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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江文章 | |
dc.contributor.author | Shin-Chiai Chen | en |
dc.contributor.author | 陳欣喬 | zh_TW |
dc.date.accessioned | 2021-05-20T20:01:15Z | - |
dc.date.available | 2010-02-04 | |
dc.date.available | 2021-05-20T20:01:15Z | - |
dc.date.copyright | 2010-02-04 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-12-30 | |
dc.identifier.citation | 吉田清尚,相良長輝。1919。薏苡仁の成分に就て。東京化學會誌 40: 483-498。
六城雅彙、西原哲三、浮田忠之進、井口定男。1950。各種藥物の吉田肉腫にすろ增殖阻止作用。Gann (Japanese J. Cancer Res.) 41: 91-92. 松島義一。1952。ハトムギの研究-1 .その脂肪油成分並にパルミチン酸の藥理學的作用に就こ。日藥理誌。48: 109-126。 小山鷹二,大和正利。1955a。じゆずたま屬植物成分の研究第一報 (じゆずたまCoix Lachryma-jobi L. 根の成分に就いて)。藥學雜誌75: 699-701。 小山鷹二,大和正利。1955b。じゆずたま屬植物成分の研究第二報 (じゆずたまCoixolの構造に就いて)。藥學雜誌75: 702-704。 中山宗春。1960。薏苡仁抗癌作用之研究。日本外科學會誌。61: 234。 鈴木雅子,奧山清美。1977。ハトムギのえぐ味成分,3,4-ジヒドロオキシベ ソズアルデヒド配糖体の檢索。榮養と食糧 30: 419-421。 鄭丙祥,鈴木平光,早川清一,金振昊,西澤幸雄。1988。ハトムギ中の血漿コレステロ-ル低下作用をもっ成分について。日食工誌。35: 618-623。 石黑幸雄,岡本賢治,阪本秀樹,園田洋次。1993。ハトムギもやし由來の新規抗菌性物質Coixinden A, B。Nippon Nogeikagaku Kaishi 67: 1405-1410。 高德錚與梁純玲。1986。省產薏苡品質之檢定。台中農業改良產研究彙報 13:11-18。 李時珍(明)。1990。本草綱目。大台北出版社。台北。 沈玉峰,周玉新,樓獻文,王清海,周良模。1991。超臨界流體色譜對油脂的分離測定。色譜 9(6):379-382。 李鳳云,陳浩然,馮曉東,柳世英,姜力。1994。中藥薏苡仁抗腫瘤作用的研究。實用腫瘤學雜誌 3 : 59。 黃士禮,陳瑤峯,江文章。1994。省產薏苡籽實中氨基酸、脂肪酸和一般組成分分析。食品科學 21(1):67-74。 李大鵬。1996。康萊特注射液治療原發性肺癌臨床報告。中醫雜誌 37:411-414。 黃士禮。1996。薏苡籽實貯藏條件、抗突變效應及抗腫瘤效應之研究。國立臺灣大學食品科技研究所博士論文。台北。 蔡至宏。1997。薏苡種皮水溶性物質之抗致突變性及其分離與純化。國立臺灣大學食品科技研究所碩士論文。台北。 徐明麗。1998。薏仁抗過敏與抗腫瘤之研究。國立臺灣大學食品科技研究所碩士論文。台北。 簡雅琳。1998。薏苡殼油溶性萃取物的抗突變性成分之分離與純化。國立臺灣大學食品科技研究所碩士論文。台北。 雷正杰,張忠義,王鵬,吳惠勤。1999。薏苡仁油脂肪酸組成分析。中藥材22(8): 405。 黃士禮與江文章。1999。薏以籽實各部位之組成及其丙酮萃取液之抗突變作 用。食品科學 26(2):121-130. 林方宜。1999。薏苡種皮油溶性成分之分離與純化。國立臺灣大學食品科技研 究所碩士論文。台北。 江文章,徐明麗,蘇瑞斌,龐飛。2000。薏仁加工食品輔助抑制腫瘤功效之評估。醫護科技學刊2:113-122。 劉桂萍。2000。薏苡殼甲醇萃取物清除自由基成分之分離與純化。國立臺灣大學食品科技研究所碩士論文。台北。 夏詩閔。2001。薏苡籽實萃取物對於大鼠卵巢性類固醇激素以及腦下腺黃體促進素和濾泡刺激素分泌之效應。國立臺灣大學食品科技研究所碩士論文。台北。 郭靜娟。2001。薏苡籽實之抗氧化成分及其抑制自由基傷害之研究。國立臺灣大學食品科技研究所博士論文。台北。 葉芝嵐。2002。薏苡殼醇類萃取物對大鼠卵巢性類固醇激素分泌之效應。國立臺灣大學食品科技研究所碩士論文。台北。 施純光。2004。薏仁對大腸癌形成之影響。國立臺灣大學食品科技研究所博士論文。台北。 李文聖。2004。生化柴油製程之監測。國立臺灣大學生物産業機電工程學系暨研究所碩士論文。台北。 向智敏,祝明,陳碧蓮,陳勇。2005。HPLC-MS分析薏苡仁油中的甘油三酯 成分。中國中藥雜誌 30(18):1436-1437。 何崇麟。2005。單一菌株 ( Rhodococcus erythropolis NTU1 ) 與混合菌株 ( TN-4 ) 處理正十四烷之研究。臺灣大學化學工程學研究所碩士論文。台北 李明怡。2008。薏仁麩皮中防癌及抗發炎活性成分之分離與鑑定。國立臺灣大學食品科技研究所博士論文。台北。 Akihisa T, Yasukawa K, Yamaura M, Ukiya M, Kimura Y, Shimizu N, Arai K. 2000. Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects. J Agric Food Chem 48 (6): 2313–2319. Anders DE and Robinson WE. 1971. Cycloalkane constituents of the bitumen from Green River Shale. Geochim Cosmochim Acta 35(7): 661-678. Mitaine-Offer AC, Hornebeck W, Sauvain M, Zeches-Hanrot M. 2002. Triterpenes and phytosterols as human leucocyte elastase inhibitors. Planta Med 68: 930-932. Arrieta J, Reyes B, Calzada F, Cedillo-Rivera R, Navarrete A. 2001. Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun. Fitoterapia 72(3): 295-297. Arrieta J, Benitez J, Flores E, Castillo C, Navarrete A. 2003. Purification of gastroprotective triterpenoids from the stem bark of Amphipterygium adstringens; role of prostaglandins, sulfhydryls, nitric oxide and capsaicin-sensitive neurons. Planta Med 69(10): 905-909. Ary MB, Shewry PR, Richardson M. 1988. The amino acid sequence of a cereal Bowman-birk type trypsin inhibitor from seeds of Job's tears (Coix lachryma-jobi L.). FEBS Lett 229(1): 111-118. Block S, Baccelli C, Tinant B, Meervelt L, Rozenberg R, Jiwan JL, Llabres G, Pauw-Gillet MC, Quetin-Leclercq J. 2004. Diterpenes from the leaves of Croton zambesicus. Phytochemistry 65(8): 1165-1172. Bradshaw HB and Walker JM. 2005. The expanding field of cannabimimetic and related lipid mediators. Br J Pharmacol 144(4): 459-465. Browser J, McCourt PJ, Somerville CR. 1986. Fatty acid composition of leaf lipids determined after combined digestion and fatty acid methyl ester formation from fresh tissue. Anal Biochem 152(1): 141-145. Cao S, Radwan MM, Norris A, Miller JS, Ratovoson F, Mamisoa A, Andriantsiferana R, Rasamison VE, Rakotonandrasana S, Kingston DGI. 2006. cytotoxic and 0ther compounds from didymochlaena truncatula from the madagascar rain forest. J Nat Prod 69 (2): 284-286. Chang KC, Duh CY, Chen IS, Tsai IL. 2003. A Cytotoxic butenolide, two new dolabellane diterpenoids, a chroman and a benzoquinol derivative Formosan Casearia membranacea. Planta Med 69(7): 667-672. Chen ZP, Cai Y, Phillipson JD. 1994. Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon's blood. Planta Med 60(6): 541-545. Chen JJ, Huang YC, Chen YC, Huang YT, Wang SW, Peng CY, Teng CM, Chen IS. 2002. Cytotoxic amides from piper sintenense. Planta Med 68(11): 980-985. Chen. JJ, Huang HY, Duh CY, Chen IS. 2003. Cytotoxic Constituents of Piper sintenense. Helv Chim Acta 86(6): 2058-2064. Chen. JJ, Huang HY, Duh CY, Chen IS. 2004. Cytotoxic Constituents from the sem bark of zanthoxylum pistaciiflorum. J Chin Chem Soc 51(3): 659-663. Chen. JJ, Lin RW, Huang HY, Duh CY, Chen IS. 2004. Flavones and cytotoxic constituents from the stem bark of muntingia calabura. J.Chin Chem Soc 51(3): 665-670. Chen JJ, Duh CY, Chen IS. 2005. Cytotoxic chromenes from Myriactis humilis. Planta Med 71(4): 370-372. Chen JJ, Chou ET, Duh CY, Yang SZ, Chen IS. 2006. New cytotoxic tetrahydrofuran- and dihydrofuran-type lignans from the stem of Beilschmiedia tsangii. Planta Med 72(4): 351-357. Christie WW. 1972. In topics in lipid