以丙二酸二酯建構可受雙重調控之酯類車輪烷型分子開關

Abstract

丙二酸二酯在鈉離子的協助下可以穿進含二乙二醇結構之大環分子的空腔中，並藉由數種不同的末端封鎖反應將之製備為車輪烷分子。我們利用這個新的分子辨識體系建構了一個可受雙重調控的分子開關，通過質子或鈉離子的添加與移除，其內鎖大環可以在丙二酸與四級銨陽離子的兩站間進行移動。

Malonate diesters act as a new recognition unit to thread into the cavity of a di(ethylene glycol)-containing macrocycle under the templating effect of a Na+ ion; the corresponding rotaxanes can be synthesized efficiently through several stoppering reactions. A molecular switch constructed with two rare recognition units (i.e. malonate and tetraalkylammonium) in which the interlocked macrocycle was manipulated through the addition of acid / base and the presence / absence of Na+ ions.