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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 謝淑貞(Shu-Chen Hsieh) | |
| dc.contributor.author | Po-Yen Chen | en |
| dc.contributor.author | 陳柏諺 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:23:07Z | - |
| dc.date.available | 2021-11-06 | |
| dc.date.available | 2022-11-24T03:23:07Z | - |
| dc.date.copyright | 2021-11-06 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-05 | |
| dc.identifier.citation | 1. 108年度水果農產品農藥殘留監測研究 成果報告. 2. 108年度蔬菜農產品農藥殘留監測研究 成果報告. 3. Timchalk, C.; Nolan, R. J.; Mendrala, A. L.; Dittenber, D. A.; Brzck, K. a.; Mattsson, L., A Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model for the Organophosphate Insecticide Chlorpyrifos in Rats and Humans.pdf. Society of Toxicology 2002, 66, 34-53. 4. Fang, B.; Li, J. W.; Zhang, M.; Ren, F. Z.; Pang, G. F., Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats. Food Chem Toxicol 2018, 111, 144-152. 5. Li, J. W.; Fang, B.; Pang, G. F.; Zhang, M.; Ren, F. Z., Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. Pestic Biochem Physiol 2019, 159, 68-79. 6. Liang, Y.; Zhan, J.; Liu, D.; Luo, M.; Han, J.; Liu, X.; Liu, C.; Cheng, Z.; Zhou, Z.; Wang, P., Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota. Microbiome 2019, 7 (1), 19. 7. Howell, G. E.; Kondakala, S.; Holdridge, J.; Lee, J. H.; Ross, M. K., Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J mice. Food Chem Toxicol 2018, 118, 821-829. 8. Matsuda, K.; Kleier, D.; Rauh, J. J.; Grauso M. and Sattelle, D. B. Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors. 2001, 22(11), 573-580. 9. Bal, R.; Erdogan, S.; Theophilidis, G.; Baydas, G.; Naziroglu, M., Assessing the effects of the neonicotinoid insecticide imidacloprid in the cholinergic synapses of the stellate cells of the mouse cochlear nucleus using whole-cell patch-clamp recording. Neurotoxicology 2010, 31 (1), 113-20. 10. 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T., Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet. Int. J. Environ. Res. Public Health 2020, 18.1, 184 38. Ventura, C.; Nieto, M. R.; Bourguignon, N.; Lux-Lantos, V.; Rodriguez, H.; Cao, G.; Randi, A.; Cocca, C.; Nunez, M., Pesticide chlorpyrifos acts as an endocrine disruptor in adult rats causing changes in mammary gland and hormonal balance. J Steroid Biochem Mol Biol 2016, 156, 1-9. 39. Hazarika, J.; Ganguly, M.; Mahanta, R., A computational insight into the molecular interactions of chlorpyrifos and its degradation products with the human progesterone receptor leading to endocrine disruption. J Appl Toxicol 2020, 40 (3), 434-443. 40. Hazarika, J.; Ganguly, M.; Borgohain, G.; Baruah, I.; Sarma, S.; Bhuyan, P.; Mahanta, R., Endocrine disruption: molecular interactions of chlorpyrifos and its degradation products with estrogen receptor. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80946 | - |
