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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 張嘉銓 | zh_TW |
dc.contributor.advisor | Chia-Chuan Chang | en |
dc.contributor.author | 林士翔 | zh_TW |
dc.contributor.author | Shih-Hsiang Lin | en |
dc.date.accessioned | 2021-06-17T03:32:36Z | - |
dc.date.available | 2023-12-15 | - |
dc.date.copyright | 2018-03-29 | - |
dc.date.issued | 2018 | - |
dc.date.submitted | 2002-01-01 | - |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/69889 | - |
dc.description.abstract | 蘭科石斛為一種傳統中國藥材,具有抗氧化、神經保護及免疫調節等作用。由於野生種石斛生長緩慢,因此,將具有生長快速之特性的品種與有效成分含量高的品種雜交,培養出的品種可能具有生長快速且有效成分含量高。為了比較其差異,本研究旨於分析石斛雜交種化學成分。
將八種石斛雜交種乙醇萃取物,以液-液分配法進行極性切割劃分為乙腈、乙酸乙酯、正丁醇和水可溶部分,再進一步對有機溶劑可溶部分進行成分分析。過程中使用Sephadex LH-20、分析及半製備級高效液相層析法、高效液相層析串聯固相萃取技術和質譜,共計鑑定出17個化合物,分別為2個苯甲酸衍生物 (benzoic acid derivatives, 1–2)、4個苯丙烷類 (phenylpropanoids, 3–6)、2個菲類 (phenanthrenes, 7–8) 及9個黃酮 (flavones, 9–17),其中6、9–13、15–17共計9個化合物為首次自石斛屬植物發現。 金皇石斛可分得最多含量之苯丙烷類,其餘石斛雜交種可分得含量多之黃酮化合物:化合物12、14、17在黃櫻石斛中之含量比其在金櫻石斛及櫻金石斛中多出2.2–3.3倍,黃米石斛中所含之9及10高於金皇及黃金石斛所含之2.8–5.0倍;另外,銅金石斛所含之13及15較金童石斛之含量高出1.3倍,然而金童石斛所含之16較銅金石斛之含量高出1.6倍。本次研究總結八種石斛雜交種之高極性化學成分,特別是苯丙烷及黃酮碳苷化合物之含量差異,可作為後續藥材開發之參考。 | zh_TW |
dc.description.abstract | Dendrobium (Shi Hu; Orchidaceae), which exhibits antioxidant, neuroprotective and immunomodulatory bioactivities, is a traditional Chinese medicine. Because of the growth of the wild type Dendrobium species is normally slow, hybridization of the fast-growing species with the rare and valuable ones is a feasible strategy to overcome the difficulties. Thus the aim of this research was to investigate the chemical constituents of the Dendrobium hybrids and to compare their differences in the chemical constituents.
The ethanolic extracts of the eight hybrids were divided into fractions soluble in ACN, EtOAc, n-BuOH, and water via liquid-liquid partitioning. Further separation was conducted on the organic solvent soluble fractions. This effort led to the identification of 17 compounds by combination of Sephadex LH-20, analytical and semi-preparative reverse phase high performance liquid chromatography (RP-HPLC), HPLC-DAD-SPE (solid phase extraction) and MS. These compounds included benzoic acid derivatives (1–2), phenylpropanoids (3–6), phenanthrenes (7–8) and flavones (9–17). Of these, nine compounds, i.e., 6, 9–13, 15–17, were new to the Dendrobium species. Their structures were elucidated by MS data and NMR spectropic analysis. Phenylpropanoids were the major compound isolated from Dendrobium Taiseed Tosnobile. Flavones could be identified as the major compounds in other Dendrobium hybrids. The amount of compounds 12, 14 and 17 in (♀) Dendrobium tosaense × (♂) Dendrobium linawianum is 2.2 to 3.3 times more than that in (♀) Dendrobium nobile × (♂) Dendrobium linawianum and in (♀) Dendrobium linawianum × (♂) Dendrobium nobile. The amount of compouds 9 and 10 in (♀) Dendrobium tosaense × (♂) Dendrobium huoshanense is 2.8 to 5 times more than that in Dendrobium Taiseed Tosnobile and (♀) Dendrobium tosaense × (♂) Dendrobium nobile. Another, the amount of compounds 13 and 15 in (♀) Dendrobium moniliforme × (♂) Dendrobium nobile is 1.3 times more than that in Dendrobium Cassiope. However, the amount of compound 16 in Dendrobium Cassiope is 1.6 times more than that in (♀) Dendrobium moniliforme × (♂) Dendrobium nobile. This research concluded the high polarity compounds of the eight Dendrobium hybrids, especially the amount of phenylpropanoids and C-glycosyl flavones, and the conclusion could be the reference for the following development of the titled medicine. | en |
