請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52714
標題: | 氟十八標記滲透性醣蛋白分子探針作為新穎正子斷層掃描藥物的研究 Study of 18F-labeled P-glycoprotein Molecular Probes as Novel Positron Emission Tomography Imaging Agents |
作者: | Yu-Chien Cheng 鄭榆蒨 |
指導教授: | 忻凌偉 |
關鍵字: | 氟十八,滲透性醣蛋白,分子探針,正子斷層掃描,造影劑, 18F,P-glycoprotein,Molecular Probes,Positron Emission Tomography,Imaging Agents, |
出版年 : | 2015 |
學位: | 碩士 |
摘要: | The purpose of this research is to develop a novel PET imaging agent for the study of P-glycoprotein (P-gp) function. A series of fluoroalkyl-aminoanthraquinone derivatives was designed and synthesized based on the skeleton of mitoxantrone (MX) and ametantrone (AT). After pharmacological studies, compound 10 was chosen as the target compound, and compounds 5 and 8 were designed and synthesized as precursors for 18F-radiolabeling. Initially, precursor 5 was easily decomposed under basic condition, but using tetrabutylammonium bicarbonate instead of commonly used base, such as potassium carbonate and potassium oxalate, heating at 100oC for 5 minutes, and then hydrolysis with 2 N hydrochloric acid at 100oC for 5 minutes to yield enough [18F]10 for animal study with microPET. In addition to the purity of precursor, radiochemical yield (RCY) increased from 0.02% to 3.3% when the equivalent of precursor increased from 4 |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52714 |
全文授權: | 有償授權 |
顯示於系所單位: | 藥學系 |
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ntu-104-1.pdf 目前未授權公開取用 | 18.01 MB | Adobe PDF |
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