利用氟化鈉插層之氟化蒙脫石及二氧化鋯製成具備雙重氟離子釋放與再填充能力之牙科複合樹酯

Abstract

齲齒是人類中最常見的口腔疾病。利用填補材料治療齲齒是目前臨床上最常使用的方法。填補材料發展至今已經多年，歷經多種不同材料的演進，然而目前市面上所販售之複合樹酯產品幾乎沒有氟離子的釋放與再填充能力，無法維持口腔中相當濃度氟離子而達到預防二次齲齒的效果。因此本研究的目的是開發一種具有優異的氟離子釋放和再填充能力的複合樹酯。我們利用氟化鈉插層之氟化蒙脫石以及矽皖化處理後的二氧化鋯作為bis-GMA基材中的兩種無機填料。X光繞射、熱重分析及紅外線光譜儀用於分析無機填料的改質。複合樹脂的機械性能分析中顯示徑向拉伸強度，彎曲強度以及耐磨性性質的平均值均明顯高於商業對照組。細胞增殖以及細胞染色實驗用於驗證該材料有良好的生物相容性。此外，口腔環境的模擬證實了該複合樹脂具有良好的氟離子釋放和再填充能力。因此，在這項研究中開發的複合樹脂可以減少二次齲齒的發生，並為將來的臨床治療提供新的選擇。

Dental caries are the most frequent oral disease in humans. Filling cavities with a dental restorative material is the most common clinical treatment. With the evolution of many different restorative materials through the years, the composite resin products currently on the market have almost no fluoride ion release and rechargeability, and cannot maintain a considerable concentration of fluoride ions in the oral cavity to prevent secondary dental caries. The purpose of this study was to develop a composite resin with excellent fluoride ion release and recharge ability. We developed a fluorinated montmorillonite intercalated with sodium fluoride and zirconium dioxide after hydrophobized treatment as two inorganic fillers in the bis-GMA matrix. X-ray diffraction, thermogravimetric analysis, and infrared spectrometry were used to analyze the modification of inorganic fillers. Mechanical property tests for diametral tensile strength, flexural strength, and wear resistance showed the average values of the developed composite resin were significantly higher than those of a commercial control group. WST-1 and Live/Dead staining were used to verify that the material had good biocompatibility. In addition, simulation of the oral environment confirmed that the composite resin showed good fluoride ion release and rechargeability. Thus, the composite resin developed in this study may reduce secondary caries and provide a new choice for future clinical treatments.