請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10704
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 戴子安(Chi-An Dai) | |
dc.contributor.author | Chien-Chun Chen | en |
dc.contributor.author | 陳建鈞 | zh_TW |
dc.date.accessioned | 2021-05-20T21:51:29Z | - |
dc.date.available | 2012-08-04 | |
dc.date.available | 2021-05-20T21:51:29Z | - |
dc.date.copyright | 2010-08-04 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-29 | |
dc.identifier.citation | 1. Department of Health, Executive Yuan, R.O.C.(Taiwan)
2. Kessler, J., EXPERIMENTS IN REFILLING THE LENS. Arch Ophthalmol 1964, 71, 412-7. 3. Reiner, J.; Speicher, L., Properties of injectable intraocular lenses. Klin Monbl Augenheilkd 1993, 202, (1), 49-51. 4. Assia, E. I., Accommodative intraocular lens: a challenge for future development. J CATARACT REFRACT SURG 1997, 23, (4), 458-60. 5. Parel, J.; Gelender, H.; Trefers, W.; Norton, E., Phaco-Ersatz: Cataract surgery designed to preserve accommodation. Graefe's Archive for Clinical and Experimental Ophthalmology 1986, 224, (2), 165-173. 6. Agarwal, M.; Gunasekaran, R. A.; Coane, P.; Varahramyan, K., Polymer-based variable focal length microlens system. Journal of Micromechanics and Microengineering 2004, 14, 1665-1673. 7. Norrby, S.; Koopmans, S.; Terwee, T., Artificial crystalline lens. Ophthalmol Clin North Am 2006, 19, (1), 143-6, vii. 8. Hettlich, H. J.; Lucke, K.; Kreiner, C. F., Light-induced endocapsular polymerization of injectable lens refilling materials. Ger J Ophthalmol 1992, 1, (5), 346-9. 9. de Groot, J. H.; van Beijma, F. J.; Haitjema, H. J.; Dillingham, K. A.; Hodd, K. A.; Koopmans, S. A.; Norrby, S., Injectable Intraocular Lens Materials Based upon Hydrogels. Biomacromolecules 2001, 2, (3), 628-634. 10. Han, Y. K.; Kwon, J. W.; Kim, J. S.; Cho, C. S.; Wee, W. R.; Lee, J. H., In vitro and in vivo study of lens refilling with poloxamer hydrogel. Br J Ophthalmol 2003, 87, (11), 1399-402. 11. Ji Won, K.; Young Keun, H.; Woo Jin, L.; Chong Su, C.; Seung Joon, P.; Dong Il, C.; Jin Hak, L.; Won Ryang, W., Biocompatibility of poloxamer hydrogel as an injectable intraocular lens: A pilot study. Journal of cataract and refractive surgery 2005, 31, (3), 607-613. 12. Escobar-Chavez, J. J.; Lopez-Cervantes, M.; Naik, A.; Kalia, Y. N.; Quintanar-Guerrero, D.; Ganem-Quintanar, A., Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations. J Pharm Pharm Sci 2006, 9, (3), 339-58. 13. de Groot, J. H.; Spaans, C. J.; van Calck, R. V.; van Beijma, F. J.; Norrby, S.; Pennings, A. J., Hydrogels for an Accommodating Intraocular Lens. An Explorative Study. Biomacromolecules 2003, 4, (3), 608-616. 14. Aliyar, H. A.; Hamilton, P. D.; Ravi, N., Refilling of ocular lens capsule with copolymeric hydrogel containing reversible disulfide. Biomacromolecules 2005, 6, (1), 204-11. 15. Matsuda, T.; Funae, Y.; Yoshida, M.; Yamamoto, T.; Takaya, T., Optical material of high refractive index resin composed of sulfur-containing aromatic methacrylates. Journal of Applied Polymer Science 2000, 76, (1), 50-54. 