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標題: | 在水溶液中以聚合物穩定之磷酸鈣的製備與應用 Preparation and Application of Polymer-Stabilized Calcium Phosphate in Aqueous Solution |
作者: | Li-Han Wang 王莉涵 |
指導教授: | 陳振中(Chun-Chung Chan) |
關鍵字: | 非晶相磷酸鈣,聚丙烯酸,塊材,聚合物誘導液相前驅物,無機離子寡聚物,牙本質敏感症, amorphous calcium phosphate,polyacrylic acid,monolith,polymer-induced liquid-precursor,inorganic ionic oligomer,dentin hypersensitivity, |
出版年 : | 2022 |
學位: | 碩士 |
摘要: | 磷酸鈣在生物醫學應用中具有良好的特性,例如生物相容性、生物可降解性、對藥物的高親和力和骨誘導性。磷酸鈣的磷灰石相與人體硬組織的主要無機成分非常相似,因此,其已被普遍用於骨科和牙科研究的系統模型。與磷酸鈣生物礦化相關的各種蛋白質都富含羧基,其中,聚丙烯酸因其高生物相容性而非常適合仿生礦化研究,聚丙烯酸不僅能有效延緩磷酸鈣的沈澱,且能抑制磷酸鈣的相轉,使其維持非晶相。結晶性樣品多呈粉末狀,因其抗斷裂能力較差,而非晶相態不具備特定生長方向,因此較易形成塊材,並具有較佳的機械強度。近年來,已有學者研發出在非水溶液環境中製備非晶相磷酸鈣的塊材。而在本研究中,我們在水溶液環境下利用聚丙烯酸製備膠狀磷酸鈣,透過不同的乾燥固化過程,既可以改變樣品的表面形貌,使其形成規則的圖案,也可以使樣品成為透明的塊材,此塊材為具有良好機械性質的有機無機複合材料。本研究亦透過固態核磁共振光譜鑑定以不同方法製備的磷酸鈣,證明磷酸鈣中的磷酸鹽種類具有顯著的結構多樣性,並能與水分子形成氫鍵。最後,我們也將磷酸鈣凝膠用於治療牙本質敏感症,該結果說明了磷酸鈣凝膠作為生物材料的多功能性,可用於脊椎動物的硬組織修復。 Calcium phosphate (CaP) exhibits favorable properties for biomedical applications such as biocompatibility, biodegradability, high affinity for drugs, and osteoinductivity. Apatitic phase of CaP resembles closely the main inorganic constituent of human hard tissues. Therefore, it has been commonly used as a model of system for the studies of orthopedics and dentistry. Various proteins relevant to the biomineralization of CaP are rich in carboxylic acids. As a result, polyacrylic acid (PAA) is well suited for biomimetic mineralization studies because of its high biocompatibility. PAA not only can effectively retard the precipitation of CaP, but also inhibit the phase transformation of amorphous CaP (ACP). Compared to crystallized powders with a poor ability to resist fracture, monolithic amorphous state has superior mechanical strength owing to its continuous internal structure. Very recently, a novel non-aqueous protocol has been developed to prepare monoliths of ACP. In this study, gel-like CaP was prepared with PAA in aqueous solution. Through various dehydration process, we can either modify the surface morphology of the samples to form a regular pattern, or make the samples become transparent monolith. The glassy monolith is homogenous organic-inorganic composite material with superior mechanical property. We also used solid-state NMR spectroscopy to probe the chemical states of various ACP samples and showed that the phosphate species in ACPs had a remarkable structural versatility. Furthermore, the CaP gel was used for treating dentin hypersensitivity. The results illustrate the versatility of CaP gel as biomaterials, which may be exploited for hard tissue repair in vertebrates. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83596 |
DOI: | 10.6342/NTU202202804 |
全文授權: | 未授權 |
顯示於系所單位: | 化學系 |
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