以籠狀冠醚分子為架構的分子開關與分子機械之研究

Abstract

以分子籠 1作為主體分子，我們發展了一個獨特的主體/客體錯合系統。由於分子籠 1對鍵結雙偶氮陽離子、雙吡啶陽離子及蒽醌分子具有不同程度的錯合能力，因此在其混合溶液中分子籠 1僅會與雙偶氮陽離子鍵結產生穩定的錯合物而留下未錯合的雙吡啶陽離子及蒽醌分子。然而藉由適當的刺激操作，分子籠 1可以選擇性地改變其錯合的客體，而分別與雙偶氮陽離子、雙吡啶陽離子及蒽醌分子等三種不同種類之客體分子鍵結。此外，我們發現分子籠 1能夠鍵結客體分子2,6-diazaanthracene-9,10-dione 13於其內部空腔中。由於客體分子2,6-diazaanthracene-9,10-dione 13羰基上的氧原子能與鉀離子配位，因此我們可以藉由加入和移除鉀離子來控制客體分子 2,6-diazaanthracene-9,10-dione 13在分子籠 1空腔內進行類似旋轉的運動，而這樣的運動模式或許可在某種程度上可以模擬一個分子迴轉儀的運轉。

Herein, we have demonstrated a crown ether based molecular cage 1 that forms extremely stable supramolecular complexes with bisdiazonium ions in solution. A system based on a molecular cage, in which bisdiazonium, bispyridinium, and anthraquinone guests can be complexed to the host sequentially through the application of suitable stimuli, is reported.We have demonstrated that the molecular cage 1 can complex the guest 2,6-diazaanthracene-9,10-dione 13 in its internal cavity. This complex may mimic the function of a molecular gyroscope in that its complexed guest changes its binding geometry with respect to the macrocyclic host upon the addition and removal of K+ ions.