chemistry (Gunstone, F. D., ed.). Paul Elek (Scientific Books), London. Vol. 3, pp. 171-197. Coussens LM, Werb Z. 2002. Inflammation and cancer. Nature 420(6917): 860-867. Coyne L, Lees G, Nicholson RA, Zheng J, Neufield KD. 2002. The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. Br J Pharmacol 135(8): 1977-1987. Cuzick J, Otto F, Baron JA, Brown PH, Burn J, Greenwald P, Jankowski J, La Vecchia C, Meyskens F, Senn HJ, Thun M.Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol 10(5): 501-507. Duh CY, Chen IS, Tsai IL, Chang KC. 2003.A Cytotoxic Butenolide, Two new dolabellane diterpenoids, a chroman and a benzoquinol derivative Formosan casearia membranacea. Planta Med 69(7): 667-672. Duke JA. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. CRC Press. Boca Raton. Florida. Diels O and Alder K. 1928. Synthesen in der hydroaromatischen Reihe. Liebigs Annalen der Chemie 460 (1): 98-122. Faizi S, Siddiqui B, Saleem R, Aftab K, Shaheen F, Gilani AH. 1998. Hypotensive Constituents from the Pods of Moringa oleifera. Planta Med 64(3): 225-228. Ghafouri N, Tiger G, Razdan RK, Mahadevan A, Pertwee RG, Martin BR, Fowler CJ. 2004. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol 143(6): 774-784. Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massagué J. 2007. ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A.104(49): 19506-19511. Han JS, Rhee AH, Cheigh HS. 1987. A study on composition of polar lipid in adlay. Korean J Food Soc Technol 16(1): 29-35. Han JS, Rhee AH, Cheigh HS. 1988. Changes of lipid in raw and precessed adlay powder during storage. Korean J Food Soc Technol 20(5): 691-698. Hanu LO, Fales HM, Spande TF, Basile AS. 1999. A gas chromatographic–mass spectral assay for the quantitative determination of Oleamide in biological fluids. Anal Biochem 270(1): 159-166. He X, Rui Hai. 2006. Cranberry phytochemicals: isolation, structure elucidation, and their antiproliferative and antioxidant activities. J Agric Food Chem 54(19): 7069–7074. Hedlund PB, Carson MJ, Sutcliffe JG, Thomas EA. 1999. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem Pharmacol 58(11): 1807-13. Heo HJ, Park YJ, Suh YM, Choi SJ, Kim MJ, Cho HY, Chang YJ, Hong B, Kim HK, Kim E, Kim CJ, Kim BG, Shin DH. 2003.Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem 67(6): 1284-1291. Heras B, Villar A, Navarro A. 2001. Anti-inflammatory and immunomodulating properties of a sterol fraction from sideritis foetens CLEM. Biol Pharm Bull 24(5): 470-473. Hoi PM, Hiley CR. 2006. Vasorelaxant effects of oleamide in rat small mesenteric artery indicate action at a novel cannabinoid receptor. Br J Pharmacol 147(5): 560-568. Houghton PJ, Retsas S, Photiou A, Jackson SJ. 2000. In Vitro