dc.description.provenance | Made available in DSpace on 2021-06-17T03:32:36Z (GMT). No. of bitstreams: 1 ntu-107-R04423023-1.pdf: 6133016 bytes, checksum: 1bbcd496939afe90bf81a5ea24a0e76c (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 總目錄
口試委員審定書 I 誌謝 II 中文摘要 III Abstract IV 總目錄 VI 目錄 VI 表目錄 X 圖目錄 XIV 流程圖目錄 XVIII 附圖目錄 XIX 辭彙 (Glossary) XX 目錄 1. 緒論及研究目的 1 1.1 研究目的 1 1.2 石斛屬植物介紹 3 1.2.1 金皇石斛 5 1.2.2 金童石斛 5 1.2.3 (♀) 櫻石斛 × (♂) 金釵石斛 5 1.2.4 (♀) 金釵石斛 × (♂) 櫻石斛 5 1.2.5 (♀) 黃花石斛 × (♂) 櫻石斛 5 1.2.6 (♀) 黃花石斛 × (♂) 霍山石斛 6 1.2.7 (♀) 黃花石斛 × (♂) 金釵石斛 6 1.2.8 (♀) 銅皮石斛 × (♂) 金釵石斛 6 1.3 石斛屬 (Dendrobium) 植物成分之文獻回顧 7 1.4 高效液相層析串聯固相萃取技術之簡介 66 2. 實驗結果與討論 69 2.1 苯甲酸衍生物 (Benzoic acid derivatives) 73 2.1.1 Vanillic acid (1) 之結構解析 73 2.1.2 Syringic acid (2) 之結構解析 74 2.2 苯丙烷類 (Phenylpropanoids) 75 2.2.1 N-trans-Feruloyltyramine (3) 之結構解析 75 2.2.2 N-trans-Cinnamoyltyramine (4) 之結構解析 77 2.2.3 N-trans-(p-Coumaroyl)tyramine (5) 之結構解析 78 2.2.4 N-cis-Feruloyltyramine (6) 之結構解析 79 2.3 菲類 (Phenanthrenes) 81 2.3.1 Denbinobin (7) 之結構解析 81 2.3.2 3-Demethoxy-9,10-dihydrodenbinobin (8) 之結構解析 82 2.4 黃酮 (Flavones) 83 2.4.1 2′′-O-α-L-Rhamnopyranosyl vitexin (9) 之結構解析 83 2.4.2 2′′-O-α-L-Rhamnopyranosyl isovitexin (10) 之結構解析 85 2.4.3 2′′-O-α-L-Rhamnopyranosyl isoscoparin (11) 之結構解析 87 2.4.4 6-C-α-L-Arabinopyranosyl vitexin (12) 之結構解析 89 2.4.5 6-C-α-L-Arabinopyranosyl-8-C-β-D-xylopyranosyl apigenin (13) 之結構解析 91 2.4.6 6-C-β-Glucosyl vitexin (14) 之結構解析 93 2.4.7 6-C-β-D-Xylopyranosyl-8-C-α-L-arabinopyranosyl apigenin (15) 之結構解析 95 2.4.8 6,8-di-C-α-L-Arabinopyranosyl apigenin (16) 之結構解析 97 2.4.9 8-C-α-D-Arabinopyranosyl isovitexin (17) 之結構解析 99 2.5 討論 101 3. 實驗部分 104 3.1 儀器與材料 104 3.1.1 理化性質測定儀器 104 3.1.2 成分分離之儀器與材料 104 3.1.3 試劑與溶媒 106 3.2 石斛雜交種材料之來源 106 3.3 石斛雜交種成分萃取與純化 106 3.3.1 金皇石斛之成分分析 108 3.3.1.1 正丁醇可溶部分之成分劃分 108 3.3.1.1.1 Fr. 5 之成分分析 108 3.3.1.2 乙酸乙酯可溶部分之成分劃分 110 3.3.1.2.1 Fr. 3 之成分分析 110 3.3.1.2.2 Fr. 4 之成分分析 112 3.3.1.2.3 Fr. 5 之成分分析 114 3.3.1.3 乙腈可溶部分之成分劃分 116 3.3.1.3.1 Fr. 3 之成分分析 116 3.3.1.3.2 Fr. 4-1 之成分分析 118 3.3.1.3.3 Fr. 5 之成分分析 120 3.3.2 金童石斛之成分分析 123 3.3.2.1 乙酸乙酯可溶部分之成分劃分 123 3.3.2.1.1 Fr. 3-1-2 之成分分析 123 3.3.2.2 乙腈可溶部分之成分劃分 126 3.3.2.2.1 Fr. 4 之成分分析 126 3.3.2.2.2 Fr. 5 之成分分析 128 3.3.2.3 正丁醇可溶部分之成分劃分 130 3.3.2.3.1 Fr. 4 之成分分析 130 3.3.3 櫻金石斛之成分分析 133 3.3.3.1 正丁醇可溶部分之成分劃分 133 3.3.3.1.1 Fr. 4 之成分分析 133 3.3.4 金櫻石斛之成分分析 136 3.3.4.1 正丁醇可溶部分之成分劃分 136 3.3.4.1.1 Fr. 4 之成分分析 136 3.3.5 黃櫻石斛之成分分析 139 3.3.5.1 正丁醇可溶部分之成分劃分 139 3.3.5.1.1 Fr. 3 之成分分析 139 3.3.6 黃米石斛之成分分析 142 3.3.6.1 正丁醇可溶部分之成分劃分 142 3.3.6.1.1 Fr. 3 之成分分析 142 3.3.7 黃金石斛之成分分析 145 3.3.7.1 正丁醇可溶部分之成分劃分 145 3.3.7.1.1 Fr. 3 之成分分析 145 3.3.8 銅金石斛之成分分析 148 3.3.8.1 正丁醇可溶部分之成分劃分 148 3.3.8.1.1 Fr. 3 之成分分析 148 參考文獻 151 表目錄 Table 1. Alkaloids isolated from Dendrobium