 127-135. Balendrian GK, Dabur R, Fraser D. 2004. The role of glutathione in cancer. Cell Biochem Funct 22(6): 343-352. Barbisan LF, Miyamoto M, Scolastici C, Salvadori DM, Ribeiro LR, Eira AF, de Camargo JL. 2002. Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J Ethnopharmacol 83(1-2): 25-32. Barbisan LF, Spinardi-Barbisan AL, Moreira EL, Salvadori DM, Ribeiro LR, da Eira AF, de Camargo JL. 2003. Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci. Cancer Science 94(2): 188-192. Bedossa P, Poynard T. 1996. An algorithm for the grading of activity in chronic hepatitis C. Hepatology 24(2): 289-293. Bellomo G, Mirabelli F, DiMonte D, Richelmi P, Thor H, Orrenius C, Orrenius S. 1987. Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone). Biochem Pharma 36(8): 1313-1320. Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, Schuppan D. 1997. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatol 26(3): 643-649. Boll M, Weber LW, Becker E, Stampfl A. 2001. Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites. J Biosciences 56(7-8): 649-659. Borek C. 2001. Antioxidant health effects of aged garlic extract. J Nutr 131(3s): 1010S-1015S. Boyer TD, Wright TL, Manns MP. 2006. Zakim and Boyer’s Hepatology :A textbook of liver disease (5th ed.). Elsevier Inc. Publication. Chen L, Shao HJ, Su YB. 2004. Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. International Immunopharmacology 4(3): 403-409. Crocenzi FA, Roma MG. 2006. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr Med Chem 13(9): 1055-1074. Cui XY, Luo Q, Yang ML. 2006. Effect of Lycium barbarum polysaccharides on the growth of human cervical carcinoma Hela cell and cell apoptosis. Chin J Public Health 22(12): 1411-1412. Fennema OR. 1996. Lipids in “Food Chemistry” 3rd ed. New York. Flora K, Hahn M, Rosen H, Benner K. 1998. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroneterol 93(2): 139-143. Frankel EN. 1984. Chemistry of free radical and singlet oxidation of lipids. Prog Lipid Res 23(4): 197-221. Friedman SL, Bansal MB. 2006. Reversal of hepatic fibrosis - fact or fantasy? Hepatology 43(2 Suppl 1): S82-88. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R. 1998. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 46(3): 147-159. Fukao T, Hosono T, Misawa S, Seki T, Ariga T. 2004. The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem Toxicol 42(5): 743-749. Gan L, Zhang SH, Yang XL, Xu HB. 2004. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int Immunopharmacol 4(4): 563-569. Ha KT, Yoon SJ, Choi DY, Kim DW, Kim JK, Kim CH. 2005. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J Ethnopharmacol 96(3): 529-535. Habig WH, Pabst MJ, Jakoby WB. 1974. Glutathione S-transferase: The first enzymatic step in mercapturic acid formation. J Biol Chem 249(22): 7130-7139. Halliwell B. 1996. Antioxidants in human health and disease. Annu Rev Nutr 16: 33-50. Halliwell B, Gutteridge JMC. 2007. “Free Radicals in Biology and Medicine.” 4th ed. Oxford : Oxford University Press. Hanna E, Sherman AC. 1999. Quality-of-life issues in head and neck cancer. Curr Oncol Rep 1(2): 124-128. Hanna PM, Mason RP. 1992. Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique. Arch Biochem Biophys 295(1): 205-213. Harris RN, Anders MW. 1981. 2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene. Drug Metab Dispos 9(6): 551-556. Hashimoto T, Nonaka Y, Minato K, Kawakami S, Mizuno M, Fukuda I, Kanazawa K, Ashida H. 2002. Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice. Biosci Biotechnol Biochem 66(7): 1610-1614. He LJ, Liu P. 2006. Effect of Lycium barbarum polysaccharides on oxidative stress of diabetic nephropathy in type 2 diabetic rats. Chin Hosp Pharm J 26(12): 1475-1478. Ishak K, Baptista A, Bianchi L, Callea F, de Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RNM, Phillips MJ, Portmann BG, Poulsen H, Scheuer PJ, Schmid M, Thaler H. 1995. Histological grading and staging of chronic hepatitis. J Hepatol 22(6): 696-699. Jin RM, Zhang XC, Chen CX, Sun ZG, Shen YR, Liu D, Hu ZB. 1999. Studies on pharmacological functions of hairy root of Astragalus membranaceus. Zhongguo Zhong Yao Za Zhi 24(10): 619-621. Jn LE, Xie XM, Chang LP. 2006. Studies on extraction of antioxidant from Lycium and its antioxidant activities. Chemistry and Industry of Forest Products 26(3): 55-58. Kadiiska MB, Gladen BC, Baird DD, Dikalova AE, Sohal RS, Hatch GE, Jones DP, Mason RP, Barrett JC. 2000. Biomarkers of oxidative stress study: are plasma antioxidants markers of CCl4 poisoning? Free Radic Biol Med 28(6): 838-845. Kameswararao B, Kesavulu MM, Apparao C. 2003. