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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林乃君(Nai-Chun Lin) | |
| dc.contributor.author | Ya-Wen Chang | en |
| dc.contributor.author | 張雅文 | zh_TW |
| dc.date.accessioned | 2022-11-24T09:25:16Z | - |
| dc.date.available | 2022-11-24T09:25:16Z | - |
| dc.date.copyright | 2021-08-06 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-26 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81652 | - |
| dc.description.abstract | "革蘭氏陰性細菌可以利用第六型分泌系統 (type VI secretion system, T6SS) 將效應蛋白運送到真核或原核細胞中，參與在其致病力、養分獲取或細菌間的競爭之中。實驗室之前的研究中發現，模式植物病原細菌 Pseudomonas syringae pv. tomato (Pst) DC3000具有 HSI-I和 HSI-II 兩套第六型分泌系統基因叢集 (gene cluster)；此外，為了找到由特定 VgrG 攜帶的效應蛋白，搜尋到基因體序列中帶有七個 vgrG 同源基因，且從 vgrG3 啟動子的高表現量推測其可能在Pst DC3000的生理活性上具有功能。因此本研究便從第六型分泌系統的角度切入，針對 VgrG3 操作組 (operon) 上的基因進行深入的探討，以了解 VgrG3 對Pst DC3000的重要性。透過生物資訊學分析，VgrG3 座落於一由PSPTO_3482-3485四個基因所組成的操作組之中，除了 PSPTO_3482的基因產物被預測為VgrG 之外，其下游的 PSPTO_3483產物為帶有DUF4123結構域的蛋白質，PSPTO_3485推測為具有 lipase 活性的效應蛋白，而 PSPTO_3484 無特殊結構域，但根據其位於 vgrG 操作組中且位於可能為效應蛋白的 PSPTO_3485 上游，故推測其可能為 PSPTO_3485 之免疫蛋白。利用半定量反轉錄聚合酶連鎖反應確定了各基因在不同醣類培養基中培養時均會表現但表現量會有不同。透過競爭試驗發現，PSPTO_3485突變株抑制 P. savastanoi pv. phaseolicola (Psph) 1448a 及 Escherichia coli MG1655 生長的能力下降，且此現象為 contact-dependent；而缺失PSPTO_3482、PSPTO_3483 與 PSPTO_3484也同樣會影響Pst DC3000對此二菌的競爭現象。將PSPTO_3485表達在Psph 1448a 及 E. coli MG1655 細胞質中，並不會對細菌生長造成影響；但如果透過加上 signal peptide 使其表達於 E. coli BL21(DE3) 的周質時，會發現 E. coli 生長被抑制，但同時表達 PSPTO_3484和 PSPTO_3485 可以緩減 PSPTO_3485 對 E. coli BL21(DE3) 的毒性。此外，若在 Psph 1448a 中表現 PSPTO_3484 時，可以緩減 Pst DC3000 對其造成的生長抑制。本研究結果顯示 PSPTO_3485 在 Pst DC3000 與其他細菌的競爭作用上是重要的，且其作用位點應該是在目標細胞的周質中；PSPTO_3484 的出現則具有保護作用，推測其可能具有免疫蛋白的功能。但由於無法確認 PSPTO_3485 是否會分泌至胞外，故尚無法確認其為 Pst DC3000 第六型分泌系統的效應蛋白。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T09:25:16Z (GMT). No. of bitstreams: 1 U0001-2207202123111900.pdf: 11423032 bytes, checksum: e4cf388998de1cdf9b6befda4ac303ce (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 致謝 i 摘要 ii Abstract iv 目錄 vi 表目錄 x 圖目錄 xi 附表 xiv 附圖 xiv 壹、前人研究 1 一、蛋白質分泌系統 1 二、第六型分泌系統 7 1.緣起 7 2.組成成員 9 3.調節 12 4.功能 14 三、第六型分泌系統效應蛋白 15 1.效應蛋白與免疫蛋白 15 2.效應蛋白之分類 15 3.效應蛋白的運遞機制 20 4.Domain of unknown function 22 5.