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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83596完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳振中(Chun-Chung Chan) | |
| dc.contributor.author | Li-Han Wang | en |
| dc.contributor.author | 王莉涵 | zh_TW |
| dc.date.accessioned | 2023-03-19T21:11:28Z | - |
| dc.date.copyright | 2022-09-05 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-08-25 | |
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Utilization of Line Surge Arrestors to Improve Overhead EHV DC Line Performance under Lightning Conditions. Int. J. Appl. Eng. Res. 2019, 14 (21), 4030–4041. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83596 | - |
| dc.description.abstract | 磷酸鈣在生物醫學應用中具有良好的特性，例如生物相容性、生物可降解性、對藥物的高親和力和骨誘導性。磷酸鈣的磷灰石相與人體硬組織的主要無機成分非常相似，因此，其已被普遍用於骨科和牙科研究的系統模型。與磷酸鈣生物礦化相關的各種蛋白質都富含羧基，其中，聚丙烯酸因其高生物相容性而非常適合仿生礦化研究，聚丙烯酸不僅能有效延緩磷酸鈣的沈澱，且能抑制磷酸鈣的相轉，使其維持非晶相。結晶性樣品多呈粉末狀，因其抗斷裂能力較差，而非晶相態不具備特定生長方向，因此較易形成塊材，並具有較佳的機械強度。近年來，已有學者研發出在非水溶液環境中製備非晶相磷酸鈣的塊材。而在本研究中，我們在水溶液環境下利用聚丙烯酸製備膠狀磷酸鈣，透過不同的乾燥固化過程，既可以改變樣品的表面形貌，使其形成規則的圖案，也可以使樣品成為透明的塊材，此塊材為具有良好機械性質的有機無機複合材料。本研究亦透過固態核磁共振光譜鑑定以不同方法製備的磷酸鈣，證明磷酸鈣中的磷酸鹽種類具有顯著的結構多樣性，並能與水分子形成氫鍵。最後，我們也將磷酸鈣凝膠用於治療牙本質敏感症，該結果說明了磷酸鈣凝膠作為生物材料的多功能性，可用於脊椎動物的硬組織修復。 | zh_TW |
| dc.description.abstract | Calcium phosphate (CaP) exhibits favorable properties for biomedical applications such as biocompatibility, biodegradability, high affinity for drugs, and osteoinductivity. Apatitic phase of CaP resembles closely the main inorganic constituent of human hard tissues. Therefore, it has been commonly used as a model of system for the studies of orthopedics and dentistry. Various proteins relevant to the biomineralization of CaP are rich in carboxylic acids. As a result, polyacrylic acid (PAA) is well suited for biomimetic mineralization studies because of its high biocompatibility. PAA not only can effectively retard the precipitation of CaP, but also inhibit the phase transformation of amorphous CaP (ACP). Compared to crystallized powders with a poor ability to resist fracture, monolithic amorphous state has superior mechanical strength owing to its continuous internal structure. Very recently, a novel non-aqueous protocol has been developed to prepare monoliths of ACP. In this study, gel-like CaP was prepared with PAA in aqueous solution. Through various dehydration process, we can either modify the surface morphology of the samples to form a regular pattern, or make the samples become transparent monolith. The glassy monolith is homogenous organic-inorganic composite material with superior mechanical property. We also used solid-state NMR spectroscopy to probe the chemical states of various ACP samples and showed that the phosphate species in ACPs had a remarkable structural versatility. Furthermore, the CaP gel was used for treating dentin hypersensitivity. The results illustrate the versatility of CaP gel as biomaterials, which may be exploited for hard tissue repair in vertebrates. | en |