species 7 Table 2. Dendrobium species containing alkaloids 9 Table 3. Flavonoids isolated from Dendrobium species 11 Table 4. Dendrobium species containing flavonoids 12 Table 5. Lignans isolated from Dendrobium species 14 Table 6. Dendrobium species containing lignans 16 Table 7. Phenylpropanoids isolated from Dendrobium species 20 Table 8. Dendrobium species containing phenylpropanoids 22 Table 9. Stilbenes isolated from Dendrobium species 25 Table 10. Dendrobium species containing stilbenes 31 Table 11. Phenanthrenes isolated from Dendrobium species 36 Table 12. Dendrobium species containing phenanthrenes 41 Table 13. Monoterpenoids isolated from Dendrobium species 46 Table 14. Dendrobium species containing monoterpenoids 46 Table 15. Sesquiterpenoids isolated from Dendrobium species 47 Table 16. Dendrobium species containing sesquiterpenoids 48 Table 17. Triterpenoids isolated from Denrobium species 52 Table 18. Dendrobium species containing triterpenoids 53 Table 19. Phenolics isolated from Dendrobium species 55 Table 20. Dendrobium species containing phenolics 56 Table 21. Anthraquinones isolated from Dendrobium species 57 Table 22. Dendrobium species containing anthraquinones 57 Table 23. Coumarins isolated from Dendrobium species 58 Table 24. Dendorbium species containing coumarins 58 Table 25. Fluorenones isolated from Dendrobium species 59 Table 26. Dendrobium species containing fluorenones 60 Table 27. Other compounds isolated from Dendrobium species 61 Table 28. Dendrobium species containing other compounds 63 Table 29. SPE cartridges phase types 68 Table 30. The amount (%) of compounds identified from the eight Dendrobium hybrids 72 Table 31. 1H NMR data of vanillic acid (1) 73 Table 32. 1H NMR data of syringic acid (2) 74 Table 33. 1H NMR data of N-trans-feruloyltyramine (3) 76 Table 34. 1H NMR data of N-trans-cinnamoyltyramine (4) 77 Table 35. 1H NMR data of N-trans-(p-coumaroyl)tyramine (5) 78 Table 36. 1H NMR data of N-cis-feruloyltyramine (6) 80 Table 37. 1H NMR data of denbinobin (7) 81 Table 38. 1H NMR data of 3-demethoxy-9,10-dihydrodenbinobin (8) 82 Table 39. 1H NMR data of 2′′-O-α-L-rhamnopyranosyl vitexin (9) 84 Table 40. 1H NMR data of 2′′-O-α-L-rhamnopyranosyl isovitexin (10) 86 Table 41. 1H NMR data of 2′′-O-α-L-rhamnopyranosyl isoscoparin (11) 88 Table 42. 1H NMR and 13C NMR data of 6-C-α-L-arabinopyranosyl vitexin (12) 90 Table 43. 1H NMR data of 6-C-α-L-arabinopyranosyl-8-C-β-D-xylopyranosyl apigenin (13) 92 Table 44. 1H NMR data of 6-C-β-glucosyl vitexin (14) 94 Table 45. 1H NMR data of 6-C-β-D-xylopyranosyl-8-C-α-L-arabinopyranosyl apigenin (15) 96 Table 46. 1H NMR data of 6,8-di-C-α-L-arabinopyranosyl apigenin (16) 98 Table 47. 1H NMR data of 8-C-α-D-arabinopyranosyl isovitexin (17) 100 Table 48. Weight of the EtOH extract and each soluble fraction from the eight Dendrobium hybrids 107 Table 49. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 5 of n-BuOH-soluble fraction of Dendrobium Taiseed Tosnobile 109 Table 50. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 111 Table 51. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 113 Table 52. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 5 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 115 Table 53. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 117 Table 54. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4-1 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 119 Table 55. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 5 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 121 Table 56. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3-1-2 of EtOAc-soluble fraction of Dendrobium Cassiope 125 Table 57. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of ACN-soluble fraction of Dendrobium Cassiope 127 Table 58. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 5 of ACN-soluble fraction of Dendrobium Cassiope 129 Table 59. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of n-BuOH-soluble fraction of Dendrobium Cassiope 131 Table 60. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of n-BuOH-soluble fraction of (♀) Dendrobium linawianum × (♂) Dendrobium nobile 134 Table 61. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of n-BuOH-soluble fraction of (♀) Dendrobium nobile × (♂) Dendrobium linawianum 137 Table 62. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium linawianum 140 Table 63. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium huoshanense 143 Table 64. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium nobile 146 Table 65. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium moniliforme × (♂) Dendrobium nobile 149 圖目錄 Figure 1. Alkaloids isolated from Dendrobium species (I) 9 Figure 2. Alkaloids isolated from Dendrobium species (II) 10 Figure 3. Flavonoids isolated from Dendrobium species (I) 12 Figure 4. Flavonoids isolated from Dendrobium species (II) 13 Figure 5. Lignans isolated from Dendrobium species (I) 16 Figure 6. Lignans isolated from Dendrobium species (II) 17 Figure 7. Lignans isolated from Dendrobium species (III) 18 Figure 8. Lignans isolated from Dendrobium species (IV) 19 Figure 9. Phenylpropanoids isolated from Dendrobium species (I) 22 Figure 10. Phenylpropanoids isolated from Dendrobium species (II) 23 Figure 11. Phenylpropanoids isolated from Dendrobium species (III) 24 Figure 12. Stilbenes isolated from Dendrobium species (I) 32 Figure 13.Stilbenes isolated from Dendrobium species (II) 33 Figure 14. Stilbenes isolated from Dendrobium species (III) 34 Figure 15. Stilbenes isolated from Dendrobium species (IV) 35 Figure 16. Phenanthrenes isolated from Dendrobium species (I) 41 Figure 17. Phenanthrenes isolated from Dendrobium species (II) 42 Figure 18. Phenanthrenes isolated from Dendrobium species (III) 43 Figure 19. Phenanthrenes isolated from Dendrobium species (IV) 44 Figure 20. Phenanthrenes isolated from Dendrobium species (V) 45 Figure 21. Monoterpenoids isolated from Dendrobium species 46 Figure 22. Sesquiterpenoids isolated from Dendrobium species (I) 49 Figure 23. Sesquiterpenoids isolated from Dendrobium species (II) 50 Figure 24. Sesquiterpenoids isolated from Dendrobium species (III) 51 Figure 25. Triterpenoids isolated from Dendrobium species (I) 53 Figure 26. Triterpenoids isolated from Dendrobium species (II) 54 Figure 