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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 段維新(Wei-Hsing Tuan) | |
| dc.contributor.author | Ying-Cen Chen | en |
| dc.contributor.author | 陳映岑 | zh_TW |
| dc.date.accessioned | 2021-06-08T03:37:01Z | - |
| dc.date.copyright | 2021-02-22 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-01-26 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/21532 | - |
| dc.description.abstract | 由於醫療發展的日新月異導致人口平均壽命日益漸增，人口老化進而骨替代材需求逐年增長，本次研究目的為找出最佳比例的骨替代材促進新骨生成。 本次研究以硫酸鈣添加硫酸鍶作為骨替代材之研究，而硫酸鈣具有三種型態，二水硫酸鈣 (CaSO4∙2H2O)、半水硫酸鈣 (CaSO4∙1/2H2O)以及無水硫酸鈣 (CaSO4) 。半水硫酸鈣作為骨填充材已有百年歷史，硫酸鈣不會引起發炎反應，還具有骨融合、骨傳導和生物相容性，以及刺激新骨細胞生成。硫酸鈣為生物陶瓷的一種，可被生物體吸收並且完全降解。過去的研究指出，鍶離子具有抗骨質疏鬆的成效，能刺激成骨前驅細胞分化成熟為成骨細胞以促進新骨生成，同時抑制蝕骨細胞吸收，以達到抑制骨質流失的效果。 本次研究，以燒結法製備無水硫酸鈣及摻雜不同比例鍶的試樣。製程是將1 wt%至50 wt%的硫酸鍶與半水硫酸鈣粉末球磨混合、經乾燥、壓錠並燒結至1100°C後持溫一小時，利用熱處理法將鍶離子與鈣離子置換並形成試樣。將試樣進行材料分析與生物分析，試樣隨時間降解並釋放鍶離子，並且找出最佳促進新骨生成之鍶離子濃度範圍。實驗結果證實，此試樣可做為骨替代材。 | zh_TW |
| dc.description.abstract | Advances in medical treatment help all humanity. With the increase of aging population, a variety of bone diseases are also increased. Nowadays, the artificial bone graft is very important for the patients with osteoporosis. In this work, the calcium sulfate added the strontium sulfate is used as the artificial bone graft. With suitable ratio, the bone graft helps on the formation of new bones. There are three forms for calcium sulfate: calcium sulfate dihydrate (CaSO4 ∙ 2H2O), calcium sulfate hemihydrate (CaSO4 ∙ 1/2H2O) and calcium sulfate anhydrate (CaSO4), in terms of its crystallized water. Calcium sulfate hemihydrate has been used as bone graft substitute for more than 100 years. It exhibits excellent biocompatibility, osseointegration and osteoconduction. Furthermore, calcium sulfate can be resorbed in vivo completely. Strontium ions can relieve osteoporosis by stimulating maturation of preosteoblasts activation, and they can also inhibit bone resorption through inactivating the functionality of osteoclasts. In the present study, sintering technique is used to prepare calcium sulfate anhydrate specimens incorporating strontium ion. The calcium sulfate hemihydrate powder was mixed with various amounts of 1 wt% - 50 wt% of strontium sulfate powder, through ball-milling technique. The bone graft was the prepared by sintering at 1100 °C for 1 hour to form the strontium-substituted calcium sulfate. The degradation results confirm the release of strontium ion during the degradation. In addition, a range of the concentration of strontium ion in calcium sulfate is investigated. The results demonstrate that the strontium-substituted calcium sulfate specimen is a potential antiosteoporotic material which can be used as a bone graft substitute. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T03:37:01Z (GMT). No. of bitstreams: 1 U0001-2001202115473600.pdf: 10924241 bytes, checksum: a1c6a61f8ce5ca5c61d1744cd3d529b3 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書………………………………………………………...……………# 致謝…………………………………………………………………………………...…# 中文摘要………… i ABSTRACT ii CONTENTS iii LIST OF FIGURES v LIST OF TABLES x Chapter 1 Introduction 1 Chapter 2 Literature review 2 2.1 Basic of bones 2 2.2 Bone graft substitutes and Bioceramics 4 2.3 Use of calcium sulfate as bioceramic 6 2.3.1 Chemical and physical properties of calcium sulfate 6 2.3.2 Biological properties of calcium sulfate 7 2.4 Biological properties of strontium sulfate 8 Chapter 3 Experimental procedures 10 3.1 Calcium sulfate and strontium sulfate 10 3.1.1 Starting materials 10 3.1.2 Processing 10 3.2 Material characterization 11 3.3 Biological properties 13 3.3.1 In vitro text 13 3.3.2 In vivo text 17 Chapter 4 Results 18 4.1 Physical properties of Strontium-added Calcium sulfate 18 4.1.1 Density and relative density 18 4.1.2 Phase identification 20 4.1.3 Raman spectrum 23 4.1.4 Thermogravimetric analysis (TGA) 25 4.1.5 Mechanical properties 26 4.1.6 Microstructure 28 4.2 Biological properties of Strontium-added calcium sulfate 35 4.2.1 In vitro test 35 4.2.2 In vivo test 52 Chapter 5 Discussion 58 5.1 Material characterization 58 5.1.1 Physicsl properties 58 5.1.2 Mechanical properties 62 5.2 Biological characterization 63 5.2.1 In vitro test 63 5.2.2 Degradation and pH test 65 5.2.3 In vivo test 67 Chapter 6 Conclusions 68 Chapter 7 Future work 69 REFERENCES 70 | |
| dc.language.iso | en | |
| dc.title | 利用燒結法將鍶添加到硫酸鈣及其在骨填充材之研究 | zh_TW |
| dc.title | Sintering of Strontium-added Calcium Sulfate Bone Void Filler | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 109-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 賴伯亮(Po-Liang Lai),張麗冠(Li-Kwan Chang),陳三元(San-Yuan Chen),許沛衣(Pei-Yi Hsu) | |
| dc.subject.keyword | 硫酸鈣,鍶離子,生物可吸收,燒結,骨替代材料, | zh_TW |
| dc.subject.keyword | calcium sulfate,strontium,bioresorbable,sintering,bone graft substitutes, | en |
| dc.relation.page | 80 | |
| dc.identifier.doi | 10.6342/NTU202100104 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2021-01-26 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 材料科學與工程學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-2001202115473600.pdf 未授權公開取用 | 10.67 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。