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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 郭錦樺 | |
dc.contributor.author | I-Lin Tsai | en |
dc.contributor.author | 蔡伊琳 | zh_TW |
dc.date.accessioned | 2021-06-15T02:41:49Z | - |
dc.date.available | 2011-10-07 | |
dc.date.copyright | 2011-10-07 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-16 | |
dc.identifier.citation | 參考文獻
1. Jabeen, R.; Payne, D.; Wiktorowcz, J.; Mohammad, A.; Petersen, J., Capillary electrophoresis and the clinical laboratory. Electrophoresis 2006, 27 (12), 2413-2438. 2. Altria, K. D., Overview of capillary electrophoresis and capillary electrochromatography. Journal of Chromatography A 1999, 856 (1-2), 443-463. 3. Quirino, J. P.; Terabe, S., Sample stacking of cationic and anionic analytes in capillary electrophoresis. Journal of Chromatography A 2000, 902 (1), 119-135. 4. Burgi, D. S.; Chien, R. L., Optimization in sample stacking for high-performance capillary electrophoresis. Analytical Chemistry 1991, 63 (18), 2042-2047. 5. Quirino, J. P.; Terabe, S., Exceeding 5000-fold concentration of dilute analytes in micellar electrokinetic chromatography. Science 1998, 282 (5388), 465-468. 6. Quirino, J. P.; Terabe, S., Approaching a million - fold sensitivity increase in capillary electrophoresis with direct ultraviolet detection: Cation - selective exhaustive injection and sweeping. Analytical Chemistry 2000, 72 (5), 1023-1030. 7. Cosgrove, S. E.; Qi, Y. L.; Kaye, K. S.; Harbarth, S.; Karchmer, A. W.; Carmeli, Y., The impact of methicillin-resistance in Staphylococcus aureus bacteremia on patient outcomes: Mortality, length of stay, and hospital charges. Infection Control and Hospital Epidemiology 2005, 26 (2), 166-174. 8. Klevens, R. M.; Morrison, M. A.; Nadle, J.; Petit, S.; Gershman, K.; Ray, S.; Harrison, L. H.; Lynfield, R.; Dumyati, G.; Townes, J. M.; Craig, A. S.; Zell, E. R.; Fosheim, G. E.; McDougal, L. K.; Carey, R. B.; Fridkin, S. K., Invasive methicillin-resistant Staphylococcus aureus infections in the United States. Jama-Journal of the American Medical Association 2007, 298 (15), 1763-1771. 9. Barna, J. C. J.; Williams, D. H.; Stone, D. J. M.; Leung, T. W. C.; Doddrell, D. M., Structure elucidation of the teicoplanin antibiotics. Journal of the American Chemical Society 1984, 106 (17), 4895-4902. 10. Williams, A. H., Gruneberg, R.N., Teicoplanin. Journal of Antimicrobial Ahemotherapy 1984, 14 (5), 441-445. 11. Borghi, A., Coronelli, C., Faniuolo, L., Allievi, G., Pallanza, R., Gallo, G.G. , Teichomycins, new antibiotics from Actinoplanes teichomyceticus nov. sp. IV. Separation and characterization of the components of teichomycin (teicoplanin). Journal of Antibiotics 1984, 32 (6), 615-620. 12. Taylor, R. B.; Reid, R. G.; Gould, I. M., Determination of teicoplanin in plasma using microbore high-performance liquid chromatography and injection-generated gradients. Journal of Chromatography: Biomedical Applications 1991, 563 (2), 451-457. 13. Cociglio, M.; Peyrière, H.; Hillaire-Buys, D.; Alric, R., Application of a standardized coextractive cleanup procedure to routine high-performance liquid chromatography assays of teicoplanin and ganciclovir in plasma. Journal of Chromatography B: Biomedical Sciences and Applications 1998, 705 (1), 79-85. 14. McCann, S. J.; White, L. O.; Keevil, B., Assay of teicoplanin in serum: comparison of high-performance liquid chromatography and fluorescence polarization immunoassay. Journal of Antimicrobial Chemotherapy 2002, 50 (1), 107-110. 