| dc.description.provenance | Made available in DSpace on 2023-03-19T21:11:28Z (GMT). No. of bitstreams: 1 U0001-2508202213541900.pdf: 62738699 bytes, checksum: 6f0b184120f510a55ae4523c43557671 (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 口試委員會審定書 I 謝誌 II 中文摘要 VIII Abstract IX 縮寫表 X 目錄 XII 圖目錄 XVI 表目錄 XXI 第一章 緒論 1 1.1 聚合物誘導液相前驅物 1 1.2 無機離子寡聚物 5 1.3 牙本質敏感症 8 1.3.1 牙本質敏感症的成因 10 1.3.1.1 牙本質暴露 10 1.3.1.2 牙本質小管開口暢通 10 1.3.2 牙本質敏感症的機制 11 1.3.2.1 造牙本質細胞感覺接受器理論 11 1.3.2.2 神經支配理論 12 1.3.2.3 流體力學理論 12 1.3.3 牙本質敏感症的治療 13 1.3.3.1 硝酸鉀 13 1.3.3.2 鍶鹽 13 1.3.3.3 氟化物 13 1.3.3.4 草酸鹽 14 1.3.3.5 戊二醛 14 1.3.3.6 生物玻璃 15 1.3.3.7 精胺酸 15 1.3.3.8 雷射 16 1.3.3.9 中孔洞二氧化矽 17 1.4 研究動機 17 第二章 化學藥品與鑑定方法 18 2.1 化學藥品與使用儀器 18 2.2 鑑定方法 21 2.2.1 掃描式電子顯微鏡 21 2.2.2 穿透式電子顯微鏡 23 2.2.3 X 光能量色散光譜儀 23 2.2.4 X 光粉末繞射 23 2.2.5 傅立葉轉換紅外線光譜儀 24 2.2.6 動態光散射粒徑分析儀 25 2.2.7 界達電位 26 2.2.8 熱重分析儀 27 2.2.9 感應耦合電漿質譜儀 27 2.2.10 固態核磁共振光譜 28 2.2.10.1 基本原理 28 2.2.10.2 交叉極化 29 2.2.10.3 異核相關二維圖譜 31 2.2.10.4 磷酸鈣標準樣品之 31P{1H} 異核相關二維圖譜及交叉極化動態 32 2.2.10.5 對稱旋轉回波飽和脈衝雙共振 33 第三章 以聚合物穩定之磷酸鈣的製備與鑑定 35 3.1 以聚合物穩定之磷酸鈣的製備 35 3.2 調控 P/Ca 濃度比與 PAA 濃度之差異 37 3.2.1 結構分析 37 3.2.2 形貌分析 41 3.3 乾燥方法之差異 46 3.3.1 結構分析 46 3.3.2 形貌分析 48 3.4 磷酸氫根之鑑定 52 第四章 牙本質小管之填充 62 4.1 以細菌纖維素薄膜擴散離子填充牙本質小管 62 4.1.1 以細菌纖維素薄膜擴散磷酸根離子 62 4.1.1.1 實驗流程 62 4.1.1.2 填充結果鑑定 65 4.1.2 以細菌纖維素薄膜擴散鈣離子與磷酸根離子 66 4.1.2.1 實驗流程 66 4.1.2.2 填充結果鑑定 70 4.2 以氟化鈣填充牙本質小管 71 4.2.1 氟化鈣之製備與鑑定 71 4.2.2 電泳實驗流程 74 4.2.3 填充結果鑑定 75 4.3 以磷酸鈣填充牙本質小管 81 4.3.1 CaP5PAA4.5% 膠狀樣品之製備與鑑定 81 4.3.2 電泳實驗流程 82 4.3.3 填充結果鑑定 82 第五章 結論與未來展望 87 參考文獻 89 附錄 102 附錄 A 不同磷酸鈣樣品之 IR 鑑定 102 附錄 B 交叉極化動態擬合結果 105 附錄 C 拉曼光譜鑑定 CaP5PAA4.5% 113 附錄 D 細菌纖維素薄膜之培養 114 | |
| dc.language.iso | zh-TW | |
| dc.subject | 牙本質敏感症 | zh_TW |
| dc.subject | 非晶相磷酸鈣 | zh_TW |
| dc.subject | 聚丙烯酸 | zh_TW |
| dc.subject | 塊材 | zh_TW |
| dc.subject | 聚合物誘導液相前驅物 | zh_TW |
| dc.subject | 無機離子寡聚物 | zh_TW |
| dc.subject | monolith | en |
| dc.subject | dentin hypersensitivity | en |
| dc.subject | amorphous calcium phosphate | en |
| dc.subject | polymer-induced liquid-precursor | en |
| dc.subject | polyacrylic acid | en |
| dc.subject | inorganic ionic oligomer | en |
| dc.title | 在水溶液中以聚合物穩定之磷酸鈣的製備與應用 | zh_TW |
| dc.title | Preparation and Application of Polymer-Stabilized Calcium Phosphate in Aqueous Solution | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 110-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖尉斯(Wei-Ssu Liao),江建文(Kien-Voon Kong),李度(Tu Lee),林俊彬(Chun-Pin Lin) | |
| dc.subject.keyword | 非晶相磷酸鈣,聚丙烯酸,塊材,聚合物誘導液相前驅物,無機離子寡聚物,牙本質敏感症, | zh_TW |
| dc.subject.keyword | amorphous calcium phosphate,polyacrylic acid,monolith,polymer-induced liquid-precursor,inorganic ionic oligomer,dentin hypersensitivity, | en |
| dc.relation.page | 115 | |
| dc.identifier.doi | 10.6342/NTU202202804 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2022-08-26 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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