27. Phenolics isolated from Dendrobium species 56 Figure 28. Anthraquinones isolated from Dendrobium species 57 Figure 29. Coumarins isolated from Dendrobium species 58 Figure 30. Fluorenones isolated from Dendrboium species 60 Figure 31. Other compounds isolated from Dendrobium species (I) 63 Figure 32. Other compounds isolated from Dendrobium species (II) 64 Figure 33. Other compounds isolated from Dendrobium species (III) 65 Figure 34. Schematic representation of the hyphenated LC-SPE-NMR 67 Figure 35. Structures of the compounds 1–17 identified from the eight Dendrobium hybrids 71 Figure 36. 1H NMR spectra of compounds 9 and 10 86 Figure 37. 1H NMR spectra of compounds 9–11 88 Figure 38. 1H NMR spectra of compounds 12 and 13 92 Figure 39. 1H NMR spectra of compounds 12 and 15 96 Figure 40. 1H NMR spectra of compounds 12 and 16 98 Figure 41. 1H NMR spectra of compounds 12 and 17 100 Figure 42. HPLC chrmatogram of identified compounds in fraction 5 of n-BuOH-soluble fraction of Dendrobium Taiseed Tosnobile 109 Figure 43. HPLC chrmatogram of identified compounds in fraction 3 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 111 Figure 44. HPLC chrmatogram of identified compounds in fraction 4 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 113 Figure 45. HPLC chromatogram of identified compounds in fraction 5 of EtOAc-soluble fraction of Dendrobium Taiseed Tosnobile 115 Figure 46. HPLC chromatogram of identified compounds in fraction 3 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 117 Figure 47. HPLC chromatogram of identified compounds in fraction 4-1 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 119 Figure 48. HPLC chromatogram of identified compounds in fraction 5 of ACN-soluble fraction of Dendrobium Taiseed Tosnobile 121 Figure 49. HPLC chromatogram of identified compounds in fraction 3-1-2 of EtOAc-soluble fraction of Dendrobium Cassiope 125 Figure 50. HPLC chromatogram of identified compounds in fraction 4 of ACN-soluble fraction of Dendrobium Cassiope 127 Figure 51. HPLC chromatogram of identified compounds in fraction 5 of ACN-soluble fraction of Dendrobium Cassiope 129 Figure 52. HPLC retention time (tR, min) and ESI-MS data of identified compounds in fraction 4 of n-BuOH-soluble fraction of Dendrobium Cassiope 131 Figure 53. HPLC chromatogram of identified compounds in fraction 4 of n-BuOH-soluble fraction of (♀) Dendrobium linawianum × (♂) Dendrobium nobile 134 Figure 54. HPLC chromatogram of identified compounds in fraction 4 of n-BuOH-soluble fraction of (♀) Dendrobium nobile × (♂) Dendrobium linawianum 137 Figure 55. HPLC chromatogram of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium linawianum 140 Figure 56. HPLC chromatogram of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium huoshanense 143 Figure 57. HPLC chromatogram of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium tosaense × (♂) Dendrobium nobile 146 Figure 58. HPLC chromatogram of identified compounds in fraction 3 of n-BuOH-soluble fraction of (♀) Dendrobium moniliforme × (♂) Dendrobium nobile 149 流程圖目錄 Scheme 1. Identification of the compounds 1–11 from the EtOH extract of Dendrobium Taiseed