16. Kyprianidou-Leodidou, T.; Caseri, W.; Suter, U. W., Size Variation of PbS Particles in High-Refractive-Index Nanocomposites. The Journal of Physical Chemistry 1994, 98, (36), 8992-8997. 17. Rogers, H. G.; Gaudiana, R. A.; Hollinsed, W. C.; Kalyanaraman, P. S.; Manello, J. S.; McGowan, C.; Minns, R. A.; Sahatjian, R., Highly amorphous, birefringent, para-linked aromatic polyamides. Macromolecules 1985, 18, (6), 1058-1068. 18. 傅雅卿; 林唯芳, Synthesis and Physical Properties of High Refractive Index Epoxy Resins 國立台灣大學材料科學與工程學研究所碩士學位論文 2001. 19. Yoshida, M.; Lal, M.; Kumar, N.; Prasad, P., TiO2 nano-particle-dispersed polyimide composite optical waveguide materials through reverse micelles. Journal of Materials Science 1997, 32, (15), 4047-4051. 20. 周德瑜; 蔣孝澈, 四氯化鈦之控制水解研究 國立中央大學化學工程研究所碩士論文 2001. 21. 鍾寶堂; 蔣孝澈, 氧化鈦奈米粒子之表面改質與分散. 國立中央大學化學工程研究所碩士論文 2005. 22. Yang, J.; Mei, S.; Ferreira, J. M. F., In situ preparation of weakly flocculated aqueous anatase suspensions by a hydrothermal technique. Journal of Colloid and Interface Science 2003, 260, (1), 82-88. 23. Yang, J.; Mei, S.; Ferreira, J. M. F., Hydrothermal synthesis of TiO2 nanopowders from tetraalkylammonium hydroxide peptized sols. Materials Science and Engineering: C 2001, 15, (1-2), 183-185. 24. Sasirekha, N.; Rajesh, B.; Chen, Y.-W., Synthesis of TiO2 sol in a neutral solution using TiCl4 as a precursor and H2O2 as an oxidizing agent. Thin Solid Films 2009, 518, (1), 43-48. 25. Moore, D. T., Gradient-index optics: a review. Appl Opt 1980, 19, (7), 1035-8. 26. Ohtsuka, Y.; Sugano, T., Studies on the light-focusing plastic rod. 14: GRIN rod of CR-39-trifluoroethyl methacrylate copolymer by a vapor-phase transfer process. Appl Opt 1983, 22, (3), 413-7. 27. Liu, J. H.; Liu, H. T.; Cheng, Y. B., Preparation and characterization of gradient refractive index polymer optical rods. Polymer 1998, 39, 5549-5552. 28. Krug, H.; Tiefensee, F.; Oliveira, P. W.; Schmidt, H. K. In Organic-inorganic composite materials: optical properties of laser-patterned and protective-coated waveguides, Sol-Gel Optics II, San Diego, CA, USA, 1992; SPIE: San Diego, CA, USA, 1992; pp 448-455. 29. Duijnhoven, F. v.; Bastiaansen, C., Gradient Refractive Index Polymers Produced in a Centrifugal Field. Advanced Materials 1999, 11, (7), 567-570. 30. J.S. Shirk; M. Sandrock; D. Scribner; E. Fleet; R. Stroman; E. Baer; Hiltner, A., Biomimetic Gradient Index (GRIN) Lenses. FEATURED RESEARCH 2006, 53-61. 31. Wang, W.; Fang, J.; Varahramyan, K. In Controlling nanoparticle distribution in hydrogel by electrophoresis for gradient refractive index lens applications, Organic Photonic Materials and Devices VII, San Jose, CA, USA, 2005; SPIE: San Jose, CA, USA, 2005; pp 344-351. 32. Niu, G.; Zhang, H.; Song, L.; Cui, X.; Cao, H.; Zheng, Y.; Zhu, S.; Yang, Z.; Yang, H., Thiol/Acrylate-Modified PEO-PPO-PEO Triblocks Used as Reactive and Thermosensitive Copolymers. Biomacromolecules 2008, 9, (10), 2621-2628. 33. Fisher, R. F., The elastic constants of the human lens. The Journal of Physiology 1971, 212, (1), 147-180. 