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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 康照洲 | |
| dc.contributor.author | Shih-Hsuan Huang | en |
| dc.contributor.author | 黃士軒 | zh_TW |
| dc.date.accessioned | 2021-06-13T00:14:57Z | - |
| dc.date.available | 2009-08-08 | |
| dc.date.copyright | 2007-08-08 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-27 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28631 | - |
| dc.description.abstract | 許多研究指出空氣污染與呼吸系統及心血管疾病的發生和致死有關，其中空氣污染物中的懸浮微粒污染影響最為嚴重，亦是一個最廣為研究的題材，在台灣由燃燒汽油的機車引擎所產生的懸浮微粒對於空氣污染的貢獻甚鉅，依據前人的研究並顯示機車廢氣懸浮微粒確實會造成許多肺部傷害，其中更包括了發炎反應的發生，由於細胞黏著分子對於發炎反應的發生扮演著一關鍵性的角色，但是在機車廢氣懸浮微粒所造成的發炎反應相關研究中，對於細胞黏著分子的研究卻很缺乏，因此本篇論文將對此作深入的研究與探討。
實驗動物以氣管滴入法給予機車廢氣懸浮微粒24小時後，即能夠明顯的觀察到肺部中細胞黏著分子ICAM-1蛋白表現增加，而在細胞層次中發現機車廢氣懸浮微粒會使第二型肺上皮細胞與內皮細胞的黏著分子表現增加，其中抗氧化劑或NF-κB抑制劑都能有效預防廢氣懸浮微粒所造成的影響，故推測機制可能是對細胞造成氧化壓力促使NF-κB活化而導致。並且利用純黑碳微粒與多環芳香烴類來探討廢氣懸浮微粒所造成的影響成分為何，結果發現黑碳微粒和多環芳香烴中的benzo[a]pyrene與chrysene具有和MEP相類似的影響與反應，推估這三種成分在MEP所造成的發炎反應中應佔有著一定的地位。 | zh_TW |
| dc.description.abstract | In lots of studies, air pollution has been linked to increasing rates of mortality and morbidity in respiratory and cardiovascular diseases. Particulate matters were the most major source and has been study extensively. In Taiwan, the motorcycle engine exhausts were considered to produce majority of particulate matters in air pollution. Previous studies showed that motorcycle exhaust particle caused many lung injuries including inflammatory responses. The cell adhesion molecules play a crucial role in the inflammatory responses. Little study on the correlation of motorcycle exhaust particles and cell adhesion molecules in inflammatory responses was conducted.
In this study, after 24 hours motorcycle exhaust particles administered by intratracheal instillation, the cell adhesion molecule ICAM-1 was significantly increased in the lung of mouse. In vitro study, motorcycle exhaust particles caused cell adhesion molecules increase in type II lung epithelial cell and endothelial cell. At molecular level, motorcycle exhaust particles treatment caused the activation of NF-κB signaling pathway. Both the expression of cell adhesion molecules and NF-κB activation could be inhibited by antioxidant and NF-κB inhibitor. It suggest that motorcycle exhaust particles induced cell adhesion molecules expression through NF-κB signaling pathway activated by oxidative stress. The major composition of exhaust particular matter like motorcycle exhaust particle is carbon black core, it surround by inorganic salt, mineral heavy metal and polycyclic aromatic hydrocarbons. In following experiment, we use carbon blacks and polycyclic aromatic hydrocarbons to distinguish the major component of motorcycle exhaust particles was take effect. As the results, carbon blacks, chrysene and benzo[a]pyrene had similar effect on ICAM-1 regulation with motorcycle exhaust particles. It was supposed that three of them had an important role in motorcycle exhaust particles caused inflammatory response. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T00:14:57Z (GMT). No. of bitstreams: 1 ntu-96-R92447008-1.pdf: 1872024 bytes, checksum: 4a0ec4ab9819aa8b9c9a1cd9c53b0aaa (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 目錄