15. Hanada, K.; Kobayashi, A.; Okamori, Y.; Kimura, T.; Ogata, H., Improved quantitative determination of total and unbound concentrations of six teicoplanin components in human plasma by high performance liquid chromatography. Biological & Pharmaceutical Bulletin 2005, 28 (10), 2023-2025. 16. Joos, B.; Luthy, R., Determination of teicoplanin concentrations in serum by high-pressure liquid-chromatography. Antimicrobial Agents and Chemotherapy 1987, 31 (8), 1222-1224. 17. Mochizuki, N.; Ohno, K.; Shimamura, T.; Furukawa, H.; Todo, S.; Kishino, S., Quantitative determination of individual teicoplanin components in human plasma and cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B 2007, 847 (2), 78-81. 18. Shen, J.; Jiao, Z.; Zhou, Y. N.; Zhu, H. L.; Song, Z. J., Quantification of teicoplanin in human plasma by liquid chromatography with ultraviolet detection. Chromatographia 2007, 65 (1-2), 9-12. 19. White, L. O.; McMullin, C.; Davis, A. J.; MacGowan, A. P.; Harding, I.; Reeves, D. S., The quality of clinical serum teicoplanin assays: an experimental European EQA distribution. Journal of Antimicrobial Chemotherapy 1996, 38 (4), 701-706. 20. Mastin, S. H.; Buck, R. L.; Mueggler, P. A., Performance of a fluorescence polarization immunoassay for teicoplanin in serum. Diagnostic Microbiology and Infectious Disease 1993, 16 (1), 17-24. 21. Cox, H.; Whitby, M.; Nimmo, G.; Williams, G., Evaluation of a novel fluorescence polarization immunoassay for teicoplanin. Antimicrobial Agents and Chemotherapy 1993, 37 (9), 1924-1926. 22. Bourget, P.; Lesne-Hulin, A.; Sertin, A.; Maillot, A.; Alaya, M.; Martin, C., Fluorescence polarization immunoassay: Does it always represent a reliable method to monitor treatment with teicoplanin?: Comparison with data obtained by high-performance liquid chromatography. International Journal of Pharmaceutics 1997, 146 (2), 167-174. 23. Taylor, R. B.; Vorarat, S.; Reid, R. G.; Boyle, S. P.; Moody, R. R., Comparisons of the separations of some neutral analytes by LC, MEKC, and CEC. Journal of Capillary Electrophoresis and Microchip Technology 1999, 6 (3-4), 131-136. 24. Dykhuizen, R. S.; Harvey, G.; Stephenson, N.; Nathwani, D.; Gould, I. M., Protein-binding and serum bactericidal activities of vancomycin and teicoplanin. Antimicrobial Agents and Chemotherapy 1995, 39 (8), 1842-1847. 25. Kuhn, R., Hoffstetter-Kuhn, S., Capillary Electrophoresis: Principles and Practice. Springer-Verlag Berlin Heidelberg: 1993. 26. Bernareggi, A.; Danese, A.; Cometti, A.; Buniva, G.; Rowland, M., Pharmacokinetics of individual components of teicoplanin in man. Journal of Pharmacokinetics and Biopharmaceutics 1990, 18 (6), 525-543. 27. Sugita, T.; Ishiwata, H.; Yoshihira, K., Release of formaldehyde and melamine from tableware made of melamine-formaldehyde resin. Food Additives and Contaminants 1990, 7 (1), 21-27. 28. WHO. Questions and answers on melamine. (Accessed November 28, 2008). http://www.who.int/csr/media/faq/QAmelamine/en/ 29. WHO. Expert meeting to review toxicological aspects of melamine and cyanuric acid, 1-4 December 2008 - description of the melamine-contamination event. (Accessed April 29, 2008) http://www.who.int/foodsafety/fs_management/infosan_events/en/. 30. Ingelfinger, J. R., Melamine and the global implications of food contamination. New England Journal of Medicine 2008, 359 (26), 2745-2748. 