效應蛋白的鑑定 23 四、番茄細菌性斑點病 Pseudomonas syringae pv. tomato DC3000 第六型分泌系統相關研究 26 貳、研究動機與目的 29 參、材料與方法 31 一、細菌菌株與生長條件 31 二、染色體 DNA 萃取 31 三、RNA 萃取 32 四、半定量反轉錄 PCR 33 五、勝任細胞製備與電穿孔轉型作用 33 六、小量質體萃取 34 七、自 agarose gel 中純化 DNA 片段 35 八、Pst DC3000 突變株製備 35 九、PSPTO_3484、PSPTO_3485 與 PSPTO_3484-3485 質體互補株建立 37 十、生長曲線測定 37 十一、細菌競爭試驗 37 十二、細菌胞外與胞內蛋白質樣品之製備 38 十三、PSPTO_3485 對 Escherichia coli BL21 (DE3) 之生長測試 39 十五、西方墨點法 40 十六、線蟲毒殺試驗 41 肆、結果 43 一、利用生物資訊學分析 PSPTO_3482、PSPTO_3483 與 PSPTO_3485 43 二、vgrG3 操作組中各基因於不同醣類條件下之表現量 46 三、PSPTO_3485 不參與 Pst DC3000 的種內競爭 47 四、刪除 PSPTO_3485 會降低Pst DC3000對 Pseudomonas savastanoi pv. phaseolicola (Psph) 1448a 與 Escherichia coli MG1655 的競爭能力 48 五、PSPTO_3485 貢獻在 Pst DC3000 對 Psph 1448a 與 E. coli MG1655 的競爭能力為 Contact-dependent. 49 六、Psph 1448a 是否具有第六型分泌系統會對 Pst DC3000 抑制 Psph 1448a 的競爭能力造成影響 50 七、刪除 PSPTO_3482、PSPTO_3483 或 PSPTO_3484 會降低 Pst DC3000 對 Psph 1448a 與 E. coli MG1655 的競爭能力 51 八、在Psph 1448a 與 E. coli MG1655 內表達 PSPTO_3485 與 PSPTO_3484-3485 不會使生長受到影響 52 九、在周質表現 PSPTO_3485 會對 E. coli BL21 (DE3) 生長造成影響 53 十、在 Psph 1448a 和 E. coli MG1655內表達 PSPTO_3484 對與 Pst DC3000 之競爭有不同的影響 54 十一、以分泌試驗無法偵測到 PSPTO_3485 的外泌現象 55 十二、推測 Pst DC3000 對線蟲造成毒殺能力與第二套第六型分泌系統無關 56 伍、討論 58 陸、參考文獻 65 柒、表… 87 捌、圖… 95 玖、附表 120 壹拾、附圖 123 | |
| dc.language.iso | zh-TW | |
| dc.subject | 免疫蛋白 | zh_TW |
| dc.subject | 第六型分泌系統 | zh_TW |
| dc.subject | 細菌間競爭 | zh_TW |
| dc.subject | VgrG | zh_TW |
| dc.subject | 效應蛋白 | zh_TW |
| dc.subject | VgrG | en |
| dc.subject | immunity protein | en |
| dc.subject | effector | en |
| dc.subject | Type VI secretion system (T6SS) | en |
| dc.subject | interbacterial competition | en |
| dc.title | Pseudomonas syringae pv. tomato DC3000 PSPTO_3482 基因操作組之特性分析 | zh_TW |
| dc.title | Characterization of the PSPTO_3482 operon in Pseudomonas syringae pv. tomato DC3000 | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 鄧文玲(Hsin-Tsai Liu),賴爾珉(Chih-Yang Tseng),吳蕙芬 | |
| dc.subject.keyword | 第六型分泌系統,細菌間競爭,VgrG,效應蛋白,免疫蛋白, | zh_TW |
| dc.subject.keyword | Type VI secretion system (T6SS),interbacterial competition,VgrG,effector,immunity protein, | en |
| dc.relation.page | 123 | |
| dc.identifier.doi | 10.6342/NTU202101677 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2021-07-26 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 農業化學研究所 | zh_TW |
| 顯示於系所單位： | 農業化學系 | |
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