Cytotoxicity of Norviburtinal and Isopinnatal from Kigelia pinnata Against Cancer Cell Lines. Planta Med 66(8): 758-761. Hovenkamp E, Demonty I, Plat J, Lütjohann D, Mensink RP, Trautwein EA. 2008. Biological effects of oxidized phytosterols: a review of the current knowledge. Prog Lipid Res 41(1): 37-49. Huang BW, Chiang MT, Yao HT, Chiang W. 2005. The effect of adlay oil on plasma lipids, insulin and leptin in rat. Phytomedicine 12(6-7): 433-439. Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Higashihara H, Mukainaka T, Iizuka M, Hayashi Y, Kimura Y. Nishino H. 2003. Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr Virus activation. J Agric Food Chem 51 (23): 6683–6688. Jin J, Lee S, Lee Y, Kim J, Heo J, Yun-Choi H. 2004. Platelet anti-aggregating triterpenoids from the leaves of Acanthopanax senticosus and the fruits of A .sessiliflorus. Planta Med 70(6): 564-566. Jordan VC. 2007. Chemoprevention of breast cancer with selective oestrogen -receptor modulators. Nat Rev Cancer 7(1): 46-53. Kolak U, Ari S, Birman H, Hasançebi S, Ulubelen S. 2001. Cardioactive diterpenoids from the roots of Salvia amplexicaulis. Planta Med 67(8): 761-763. Kondo Y, Nakajima K, Nozoe S, Suzuki S. 1988. Isolation of ovulatory active substances from crops of Job's tears (Coix lachryma-jobi var. ma-yuen Stapf.). Chem Pharm Bull 36(8): 3147-3152. Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S, Sakuda SH, Nagasawa H, Shimizu M. 2004. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol 143(3): 379-387. Kritchevsky D and Chen SC. 2005. Phytosterols-health benefits and potential concerns: a review. Nutr Res 25: 413-428. Lees G, Edwards MD, Hassoni AA, Ganellin CR, Galanakis D. 1999. Modulation of GABAA receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA). Br J Pharmacol 124(5): 873-882. Leggett JD, Aspley S, Beckett SR, D’Antona AM, Kendall DA. 2004. Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br J Pharmacol 141(2): 253-262. Li DP, Huang JM, Su WA, Shen KK, Jiang LL, Shi JY. 1999. The analysis of chemical composition in the Coix lipid. Trad Chin Drug Res & Clin Pharmacol 10, 35-37. Li DP. 2001. Clinical applications of Kanglaite injection (KLT). Jpn J Clin Oncol 2(12): 300-302. Lin WY, Kuo YH, Chang YL, Teng CM, Wang EC, Ishikawa T, Chen IS. 2003. Anti-platelet aggregation and chemical constituents from the rhizome of Gynura japonica. Planta Med 69(8): 757-764. Liu YC, Wu SN. 2003. Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells. Eur J Pharmacol 458(1-2): 37-47. Lo YK, Tang KY, Chang WN, Lu CH, Cheng JS, Lee KC, Chou KJ, Liu CP, Chen WC, Su W, Law YP, Jan CR. 2001. Effect of oleamide on Ca2+ signaling in human bladder cancer cells. Biochem Pharmacol 62(10): 1363-1369. Matos MFC, Leite LISP, Brustolim D, de Siqueira JM, Carollo CA, Hellmann AR, Pereira NFG, da Silva DB. 2006. Antineoplastic activity of selected constituents of Duguetia glabriuscula. Fitoterapia 77(3): 227-229. Moreau RA, Whitaker BD, Hicks KB. 2002. Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis and health-promoting uses. Prog Lipid Res 41(6): 457- 500. Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. 2005. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med 11(3): 312-319. Nakao J, Ooyama T, Chang WC, Murota S, Orimo H. 1985. Platelets stimulate aortic smooth muscle cell migration in vitro. Involvement of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. Atherosclerosis 43(2-3): 143-150. Newman DJ, Cragg GM. 2007. Natural products as sources of new drugs over the last 25 years. J Nat Prod 70(3): 461-477. Nguyen AT, Malonne H, Duez P, Vanhaelen-Fastre R, Vanhaelen M, Fontaine J. 2004. Cytotoxic constituents from Plumbago zeylanica. Fitoterapia 75(5): 500-504. Numata M, Yamamoto A, Moribayashi A, Tamada H. 1994. Antitumor compounds isolated from the Chinese herbal medicine Coix lachryma-jobi. Planta Med 60(4): 356-359. Ohtsubo KI, Yanagi SO, Yanase H. 1985. Properties of a trypsin inhibitor from Job's tears (Coix lachryma-jobi L.var. ma-yuen Stapf). Agric Biol Chem 49(7): 1985-1991. Otsuka H, Hirai Y, Nagao T, Yamaski K. 1988. Anti-inflammatory activity of benzoxaninoids from roots of Coix lachryma-jobi L. var. ma-yuen. J Natu Prod 51(1): 73-79. Park Y, Okamura K, Mitsuyama S, Saito T, Koh J, Kyono S, Higaki K, Ogita M, Asaga T, Inaji H, Komichi H, Kohno N, Yamazaki K, Tanaka F, Ito T, Nishikawa H, Osaki A, Koyama H, Suzuki T. 2009. Uracil-tegafur and tamoxifen vs cyclophosphamide, methotrexate, fluorouracil, and tamoxifen in post-operative adjuvant therapy for stage I, II, or IIIA lymph node-positive breast cancer: a comparative study. Br J Cancer advance online publication 28 July. Peterson DW. 1951. Effect of soybean sterols in the diet on plasma and liver cholesterol in chicks. Proc Soc Exp Biol Med 78(1): 143-147. Peterson DW, Nichols Jr CW, Shneour EA. 1952. Some relationships among dietary sterols, plasma and liver cholesterol levels, and atherosclerosis in chicks. J Nutr 47(1): 57-65. Peterson DW, Shneour EA, Peek NF. 1953. Dietary constituents affecting plasma and liver cholesterol in cholesterol-fed chicks. J Nutr 50(2): 191-201. Pollak OJ. 1953. Reduction of blood cholesterol in man. Circulation 7(5): 702-706. Qian J, Qin SL, Yang LQ, Chen YX, Shao ZJ, 2004. The clinical study of Gefitnib combination with Kanglaite injection in treatment of non-small-cell lung cancer. Chin Clin Oncol 9(6): 568-570. Rahman MM and