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in allxan-diabetic rats. Fitoterapia 74(1-2): 7-13. Kaneno R, Fontanari LM, Santos SA, Di Stasi LC, Filho ER, Eira AF. 2004. Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice. Food Chem Toxicol 42(6): 909-916. Kao JH, Tsai SL, Chen PJ, Yang PM, Sheu JC, Lai MY, Hsu HC, Sung JL, Wang TH, Chen DS. 1994. A clinicopathologic study of chronic non-A, non-B (type C) hepatitis in Taiwan: comparsion between posttransfusion and sporadic patients. J Hepatol 21(2): 244-249. Kasai H, He LM, Kawamura M, Yang PT, Deng XW, Munkanta M, Yamashita A, Terunuma H, Hirama M, Horiuchi I, Natori T, Koga T, Amano Y, Yamaguchi N, Ito M. 2004. IL-12 production induced by Agaricus blazei fraction H (ABH) involves Toll-like receptor (TLR) Evid Based Complement Alternat Med 1(3): 259-267. Ker YB, Chen KC, Chyau CC, Chen CC, Guo JH, Hsieh CL, Wang HE, Peng CC, Chang CH, Peng RY. 2005. Antioxidant capability of polysaccharides fractionated from submerge-cultured Agaricus blazei mycelia. J Agric Food Chem 53(18): 7052-7058. Kim SY, Lee EJ, Kim HP, Kim YC, Moon A, Kim YC. 1999. A novel cerebroside from Lycii fructus preserves the hepatic glutathione redox system in primary cultures of rat hepatocytes. Biol Pharm Bull 22(8): 873-875. Kim YW, Kim KH, Choi HJ, Lee DS. 2005. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett 27(7): 483-487. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. 1981. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1(5): 431-435. Kuroiwa Y, Nishikawa A, Imazawa T, Kanki K, Kitamura Y, Umemura T, Hirose M. 2005. Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats. Food Chem Toxicol 43(7): 1047-1053. Lawrence RA, Burk RF. 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun 71(4): 952-958. Lee KY, Jeon YJ. 2005. Marcophage activation by polysaccharide isolated from Astragalus membranaceus. Int Immunopharmacol 5(7-8): 1225-1233. Lee SY, Park JG, Lee YH, Lee CG, Min BS, Kim JH, Lee HK. 2004. Anti-complementary activity of triterpenoides from fruits of Zizyphus jujube. Biol Pharm Bull 27(11): 1883-1886. Letteron P, Labbe G, Degott C, Berson A, Fromenty B, Delaforge M, Larrey D, Pessayre D. 1990. Mechanism for the protective effects od silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Biochem Pharmacol 39(12): 2027-2034. Li JW, Ding SD, Ding XL. 2005. Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube. Process Biochem 40(11): 3607-3613. Liaw YF, Tai DI, Chu CM, Chen TJ. 1988. The developement of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology 8(3): 493-496. Lieber CS. 1999. Prevention and treatment of liver fibrosis based on pathogenesis. Alcohol Clin Exp Res 23(5): 944-949. Lin J, Dong HF, Oppenheim JJ, Howard OM. 2003. Effects of astragali radix on the growth of different cancer cell lines. World J Gastroenterol 9(4): 670-673. Lin JM, Lin CC, Chiu HF, Yang JJ, Lee SG. 1993. Evaluation of the anti-inflammatory and liver -protective effects of Anoectochilus formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. Am J Chin Med 21(1): 59-69. Lin SC, Lin YH, Chen CF, Chung CY, Hsu SH. 1997. The hepatoprotective and therapeutic effects of propolic ethanol extract on chronic alcohol-induced liver injuries. Am J Chin Med 25(3-4): 325-332. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193(1): 265-275. Luckey SW, Petersen DR. 2001. Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats. Exp Mole Patho 71(3): 226-240. Ma LJ, Sun HS, Yang WB, Chen QL, Xi SM, Wan XD, Chen QL. 2006. Experimental study of Lycium barbarum polysaccharide against atherosclerosis in rabbits. Journal of Henan University (Medical Science) 25(3): 24-26. McGregor D, Lang M. 1996. Carbon tetrachloride: Genetic effects and other modes of action. Mutat Res 366(3): 181-195. Mann DA, Smart DE. 2002. Transcriptional regulation of hepatic stellate cell activation. Gut 50(6): 891-896. Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical inthe oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3): 469-474. Mato JM, Camara J, de Paz JF, Caballeria L, Coll S, Caballero A, Garica-Buey L, Beltran J, Benita V, Caballeria J, Sola R, Moreno-Otero R, Barrao F, Martin-Duce A, Correa JA, Pares A, Barrao E, Garcia-Magaz I, Puetra JL, Moreno J, Boissard G, Ortiz P, Rodes J. 1999. S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 30(6): 1081-1089. Miao MS. 2004. Effects of jujube polysaccharide on the levels of interleukin-2 and its receptor in immunosuppressive mice. Chinese Journal of clinical rehabilitation 8(30): 6692-6693. Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. 1999. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei Mill. Biochem Mol Biol Int 47(4): 707-714. Mizuno M, Morimoto M, Minato K, Tsuchida H. 1998. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechno Biochem 62(3): 434-437. Mizuno T. 1995. Bioactive biomolecules of mushrooms-food, function and medicinal effect of mushrooms fungi. Food Review International 11: 7-21. Nakajima A, Ishida T, Koga M, Takeuchi T, Mazda O, Takeuchi M. 2002. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice. Int Immunopharmacol 2(8): 1205-1211. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissue by thiobarbituric acid reaction. Anal Biochem 95(2): 351-358. Olson JA. 1996. Benefits and liabilities of vitamin A and carotenoids. J Nutr 126(4 Suppl): 1208s-1212s. Osman E, Owen JS, Burroughs AK. 1993. Review article: S-adenosyl-L-methionine- a new therapeutic agent in liver disease? Aliment Pharmacol Ther 7: 21-28. Park EY, Ki SH, Ko MS, Kim CW, Lee MH, Lee YS, Kim SG. 2005. Garlic oil and DDB, comprised in a pharmaceutical composition for the treatment of patients with viral hepatitis, prevents acute liver injuries potentiated by glutathione deficiency in rats. Chem Biol Interact 155(1-2): 82-96. Pinheiro F, Faria RR, de Camargo JL, Spinardi-Barbisan AL, da Eira AF, Barbisan LF. 2003. Chemoprevention of preneoplastic liver foci development by the dietary mushroom Agaricus blazei Murrill in the rat. Food Chem Toxicol 41(11): 1543-1550. Poyer JL, McCay PB, Lai EK, Janzen EG, Davis ER. 1980. Confirmation of assignment of the trichloromethyl radical spin adduct detected by spin trapping during 13C-carbon tetrachloride metabolism in vitro and in vivo. Biochem Biophys Res Commun 94(4): 1154-1160. Qian JY, Liu D, Huang AG. 2004. The efficiency of flavonoids in polar extracts of Lycium chinense Mill fruits as free radical scavenger. Food Chem 87(2): 283-288. Raja S, Ahamed KF, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK. 2007. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol 109(1): 41-47. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW, Potter DW. 1980. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Ana Biochem 106(1): 55-62. Reitman S, Frankel S. 1957. A colorimetric method for determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 25: 56-63. Reznick AZ, Packer L. 1994. Oxidative damage to proteins: spectrophotometric method for carbonyl assay. Methods Enzymol 233: 357-363. Ruwart MJ, Wilkinson KF, Rush BD, Vidmar TJ, Peters KM, Henley KS, Appelman HD, Kim KY, Schuppan D, Hahn EG. 1989. The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat. Hepatol 10(5): 801-806. Sastre J, Pallardo FV, Pla R, Pellin A, Juan G, O’Connor JE, Estrela JM, Miquel J, Vina J. 1996. Aging of the liver: age-associated mitochondrial damage in intact hepatocytes. Hepatol 24(5): 1199-1205. Sheen LY, Lii CK, Sheu SF, Meng RH, Tsai SJ. 1996. Effect of the active principle of garlic--diallyl sulfide--on cell viability, detoxification capability and the antioxidation system of primary rat hepatocytes. Food Chem Toxicol 34(10): 971-978. Sheen LY, Sheu SF, Tsai SJ, Meng RH, Lii CK. 1999. Effect of garlic active principle, diallyl disulfide, on cell viability, lipid peroxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes. Am J Chinese Med 27(1): 95-105. Sheen LY, Wu CC, Lii CK, Tsai SJ. 2001. