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標題: | 研發新型抗菌改質熱塑性聚胺酯及胺酯壓克力樹脂材料於牙科根管充填 Development of novel antibacterial-modified thermoplastic polyurethane and urethane-acrylate materials for dental root canal filling |
作者: | Tung-Jung Chiang 蔣東融 |
指導教授: | 林俊彬 |
共同指導教授: | 謝國煌 |
關鍵字: | 牙科根管充填,熱塑性聚胺酯,胺酯壓克力樹脂,細胞毒性,抗菌性質, Root canal filling,Thermoplastic polyurethane,Urethane-acrylate resin,Cytotoxicity,Antibacterial effect, |
出版年 : | 2015 |
學位: | 碩士 |
摘要: | 傳統型根管封填材料主要以馬來膠錐體( Gutta-percha )搭配各類傳統根管封填劑,然而馬來膠錐體及各類傳統封填劑之間黏著力不足,根管封填劑和牙本質之黏著亦不理想,因此無法達到有效根管密封的目的。本研究團隊以聚己二酸丁二醇( Polybutylene adipate, PBA )合成之聚胺酯根管封填材料在臨床操作上有極佳的機械性質及熱性質,並且與牙本質有非常好的鍵結,可達到良好密封性的目的,但此類材料接觸組織液時,仍有水解之疑慮。
本研究乃利用聚胺酯及胺酯壓克力樹脂徑而開發新穎牙科根管充填材料。實驗主要分為兩部份,第一部分為根管封填錐體,首先探討聚四亞甲基醚二醇( Polytetramethylene oxide, PTMO )合成低水解根管封填錐體材料,結果顯示其熔點低於體溫不利臨床操作,因此以PBA-based進行後續聚胺酯合成,並利用熱塑性聚胺酯做為基材以化學鍵結方式接枝氯己定( Chlorhexidine, CHX );第二部份為根管封填劑,是利用紫外光硬化之胺酯壓克力樹脂做為基材並以化學鍵結方式接枝氯己定,及使用三丙烯乙二醇雙丙烯酸脂( Tripropylene glycol diacrylate, TPGDA )做為稀釋單體,提高胺酯壓克力樹脂於牙科根管封填劑上之可行性。並使用傅立葉轉換紅外線光譜儀( Fourier-Transformed Infrared Spectrometer, FTIR )、核磁共振儀( Nuclear magnetic resonance, NMR )證實氯己定以化學鍵結方式接枝在基材上;熱重損失分析儀( Thermo Gravimetric Analysis, TGA )、微差掃瞄卡計儀( Differential Scanning Calorimetry, DSC )顯示其熱裂解溫度及熔點符合臨床操作溫度;細胞毒性結果顯示都優於ISO 10993-5的規範;抗菌結果可以發現改質後的根管封填材料都具有抗菌性,並在濃度0.6 wt%時達到一穩定較佳的抗菌效果。 Conventional root canal materials do not have enough dentinal adhesion and cannot achieve the ideal sealing properties with cone materials. Our research team have developed the polyurethane root canal obturation system containing PBA polyol-based cone materials and dual cured urethane acrylate sealer. Although these materials have good mechanical properties and bonding strength to dentin, the cytotoxicity and hydrolytic stability are questioned. The purpose of this study was to develop a novel polyurethane-based root obturation material, including cone and sealer materials. At first, we developed the low hydrolytic polyurethane cone material by replacing the PBA polyol with PTMO polyol and investigated the thermal properties. The results showed that the PTMO-based polyurethane cone material cannot be used in human body because the low melting point. Thus, cone materials was synthesized from polyester-type polyol and covalently bonded with CHX. For the sealer materials, ultraviolet-light photo polymerization urethane-acrylate oligomer was synthesized and covalently bonded with CHX to mix with dilute monomer to form UA/TPGDA resin. From FT-IR and NMR analysis, CHX have covalently bonded with matrix. TGA and DSC showed thermal properties appropriate for the clinical temperature. The consequences of the Cytotoxicity was better than ISO 10993-5 standard and antibacterial evaluation revealed that 0.6 wt% reached to a stable antibacterial effect. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18118 |
全文授權: | 未授權 |
顯示於系所單位: | 高分子科學與工程學研究所 |
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