34. Cheng, H.; Ma, J.; Zhao, Z.; Qi, L., Hydrothermal Preparation of Uniform Nanosize Rutile and Anatase Particles. Chemistry of Materials 1995, 7, (4), 663-671. 35. Chau, J. L. H.; Lin, Y.-M.; Li, A.-K.; Su, W.-F.; Chang, K.-S.; Hsu, S. L.-C.; Li, T.-L., Transparent high refractive index nanocomposite thin films. Materials Letters 2007, 61, (14-15), 2908-2910. 36. Larson, I.; Drummond, C. J.; Chan, D. Y. C.; Grieser, F., Direct force measurements between titanium dioxide surfaces. Journal of the American Chemical Society 1993, 115, (25), 11885-11890. 37. Koopmans, S. A.; Terwee, T.; Barkhof, J.; Haitjema, H. J.; Kooijman, A. C., Polymer Refilling of Presbyopic Human Lenses In Vitro Restores the Ability to Undergo Accommodative Changes. Invest. Ophthalmol. Vis. Sci. 2003, 44, (1), 250-257. 38. My Eye World (http://www.myeyeworld.com/files/eye_structure.htm) 39. Royal National Institute for the Blind (http://www.jwgrundy.co.uk/cataracts.htm) 40. The Center for Eye Care (http://lasikbiloxi.com/services/iol/) 41. Lerman, S., Radiant Energy and the Eye. MacMillan Publishing Company 1980, chap 2 42. Kabanov, A. V.; Batrakova, E. V.; Alakhov, V. Y., Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. Journal of Controlled Release 2002, 82, (2-3), 189-212. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/10704 | - |
dc.description.abstract | 此篇論文中揭示了一種注入型水晶體材料的開發與光學性質之量測。本實驗以尾端改質且具熱敏感性之泊洛沙姆(Poloxamer)高分子為主體,藉由光起始作用進行交聯,以形成人工水晶體材料。泊洛沙姆之尾端氫氧官能基經由丙烯酰氯反應而形成具有丙烯酸官能基高分子,並經由核磁共振(NMR)及紅外光吸收光譜(FTIR)確認。由於泊洛沙姆高分子具有溶液-凝膠轉變的現象,而凝膠狀態可以防止材料注入水晶體時所造成的滲漏現象。改質過後的泊洛沙姆高分子其溶液-凝膠轉變溫度在濃度低於20%時高於未改質之泊洛沙姆高分子,但濃度若高於22%時則兩者表現幾乎相同。經由光起始交聯的泊洛沙姆水膠的楊氏係數會隨著水膠中未改質的泊洛沙姆高分子比例的增加或紫外光起始時間的減少,其楊氏係數會由230kPa降低到18kPa,但光起始劑濃度的影響卻不明顯。
為了增加泊洛沙姆水膠的折射度以符合水晶體需求,在水膠中加入利用四氯化鈦為原料所製作出的奈米二氧化鈦粒子。四氯化鈦經由水解、中和、沈澱、過濾及膠解的過程,可以做出分散在水溶液狀態下的奈米二氧化鈦粒子溶液。根據泊洛沙姆水膠中奈米二氧化鈦粒子濃度的增加,折射率會從原本的1.355提升至1.407,且含有奈米二氧化鈦粒子之泊洛沙姆水膠在可見光範圍皆有良好的穿透度(~90%),約略等於人類5歲時水晶體的穿透度。 在變焦實驗中,填入高折射率的泊洛沙姆水膠水晶體囊袋其焦距變化(2.53D)比填入低折射率的水晶體囊袋變化(0.87D)來的大,但平均變焦比例幾乎相同(16.57%),且皆高於人體水晶體(8.37%)。 此論文中也利用電場擴散的方法來模擬人體水晶體中的折射梯度結構的製作。實驗結果證明,利用電場法在低電場強度時即可使奈米二氧化鈦粒子以輻射的方式進行擴散,形成折射梯度之結構。最後藉由光起始交聯的網狀結構使奈米二氧化鈦粒子被固定在泊洛沙姆水膠中,使具有折射梯度之結構被固定。實驗結果也可看出折射梯度的形成能夠提升透鏡成像之品質。利用以上之實驗結果,我們研發出一種有機/無機混合之新穎性材料,對於人工水晶體之研發具有相當之潛力。 | zh_TW |
dc.description.abstract | In this study, the potentiality to investigate hydrogel which can be injected into crystalline lens is studied. Hydrogel base on thermo-sensitive poloxamer 407 block copolymer is prepared by photo-polymerization. The terminal hydroxyl groups in poloxamer 407 are acrylated to form poloxamer 407 macromer as the reactive polymer, and is confirmed using NMR and FTIR spectrometry. The lower critical sol-gel temperature of poloxamer 407 macromer is higher than poloxamer 407 itself when the concentration is below 20%, but not significant above 22%. The Young’s modulus would be decreased according to the higher ratio of poloxamer 407 that in poloxamer hydrogel or shorter UV irradiation times, but the concentration of photo initiator is not significant.