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the aflatoxin B(1)-induced DNA damage in primary rat hepatocytes. Toxicol Lett 122(1): 45-52. Shimizu I. 2000. Sho-saiko-to: Japanese herbal medicine for protection against hepatic fibrosis and carcinoma. J Gastroenterol Hepatol 15(Suppl): D84-D90. Song FF, Qi XY, Chen WJ, Jia WB, Yao P, Nussler AK, Sun XF, Liu LG. 2007. Effect of Momordica grosvenori on oxidative stress pathways in renal mitochondria of normal and alloxan-induced diabetic mice. Eur J Nutr 46(2): 61-69. Sturgill MG, Lambert GH. 1997. Xenobiotic-induced hepatotoxicity: mechanisms of liver injury and methods of monitoring hepatic function. Clin Chem 43(8 Pt 2): 1512-1526. Sung JL. 1981. Hepatitis B virus infection and its sequalae in Taiwan. Proc Natl Sci Counc. 5: 385-389. Svegliati-Baroni G, Di Sario A, Casini A, Ferretti G, D'Ambrosio L, Ridolfi F, Bolognini L, Salzano R, Orlandi F, Benedetti A. 1999. The Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat hepatic stellate cells. J Hepatol 30: 868-875. Takaku T, Kimura Y, Okuda H. 2001. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 131(5): 1409-1413. Takasaki M, Konoshima T, Murata Y, Sugiura M, Nishino H, Tokuda H, Matsumoto K, Kasai R, Yamasaki K. 2003. Anticarcinogenic activity of natural sweeteners, cucurbitane glycosides, from Momordica grosvenori. Cancer Letters 198(1): 37-42. Takeo E, Yoshida H, Tada N, Shingu T, Matsuura H, Murata Y, Yoshikawa S, Ishikawa T, Nakamura H, Ohsuzu F, Kohda H. 2001. Sweet elements of Siraitia grosvenori inhibit oxidative modification of low-density lipoprotein. J Atheroscler Thromb 9(2): 114-120. Tamayo RP. 1983. Is cirrohosis of the liver experimentally produced by CCl4 and adequate model of human cirrohosis? Hepatology 3(1): 112-120. Tangkijvanich P, Yee HF Jr.. 2002. Cirrosis-can we reverse hepatic fibrosis? Eur J Surg (Suppl 587) 168(11): 100-112. Thomas MJ. 1995. The role of free radicals and antioxidant: how do we know that they are working? Crit Rev Food Sci Nutr 35(1-2): 21-39. Toda S, Yase Y, Shirataki Y. 2000. Inhibitory effects of astragali radix, crude drug in Oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain homogenate by copper. Phytother Res 14(4): 294-296. Tsang KY, Ng TB. 2001. Isolation and characterization of a new ribosome inactivating protein, momorgrosvin, from seeds of the monk’s fruit Momordica grosvenorii. Life Sci 68(7): 773-784. Ukiya M, Akihisa T, Tokuda H, Toriumi M, Mukainaka T, Banno N, Kimura Y, Hasegawa JI, Nishino H. 2002. Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on Epstein-Barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate. J Agric Food Chem 50(23): 6710-6715. Wang JH, Cheng F, Chen XQ. 2006. A research on the effect of Lycium chinenses Mill decoction on the total SOD activity of mouse liver. Journal of Xinliang Normal University (Naural Science Edition) 25(4): 58-60. Witting LA. 1975. Vitamin E as a food additive. J Am Oil Chem Soc 52(2): 64-68. Wu Y, Ou-Yang JP, Wu KE, Wang Y, Zhou YF, Wen CY. 2005. Hypoglycermic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacologica Sinaca. 26(3): 345-352. Xiao G, Wang Q. 2006. Research advance of Momordica grosvenori Swingle. SH J TCM 40(11): 71-73. Yang C., Zeisberg M., Mosterman B., Sudhakar A., Yerramalla U., Holthaus K., Xu L., Eng F., Afdhal N., Kalluri R. 2003. Liver fibrosis: Insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 124(1): 147-159. Yang PM, Huang GT, Lin JT, Yang PM, Sheu JC, Lai MY, Su IJ, Hsu HC, Chen DS, Wang TH, Sung JL. 1988. Ultrasonography in the diagnosis of benign diffuse parenchymal liver disease: a prospective study. J Formos Med Assoc 87(10): 966-977. Zhang Z, Wu MD. 2006. Protective effect of jujube dates polysaccharide on chemical liver injury in mice and antifatigue effect. Journal of Nanjing Agricultural University 29(1): 94-97. Zhao KW, Kong HY. 1993. Effect of Astragalan on secretion of tumor necrosis factors in human peripheral blood mononuclear cells. Zhongguo Zhong Xi Yi Jie He Za Zhi 13(5): 263-265. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28811 | - |
