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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝學真(Hsyue-Jen Hsieh) | |
dc.contributor.author | Cuei-Fang Jhang | en |
dc.contributor.author | 張翠芳 | zh_TW |
dc.date.accessioned | 2021-06-16T10:36:03Z | - |
dc.date.available | 2023-12-31 | |
dc.date.copyright | 2013-08-27 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-13 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60912 | - |
dc.description.abstract | 本研究針對以電紡絲法製備幾丁聚醣與聚乙烯醇的同軸奈米纖維進行探討。由於幾丁聚醣為帶有正電的高分子材料,在一般電紡絲法中難以形成連續的奈米纖維,而同軸電紡法正好可以改善這個缺點。過程中針對不同的電紡參數進行測試,藉由改變溶液濃度、流速、溶劑中醋酸的比例、核殼層溶液選擇,觀察其對電紡結果的影響。接著選出幾組奈米纖維型態較佳的組別,進行一連串的性質測定。另外,使用戊二醛對奈米纖維進行交聯以固定纖維型態。最後將其應用於藥物釋放,期許能有穩定的釋放曲線。
本實驗成功製備出具有同軸結構的奈米纖維,其核層為聚乙烯醇,殼層為幾丁聚醣。由於殼層部分是兼具生物相容性與生物降解性的幾丁聚醣,若再搭配藥物穩定釋放的特性(其中藥物可選用幫助細胞增殖分化的生長因子等),相信在細胞培養以及組織工程應用上會有更廣泛的發展空間,因此是極具潛力的生醫材料。 | zh_TW |
dc.description.abstract | In this research, coaxial electrospinning method was used to prepare chitosan and polyvinyl alcohol (PVA) nanofibers with a core-shell structure. Chitosan is a cationic biopolymer that is challenging to electrospin, but this difficulty could be overcome by using coaxial electrospinning. Various solutions with different concentrations and compositions of chitosan and PVA were prepared. The solution concentrations and flow rates in core and shell layers were varied to observe the results of coaxial electrospinning. Nanofibers with best morphology were chosen for further analyses and crosslinked using glutaraldehyde to improve their mechanical strength. In the application of the nanofibers in drug delivery, a sustained release of drugs was expected.
The core/shell (PVA/chitosan) structured nanofibers were successfully obtained in this research. In addition, the shell layer was made up of chitosan which has good biocompatibility and biodegradability. With the sustained release of drugs (such as growth factors which favor cell proliferation and differentiation), it is believed that the prepared coaxial nanofibers can be used as biomaterials and have potential in cell culture and tissue engineering-related applications. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T10:36:03Z (GMT). No. of bitstreams: 1 ntu-102-R00524041-1.pdf: 8559414 bytes, checksum: e12ebd275b9ffa1ea838e6adb9ec0eed (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 誌謝 I
摘要 III Abstract V 目錄 VII 圖目錄 XI 表目錄 XVII 縮寫與符號說明 XIX 中英對照表 XXI 第1章、緒論 1 1.1 研究背景與動機 1 1.2 研究架構 2 第2章、文獻回顧 5 2.1 生醫材料 5 2.2 同軸奈米纖維 6 2.2.1 靜電紡絲法之特性與原理 6 2.2.2 同軸電紡法之特性 8 2.2.3 同軸電紡法之裝置 8 2.2.4 同軸電紡絲之工作參數 10 2.2.5 同軸奈米纖維相關應用 15 2.3 幾丁聚醣 17 2.4 聚乙烯醇 18 2.5 天然多醣 20 2.6 交聯劑 21 2.7 同軸奈米纖維之藥物釋放應用 23 第3章、實驗材料、儀器與方法 25 3.1 實驗材料 25 3.2 實驗儀器 25 3.3 實驗方法 27 3.3.1 溶液配製 27 3.3.2 溶液性質分析 29 3.3.3 同軸電紡法 31 3.3.4 奈米纖維之交聯方法 34 3.3.5 奈米纖維之分析 34 3.3.6 同軸奈米纖維的藥物釋放應用 37 第4章、結果與討論 41 4.1 溶液性質分析 41 4.1.1 pH值 41 4.1.2 黏度 43 4.1.3 表面張力 46 4.1.4 導電度 48 4.2 製程參數對同軸電紡法的影響 50 4.2.1 核層/殼層分別為幾丁聚醣/聚乙烯醇 51 4.2.2 核層/殼層分別為聚乙烯醇/幾丁聚醣 55 4.3 電紡結果之無因次群分析 78 4.3.1 Reynolds number之影響 83 4.3.2 Capillary number之影響 85 4.3.3 Weber number之影響 86 4.3.4 無因次群分析結果之歸納 87 4.4 同軸奈米纖維的性質測定 88 4.4.1 同軸奈米纖維結構探討 88 4.4.2 同軸奈米纖維成分測定 90 4.4.3 熱性質測定 92 4.4.4 機械強度測試 96 4.5 藥物釋放應用 98 4.5.1 茶鹼(theophylline) 98 4.5.2 牛血清蛋白(BSA) 101 4.5.3 藥物釋放之動力學探討 103 第5章、結論與未來研究方向 109 5.1 結論 109 5.2 未來研究方向 111 第6章、參考文獻 113 | |
dc.language.iso | zh-TW | |
dc.title | 以電紡絲法製備幾丁聚醣/聚乙烯醇同軸奈米纖維及其應用 | zh_TW |
dc.title | Fabrication and Application of Chitosan/Polyvinyl Alcohol Coaxial Nanofibers by Electrospinning | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林忻怡(Hsin-Yi Lin),胡晉嘉(Jin-Jia Hu) | |
dc.subject.keyword | 電紡絲,同軸奈米纖維,幾丁聚醣,聚乙烯醇,核殼結構,藥物釋放, | zh_TW |
dc.subject.keyword | Electrospinning,Coaxial nanofibers,Chitosan,Polyvinyl alcohol,Core-shell structure,Drug release, | en |
dc.relation.page | 119 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-14 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 化學工程學研究所 | zh_TW |
顯示於系所單位: | 化學工程學系 |
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