口試委員會審定書............................................................................i 誌謝....................................................................................................ii 中文摘要............................................................................................iii 英文摘要.............................................................................................iv 目錄.....................................................................................................vi 圖表集目錄………………………………………………………….vii 縮寫表……………………………………………………………….viii 第一章序論.........................................................................................1 1. 空氣污染與健康危害..............................................................2 2. 空氣污染物質..........................................................................2 3. 多環芳香烴(polycyclic aromatic hydrocarbon；PAH)…...5 4. 呼吸系統……………………………………...……………..11 5. 發炎反應與細胞黏著分子………………………………….14 6. 細胞黏著分子(Cell adhesion molecules；CAMs)………...16 7. ICAM與發炎疾病………………………………………….17 8. ICAM-1簡介………………………………………………..17 研究目的………………………………………………………...20 第二章材料與方法............................................................................21 第三章結果........................................................................................31 第四章討論........................................................................................37 第五章參考文獻................................................................................43 圖表集................................................................................................60 圖表集目錄 Table 1. PAH於交通工具與燃燒所產生的懸浮微粒分布情形……61 Table 2. IARC人類致癌物質分類表………………………………..62 Table 3.美國環保署公告監測的16種非取代基PAH……………...63 Table 4. PAH的游離能………………………………………………66 Figure 1.懸浮微粒組成示意圖…………………..…………………..67 Figure 2. K區域與峽灣區域二氫二醇環氧化PAH………………..68 Figure 3.形成PAH自由基陽離子過程圖…………………………..69 Figure 4.代謝活化生成PAH-o-quinone…………………...………...70 Figure 5.白血球召集流程圖與期間的調控因子................................71 Figure 6.MEP對於BALB/c小鼠肺部ICAM-1表現的影響……....72 Figure 7.MEP對THP-1細胞黏附的影響…………………………..73 Figure 8.MEP對內皮細胞表現細胞黏著分子mRNA的影響……..74 Figure 9.MEP對內皮細胞表現細胞黏著分子蛋白的影響…………75 Figure 10.MEP對NF-κB訊息傳導的影響………………………….76 Figure 11.抗氧化劑對NF-κB活化與ICAM-1表現的影響………...77 Figure 12.CB對ICAM-1表現的影響………………………………..78 Figure 13.PAH對ICAM-1表現的影響………………………………79 Figure 14.抗氧化劑對CB與PAH對ICAM-1表現的影響…………80 Figure 15.CB與PAH對NF-κB訊息傳導的影響……………………81 | |
| dc.language.iso | zh-TW | |
| dc.subject | 氧化壓力 | zh_TW |
| dc.subject | 黑碳微粒 | zh_TW |
| dc.subject | 多環芳香烴 | zh_TW |
| dc.subject | 發炎反應 | zh_TW |
| dc.subject | 細胞黏著分子 | zh_TW |
| dc.subject | NF-κB | zh_TW |
| dc.subject | 機車廢氣懸浮微粒 | zh_TW |
| dc.subject | NF-κB | en |
| dc.subject | carbon black | en |
| dc.subject | cell adhesion molecule | en |
| dc.subject | inflammatory response | en |
| dc.subject | Motorcycle exhaust particle | en |
| dc.subject | oxidative stress | en |
| dc.subject | polycyclic aromatic hydrocarbon | en |
| dc.title | 機車廢氣懸浮微粒對於人類臍帶靜脈內皮細胞細胞黏著分子表現的影響 | zh_TW |
| dc.title | Effects of Motorcycle Exhaust particle on the Cell Adhesion Molecule expression on Human Umbilical Vein Endothelial Cell | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 彭福佐,蕭哲志 | |
| dc.subject.keyword | 機車廢氣懸浮微粒,發炎反應,細胞黏著分子,多環芳香烴,黑碳微粒,氧化壓力,NF-κB, | zh_TW |
| dc.subject.keyword | Motorcycle exhaust particle,inflammatory response,cell adhesion molecule,polycyclic aromatic hydrocarbon,carbon black,oxidative stress,NF-κB, | en |
| dc.relation.page | 81 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2007-07-27 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 毒理學研究所 | zh_TW |
| 顯示於系所單位： | 毒理學研究所 | |
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