| dc.description.abstract | 本研究為利用衛生署公告之護肝功能動物模式，探討味全公司研發之養甘露樣品，是否具有對於四氯化碳誘導大鼠肝損傷保護作用。本實驗分為六組，分別為正常控制組 (未經四氯化碳處理)、四氯化碳處理負對照組 (僅投予四氯化碳之處理組)、Silymarin處理正對照組 (四氯化碳+Silymarin處理組) 及1X、2X、5X劑量實驗組 (四氯化碳+740、1480、3700 mg/kg bw/day養甘露樣品處理組)。實驗結果顯示，經連續餵食八週養甘露樣品後，三種劑量之養甘露樣品皆可以增加肝臟中抗氧化物質glutathione (GSH) 的含量並且使大鼠肝臟中脂質過氧化情況改善以及肝臟生化功能指標酵素丙胺酸轉胺酶 (alanine aminotransferase, ALT)、天門冬胺酸轉胺酶 (aspartate aminotransferase, AST) 數值顯著的減少，表示應具有護肝之功能 (p < 0.05)。在肝臟抗氧化及解毒代謝酵素活性方面，2X、5X劑量養甘露樣品處理組之麩胱甘肽過氧化酶 (glutathione peroxidase, GPx1)、麩胱甘肽還原酶 (glutathione reductase, GRd)、麩胱甘肽硫轉移酶 (glutathione S-transferase, GST)、超氧化物歧化酶 (superoxide dismutase, SOD) 酵素活性均顯著高於四氯化碳處理負對照組 (p < 0.05)。在四氯化碳投予後之第八週血清中三酸甘油酯 (triglyceride, TG) 值方面，三種劑量養甘露樣品處理實驗組之TG均較四氯化碳處理負對照組低且達顯著性差異 (p < 0.05)。此外，肝臟組織病理學觀察方面，5X劑量養甘露樣品可使肝細胞發炎壞死、脂肪變性及肝臟纖維化等現象都有顯著的改善 (p < 0.05)。由以上實驗結果推測養甘露樣品對於保護肝臟應具有正面的效果。 | zh_TW |
| dc.description.abstract | Mushrooms have been used as an important source of nutrition and/or therapy throughout the world since ancient times. Agaricus blazei polysaccharides has been reported to induced with immunomodulatory and antitumor activities. This study was designed to evaluate the effects of Agaricus blazei-based herbal extract on CCl4-induced chronic hepatotoxicity in rats. Male Wistar rats (210 ±10 g) were divided into six groups in this study, including normal control (not treated with CCl4) and groups treated with CCl4, i.e. negative control (only treated with CCl4), positive control (treated with CCl4 and Silymarin), and three experimental groups (treated with CCl4 and low, medium or high dose of Agaricus blazei-based herbal extract, i.e. 0.74, 1.48, or 3.7g/kg bw/day Agaricus blazei-based herbal extract, respectively). On the other hand, rats were administrated with Agaricus blazei-based herbal extract for one week before the administration of CCl4. Rats were treated with Agaricus blazei-based herbal extract once a day until the eighth week of CCl4 treatment. Blood samples were collected for assaying serum biological parameters. The livers were excised for evaluating peroxidation products and antioxidant substances, as well as the activities of antioxidant enzymes. Pathological histology was also performed. The results showed that the Agaricus blazei-based herbal extract significantly (p<0.05) lowered the serum levels of hepatic enzyme markers (alanine aminotransferase, aspartate aminotransferase), inhibited inflammation, necrosis, fatty degeneration and fibrosis. Also reduced the content of the peroxidation product malondialdehyde, and the elevated the content of reduced form of glutathione (GSH). Treatment of rats with Agaricus blazei-based herbal extract could increase the activities of glutathione peroxidase (GPx1), glutathione reductase (GRd) and glutathione S-transferase (GST) in liver when compared with CCl4-treated group (p<0.05). Therefore, the results of this study show that Agaricus blazei-based herbal extract can be proposed to protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its antioxidant and free radical scavenger effects. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T00:23:55Z (GMT). No. of bitstreams: 1 ntu-96-R94641025-1.pdf: 1095977 bytes, checksum: efbc858a65bff7447c6a36d5249905c0 (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 目錄.................................................................................................................................Ⅰ