31. Andersen, W. C.; Turnipseed, S. B.; Karbiwnyk, C. M.; Clark, S. B.; Madson, M. R.; Gieseker, C. M.; Miller, R. A.; Rummel, N. G.; Reimschuessel, R., Determination and confirmation of melamine residues in catfish, trout, tilapia, salmon, and shrimp by liquid chromatography with tandem mass spectrometry. Journal of Agricultural and Food Chemistry 2008, 56 (12), 4340-4347. 32. WHO. Experts set tolerable level for melamine intake. (Accessed April 27, 2009) http://www.who.int/mediacentre/news/releases/2008/pr48/en/. 33. Hirt, R. C.; Schmitt, R. G., Ultraviolet absorption spectra of derivatives of symmetric triazine: 2. Oxo-triazines and their acyclic analogs. Spectrochimica Acta 1958, 12 (2-3), 127-138. 34. Bardalaye, P. C.; Wheeler, W. B.; Meister, C. W., Gas-chromatographic determination of cyromazine and its degradation product, melamine, in chinese-cabbage. Journal of the Association of Official Analytical Chemists 1987, 70 (3), 455-457. 35. Litzau, J. J., Mercer, G.E., Mulligan, K.J. , GC-MS screen for the presence of melamine, ammeline, ammelide, and cyanuric acid. Laboratory Information Bulletin 2008, 4423. 36. Lin, M.; He, L.; Awika, J.; Yang, L.; Ledoux, D. R.; Li, H.; Mustapha, A., Detection of melamine in gluten, chicken feed, and processed foods using surface enhanced raman spectroscopy and HPLC. Journal of Food Science 2008, 73 (8), T129-T134. 37. Chou, S. S.; Hwang, D. F.; Lee, H. F., High performance liquid chromatographic determination of cyromazine and its derivative melamine in poultry meats and eggs. Journal of Food and Drug Analysis 2003, 11 (4), 290-295. 38. Ali, M. S.; Rafiuddin, S.; Ghori, M.; Khatri, A. R., Simultaneous determination of metformin hydrochloride, cyanoguanidine and melamine in tablets by mixed-mode HILIC. Chromatographia 2008, 67 (7-8), 517-525. 39. Heller, D. N.; Nochetto, C. B., Simultaneous determination and confirmation of melamine and cyanuric acid in animal feed by zwitterionic hydrophilic interaction chromatography and tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2008, 22 (22), 3624-3632. 40. Turnipseed, S., Casey, C., Nochetto, C., Heller, D.N., Determination of melamine and cyanuric acid residues in infant formula using LC-MS/MS. Laboratory Information Bulletin 2008, 4421. 41. Andersen, W. C., Turnipseed, S.B., Karbiwnyk, C.M., Madson, M.R., Determination of melamine residues in catfish tissue by triple quadrupole LC-MS-MS with HILIC chromatography. Laboratory Information Bulletin 2007. 42. Smoker, M., Krynitsky, A.J., Interim method for determination of melamine and cyanuric acid residues in foods using LC-MS/MS: Version 1.0. Laboratory Information Bulletin 2008, 4422. 43. Corkum, P., DART rapidly detects melamine. Trac-Trends in Analytical Chemistry 2009, 28 (1), iii. 44. Huang, G.; Zheng, O.; Cooks, R. G., High-throughput trace melamine analysis in complex mixtures. Chemical Communications 2009, (5), 556-558. 45. Zhu, L.; Gamez, G.; Chen, H.; Chingin, K.; Zenobi, R., Rapid detection of melamine in untreated milk and wheat gluten by ultrasound-assisted extractive electrospray ionization mass spectrometry (EESI-MS). Chemical Communications 2009, (5), 559-561. 46. Cook, H. A.; Klampfl, C. W.; Buchberger, W., Analysis of melamine resins by capillary zone electrophoresis with electrospray ionization-mass spectrometric detection. Electrophoresis 2005, 26 (7-8), 1576-1583. 47. Yan, N.; Zhou, L.; Zhu, Z.; Chen, X., Determination of melamine in dairy products, fish feed, and fish by capillary zone electrophoresis with diode array detection. Journal of Agricultural and Food Chemistry 2009, 57 (3), 807-811. 