Gray AI. 2005. A benzoisofuranone derivative and carbazole alkaloids from Murraya koenigii and their antimicrobial activity. Phytochemistry 66(13): 1601-1606. Schneider I, Gibbons S, Bucar F. 2004. Inhibitory activity of Juniperus communis on 12(S)-HETE production in human platelets. Planta Med 70(5): 471-474. Setzer WN, Setzer MC, Schmidt JM, Moriarity DM, Vogler B, Reeb S, Holmes AM. Haber WA. 2000. Cytotoxic components from the bark of Stauranthus perforatus from Monteverde. Planta Med 66(5): 493-494. Sporn MB. 1976. Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36(7 part 2): 2699-2702. Soria JC, Kim ES, Fayette J, Lantuejoul S, Deutsch E and Hong WK. 2003. Chemoprevention of lung cancer Lancet Oncol 4(11): 659-669. Sun SY, Hail N Jr, Lotan R. 2004. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96(9): 662-672. Tanaka T and Takatsuto S. 2001. Sterols in the seeds of Job`s Tears ( Coix lacryma-jobi var. ma-yuen). J. Oleo Sci 50(12): 957-960. Tsai IL, Duh, CY, Lee KH, Chen IS, Lin RW. 2004. New lignans and cytotoxic constituents from Wikstroemia lanceolata. Planta Med 70(3): 234-238. Tokuda H, Matsumoto T, Konoshima T, Kozuka M, Nishino H, Iwashima A. 1990. Inhibitory effect on Epstein-Barr virus activation and anti-tumor promoting activities of Coix seed. Planta Med 56(6): 653-654. Tsai IL, Lin WY, Teng CM, Ishikawa T, Doong SL, Huang MW, Chen YC, Chen IS. 2000. Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium. Planta Med 66(7): 618-623. Tsao AS, Kim ES and Hong WK. 2004. Chemoprevention of Cancer. CA Cancer J Clin 54(3): 150-180. Ulrich CM, Bigler J, Potter JD. 2006. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer 6(2): 130-140. Ukita T and Tanimura A. 1961. Studies on the anti-tumor component in the seeds of Coix lachryma-jobi L. var. ma-yuen (Roman) stapf I. Isolation and anti-tumor activity of coixenolide. Chem Pharm Bull 9: 43-46. Verdon B, Zheng J, Nicholson RA, Ganellin CR, Lees G. 2000. Stereoselective modulatory actions of oleamide on GABAA receptors and voltage-gated Na+ channels in vitro: a putative endogenous ligand for depressant drug sites in CNS. Br J Pharmacol 129(2): 283-290. Wall ME and Wani MC. 1995. Camptothecin and taxol: discovery to clinic--thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res 55(4): 753-760. W00 JW, Lee MS, Lee HJ, Kim HS. 1989. Comparative studies on the dietary fiber, amino acid and lipid components of Yullmoo and Yeomjoo. Korean J Food Soc Technol 21(2): 269-275. Woo JH, Li D, Wilsbach K, Orita H, Coulter J, Tully E, Kwon TK, Xu S, Gabrielson E. 2007. Coix seed extract, a commonly used treatment for cancer in China, inhibits NFkappaB and protein kinase C signaling. Cancer Biol Ther 6(12): 