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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蔣丙煌 | |
| dc.contributor.author | Hsiu-Ju Wang | en |
| dc.contributor.author | 王秀如 | zh_TW |
| dc.date.accessioned | 2021-06-16T17:13:56Z | - |
| dc.date.available | 2017-08-27 | |
| dc.date.copyright | 2012-08-27 | |
| dc.date.issued | 2012 | |
| dc.date.submitted | 2012-08-19 | |
| dc.identifier.citation | 行政院衛生署。2010。健康食品調節血糖功能評估方法修正草案 (衛署食字第0991301352號)。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/63555 | - |
| dc.description.abstract | 本研究使用五味子 (Schizandra chinensis Baill.)、黃連 (Coptis chinensis)、番石榴葉 (Psidium guajava L. leaves) 與桑葉 (Morus alba L. leaves) 做為全新的調節血糖中藥複方，首先根據其抑制α-glucosidase能力、抑制DPP-4能力與抑制AGE形成能力 (in vitro) 並配合反應區面法 (response surface methodology, RSM) 尋找其較適配方，接著以動物實驗進一步確認該較適化中藥複方之調節血糖效果。反應曲面法結果顯示較適的調節血糖中藥複方之配方為五味子 (3000 μg/mL)、黃連(80 μg/mL)、番石榴葉 (374.56 μg/mL) 與桑葉 (480 μg/mL)。動物實驗結果則顯示以高熱量飼料餵食小鼠六週可成功誘導成為胰島素阻抗小鼠，而給予調節血糖中藥複方後，可顯著降低其任食血糖值，且在胰島素阻抗性試驗中，調節血糖中藥複方也可顯著降低血糖，以上結果指出此中藥複方調節血糖機制可能是因為其可改善胰島素阻抗性。高劑量中藥複方組的血清中果糖胺含量顯著低於高熱量對照組與正常對照組，也顯示出調節血糖中藥複方可改善中長期血糖值與降低糖尿病併發症發生的風險。此外在動物實驗中我們也發現此中藥複方並不會對於小鼠肝臟與胰臟造成傷害，也不會對於小鼠血漿中的脂質與脂蛋白含量有所影響。Berberine與1-deoxynojirimycin為可能的活性成分，其在中藥複方中的含量分別為4.7 ± 0.4與77.1 ± 1.1 μg/mL，此兩化合物的含量在未來可以當作大量生產時的品管指標。 | zh_TW |
| dc.description.abstract | An anti-diabetic TCM formula consisting of Schizandra chinensis Baill. (SC), Coptis chinensis (CC), Psidium guajava L. leaves (PG) and Morus alba L. leaves (MA) was developed based on its α-glucosidase, DPP-4 and AGE inhibitory activities in vitro using response surface methodology (RSM). Then, the in vivo study was carried out to confirm the anti-diabetic function of the formula. RSM results showed that the optimum anti-diabetic TCM formula is the combination of SC (3000 μg/mL), CC (80 μg/mL), PG (374.56 μg/mL) and MA (480 μg/mL). For in vivo study, insulin resistant mice were induced by high-fat/high-sucrose (HF/HS) feeding for 6 weeks. Administration of the developed formula significantly decreased non-fasting blood glucose in the HF/HS diet mice. Moreover, the formula decreased blood glucose levels in the insulin tolerance test. These results indicated that the anti-diabetic mechanism of the formula might be due to decreased insulin resistance. The serum fructosamine level in high dose group was significantly lower than HF/HS and normal control groups, indicating that the formula could improve middle term glucose levels and reduce risks for complications. In addition, the formula had no adverse effects on liver as well as kidney and it did not change plasma lipid profile parameters. The contents of berberine and 1-deoxynojirimycin in the formula were 4.7 ± 0.4 and 77.1 ± 1.1 μg/mL, respectively. These two compounds can be used as indicators for quality control during production. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T17:13:56Z (GMT). No. of bitstreams: 1 ntu-101-D94641008-1.pdf: 1769612 bytes, checksum: 8c880432d2f7d81299f7d302a7ff323d (MD5) Previous issue date: 2012 | en |
