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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65384
標題: | 表面電漿共振增益型化學感測器 Chemical Sensor Based on Surface Plasmon Resonance |
作者: | Min-Ping Lin 林旻平 |
指導教授: | 林唯芳 |
關鍵字: | 表面電漿共振,拉曼散射光譜,自組裝,有機染料,塑化劑,愷他命, surface plasmon resonance,Raman scattering spectrum,self-assembly,organic dyes,plasticizers,ketamine, |
出版年 : | 2012 |
學位: | 碩士 |
摘要: | 近幾年食品汙染頻傳,從2008年的三聚氰胺事件到2011年的塑化劑事件,無不讓民眾陷入人心惶惶的食品安全黑暗期,因此快速且準確的檢測分析方式是必要的。引入表面增強拉曼散射之技術,利用其量測快速、靈敏度高之優點來開發適用於廢水污染監測、毒品檢驗、殘留化學物檢測分析等之基材為當前熱門的研究方向。
本論文的構想是以製程快速、成本低廉的方式來製作具有表面增強拉曼散射效應之基材。本研究利用旋鍍二氧化矽次微米球的方式,製作出大面積的週期性結構,並採用熱蒸鍍方法來製備覆蓋於結構表面的金屬銀薄膜。透過製程參數的調控,使基材本身的光學性質產生變化,進而增強表面電漿共振效應。同時也研究待測物其吸收光譜與拉曼量測激發波長的相關性,得出待測物吸收波長與拉曼量測激發波長位置越相近,則其拉曼訊號增顯效果越佳。 利用本研究所製備之表面增強拉曼散射效應基材用來檢測有機染料、塑化劑與愷他命等有機化合物。在有機染料方面,其拉曼散射訊號最高可增強40,000倍。在塑化劑方面,除了其增顯因子可達21,000倍外,同時以簡單萃取分離的方法,快速有效將干擾物去除,得到目標分析物拉曼圖譜,其偵測極限可達40 ppm。而我們也針對愷他命在尿液中的檢測分析,經由萃取分離的方法,其偵測極限可達20 ppm,相較目前市售的愷他命檢測試片的100 ppm偵測極限,本研究出色許多。 本研究所開發之表面增強拉曼散射基材的靈敏性可超越目前市售的檢測片,且由於其製作成本低廉,準確性高與快速量測的優點,預計可大量生產並商品化,應用於各項汙染監測,也可運用至毒品檢測,替人民的治安作進一步的把關。 Numerous food safety incidents take place in recent years. For example, the 2008 Chinese milk scandal of which adulterated melamine was found in infant milk powder. Additionally, plasticizer (such as, bis(2-ethylhexyl) phthalate(DEHP), Benzyl butyl phthalate(BBP), dibutyl phthalate(DBP)) was used to replace palm oil in foods and drinks as a clouding agent in 2011, Taiwan. Therefore, to quickly and accurately characterize food or ingredients is extremely important for preventing damage from toxic substances. To approach this goal, there is a novel methodology of rapid detection by adopting surface-enhanced Raman scattering (SERS) effect on highly sensitive substrate. It will be powerful in detecting drugs and chemicals. In this study, we develop a simple and low cost solution process to fabricate a novel Ag coated monodispersive silica colloid monolayer substrate to enhance Raman scattering signals of organic dyes, plasticizer and ketamine. By tuning the process parameters, a significant enhancement of Raman scattering by surface plasmon was observed. We also found that there is a relationship between the absorption wavelength of chemicals and the Raman excitation wavelength. The enhancement factor of Raman signal would be higher since the overlapped wavelength. The enhancement factor of organic dyes on our SERS substrate is 40,000 times. For the plasticizers, the enhancement factor of plasticizers on our SERS substrate is 21,000 times. A simple extraction method was used to remove the interference efficiently, leading to the lowest detecting limits 40 ppm and 20 ppm of plasticizer and ketamine respectively. Consequently, the developed SERS method with high sensitivity, low cost and quick detection in this study will be beneficial for the design and fabrication of functional devices and sensors. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65384 |
全文授權: | 有償授權 |
顯示於系所單位: | 高分子科學與工程學研究所 |
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