48. Osbourn, D. M.; Weiss, D. J.; Lunte, C. E., On-line preconcentration methods for capillary electrophoresis. Electrophoresis 2000, 21 (14), 2768-2779. 49. Hempel, G., Strategies to improve the sensitivity in capillary electrophoresis for the analysis of drugs in biological fluids. Electrophoresis 2000, 21 (4), 691-698. 50. Albert, M.; Debusschere, L.; Demesmay, C.; Rocca, J. L., Large-volume stacking for quantitative analysis of anions in capillary electrophoresis. 1. Large-volume stacking with polarity switching. Journal of Chromatography A 1997, 757 (1-2), 281-289. 51. Quirino, J. P.; Terabe, S., Large volume sample stacking of positively chargeable analytes in capillary zone electrophoresis without polarity switching: Use of low reversed electroosmotic flow induced by a cationic surfactant at acidic pH. Electrophoresis 2000, 21 (2), 355-359. 52. Urbanek, M.; Krivankova, L.; Bocek, P., Stacking phenomena in electromigration: From basic principles to practical procedures. Electrophoresis 2003, 24 (3), 466-485. 53. Musijowski, J.; Pobozy, E.; Trojanowicz, M., On-line preconcentration techniques in determination of melatonin and its precursors/metabolites using micellar electrokinetic chromatography. Journal of Chromatography A 2006, 1104 (1-2), 337-345. 54. Juan-Garcia, A.; Font, G.; Pico, Y., On-line preconcentration strategies for analyzing pesticides in fruits and vegetables by micellar electrokinetic chromatography. Journal of Chromatography A 2007, 1153 (1-2), 104-113. 55. Weng, Q. F.; Xu, G. W.; Yuan, K. L.; Tang, P., Determination of monoamines in urine by capillary electrophoresis with field-amplified sample stacking and amperometric detection. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2006, 835 (1-2), 55-61. 56. Chou, Y. W.; Huang, W. S.; Chen, C. C.; Lin, S. J.; Wu, H. L.; Chen, S. H., Trace analysis of zotepine and its active metabolite in plasma by capillary electrophoresis with solid phase extraction and head-column field-amplified sample stacking. Journal of Chromatography A 2005, 1087 (1-2), 189-196. 57. Zhang, C. X.; Thormann, W., Head-column field-amplified sample stacking in binary system capillary electrophoresis: A robust approach providing over 1000-fold sensitivity enhancement. Analytical Chemistry 1996, 68 (15), 2523-2532. 58. Chien, R. L., Mathematical-modeling of field-amplified sample injection in high-performance capillary electrophoresis. Analytical Chemistry 1991, 63 (24), 2866-2869. 59. Zhang, C. X.; Thormann, W., Head-column field-amplified sample stacking in binary system capillary electrophoresis. 2. Optimization with a preinjection plug and application to micellar electrokinetic chromatography. Analytical Chemistry 1998, 70 (3), 540-548. 60. Zhao, Y.; Kong, Y.; Wang, B.; Wu, Y.; Wu, H., On-line concentration and determination of all-trans- and 13-cis-retinoic acids in rabbit serum by application of sweeping technique in micellar electrokinetic chromatography. Journal of Chromatography A 2007, 1146 (1), 131-135. 61. Quirino, J. P.; Terabe, S.; Bocek, P., Sweeping of neutral analytes in electrokinetic chromatography with high-salt-containing matrixes. Analytical Chemistry 2000, 72 (8), 1934-1940. 62. IRMM Melamine proficiency test. (Accessed Aprial 27, 2009). http://irmm.jrc.ec.europa.eu/html/activities/melamine/proficiency/index.htm 63. WHO Tuberculosis. (Accessed April 15, 2011) http://www.who.int/mediacentre/factsheets/fs104/en/. 