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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18118完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林俊彬 | |
| dc.contributor.author | Tung-Jung Chiang | en |
| dc.contributor.author | 蔣東融 | zh_TW |
| dc.date.accessioned | 2021-06-08T00:51:45Z | - |
| dc.date.copyright | 2015-07-20 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-06-29 | |
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Journal of Endodontics, 2006. 32(7): p. 656-662. 77. Merdad, K., et al., Short-Term Cytotoxicity Assessment of Components of the Epiphany Resin-Percha Obturating System by Indirect and Direct Contact Millipore Filter Assays. Journal of Endodontics, 2007. 33(1): p. 24-27. 78. Lodienė, G., et al., Toxicity evaluation of root canal sealers in vitro. International Endodontic Journal, 2008. 41(1): p. 72-77. 79. Klaiber, B., et al., [Determination of the toxicity of root canal filling materials and thier separate components in cell cultures]. Deutsche zahnarztliche Zeitschrift, 1981. 36(4): p. 212-216. 80. Hume, W.R., The pharmacologic and toxicological properties of zinc oxide-eugenol. The Journal of the American Dental Association, 1986. 113(5): p. 789-791. 81. Segura, J.J. and A. Jiménez-Rubio, Effect of eugenol on macrophage adhesion in vitro to plastic surfaces. Dental Traumatology, 1998. 14(2): p. 72-74. 82. Abdulkader, A., R. Duguid, and E.M. Saunders, The antimicrobial activity of endodontic sealers to anaerobic bacteria. International Endodontic Journal, 1996. 29(4): p. 280-283. 83. Çobankara, F.K., et al., In Vitro Antibacterial Activities of Root-Canal Sealers By Using Two Different Methods. Journal of Endodontics, 2004. 30(1): p. 57-60. 84. Saleh, I.M., et al., Survival of Enterococcus faecalis in infected dentinal tubules after root canal filling with different root canal sealers in vitro. International Endodontic Journal, 2004. 37(3): p. 193-198. 85. Leonardo, M.R., et al., Release of formaldehyde by 4 endodontic sealers. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 1999. 88(2): p. 221-225. 86. Barkhordar, R.A., Evaluation of antimicrobial activity in vitro of ten root canal sealers on Streptococcus sanguis and Streptococcus mutans. Oral Surgery, Oral Medicine, Oral Pathology, 1989. 68(6): p. 770-772. 87. Pumarola, J., et al., Antimicrobial activity of seven root canal sealers: Results of agar diffusion and agar dilution tests. Oral Surgery, Oral Medicine, Oral Pathology, 1992. 74(2): p. 216-220. 88. Torabinejad, M., et al., Antibacterial effects of some root end filling materials. Journal of Endodontics, 1995. 21(8): p. 403-406. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18118 | - |
| dc.description.abstract | 傳統型根管封填材料主要以馬來膠錐體( Gutta-percha )搭配各類傳統根管封填劑，然而馬來膠錐體及各類傳統封填劑之間黏著力不足，根管封填劑和牙本質之黏著亦不理想，因此無法達到有效根管密封的目的。本研究團隊以聚己二酸丁二醇( Polybutylene adipate, PBA )合成之聚胺酯根管封填材料在臨床操作上有極佳的機械性質及熱性質，並且與牙本質有非常好的鍵結，可達到良好密封性的目的，但此類材料接觸組織液時，仍有水解之疑慮。
本研究乃利用聚胺酯及胺酯壓克力樹脂徑而開發新穎牙科根管充填材料。實驗主要分為兩部份，第一部分為根管封填錐體，首先探討聚四亞甲基醚二醇( Polytetramethylene oxide, PTMO )合成低水解根管封填錐體材料，結果顯示其熔點低於體溫不利臨床操作，因此以PBA-based進行後續聚胺酯合成，並利用熱塑性聚胺酯做為基材以化學鍵結方式接枝氯己定( Chlorhexidine, CHX )；第二部份為根管封填劑，是利用紫外光硬化之胺酯壓克力樹脂做為基材並以化學鍵結方式接枝氯己定，及使用三丙烯乙二醇雙丙烯酸脂( Tripropylene glycol diacrylate, TPGDA )做為稀釋單體，提高胺酯壓克力樹脂於牙科根管封填劑上之可行性。並使用傅立葉轉換紅外線光譜儀( Fourier-Transformed Infrared Spectrometer, FTIR )、核磁共振儀( Nuclear magnetic resonance, NMR )證實氯己定以化學鍵結方式接枝在基材上；熱重損失分析儀( Thermo Gravimetric Analysis, TGA )、微差掃瞄卡計儀( Differential Scanning Calorimetry, DSC )顯示其熱裂解溫度及熔點符合臨床操作溫度；細胞毒性結果顯示都優於ISO 10993-5的規範；抗菌結果可以發現改質後的根管封填材料都具有抗菌性，並在濃度0.6 wt%時達到一穩定較佳的抗菌效果。 | zh_TW |
| dc.description.abstract | Conventional root canal materials do not have enough dentinal adhesion and cannot achieve the ideal sealing properties with cone materials. Our research team have developed the polyurethane root canal obturation system containing PBA polyol-based cone materials and dual cured urethane acrylate sealer. Although these materials have good mechanical properties and bonding strength to dentin, the cytotoxicity and hydrolytic stability are questioned.
