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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79720完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 廖憶純(Yi-Chun Liao) | |
| dc.contributor.author | Cheng-Jui Huang | en |
| dc.contributor.author | 黃政睿 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:08:43Z | - |
| dc.date.available | 2026-08-22 | |
| dc.date.available | 2022-11-23T09:08:43Z | - |
| dc.date.copyright | 2021-09-02 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-23 | |
| dc.identifier.citation | 李昌恆 (2014) 探討 Cten 與β-catenin 和 α-actinin4 之間的交互作用及 Cten 於細胞質和細胞核間穿梭的機制，碩士論文，國立臺灣大學生命科學院生化科技學系 潘妍卉 (2016) CTEN 磷酸化與其於核質間穿梭之調控機制，碩士論文，國立臺灣大學生命科學院生化科技學系 林芷萱 (2017) 表皮生長因子促進 CTEN 基因表達及磷酸化之調控機制，碩士論文，國立臺灣大學生命科學院生化科技學系 吳偉銘 (2018) 探討 CTEN 於人類前列腺上皮細胞所扮演的角色，博士論文，國立臺灣大學生命科學院生化科技學系 蔡孟樵 (2019) 表皮生長因子受體訊息路徑調控 CTEN 磷酸化之功能與機制探討，碩士論文，國立臺灣大學生命科學院生化科技學系 Albasri, A., M. Aleskandarany, A. Benhasouna, D. G. Powe, I. O. Ellis, M. Ilyas and A. R. Green (2011a). CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis. Breast Cancer Res Tr 126, 47-54. Albasri, A., S. Al-Ghamdi, W. Fadhil, M. Aleskandarany, Y. C. Liao, D. Jackson, D. N. Lobo, S. H. Lo, R. Kumari, L. Durrant, S. Watson, K. B. Kindle and M. Ilyas (2011b). Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 30, 2997-3002. Alessi, D. R., F. B. Caudwell, M. Andjelkovic, B. A. Hemmings and P. Cohen (1996). 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79720 | - |
| dc.description.abstract | "Tensin 家族都包含一個可以結合磷酸化酪胺酸 (pTyr) 的 Src 同源結構域 (SH2)，參與了許多訊息傳導的路徑。其中，tensin4 (CTEN) 在多種癌症中高度表達，且許多癌症相關生長因子都會誘導CTEN的表現量。當生長因子受體被細胞外配體活化，會引發一連串的訊息級聯反應而導致下游蛋白質的磷酸化。本實驗室先前的研究證實，當表皮生長因子受體 (EGFR) 信號被活化時，CTEN 的表現量不但上升，且 CTEN 蛋白質會被磷酸化。我們進一步發現 EGF 的刺激會經由 PI3K/AKT 和 MAPK/ERK 的訊息傳導路徑將 CTEN 上的 T347、S350 和 S386 三個位點磷酸化。然而，目前尚未得知磷酸化 CTEN 的激酶，以及磷酸化 CTEN 對癌細胞的影響。在本論文中，我們藉由 GST pull down 的實驗證明了 ERK 激酶會與 CTEN 結合，顯示 CTEN 有可能是 ERK 的受質。我們也發現除了 EGF，類胰島素生長因子 (IGF)、乙型轉化生長因子 (TGF-β) 和血小板衍生生長因子 (PDGF) 也能誘導 CTEN 的磷酸化。在穩定表達野生型 CTEN (CTEN-WT) 或三個磷酸化位點突變 CTEN (CTEN-M3) 的兩種細胞株中，CTEN 磷酸化與否對於一些上皮間質轉化標誌蛋白質如：N-Cadherin，與 CTEN 在細胞中的位置影響並不明顯，但會影響一些上皮間質轉化標誌如：Claudin-1, β-catenin, Snail 的蛋白質含量。另外，我們發現在 HeLa 細胞中，CTEN-WT 而非 CTEN-M3 能夠減緩 EGF 誘導的 EGFR 降解，推測 CTEN 磷酸化可能會促進 EGFR的穩定，進而有助於細胞的癌化。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:08:43Z (GMT). No. of bitstreams: 1 U0001-2208202120110800.pdf: 2132221 bytes, checksum: 72157c124ef48a027ae3245b8ecbe07f (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 目錄 i 縮寫表 iii 摘要 v Abstract vi 1 本論文之研究基礎 1 1.1 Focal adhesion 1 1.2 Tensin 家族的蛋白質結構與其功能 1 1.3 CTEN 表現的調控與功能 2 1.4 PI3K/AKT 以及 MEK/ERK 訊息傳導路徑 5 1.5 表皮生長因子與CTEN磷酸化現象 7 1.6 本論文研究目的 8 2 實驗材料與方法 9 2.1 實驗材料 9 2.1.1 菌種 9 2.1.2 質體 DNA 9 2.1.3 細胞株 10 2.1.4 細胞培養液 10 2.1.5 抗體及生長因子及激酶抑制劑 10 2.2 實驗方法 10 2.2.1 細胞相關實驗 10 2.2.2 蛋白質相關實驗 12 2.2.3 DNA、RNA 分析及質體建構 14 3 研究結果 17 3.1 分析可以磷酸化 CTEN 的激酶 17 3.2 EGF、TGF-、IGF-1、PDGF-BB 都能誘導 CTEN 磷酸化 18 3.3 CTEN 磷酸化對於 EMT marker 的影響 18 3.4 CTEN 磷酸化對於 CTEN 在細胞中位置的影響 20 3.5 CTEN 磷酸化對於 EGFR 蛋白質穩定性的影響 21 4 討論與未來實驗方向 23 5 參考文獻 28 6 圖與表 37 7 附錄 52 | |
| dc.language.iso | zh-TW | |
| dc.subject | 表皮生長因子 | zh_TW |
| dc.subject | CTEN | zh_TW |
| dc.subject | 磷酸化 | zh_TW |
| dc.subject | phosphorylation | en |
| dc.subject | epidermal growth factor receptor | en |
| dc.subject | CTEN | en |
| dc.title | CTEN 磷酸化的調控機制及功能 | zh_TW |
| dc.title | Regulatory mechanisms and functions of CTEN phosphorylation | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 賴韻如(Hsin-Tsai Liu),謝淑貞(Chih-Yang Tseng),黃楓婷 | |
| dc.subject.keyword | 表皮生長因子,CTEN,磷酸化, | zh_TW |
| dc.subject.keyword | epidermal growth factor receptor,CTEN,phosphorylation, | en |
| dc.relation.page | 55 | |
| dc.identifier.doi | 10.6342/NTU202102593 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-08-24 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| dc.date.embargo-lift | 2026-08-22 | - |
| 顯示於系所單位： | 生化科技學系 | |
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