Tosnobile 122 Scheme 2. Identication of the compounds 3, 5, 8, 13, 15–16 from the EtOH extract of Dendrobium Cassiope 132 Scheme 3. Identification of the compounds 12, 14 and 17 from the n-BuOH-soluble layer of (♀) Dendrobium linawianum × (♂) Dendrobium nobile 135 Scheme 4. Identification of the compounds 12, 14 and 17 from the n-BuOH-soluble layer of (♀) Dendrobium nobile × (♂) Dendrobium linawianum 138 Scheme 5. Identification of the compounds 12, 14 and 17 from the n-BuOH-soluble layer of (♀) Dendrobium tosaense × (♂) Dendrobium linawianum 141 Scheme 6. Identification of the compounds 9–11 from the n-BuOH-soluble layer of (♀) Dendrobium tosaense × (♂) Dendrobium huoshanense 144 Scheme 7. Identification of the compounds 9–11 from the n-BuOH-soluble layer of (♀) Dendrobium tosaense × (♂) Dendrobium nobile 147 Scheme 8. Identification of the compounds 13, 15 and 16 from the n-BuOH-soluble layer of (♀) Dendrobium moniliforme × (♂) Dendrobium nobile 150 附圖目錄 Figure S1. 1H NMR spectrum of compound 1 (CD3OD, 600 MHz) 169 Figure S2. 1H NMR spectrum of compound 2 (CD3OD, 600 MHz) 170 Figure S3. 1H NMR spectrum of compound 3 (CD3OD, 500 MHz) 171 Figure S4. 1H NMR spectrum of compound 4 (CD3OD, 600 MHz) 172 Figure S5. 1H NMR spectrum of compound 5 (CD3OD, 500 MHz) 173 Figure S6. 1H NMR spectrum of compound 6 (CD3OD, 400 MHz) 174 Figure S7. 1H NMR spectrum of compound 7 (CD3OD, 400 MHz) 175 Figure S8. 1H NMR spectrum of compound 8 (CD3OD, 400 MHz) 176 Figure S9. 1D NOESY spectrum of compound 8 (CD3OD, 500 MHz) 177 Figure S10. 1H NMR spectrum of compound 9 (CD3OD, 500 MHz) 178 Figure S11. 1H NMR spectrum of compound 10 (CD3OD, 600 MHz) 179 Figure S12. 1H NMR spectrum of compound 11 (CD3OD, 600 MHz) 180 Figure S13. 1D NOESY spectrum of compound 11 (CD3OD, 600 MHz) 181 Figure S14. 1H NMR spectrum of compound 12 (CD3OD, 600 MHz) 182 Figure S15. HSQC spectrum of compound 12 (CD3OD, 600 MHz) (I) 183 Figure S16. HSQC spectrum of compound 12 (CD3OD, 600 MHz) (II) 184 Figure S17. 1H NMR spectrum of compound 13 (CD3OD, 600 MHz) 185 Figure S18. 1H NMR spectrum of compound 14 (CD3OD, 600 MHz) 186 Figure S19. 1H NMR spectrum of compound 15 (CD3OD, 600 MHz) 187 Figure S20. 1H NMR spectrum of compound 16 (CD3OD, 600 MHz) 188 Figure S21. 1H NMR spectrum of compound 17 (CD3OD, 600 MHz) 189 | - |
dc.language.iso | zh_TW | - |
dc.title | 石斛雜交種化學成分之研究 | zh_TW |
dc.title | Chemical investigation of Dendrobium hybrids | en |
dc.type | Thesis | - |
dc.date.schoolyear | 106-1 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 黃鈺玲;李水盛 | zh_TW |
dc.contributor.oralexamcommittee | Yu-Ling Huang;Shoei-Sheng Lee | en |
dc.subject.keyword | 石斛雜交種,金皇石斛,金童石斛,高效液相層析串聯固相萃取技術,黃酮化合物, | zh_TW |
dc.subject.keyword | Dendrobium hybrids,Dendrobium Taiseed Tosnobile,Dendrobium Cassiope,High performance liquid chromatography hyphenated solid phase extraction,flavones, | en |
dc.relation.page | 189 | - |
dc.identifier.doi | 10.6342/NTU201800602 | - |
dc.rights.note | 未授權 | - |
dc.date.accepted | 2018-02-14 | - |
dc.contributor.author-college | 醫學院 | - |
dc.contributor.author-dept | 藥學研究所 | - |
顯示於系所單位: | 藥學系 |
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