中文摘要.........................................................................................................................Ⅴ 英文摘要.........................................................................................................................Ⅵ 表次.................................................................................................................................Ⅷ 圖次.................................................................................................................................Ⅹ 第一章 前言...................................................................................................................1 第二章 文獻整理...........................................................................................................3 第一節 肝臟之生理功能及肝臟疾病...................................................................3 一、肝臟的生理結構與功能.............................................................................3 二、肝臟損傷的機制.........................................................................................6 三、四氯化碳誘導肝損傷機制.........................................................................8 四、護肝成分介紹...........................................................................................12 第二節 自由基與氧化.........................................................................................14 一、自由基及活性氧的定義...........................................................................14 二、脂質過氧化物的產生...............................................................................14 三、氧化狀態失調與疾病...............................................................................17 四、生物體內抗氧化防禦機制之介紹...........................................................17 第三節 巴西洋菇的相關研究資料.....................................................................21 一、簡介...........................................................................................................21 二、生理機能...................................................................................................21 第四節 羅漢果的相關研究資料.........................................................................24 一、簡介...........................................................................................................24 二、生理機能...................................................................................................24 第五節 枸杞子的相關研究資料.........................................................................26 一、簡介...........................................................................................................26 二、生理機能...................................................................................................26 第六節 大棗的相關研究資料.............................................................................28 一、簡介...........................................................................................................28 二、生理機能...................................................................................................28 第七節 黃耆的相關研究資料.............................................................................30 一、簡介.........................................................................................................30 二、生理機能...................................................................................................30 第三章 研究目的與實驗架構.....................................................................................33 一、急性動物實驗架構...................................................................................33 二、慢性動物實驗架構...................................................................................34 第四章 材料與方法.....................................................................................................35 第一節 材料...........................................................................................................35 一、實驗材料...................................................................................................35 二、實驗動物...................................................................................................36 三、實驗藥品...................................................................................................36 四、實驗儀器...................................................................................................37 五、四氯化碳誘導大鼠急性肝損傷實驗模式...............................................38 六、四氯化碳誘導大鼠慢性肝損傷實驗模式...............................................38 第二節 方法...........................................................................................................39 一、肝功能生化指數的檢測...........................................................................39 二、肝臟與血漿脂質過氧化之分析...............................................................39 