The purpose of this study was to develop a novel polyurethane-based root obturation material, including cone and sealer materials. At first, we developed the low hydrolytic polyurethane cone material by replacing the PBA polyol with PTMO polyol and investigated the thermal properties. The results showed that the PTMO-based polyurethane cone material cannot be used in human body because the low melting point. Thus, cone materials was synthesized from polyester-type polyol and covalently bonded with CHX. For the sealer materials, ultraviolet-light photo polymerization urethane-acrylate oligomer was synthesized and covalently bonded with CHX to mix with dilute monomer to form UA/TPGDA resin. From FT-IR and NMR analysis, CHX have covalently bonded with matrix. TGA and DSC showed thermal properties appropriate for the clinical temperature. The consequences of the Cytotoxicity was better than ISO 10993-5 standard and antibacterial evaluation revealed that 0.6 wt% reached to a stable antibacterial effect. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T00:51:45Z (GMT). No. of bitstreams: 1 ntu-104-R02549017-1.pdf: 3051093 bytes, checksum: 790479daccd752ea0e5c366faef00b98 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 致謝 I
摘要 II Abstract III 目錄 IV 圖目錄 VIII 表目錄 X 第一章 緒論 1 1.1 前言 1 1.2 研究目的 4 第二章 文獻回顧 5 2.1 理想的根管封填 5 2.2 傳統根管封填材料的發展 6 2.2.1 根管封填錐體材料( cone materials ) 6 2.2.2 根管封填劑材料( sealer materials ) 7 2.3 高分子根管封填系統 8 2.3.1 ResilonTM/ EpiphanyTM根管封填系統 8 2.3.2 EndoREZTM根管封填系統 11 2.4 聚胺酯材料作為高分子根管封填系統的潛力 12 2.4.1 熱塑性聚胺酯( thermoplastic polyurethane ) 12 2.4.2 本研究團隊初步試驗結果 13 2.5 根管材料生物相容性之測試 14 2.5.1 AlamarBlue assay 15 2.5.2 LDH assay 16 2.6 根管材料之抗菌測試 16 2.6.1 瓊脂凝膠擴散法( Agar diffusion test ) 16 2.6.2 直接接觸法( Direct contact test ) 17 2.6.3 細菌計數法 17 第三章 實驗方法 19 3.1 實驗藥品 19 3.2 實驗儀器 23 3.3 實驗步驟 26 3.3.1 低水解聚胺酯根管封填錐體製備 26 3.3.2 抗菌改質根管封填錐體 27 3.3.3 抗菌改質根管封填劑 30 3.4 材料性質測試 32 3.4.1 傅立葉轉換紅外線光譜儀( Fourier Transformed Infrared Spectra, FT-IR )分析測試 32 3.4.2 熱重分析儀( Thermo Gravimetric Analysis, TGA )分析測試 32 3.4.3 微差掃描卡計儀( Differential Scanning Calorimetry, DSC )分析測試 32 3.4.4 核磁共振儀( Nuclear magnetic resonance, NMR )分析測試 33 3.5 材料細胞毒性測試 33 3.5.1 磷酸鹽緩衝溶液配製 33 3.5.2 3T3纖維母細胞培養基配製 33 3.5.3 Trypsin配製 34 3.5.4 解凍細胞 34 3.5.5 細胞計數 34 3.5.6 細胞繼代培養 35 3.5.7 材料樣本與萃取液製備 36 3.5.8 LDH assay 37 3.5.9 AlamarBlue assay 38 3.6 材料抗菌測試 39 3.6.1 培養基配製 39 3.6.2 菌種培養 39 3.6.3 細菌計數 40 3.6.4 材料樣品製備 41 3.6.5 抗菌測試 42 3.7 統計分析 42 第四章 結果與討論 43 4.1 傅立葉轉換紅外線光譜分析 43 4.1.1 低水解聚胺酯材料之傅立葉轉換紅外線光譜分析 43 4.1.2 抗菌改質根管封填錐體之傅立葉轉換紅外線光譜分析 44 4.1.3 抗菌改質根管封填劑之傅立葉轉換紅外線光譜分析 47 4.2 熱重分析儀分析 49 4.3 微差掃描卡計儀分析 52 4.4 核磁共振儀分析 55 4.4.1 抗菌改質根管封填錐體之核磁共振分析 55 4.4.2 抗菌改質根管封填劑之核磁共振分析 60 4.5 根管封填材料之細胞毒性分析 63 4.5.1 AlamarBlue assay 63 4.5.2 LDH assay 64 4.5.3 根管封填材料細胞毒性之探討 66 4.6 根管封填材料之抗菌分析 68 4.6.1 Antibacterial assay for drop-plating method 68 4.6.2 根管封填材料抗菌性質之探討 70 第五章 結論 71 參考文獻 72 | |
| dc.language.iso | zh-TW | |
| dc.title | 研發新型抗菌改質熱塑性聚胺酯及胺酯壓克力樹脂材料於牙科根管充填 | zh_TW |
| dc.title | Development of novel antibacterial-modified thermoplastic polyurethane and urethane-acrylate materials for dental root canal filling | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 謝國煌 | |
| dc.contributor.oralexamcommittee | 張志豪,林弘萍,章浩宏 | |
| dc.subject.keyword | 牙科根管充填,熱塑性聚胺酯,胺酯壓克力樹脂,細胞毒性,抗菌性質, | zh_TW |
| dc.subject.keyword | Root canal filling,Thermoplastic polyurethane,Urethane-acrylate resin,Cytotoxicity,Antibacterial effect, | en |
| dc.relation.page | 80 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2015-06-29 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-104-1.pdf 目前未授權公開取用 | 2.98 MB | Adobe PDF |
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