| dc.description.tableofcontents | 第一章 文獻整理 1
1. 糖尿病 1 1.1 糖尿病的流行病學 1 1.2 糖尿病簡介 1 1.3 糖尿病之分類 2 2. 葡萄糖代謝與胰島素訊息傳遞 5 2.1 胰島素 5 2.2 胰島素訊息傳遞與葡萄糖運送 7 2.3 胰島素阻抗性 9 3. 糖尿病之治療方法 9 3.1 胰島素補充與替代品 (insulin replacement) 9 3.2 促進胰島素分泌 (insulin secretagogues) 10 3.3 改善胰島素阻抗 (insulin sensitizers) 10 3.4 減緩碳水化合物吸收 (starch blocker) 10 3.5 GLP-1類似物 (GLP-1 analogues) 13 3.6 DPP-4抑制劑 (DPP-4 inhibitor) 14 4. 高血糖、氧化壓力與胰島素阻抗性 24 4.1 高血糖與自由基之生成 24 4.2 胰島素阻抗與氧化壓力 26 5. 糖化終產物與糖尿病併發症 27 5.1 糖尿病併發症 27 5.2 糖化終產物 27 5.3 糖化終產物與糖尿病併發症之關係 31 6. 中草藥 32 6.1 五味子 32 6.2 黃連 32 6.3 番石榴葉 32 6.4 桑葉 33 第二章 前言 35 第三章 材料與方法 38 1. 試驗材料 38 2. 化學藥品 38 3. 儀器設備 38 4. 調節血糖中藥複方之製備 39 5. 調節血糖中藥複方之較適化 (in vitro) 39 5.1 抑制α-glucosidase之測定 40 5.2 抑制DPP-4之測定 40 5.3 抑制AGE之測定 40 6. 中藥複方之調節血糖功效 (in vivo) 41 6.1 實驗動物 41 6.2 口服葡萄糖耐受性測試 42 6.3 胰島素阻抗性測試 42 6.4 任食血糖含量 42 6.5 血清中胰島素與果糖胺含量 42 6.6 肝功能評估 42 6.7 腎功能評估 43 6.8 血脂含量 43 7. 調節血糖中藥複方之成分分析 43 7.1 schisandrin B含量 43 7.2 berberine含量 43 7.3 1-deoxynojirimycin含量 43 8. 數據統計分析 44 第四章 結果 48 1. 調節血糖中藥複方較適化配方之探討 (in vitro) 48 1.1 黃連、番石榴葉與桑葉對α-glucosidase抑制率之影響 48 1.2 黃連、番石榴葉與桑葉對DPP-4抑制率之影響 53 1.3 黃連、番石榴葉與桑葉對AGE抑制率之影響 57 2. 中藥複方調節血糖活性評估 (in vivo) 61 2.1 肥胖、葡萄糖耐受不良的C57BL/6JNarl小鼠之誘導 61 2.2 中藥複方之攝取對於C57BL/6JNarl小鼠體重之影響 61 2.3 口服葡萄糖耐受性測試 64 2.4 胰島素阻抗性測試 64 2.5 中藥複方之攝取對於C57BL/6JNarl小鼠任食血糖之影響 65 2.6 中藥複方之攝取對於C57BL/6JNarl小鼠血清中胰島素與果糖胺之影響 65 2.7 中藥複方之攝取對於C57BL/6JNarl小鼠肝功能之影響 73 2.8 中藥複方之攝取對於C57BL/6JNarl小鼠腎功能之影響 73 2.9 中藥複方之攝取對於C57BL/6JNarl小鼠血脂之影響 73 3. 調節血糖中藥複方活性成分之探討 82 第五章 討論 88 第六章 結論 94 第七章 參考文獻 95 | |
| dc.language.iso | zh-TW | |
| dc.title | 調節血糖中藥複方產品之開發與評估 | zh_TW |
| dc.title | Development and Evaluation of an Anti-diabetic Traditional Chinese Medicine Formula | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 100-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 何其儻,沈雅敬,吳瑞碧,陳旦生 | |
| dc.subject.keyword | 五味子,黃連,番石榴,桑葉,調節血糖功效,α-glucosidase抑制活性,DPP-4抑制活性,AGE抑制活性,中藥, | zh_TW |
| dc.subject.keyword | Schizandra chinensis Baill.,Coptis chinensis,Psidium guajava L.,Morus alba L.,anti-diabetic effect,α-glucosidase inhibitory activity,DPP-4 inhibitory activity,AGE inhibitory activity,traditional Chinese medicine, | en |
| dc.relation.page | 105 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2012-08-20 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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