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標題: | 新穎的抗菌鈦鎳銅銀形狀記憶薄膜在生物醫學應用之研究 Novel antibacterial TiNiCuAg shape memory alloy films for biomedical applications |
作者: | Wei-Ting Jhou 周葦葶 |
指導教授: | 薛承輝(Chun-Hway Hsueh) |
關鍵字: | 形狀記憶薄膜,形狀記憶效果,抗菌效果,細胞毒性,磁控濺鍍, Shape memory film,Shape memory effect,Antibacterial effect,In vitro cytotoxicity assay,Magnetron Sputtering, |
出版年 : | 2017 |
學位: | 碩士 |
摘要: | 鈦鎳基形狀記憶合金(SMA)已被廣泛用於支架,義肢和矯正植入器。然而醫療器具植入後的細菌感染問題是最常見的併發症,因此開發具有抗菌效果的鈦鎳基形狀記憶合金材料是極為重要的。在本研究中,通過在鈦鎳基體中添加銀和銅,成功研製出新型具有抗菌效果的鈦鎳銅銀形狀記憶合金膜(SMAF)。鈦鎳銅銀形狀記憶合金膜的機械和生物學特性被系統化的研究,包括晶體結構,相變溫度,形狀記憶效應,抗菌能力和細胞毒性。結果表明,隨著銀含量的增加,銀開始析出以及相變溫度逐漸降低。透過DSC觀察結果發現,TiNiCu和TiNiCuAg1,薄膜中會發生一階相轉B2↔B19,而TiNiCuAg1.5,TiNiCuAg5.6 和TiNiCuAg7薄膜中發生二階相轉B2↔R↔B19'。此外,TiNiCuAg膜相較於TiNiCu膜具有更好的形狀記憶效應。且在L929細胞毒性測定的結果觀察到TiNiCuAg膜和TiNiCu膜對L929細胞並沒有顯示具有細胞毒性,說明了所有的膜都保持良好的生物相容性。而在抗菌試驗中觀察到TiNiCuAg膜相對於TiNi和TiNiCu膜對金黃色葡萄球菌(S. aureus)和大腸桿菌(E.coli)具有最好的抗菌能力。因此,良好的抗菌能力和生物相容性說明了鈦鎳銅銀形狀記憶薄膜具有應用在醫療植入器的潛力。 TiNi-based shape memory alloys (SMAs) have been largely utilized in stents, orthopedic endo-prostheses and orthodontic implants. While bacterial infection in medical implants is the most common complication, development of antibacterial TiNi-based SMAs is important. In the present study, a novel antibacterial TiNiCuAg shape memory alloy film (SMAF) was successfully developed by adding silver and copper into TiNi matrix. The mechanical and biological properties of TiNiCuAg SMAF, including crystal structures, phase transformation temperatures, shape memory effect, antibacterial ability and cell cytotoxicity were systematically investigated. The results exhibited that the phase transformation temperature gradually decreased and silver started to precipitate with the increasing silver content. The single-stage B2 ↔ B19’ transformation occurred in TiNiCu and TiNiCuAg1 films, while the two-stage B2 ↔ R ↔ B19’ transformation occurred in TiNiCuAg1.5, TiNiCuAg5.6 and TiNiCuAg7 films. Moreover, compared to TiNiCu films, TiNiCuAg films performed better shape memory effect. For cytotoxicity assay, all films maintained good biocompatibility and revealed no cell toxicity for L929 cells. For antibacterial tests, the TiNiCuAg films had the best antibacterial ability for S. aureus and E. coli compared to those of TiNi and TiNiCu films. As a result, excellent antibacterial ability and good biocompatibility suggested TiNiCuAg SMAFs had potential applications for medical implant to avoid bacterial infection. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/67832 |
DOI: | 10.6342/NTU201701906 |
全文授權: | 有償授權 |
顯示於系所單位: | 材料科學與工程學系 |
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