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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘子明 | |
| dc.contributor.author | Sih-Han Chao | en |
| dc.contributor.author | 趙偲涵 | zh_TW |
| dc.date.accessioned | 2021-06-15T12:37:34Z | - |
| dc.date.available | 2026-08-01 | |
| dc.date.copyright | 2016-08-03 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-07-29 | |
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BMC Complement Altern Med. 11: 53. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/50357 | - |
| dc.description.abstract | 便秘為常見之腸胃道症狀，飲食及生活習慣改變或代謝、神經系統等方面疾病會導致便秘，便秘也會使腸道老化，其亦為大腸癌之風險因子之一。目前已有許多文獻指出乳酸菌可增加便秘患者之排便頻率及糞便含水量。本研究以 Lactobacillus paracasei subsp. paracasei NTU 101 原末菌粉評估便秘之改善功效。以每日 2 次皮下注射 loperamide (2 mg/kg BW) 減緩 Sparque-Dawley (SD) 大鼠腸道蠕動速率誘導便秘產生，同時介入低、中、高劑量之 NTU 101 原末菌粉 (1.3、2.6、13.0 mg/kg BW) 探討其改善效果。結果顯示管餵 NTU 101 菌粉低、中、高劑量均可增加腸道蠕動速率，分別較誘導組上升 12.4%、13.2% 與 15.0%；並可增加糞便含水量，分別較誘導組增加7.6%、8.4% 與 10.9%，此結果顯示低劑量即有改善排便之功效，且隨著劑量增加效果更佳。此外，餵食 NTU 101 原末菌粉可增加糞便中Bifidobactrium spp. 菌數，減少Clostridium perfringens 菌數，增加糞便短鏈脂肪酸濃度及降低 pH 值，並能夠增加結腸黏膜層厚度 (mucosal thickness)、分泌黏液之杯狀細胞 (goblet cells) 及卡哈氏間質細胞 (interstitial cells of Cajal, ICC)。綜合以上結果，NTU 101 原末菌粉可改善由 loperamide 所引起之便秘症狀外，也具有改善腸胃道功能之效果。 | zh_TW |
| dc.description.abstract | Constipation is a common gastrointestinal symptom. Life style, eating habit, metabolic conditions and neurological disorders could cause the constipation which is also one of the risk factors of colorectal cancer. Lactic acid bacteria have been reported to improve defecation frequency and fecal water content so far. This study evaluates the effect of Lactobacillus paracasei subsp. paracasei NTU 101 on constipation. Sparque-Dawley (SD) rats were subcutaneously injected loperamide (2 mg/kg BW) twice a day with 1.3, 2.6, and 13.0 mg/kg BW/rat/day of NTU 101 powder, respectively. As a result, three doses of NTU 101 powder improved 12.4%, 13.2%, and 15.0% of intestinal motility, respectively, compared with loperamide group. It also improved 7.6%, 8.4%, and 10.9% of fecal water content, respectively, compared with loperamide group. This result shows that low dosage has the effect of improving defecation, and that has the better effect with dose ascension. In addition, NTU 101 powder increased Bifidobacterium spp. and decreased Clostridium perfringens contents in feces. It also enhanced concentration of short chain fatty acids and reduced pH value in feces. Moreover, it could promote colonic mucosal thickness, mucin producing-goblet cell, and interstitial cells of Cajal (ICC). Based on the above results, NTU 101 powder can not only improve the constipation induced by loperamide, but also improve the function of gastrointestinal tract. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T12:37:34Z (GMT). No. of bitstreams: 1 ntu-105-R03B22036-1.pdf: 4976244 bytes, checksum: adf87acf1e1ca90a71c9ae23220e864e (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 目錄
縮寫表 I 中文摘要 III 英文摘要 IV 目錄 V 圖目錄 VIII 表目錄 X 第一章 前言 1 第二章 文獻回顧 2 一、便秘 2 (一) 便秘簡介 2 (二) 便秘分類 2 (三) 便秘之流行病學 5 (四) 便秘臨床診斷 5 (五) 便秘治療方式 11 二、便秘誘導模式 15 (一) Loperamide 誘導模式 15 (二) 低纖飲食誘導模式 16 三、乳酸菌 18 (一) 乳酸菌簡介 18 (二) 乳酸菌之功效 18 (三) 副乾酪乳酸桿菌副乾酪亞種 NTU 101 (Lactobacillus paracasei subsp. paracasei NTU 101) 26 第三章 研究動機與架構 27 一、研究動機 27 二、研究架構 27 第四章 材料與方法 31 一、實驗材料 31 (一) 菌株 31 (二) 儀器設備 31 (三) 一般藥品 32 (四) 免疫組織染色試劑 32 二、實驗方法 33 (一) 實驗動物 33 (二) 實驗設計及組別配置 33 (三) 糞便檢體分析 35 (四) 腸道菌相檢測 35 (五) 腸道蠕動測定 38 (六) 短鏈脂肪酸分析 39 (七) 結腸組織分析 43 (八) 安全性分析 44 (九) 統計分析方法 44 第五章 結果 45 一、大鼠實驗期間之體重、攝食量及飲水量 45 二、大鼠實驗期間之糞便分析 45 三、大鼠腸道菌相測定 54 四、大鼠腸道蠕動速率 54 五、大鼠糞便中之短鏈脂肪酸濃度 61 六、大鼠結腸黏膜層厚度與杯狀細胞 61 七、大鼠結腸之卡哈式間質細胞 (interstitial cells of Cajal, ICC) 68 八、大鼠結腸組織發炎情形 68 九、安全性分析 68 十、結果總整理 74 第六章 綜合討論 77 一、NTU 101 原末菌粉與短鏈脂肪酸之關聯性 77 二、NTU 101原末菌粉增進腸道運動之可能機制推測 80 (一) 短鏈脂肪酸 80 (二) 卡哈氏間質細胞 81 三、腸道菌相與便秘之關聯性 81 四、NTU 101 原末菌粉調節腸道功能之機制 82 五、NTU 101 原末菌粉改善便秘整體機制 82 六、其他 83 第七章、結論 85 第七章 參考文獻 86 | |
| dc.language.iso | zh-TW | |
| dc.title | Lactobacillus paracasei subsp. paracasei NTU 101 菌粉對於 loperamide 誘導便秘大鼠之改善效果評估 | zh_TW |
| dc.title | The evaluation of improving effect of Lactobacillus paracasei subsp. paracasei NTU 101 powder on loperamide-induced constipation in rats | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 廖啟成,周正俊,蔡宗佑,蔣慎思 | |
| dc.subject.keyword | Lactobacillus paracasei subsp. paracasei NTU 101,便秘,短鏈脂肪酸,腸道蠕動,腸道菌相, | zh_TW |
| dc.subject.keyword | Lactobacillus paracasei subsp. paracasei NTU 101,constipation,short chain fatty acids,intestinal motility,intestinal microflora, | en |
| dc.relation.page | 98 | |
| dc.identifier.doi | 10.6342/NTU201601609 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-07-29 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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