In order to increase the refractive index of poloxamer hydrogel, titanium dioxide nanoparticle is introduced using the titanium (Ⅳ) chloride as titanium source. Titanium chloride through the process of hydrolysis, adjust pH, precipitate and acid-peptization can get the rutile phase titanium dioxide nanoparticles solution. The refractive index of poloxamer hydrogel can increase from 1.355 to 1.407 according to the concentration of titanium dioxide nanoparticles, and all samples had a good transmission (~90%) comparable to a 5-year-old natural crystalline lens. Stretch and unstretch experiment shows the PDMS capsule which filled with the highest refractive index poloxamer hydrogel has the largest change of diopter (2.53D), and the lowest refractive index poloxamer hydrogel shows the smallest change (0.87D). The average change ability is 16.57%, better than the human crystalline lens, about 8.37%. The gradient refractive index structure in the human crystalline lens also reconstruct by using the electric field method. The distribution of titanium dioxide nanoparticles can be controlled by electric field in poloxamer hydrogel, which presents the radial gradient refractive index profiles. Finally we cross-linked poloxamer hydrogel that the gradient refractive index structure can be maintained. The experiment data also show the gradient refractive index does have the ability to increase the image quality. The novel organic/inorganic hybrid materials show the potential to be used for crystalline lens applications. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T21:51:29Z (GMT). No. of bitstreams: 1 ntu-99-R97524024-1.pdf: 1898969 bytes, checksum: d56097da771e3314a6ba444172846e34 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 誌謝 I
中文摘要 II Abstract IV Table of Contents VI List of Figures VIII List of Tables XI Chapter 1 Introduction 1 Chapter 2 Paper review 3 2.1. Injectable materials 3 2.1.1. Silicon gelation 4 2.1.2. Hydrogel 5 2.1.2.1. Pluronic tri-block-co-polymers10-12 6 2.1.3. Polyurethane 7 2.1.4. Disulfide gelation 7 2.2. The high refractive index materials 8 2.2.1 Titanium dioxide20, 21 8 2.3. Gradient refractive index (GRIN) structure 10 Chapter 3 Experiment 13 3.1. Experiment materials 13 3.2. Experiment Instruments 14 3.3. Experimental Procedure 16 3.4. Experiment Methods 17 3.4.1. Modification of the terminal groups of poloxamer 40732 17 3.4.2. The lower critical sol-gel temperature of poloxamer hydrogel 18 3.4.3. The mechanism property of poloxamer hydrogel 19 3.4.4. Preparing the titanium dioxide nanoparticles 20 3.4.5. Refractive index of poloxamer/titanium dioxide nanoparticles hybrids 21 3.4.6. Measuring the focal length based on PDMS capsule 22 3.4.7. Reconstruct the 1-dimension gradient refractive index structure 23 3.4.7.1. The Fick’s law diffusion method 23 3.4.7.2. The centrifuged method 23 3.4.7.3. The electric field method 23 3.4.8. The image quality tests 24 Chapter 4 Results and Discussion 25 4.1. Modification of the terminal groups of poloxamer 407 25 4.2. The lower critical sol-gel temperature of poloxamer hydrogel 26 4.3. The mechanism properties of poloxamer hydrogel 27 4.4. Identification of titanium dioxide nanoparticles 28 4.5. Absorption and transparency of poloxamer hydrogel 29 4.6. Refractive index of poloxamer/titanium dioxide nanoparticles hybrids 30 4.7. Reconstruct the gradient refractive index structure using different methods 32 4.8. Measuring the focal length based on PDMS capsule 36 4.9. The image quality tests 38 Chapter 5 Conclusion 39 Chapter 6 References 41 | |
dc.language.iso | en | |
dc.title | 利用具有自組裝能力之兩性高分子及奈米粒子混參材料製作軟性仿生透鏡 | zh_TW |
dc.title | Bionic Soft Lens Materials Based on Self-Assembling Amphiphilic Block Copolomer/Nanoparticle Hybrids | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 何國川(Kuo-Chuan Ho),吳嘉文(Chia-Wen Wu),施文彬(Wen-Pin Shih),張國華 | |
dc.subject.keyword | 泊洛沙姆水膠,溶液-凝膠,奈米二氧化鈦粒子,折射梯度,可注射式材料, | zh_TW |
dc.subject.keyword | poloxamer hydrogel,lower critical sol-gel temperature,titanium dioxide nanoparticles,gradient refractive index,injectable materials, | en |
dc.relation.page | 67 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2010-07-30 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
顯示於系所單位: | 化學工程學系 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-99-1.pdf | 1.85 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。