2005-2011. Wu TT, Charles AL, Huang TC. 2007. Determination of the contents of the main biochemical compounds of Adlay (Coxi lachrymal-jobi). Food Chem 104: 1509-1515. Yamada, J. and Tomita, Y. 1996. Antimutagenic activity of caffeic acid and related compounds. Biosc. Biotech.Biochem 60(2): 328-329. Yoshikazu K, Kenji N, Shigeo N, Shuetsu S. 1987. Isolation of ovulatory-active substances from crops of Job`s tears. Chem Pharm Bull 36(8): 3147-3152. Zhang Y, Jayaprakasam B, Seeram NP, Olson LK, DeWitt D, Nair MG. 2004. Insulin secretion and cyclooxygenase enzyme inhibition by Cabernet sauvignon grape skin compounds. J Agric Food Chem 52 (2): 228–233. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8787 | - |
dc.description.abstract | 薏苡 (adlay) 為禾本科一年生草本植物,學名 Coix lachrymal-jobi L. var. ma-yuen Stapf。根據本草綱目記載薏苡籽實薏仁為藥食兼備的食材,於中國與日本自古就在傳統醫學與民間療法中被廣泛的使用。近年學者也陸續發表薏仁萃取物、薏仁油脂、薏仁加工食品均具有抑制癌細胞生長、轉移和抗腫瘤之功效,且帶有麩皮的薏仁較精白薏仁效果為佳。中國大陸學者使用超臨界二氧化碳萃取薏苡籽實所得的油狀萃取物,以針劑 (康萊特注射劑) 方式施打於實驗動物後發現,可有效抑制腫瘤生長並延長其壽命,具有抗腫瘤與抗惡質化之效用,該學者更進一步發現,此油狀萃取物之主要成分為三酸甘油酯,推測薏仁中之有效抗癌成分可能來自於富含油脂的麩皮。薏仁麩皮油脂含量高達25% (Wt%),但除少數文獻外,鮮少研究其組成分、物理化學特性以及生理功效,因此本實驗以薏仁麩皮萃取物之低極性區分層 (薏仁麩皮乙醇萃取物正己烷區分層) 為材料,以氣相層析質譜儀分析進行成分之定性分析並使用管柱層析以分離純化合物。
氣相層析質譜分析共可得32個化合物,7個植物固醇(phytosterol);3個單酸甘油酯 (monoglyceride);7個脂肪酸與其酯化物 (free fatty acid & ester);1個醯胺 (amide);1個醇類 (alcohol);1烯類 (alkene);7個醛類 (aldehyde);5個其他類化合物 (others)。另外經分離純化鑑定所得之化合物為3-O-feruloyl-5beta-sitostan-3-ol、stigmasterol、beta-sitosterol與1,2-、1,3-diglyceride混合物。以文獻搜索探討薏仁麩皮乙醇萃取物正己烷區分層之機能性,推測植物固醇、單酸甘油酯以及脂肪酸醯胺為其可能之活性成分。 | zh_TW |
dc.description.abstract | Adlay (Coix lachrymal-jobi L. var. ma-yuen Stapf) is an one year grass crop
that has long been used as traditional Chinese medicine and a nourishing food. Recent studies have shown the effects of adlay are benefit to treat tumor and inflammation. Furthermore, the dehulled adlay has higher activity than polished adlay, especially in the adlay bran. In China, adlay seed was extracted with supercritical CO2 to get the oily extract that is formulated into an emulsion for injection (Kanglaite injection (KLT)). KLT injection showed the antitumor proliferation and life extension in animal tumor models. It demonstrated the potential for antitumor and anti-cachexia activity of the low polarity fraction of adlay seed. The adlay bran contain about 25% crude fat (Wt%), however, there are less research results shown the characteristic of the low polarity fraction of adlay seed or bran. Therefore the aim of this study is to analyze the composition in the n-hexane fraction of adlay bran ethanolic extract by gas chromatography / mass spectrometer (GC / MS).And column chromatography were employed to afford pure compounds. The study results revealed