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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 呂廷璋(Ting-Jang Lu) | |
| dc.contributor.author | Yun-Hua Hsu | en |
| dc.contributor.author | 許芸華 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:11:55Z | - |
| dc.date.available | 2020-08-28 | |
| dc.date.copyright | 2015-08-28 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-18 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52325 | - |
| dc.description.abstract | 植物體中之植物固醇，有以下幾種主要型態，包含自由態(Sterols)、以及酯化態(Steryl Esters, SE)、Steryl Ferulate (SF)、醣苷態(Steryl Glycoside, SG)與酯化醣苷態(Acylated Steryl Glycoside, ASG)等結合態。傳統的植物固醇分析採用水解法，用皂化後產生的自由態固醇進行總固醇定量，缺點是方法繁瑣且無法測得不同結合型態之植物固醇；本研究目的為建立同步分析自然存在不同型態植物固醇之分析方法，進一步了解糙米、發芽糙米與米製加工品之植物固醇含量。樣品前處理以Folch法萃取總脂質，以酸水解鹼皂化方式取得總植物固醇含量，而萃取液以NH2固相萃取管淨化可去除三酸甘油酯及酯化態固醇，獲得完整結合態植物固醇。儀器檢測以Diol正相液相層析管柱搭配蒸發光散射偵檢器(ELSD)可檢測不同型態植物固醇總量，而逆相液相層析採用BEH Shield RP18管柱串聯質譜儀，以大氣壓化學游離法(Atmospheric Pressure Chemical Ionization, APCI)游離後，固醇基團脫去一分子水為植物固醇之特徵離子訊號，自由態固醇偵測極限介於4.5-51.7 ppb。利用建立之方法分析台南11號與台稉2號之糙米與發芽糙米，植物固醇以自由態β-sitosterol、campesterol、stigmasterol為主，並含有相當含量之米糠醇(γ-oryzanol)32.94-105.17 mg/100 g與少量之醣苷態與酯化醣苷態固醇；經熱加工蒸煮後之糙米與發芽糙米，總植物固醇含量為50.95-147.37 mg/100 g；市售條類米製品之植物固醇含量標示100%純米製造者檢測出米糠醇植物固醇含量為0.77-2.89 mg/100 g，而稻米含量占成品比例少於50%或原物料非以稻米為主之樣品，米糠醇含量為未檢出。 | zh_TW |
| dc.description.abstract | Phytosterol has been proved to have biological activities of reducing blood LDL-cholesterol, anti-cancer activity and anti-inflammatory activity. Phytosterols can be separated into free form sterols, and conjugated sterols, including steryl esters, steryl ferulates, steryl glycoside and acylated steryl glycoside. It is well known that the analysis of phytosterols to use acid hydrolysis, basic saponification and purification to release free form sterols. The aim of this study is to separate and detemine the diversiform phytosterols in brown rice andgerminated brown rice. Sample preparation includes the extraction of lipids by Folch method, saponification or acid hydrolysis, extraction of unsaponification matter and NH2 solid phase extraciton to partial purification of sterols. Sterols were separated by normal or reverse phase liquid chromatography and determinated and quantified by evaprated light scattering detector (ELSD) or mass sepctrometry in positve atmospheric pressure chemical ionization (APCI). We found almost all phytosterols to have the most abundant signal corresponding to a protonated fragment ion [M+H-H2O]+, which was chosen for the identification. The limit of detection (LOD) for free sterols was 4.5-51.7 ppb. It is found that the main free form phytosterols in two cultivars of brown rice and germinated brown rice including β-sitosterol, campesterol and stigmasterol, the content of γ-oryzanol ranges from 32.94 to 105.17 mg/100 g, and trace amount of steryl glycoside and aclyated steryl glycoside were also be detected. The total phytosterol contents in porridge and steamed brown rice were 50.95-147.37 mg/100 g. The content of γ-oryzanol were found to have 0.77-2.89 mg/100 g in commercial rice products made of 100% rice material, and others were made no more than 50% of rice material were not detected. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:11:55Z (GMT). No. of bitstreams: 1 ntu-104-R00641032-1.pdf: 1915028 bytes, checksum: 13a829e79509924661116821cf85a1d0 (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 中文摘要 I ABSTRACT II 總目錄 III 表目錄 VI 第一章、前言 1 第二章、文獻回顧 2 第一節、稻米 2 一、簡介 2 二、營養成分與生理活性物質 2 第二節、植物固醇 5 一、簡介 5 二、化學結構與型態 8 三、生理活性概述 11 四、植物固醇在植物體中生理功能 12 第三節、植物固醇分析方法 13 一、儲存條件與固醇氧化 13 二、溶劑萃取 14 三、固醇分離 15 四、化學及酵素水解 15 第四節、植物固醇之檢測 16 一、氣相層析法(Gas chromatography, GC) 16 二、液相層析法(High performance liquid chromatography, HPLC) 17 三、偵測器 18 第三章、研究目的與實驗架構 23 第四章、材料與方法 24 第一節、實驗材料 24 第二節、藥品與試劑 25 第三節、儀器設備 26 第四節、實驗方法 28 第五章、結果與討論 36 第一節、樣品製備與植物固醇萃取 36 一、化學水解樣品之結合態植物固醇 36 二、樣品中非固醇物質及雜質 36 第二節、正相液相層析法搭配蒸發光散射偵檢器檢測植物固醇總量 39 一、建立植物固醇正相液相層析法 39 二、檢量線線性、儀器偵測極限與定量極限 42 三、正相液相層析法搭配蒸發光散射偵檢器檢測不同型態植物固醇總量 46 第三節、極致逆相液相層析串聯質譜法檢測植物固醇 49 一、建立逆相液相層析法分離不同型態植物固醇 49 二、質譜儀游離化參數條件設定與植物固醇特徵離子片段 53 三、方法選擇性、準確性、檢量線線性與回收率 60 第四節、樣品中植物固醇含量 63 一、有機糙米與有機發芽糙米 63 二、有機糙米飯(粥)與有機發芽糙米飯(粥) 70 三、稻米與米加工品 75 四、市售米製加工品 75 第六章、結論 81 第七章、參考文獻 82 | |
| dc.language.iso | zh-TW | |
| dc.title | 以液相層析串聯質譜法分析糙米與條類米製品之植物固醇含量 | zh_TW |
| dc.title | Separation and determination of phytosterols in brown rice and rice vermicelli using UPLC-APCI-MS/MS | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 盧訓(Shin Lu),張永和(Yung-Ho Chang),王惠珠(Huei-Ju Wang),陳宏彰(Hong-Jhang Chen) | |
| dc.subject.keyword | 植物固醇,米糠醇,糙米,發芽糙米,液相層析串聯質譜儀,蒸發光散射偵檢器, | zh_TW |
| dc.subject.keyword | phytosterol,γ-oryzanol,brown rice,germinated brown rice,,liquid chromatography-tandem mass spectrometry,evaporative light scattering detector, | en |
| dc.relation.page | 91 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-18 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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