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標題: | 多孔性纖維素之製備及其特性 Preparation of porous cellulose and its characteristics |
作者: | Chuan-Chih Kao 高絹智 |
指導教授: | 葉安義 |
關鍵字: | 纖維素,多孔性,麥芽糊精,介質研磨,噴霧乾燥, cellulose,porosity,maltodextrin,media milling,spray drying, |
出版年 : | 2013 |
學位: | 碩士 |
摘要: | 纖維素是自然界中分布最廣、含量最多的多醣,已被證實對維持人體健康有所助益,例如促進腸胃蠕動、預防便秘與結腸癌、以及降低膽固醇等。多孔性纖維素則在生物技術與生物化學領域中,應用於藥物輸送系統,作為標靶藥物的載體,可延長藥物循環時間,以增加治療的效率。文獻中多孔性纖維素的製備方式有酸水解、鹼處理以及化學處理等,這些處理方式所產生的多孔性纖維素則有許多缺點,如成本高、不易量產、廢棄物或廢水的處理以及溶劑回收等問題。本實驗在探討混合不同比例的纖維素與麥芽糊精經由濕式介質研磨 (media milling),與噴霧乾燥後的纖維素-糊精粉末之物化特性,以及粉末復水後多孔性纖維素的孔洞性。
纖維素20 g 加入380 g 去離子水混勻,添加不同比例之麥芽糊精,研磨45分鐘後,以噴嘴進料溫度 200 ℃進行噴霧乾燥。實驗結果顯示,介質研磨可以使纖維素粒子粒徑降至奈米/次微米等級,而麥芽糊精的添加會造成纖維素懸浮液的體積平均粒徑增加,以及界面電位的下降,皆呈現中度穩定的狀態。噴霧乾燥纖維素-糊精粉末之體積平均粒徑在8-12 μm之間,以掃描式電子顯微鏡 (SEM) 觀察粉末型態,發現纖維素-糊精粉末表面皺縮無孔洞性,復水過後會形成多孔性的顆粒,噴乾粉末復水後之其比表面積皆有增加,以麥芽糊精添加比例為1.5具有最大的比表面積;由界面電位觀測其穩定性,未添加麥芽糊精之噴乾粉末之穩定性最佳為 -30.3 mV,有添加麥芽糊精之噴乾粉末之界面電位介於 -23.8 mV 與 -26.2 mV之間,表噴乾粉末復水後,纖維素懸浮液仍處於中度穩定的狀態。 Cellulose is the most abundant polysaccharides in nature. It has been proved that cellulose has many benefits to human health, such as promoting gastrointestinal peristalsis, preventing constipation and colon cancer, and reducing cholesterol. Porous cellulose would be a valuable carrier or support in biotechnology and biochemistry for applications in the drug delivery system, prolongation of drug circulation, and specific targeting at the sites of the tumor. There have been many reports concerning preparation of porous cellulose by chemical method, such as acid hydrolysis or NaOH treatment. However, high cost, low applicability and requirement of waste treatment for environmental protection were some disadvantages. In this study, the physicochemical properties of nano/submricon porous cellulosic powder, which was prepared by media milling along with spray drying, were investigated, and the comparison between the original milled cellulose suspension and the rehydrated suspension was discussed. Mixtures of 20 g microcrystalline cellulose and 380 g deionic distilled water with addition of different levels of maltodextrin was processed by media mill for 45 min, and the product was spray dried in 200oC environment. It showed that media milling can reduced the volume mean diameter of cellulose to nano/submicron scale. Addition of maltodextrin slightly increased the mean diameter and decrease the zeta potential of milled cellulose, and the suspension performed meta-stable. Scanning electron microscope images of the spray dried powder illustrated the shrinkage at the surface without porosity, which the mean particle size ranged in 8-12 |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/62596 |
全文授權: | 有償授權 |
顯示於系所單位: | 食品科技研究所 |
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