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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 潘敏雄(Min-Hsiung Pan) | |
dc.contributor.author | Keng-Wen Lien | en |
dc.contributor.author | 連耿汶 | zh_TW |
dc.date.accessioned | 2021-06-16T02:35:32Z | - |
dc.date.available | 2020-08-07 | |
dc.date.copyright | 2020-08-07 | |
dc.date.issued | 2020 | |
dc.date.submitted | 2020-08-06 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/53984 | - |
dc.description.abstract | 臺灣食品藥物管理署(簡稱:食藥署)在2011至2019年間共查驗超過15萬批自日本進口至臺灣之食品,輻射檢驗結果皆符合食品中原子塵或放射能污染容許量標準,然而多數民眾仍認為日本進口食品中之放射能污染會對民眾健康構成威脅。黃麴毒素是真菌之次級代謝產物,具有遺傳毒性與致癌性,會對健康造成嚴重之不良影響;臺灣氣候溫熱潮濕,適合真菌生長,食物易受黃麴毒素污染,當中又以花生及其製品最常被檢測到黃麴毒素。因此本研究之目的分為兩個部分:評估國人因食用日本核災五縣市外之進口食品與攝食國內花生及其製品中可能存在之黃麴毒素導致健康危害風險。利用食藥署邊境查驗之公開資料,蒐集2011至2019年間之輻射檢測數據,並以最壞情境估計臺灣民眾經由日本進口食品攝入之內部輻射劑量與其終生癌症風險。結果顯示,即便在最壞的情境下,以15-19歲男性為例,因攝入放射性同位素銫累積之約定年有效劑量(committed effective dose, CED)為每年0.0057毫西弗,遠低於每年安全劑量1毫西弗。在癌症風險部分,以食品中檢出之最高劑量計算其名義風險(nominal risks),以19-65歲女性族群為例,實體癌、白血病、甲狀腺和乳癌之終生名義風險分別為每萬人中有3.82、0.87、0.96與5.04例癌症可能發生。另利用2005至2015年間食藥署後市場監測之公開資料,蒐集花生中黃麴毒素之濃度數據(1.84±4.03 ppb),計算因攝食受黃麴毒素污染花生導致肝癌發生之風險,並依據歐洲食品安全局建議之基準劑量下限10%(BMDL10) 0.4 μg / kg bw/day,來計算暴露限值(margin of exposure, MOE)。結果顯示,攝食受黃麴毒素污染之花生及其製品導致之肝癌風險為0.0007至0.2713例/十萬人/年。結論,在目前的監管政策與暴露情境下,民眾不會因攝食日本進口食品而顯著增加癌症風險。花生及其製品中之黃麴毒素污染應非造成國人肝癌發生之主因;另黃麴毒素限量標準降至4 µg/kg後,暴露限值將大於10,000(屬低度風險),可降低肝癌發生之風險。 | zh_TW |
dc.description.abstract | During 2011 to 2019, more than 150,000 batches of Japanese foodstuffs were inspected at the border inspection of Taiwan. Among these, only trace levels of radiation were detected in 226 batches. Nevertheless, there is a growing concern in Taiwan about the threat posed by radionuclide contamination to food safety. Aflatoxins are secondary metabolites naturally occurring in many foods such as peanuts, spices, rice, tree nuts, and maize. Aflatoxins are both genotoxic and carcinogenic substances and can cause severe adverse health effects. The purpose of this study is to estimate exposure risk of residual radiation level of imported foods from Japan and aflatoxin level in Taiwan local peanut products. Radionuclide contamination concentration data were gathered from the Taiwan Food and Drug Administration (TFDA) between 2011 and 2019. The results indicated that in the worst-case scenario, the highest exposure level of the annual committed effective dose (CED) from ingestion of cesium radionuclides within males aged 15-19 years old was 0.0057 mSv per year. This value was well below the CED of 1 mSv per year for radionuclides. Moreover, in the worst-case scenario, in 19-65 years old of the female group, the nominal risks for solid cancers, leukemia, thyroid and breast cancer were 3.82, 0.87, 0.96 and 5.04 per 10,000 cases, respectively. The aflatoxin contamination concentration data (1.84±4.03 ppb) were gathered from the TFDA between 2005 and 2015. According to the benchmark dose lower confidence limit, 10% (BMDL10) 400 ng/kg bw/day suggested by the European Food Safety Authority, the calculated margin of exposure (MOE) value cannot reach 10,000. Cancer potency data from the Joint FAO/WHO Expert Committee on Food Additives indicates that the estimated population risk ranges from 0.0007 to 0.2713 cancers/100,000 population per year. In the general situation, we posit that in the current regulatory policy and radioactivity exposure scenario, radionuclides present in food pose no significant safety risk in Taiwan. And aflatoxin contamination does not seem to largely account for the occurrence of liver cancer in Taiwan. MOE calculations point out that when the maximum residue limits of aflatoxin are 4 µg/kg can reduce the concerns of causing potential liver cancer. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T02:35:32Z (GMT). No. of bitstreams: 1 U0001-0408202011484700.pdf: 3250261 bytes, checksum: 92d48d26ac3a709e638f8966e2926329 (MD5) Previous issue date: 2020 | en |
dc.description.tableofcontents | 口試委員會審定書 I 中文摘要 II ABSTRACT III 圖次 VII 表次 VIII 名詞與縮寫對照表 IX 第一章 研究背景與目的 1 第二章 文獻整理與回顧 4 2.1風險分析 4 2.2食品風險評估的四個步驟 7 2.3不確定性分析 10 2.4各國對福島事件後之輻射劑量風險評估 10 2.5各國對食品中黃麴毒素之風險評估 12 第三章 材料與方法 14 3.1危害辨識 17 3.1.1食品中輻射之危害辨識 17 3.1.2花生中黃麴毒素之危害辨識 18 3.2劑量反應評估 25 3.2.1食品中輻射之劑量反應評估 25 3.2.2花生中黃麴毒素之劑量反應評估 26 3.3暴露評估 27 3.3.1日本進口食品中輻射劑量之暴露評估 27 3.3.1.1日本食品輸入查驗數據蒐集 28 3.3.1.2食品中放射性同位素輻射劑量分析 30 3.3.2花生中黃麴毒素之暴露評估 32 3.4風險特性描述 33 3.4.1日本進口食品中輻射劑量和暴露風險之風險特徵描述 33 3.4.2國人攝食花生及其製品受黃麴毒素污染之風險特徵描述 34 3.5情境假設 36 第四章 結果與討論 37 4.1評估日本核災五縣市外之進口食品中輻射劑量和暴露風險 37 4.1.1食品中原子塵或放射能污染容許量標準 37 4.1.2食品中放射性同位素輻射劑量評估結果 39 4.1.3癌症風險評估 47 4.2國人攝食花生及其製品受黃麴毒素污染之風險評估 52 4.2.1黃麴毒素污染濃度分布和日常消費數據 53 4.2.2暴露限值 55 4.2.3原發性肝癌的人群風險 58 4.2.4風險管理建議 58 4.3不確定性分析 61 第五章 結論 63 第六章 未來展望 64 參考文獻 66 | |
dc.language.iso | zh-TW | |
dc.title | 臺灣食品安全風險評估:以日本進口食品輻射及國內花生製品中黃麴毒素之暴露風險為例 | zh_TW |
dc.title | Food safety risk assessment in Taiwan: Exposure risk of residual radiation level of imported foods from Japan and of aflatoxin level in local peanut products as examples. | en |
dc.type | Thesis | |
dc.date.schoolyear | 108-2 | |
dc.description.degree | 博士 | |
dc.contributor.author-orcid | 0000-0001-5668-7161 | |
dc.contributor.oralexamcommittee | 周志輝(Chi-Fai Chau),許輔(Fuu Sheu),陳欣郁,凌明沛,姜至剛 | |
dc.subject.keyword | 日本進口食品,輻射,黃麴毒素,花生,健康風險評估, | zh_TW |
dc.subject.keyword | Japanese imported food,radionuclide,aflatoxin,Taiwan local peanut,health risk assessment, | en |
dc.relation.page | 74 | |
dc.identifier.doi | 10.6342/NTU202002356 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2020-08-06 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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