| dc.description.abstract | "隨著社會的進步，農藥的危害也日漸受到重視。台灣農藥使用量高，其中以殺蟲劑的佔比最大，因此本研究以殺蟲劑為標的研究其危害。目前已知各類殺蟲劑會造成肝毒性，影響代謝功能，影響腦部分神經，損害生殖系統和影響生物體活動等等，但先前研究使用之劑量均較高，並非日常可能接觸到之曝露量。為了更了解實際曝露對於人體影響，本研究利用台灣膳食暴露評估模型(TEDDM)結合國民營養健康狀況變遷調查(Nutrition And Health Survey in Taiwan, NAHSIT)中24小時飲食回顧和台灣總膳食調查計畫(Total Diet Survey, TDS)中農藥殘留結果推估陶斯松，益達胺和賽滅寧個人每日平均曝露量，並進一步分析曝露量與國民營養健康狀況變遷調查中生化指標相關性(n=1294)。在單變項回歸分析顯示許多出不同族群暴露量與生化指標具相關性，再經過考慮貢獻因子之多變項回歸後發現在老年族群中陶斯松與血三酸甘油脂有正相關性(n = 155, B = 0.03, p value = 0.035)，進一步發現老年族群中女性有正相關性(n = 155, B = 0.03, p value = 0.035)男性則無，另代謝症候族群中益達胺暴露量和低密度膽固醇有正相關性(n = 241, B = 0.02, p value = 0.041)。在考慮貢獻因子羅吉斯回歸中發現陶斯松老年Q4曝露族群會提升代謝症候群盛行率(OR: 2.413, 95% CI: 1.142 to 5.099, p value = 0.021)，進一步發現僅女性(OR: 2.906, 95% CI: 1.058 to 7.980, p value = 0.038)有此結果而男性則無，而在益達胺的部分則發現在Q2、Q3和Q4曝露量會提高女性血糖提高的盛行率(Q2之OR: 2.461, 95% CI: 1.144 to 5.294, p value = 0.021 ; Q3之OR: 2.531, 95% CI: 1.231 to 5.203, p value = 0.012 ; Q4之OR: 2.711 , 95% CI: 1.207 to 6.091, p value = 0.016)。後續進行細胞實驗欲進一步了解低劑量陶斯松對於脂肪代謝情況，使用FL83B肝細胞添加Oleic Acid的模式來分析陶斯松對於油酯累積影響，並且使用3T3-L1前脂肪細胞來研究陶斯松對於脂質細胞分化和油脂累積的影響，結果顯示接近人體暴露劑量的處理下對上述兩種細胞的脂質堆無顯著影響，推測可能因為農藥對於生物體影響難以單用細胞模式評估，未來當以多細胞的培養方式或是動物實驗來釐清陶斯松對生物體脂質代謝可能的影響。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:23:07Z (GMT). No. of bitstreams: 1 U0001-1109202119072300.pdf: 5010303 bytes, checksum: 7640fffa5db17c98e6afbb0ed0bd8368 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "目錄 謝誌 I 摘要 II Abstract IV 圖目錄 IX 表目錄 X 縮寫表 XII 第一章、前言與研究動機 1 第二章、文獻回顧 2 第一節 台灣農藥目前使用狀況 2 第二節 陶斯松(Chlorpyrifos,CPF) 2 2.2.1 基本介紹 2 2.2.2 代謝影響文獻回顧 3 第三節 益達胺(Imidacloprid, IMI) 4 2.3.1基本介紹 4 2.3.2 代謝影響文獻回顧 5 第四節 賽滅寧(Cypermethrin, CPY) 6 2.4.1基本介紹 6 2.4.2代謝影響文獻回顧 6 第五節 膳食暴露評估 7 2.5.1食品風險評估 7 2.5.2臺灣膳食暴露評估模型 8 2.5.3 曝露量計算 9 第三章、實驗架構 12 第一節 數據分析 12 第二節 細胞實驗 13 第四章、材料與研究方法 14 第一節 實驗材料 14 4.1.1 細胞培養 14 4.1.2 實驗藥品 14 第二節 研究材料 15 4.2.1 臺灣國民營養健康狀況變遷調查Nutrition and Health Survey in Taiwan (NAHSIT) 15 4.2.2 總膳食調查 Total Diet Survey (TDS) 15 第三節 統計方法 16 4.3.1資料前處理 16 4.3.2數據分析步驟 17 第四節 細胞實驗 18 4.4.1 TDEEM之EDI轉換為細胞劑量 18 4.4.2所使用試劑之配置方法 18 4.4.3 3T3-L1細胞實驗 19 4.4.4 FL83B細胞實驗 20 4.4.5 油紅染色(Oil Red O assay) 21 4.4.6 細胞存活率測定(MTT assay) 21 第五節 細胞實驗統計方法 22 第五章、實驗結果 23 第一節 本研究研究群體基本資訊 23 第二節 比對NAHSIT和TDS資料庫分析CPF曝露量與人體代謝相關指標之相關性 24 5.2.1 單變項回歸結果 24 5.2.2 多變項回歸結果 24 5.2.3 羅吉斯回歸結果 25 第三節 比對NAHSIT和TDS資料庫分析IMI曝露量與人體代謝相關指標之相關性 25 5.3.1 單變項回歸結果 25 5.3.2 多變項回歸結果 25 5.3.3 羅吉斯回歸結果 26 第四節 比對NAHSIT和TDS資料庫分析CYP曝露量與人體代謝相關指標之相關性 26 5.4.1 單變項回歸結果 26 5.4.2 多變項回歸結果 27 5.4.3 羅吉斯回歸結果 27 第五節 陶斯松對於FL83B細胞脂肪堆積的影響 27 第六節 陶斯松對於3T3-L1細胞分化以及分化後油脂含量的影響 28 第六章、結果討論 30 第一節 陶斯松對於血三酸甘油脂與脂肪代謝的影響 30 第二節 益達胺對於血中低密度膽固醇與其代謝的影響 32 第三節 益達胺對於血糖的影響 32 第四節 賽滅寧對於生物體影響 34 第七章、結論 35 圖與表 36 附錄 72 參考文獻 75" | |
| dc.language.iso | zh-TW | |
| dc.subject | 脂肪代謝 | zh_TW |
| dc.subject | 益達胺 | zh_TW |
| dc.subject | 賽滅寧 | zh_TW |
| dc.subject | 殺蟲劑 | zh_TW |
| dc.subject | 陶斯松 | zh_TW |
| dc.subject | imidacloprid | en |
| dc.subject | cypermethrin | en |
| dc.subject | insecticide | en |
| dc.subject | lipid metabolism | en |
| dc.subject | chlorpyrifos | en |
| dc.title | 陶斯松、益達胺及賽滅寧之個體暴露劑量對人體代謝影響之評估與細胞模式驗證 | zh_TW |
| dc.title | Effect of the individual exposure to chlorpyrifos imidacloprid and cypermethrin on human metabolism and the verification in cell models | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 呂瑾立(Chin-li Lu) | |
| dc.contributor.oralexamcommittee | 郭靜娟(Hsin-Tsai Liu),江舟峰(Chih-Yang Tseng) | |
| dc.subject.keyword | 陶斯松,益達胺,賽滅寧,殺蟲劑,脂肪代謝, | zh_TW |
| dc.subject.keyword | chlorpyrifos,imidacloprid,cypermethrin,insecticide,lipid metabolism, | en |
| dc.relation.page | 80 | |
| dc.identifier.doi | 10.6342/NTU202103124 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-06 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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