三、肝臟麩胱甘肽濃度之分析.......................................................................40 四、麩胱甘肽過氧化酶活性之分析...............................................................42 五、麩胱甘肽還原酶活性之分析...................................................................42 六、麩胱甘肽硫轉移酶活性之分析...............................................................42 七、超氧化物歧化酶之測定...........................................................................43 八、過氧化氫酶之測定...................................................................................43 九、蛋白質濃度之測定...................................................................................43 十、組織病理學的觀察...................................................................................44 十一、統計方法...............................................................................................45 第五章 結果.................................................................................................................48 第一節 四氯化碳誘導大鼠急性肝損傷實驗.......................................................48 一、平均體重變化...........................................................................................48 二、臟器相對重量...........................................................................................48 三、肝臟與血漿中脂質過氧化.......................................................................48 四、肝臟中抗氧化物質麩胱甘肽含量...........................................................49 五、血清中ALT、AST值.................................................................................49 六、肝臟抗氧化與解毒代謝酵素活性...........................................................50 七、肝臟與血清中三酸甘油酯與總膽固醇含量...........................................50 第二節 四氯化碳誘導大鼠慢性肝損傷實驗.......................................................51 一、平均體重變化...........................................................................................51 二、臟器相對重量...........................................................................................51 三、肝臟與血漿中脂質過氧化.......................................................................52 四、肝臟中抗氧化物質麩胱甘肽含量...........................................................52 五、血清中ALT、AST值.................................................................................52 六、肝臟抗氧化與解毒代謝酵素活性...........................................................54 七、肝臟與血清中三酸甘油酯與總膽固醇含量...........................................55 八、肝臟組織病理切片觀察...........................................................................56 第六章 討論.................................................................................................................59 第七章 結論.................................................................................................................64 第八章 圖表.................................................................................................................65 第九章 參考文獻.........................................................................................................89 附錄...............................................................................................................................103 | |
| dc.language.iso | zh-TW | |
| dc.subject | 解毒代謝 | zh_TW |
| dc.subject | 四氯化碳 | zh_TW |
| dc.subject | 巴西洋菇 | zh_TW |
| dc.subject | 麩胱甘肽 | zh_TW |
| dc.subject | 抗氧化 | zh_TW |
| dc.subject | 肝臟 | zh_TW |
| dc.subject | detoxification | en |
| dc.subject | liver | en |
| dc.subject | Agaricus blazei | en |
| dc.subject | carbon tetrachloride | en |
| dc.subject | glutathione | en |
| dc.subject | antioxidant property | en |
| dc.title | 巴西洋菇食療方對四氯化碳誘導大鼠氧化性肝損傷之護肝功效評估 | zh_TW |
| dc.title | Evaluation of hepatic protection of Agaricus blazei-based herbal extract against CCl4-induced oxidative liver injury | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 胡淼琳,鍾景光,邱智賢 | |
| dc.subject.keyword | 肝臟,巴西洋菇,四氯化碳,麩胱甘肽,抗氧化,解毒代謝, | zh_TW |
| dc.subject.keyword | liver,Agaricus blazei,carbon tetrachloride,glutathione,antioxidant property,detoxification, | en |
| dc.relation.page | 102 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-27 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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