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標題: | 雷射針灸刺激引起之
大腦預設模式網路改變的初步研究 Preliminary Research: the Alternations in Default Mode Network Induced by Laser Acupuncture |
作者: | Chun-Hao Tseng 曾俊豪 |
指導教授: | 陳志宏 |
關鍵字: | 雷射針灸,靜息態功能性磁振造影,功能性連結,大腦預設模式網路, Laser acupuncture,Resting-state functional magnetic image,Functional connectivity,Default mode network, |
出版年 : | 2012 |
學位: | 碩士 |
摘要: | 中文摘要
針灸刺激對人體的影響可分為短時間的即時效應與長時間的持續性效應,過去的針灸相關研究因實驗方法的限制都以即時效應為主。然而,隨著靜息態磁振造影(resting-state functional magnetic resonance image)的發展,利用其不需執行作業的特性,傳統針灸的持續性研究已有進展。但是雷射針灸的持續性效應仍無直接證據,故本研究以探討雷射針灸的持續性效應為主要目的。 本研究所選定的雷射針灸刺激穴位是左腳湧泉穴。19個慣用右手且無中樞神經系統疾病的健康受試者參與本研究。靜息態的大腦預設模式網路是使用後扣帶皮層(posterior cingulate cortex)為種子點,進而獲得種子點與其他腦區的時間相關性。 研究結果發現,血氧濃度相依對比與大腦預設模式在左側前腦島(Anterior insula)都有顯著增加。此外,在記憶功能上扮演重要角色的海馬迴也是雷射針灸刺激所活化的腦區。本研究的成果首次展示雷射針灸刺激的持續性效應,在刺激停止後仍然產生大腦預設模式網路的改變。 ABSTRACT The instant effect and sustained effect are all induced by acupuncture stimulating. The former denotes the effect is occurred immediately while the acupuncture is stimulating, the latter denotes the effect is still functioning after the acupuncture stimulate is accomplished. The instant effect was the major research topic in the past two decades; however, the development of resting state fMRI study brings up the opportunity to investigate the task-free brain activities, such as sustained effect. Although the sustained effect of traditional acupuncture stimulating was reported in some studies, there are no direct evidence to reveal the sustain effect of the laser acupuncture. Therefore, I am aiming to investigate the sustain effect of laser acupuncture stimulating in this study. The acupoint Yongquan, locate at the sole of left foot, was stimulated in this study. All of 19 healthy subjects participate in this study. The default mode network (DMN) was obtain by calculating the temporal correlation between the seed point posterior cingulate cortex and the other brain regions. In the results, both of the BOLD contrast of laser acupuncture stimulating and the functional connectivity of DMN after laser acupuncture stimulated showed the greater activation in anterior insula. Moreover, BOLD contrast of laser acupuncture stimulating showed the greater activation in hippocampus, which plays an important role in the memory. In summary, this study demonstrates the sustain effect of laser acupuncture stimulating, which showed the increase functional connectivity of DMN after acupuncture stimulating. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15765 |
全文授權: | 未授權 |
顯示於系所單位: | 電機工程學系 |
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