that there are 32 components identified in the GC / MS analysis, including 7 phytosterol; 3 monoglyceride; 7 free fatty acid & its ester; 1 amide; 1 alcohol; 1 alkene; 7 aldehyde; 5 other species of components. In addition, 3 pure compounds are isolated and identified: stigmasterol, beta-sitosterol, 3-O-feruloyl-5beta-sitostan-3-ol, and 1, 2-, 1, 3-diglyceride mixture. According to the literature review, the possible active components in the n-hexane fraction of adlay bran ethanolic extractare are phytosterol, monoglyceride, and fatty acid amide. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T20:01:15Z (GMT). No. of bitstreams: 1 ntu-98-R96641016-1.pdf: 1616614 bytes, checksum: ddb8eefae0a5e3c4e05e4e21f204689b (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 中文摘要 I
ABSTRACT II 目錄 III 圖目錄 V 表目錄 VII 壹、前言 1 貳、文獻整理 3 一、癌症 3 (一) 癌症的發生與癌症化學預防 3 (二) 發炎反應與癌症形成及發展之關係 4 二、薏苡 5 (一) 薏苡簡介 5 (二) 薏苡成分 6 (三) 薏苡成分分析文獻回顧…………………………………………………...8 (四) 薏苡之成分機能性 10 (五) 薏仁油脂之機能性研究 15 參、研究動機與目的 19 肆、實驗目的與架構 19 伍、材料與方法 21 一、實驗材料 21 (一) 薏仁麩皮原料 21 (二) 試驗藥品 21 (三) 分離純化用品 21 (四) 儀器設備 22 二、實驗方法 22 (一) 薏仁麩皮乙醇萃取物正己烷區分層之製備 22 1. 薏仁麩皮乙醇萃取物(Adlay bran ethanolic extract, ABE)之製備 22 2. 薏仁麩皮乙醇萃取物之正己烷區分層之製備 22 (二) 薏仁麩皮乙醇萃取物正己烷區分層之不同極性區分層與非皂物之製備 24 1. 薏仁麩皮乙醇萃取物正己烷區分層冬化(winterization)處理 24 2. 薏仁麩皮乙醇萃取物正己烷區分層非皂化物(non saponifiable matters)之製備 24 3. 以Flash column 製備薏仁麩皮乙醇萃取物正己烷區分層之不同極性區分層 26 (三) 薏仁麩皮乙醇萃取物正己烷區分層氣相層析質譜儀分析 28 1. 預備實驗 28 (1) 預備實驗儀器設備條件 28 (2) 預備實驗分析樣品濃度 28 (3) 預備實驗結果 28 2. 氣相層析質譜儀分析樣品 32 3. 實驗儀器設備條件 32 4. 資料分析 32 (四) 薏仁麩皮乙醇萃取物正己烷區分層之化學分離與純化 35 1. 化學分離純化之策略 35 2. 配合分離純化之TLC spot檢出工作 35 3. 化合物的結構鑑定與分析 36 (1) 核磁共振光譜儀鑑定 36 (2) 紅外線光譜儀鑑定 36 (3) 質譜儀鑑定 37 陸、結果 38 一、薏仁麩皮乙醇萃取物正己烷區分層氣相層析質譜儀分析 38 (一) 薏仁麩皮乙醇萃取物正己烷區分層冬化後液體油區分層 38 (二) 薏仁麩皮乙醇萃取物正己烷區分層冬化後固體脂區分層 49 (三) 薏仁麩皮乙醇萃取物正己烷區分層非皂化物 56 二、ABE-HEX之成分分離純化 59 1. 純化合物結構摘要 61 (1). 化合物S1:3-O-Feruloyl-5b-sitostan-3-ol 61 (2). 化合物S2:Stigmasterol 61 (3). 化合物S3:b-Sitosterol 61 2. 化合物之結構分析與鑑定 62 柒、討論 70 一、薏仁麩皮乙醇萃取物正己烷區分層成分分析 70 二、薏仁麩皮乙醇萃取物正己烷區分層之植物化學物與機能性 79 捌、結論 88 參考文獻 89 | |
dc.language.iso | zh-TW | |
dc.title | 薏仁麩皮乙醇萃取物正己烷區分層之成分分析與純化鑑定 | zh_TW |
dc.title | Component analysis and Identification of the n-Hexane Fraction in Ethanolic Extract of Adlay Bran | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-1 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 郭悅雄 | |
dc.contributor.oralexamcommittee | 何其儻,林雲蓮,許輔 | |
dc.subject.keyword | 薏仁麩皮,氣相層析質譜,植物固醇,單酸甘油酯,脂肪酸醯胺, | zh_TW |
dc.subject.keyword | adlay bran,GC / MS,phytosterol,monoglyceride,fatty acid amide, | en |
dc.relation.page | 99 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2010-01-03 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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