64. Berning, S. E.; Huitt, G. A.; Iseman, M. D.; Peloquin, C. A., Malabsorption of antituberculosis medications by a patient with AIDS. New England Journal of Medicine 1992, 327 (25), 1817-1818. 65. Ray, J.; Gardiner, I.; Marriott, D., Managing antituberculosis drug therapy by therapeutic drug monitoring of rifampicin and isoniazid. Internal Medicine Journal 2003, 33 (5-6), 229-234. 66. Moussa, L. A.; Khassouani, C. E.; Soulaymani, R.; Jana, M.; Cassanas, G.; Alric, R.; Hue, B., Therapeutic isoniazid monitoring using a simple high-performance liquid chromatographic method with ultraviolet detection. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2002, 766 (1), 181-187. 67. Patel, K. B.; Belmonte, R.; Crowe, H. M., Drug malabsorption and resistant tuberculosis in HIV-infected patients New England Journal of Medicine 1995, 332 (5), 336-337. 68. Ellard, G. A.; Wallace, S. M.; Gammon, P. T., Determination of isoniazid and its metabolites acetylisoniazid, monoacetylhydrazine, diazetylhydrazine, isonicotinic acid and isonicotinylglycine in serum and urine. Biochemical Journal 1972, 126 (3), 449-458. 69. Eidus, L.; Harnanan.Am, More sensitive spectrophotometric method for determination of isoniazid in serum or plasma. Clinical Chemistry 1971, 17 (6), 492-494. 70. Devani, M. B.; Shishoo, C. J.; Patel, M. A.; Bhalara, D. D., Spectrophotometric determination of isoniazid in presence of its hydrazones. Journal of Pharmaceutical Sciences 1978, 67 (5), 661-663. 71. Lever, M., Rapid fluorometric or spectrophotometric determination of isoniazid. Biochemical Medicine 1972, 6 (1), 65-71. 72. Zhou, Z. F.; Chen, L. Y.; Liu, P.; Shen, M.; Zou, F., Simultaneous determination of isoniazid, pyrazinamide, rifampicin and acetylisoniazid in human plasma by high-performance liquid chromatography. Analytical Sciences 2010, 26 (11), 1133-1138. 73. Milan-Segovia, R.; Perez-Flores, G.; Torres-Tirado, J. D.; Hermosillo-Ramirez, X.; Vigna-Perez, M.; Romano-Moreno, S., Simultaneous HPLC determination of isoniazid and acetylisoniazid in plasma. Acta Chromatographica 2007, 19, 110-118. 74. Mahjub, R.; Khalili, H.; Amini, M., Development and validation of a novel gradient LC method for simultaneous determination of isoniazid and acetylisoniazid in human plasma. Chromatographia 2010, 71 (5-6), 419-422. 75. Unsalan, S.; Sancar, M.; Bekce, B.; Clark, P. M.; Karagoz, T.; Izzettin, F. V.; Rollas, S., Therapeutic monitoring of isoniazid, pyrazinamide and rifampicin in tuberculosis patients using LC. Chromatographia 2005, 61 (11-12), 595-598. 76. Sadeg, N.; Pertat, N.; Dutertre, H.; Dumontet, M., Rapid, specific and sensitive method for isoniazid determination in serum. Journal of Chromatography B 1996, 675 (1), 113-117. 77. Lacroix, C.; Laine, G.; Goulle, J. P.; Nouveau, J., Determination of isoniazid and acetylisoniazid in plasma or serum by high-performance liquid chromatography. Journal of Chromatography 1984, 307 (1), 137-144. 78. Svensson, J. O.; Muchtar, A.; Ericsson, O., Ion-pair high-performance liquid-chromatographic determination of isoniazid and acetylisoniazid in plasma and urine - application for acetylator phenotyping. Journal of Chromatography 1985, 341 (1), 193-197. 79. Ioannou, P. C., A more simple, rapid and sensitive fluorimetric method for the determination of isoniazid and acetylisoniazid in serum. Application for acetylator phenotyping. Clinica Chimica Acta 1988, 175 (2), 175-181. 80. Defilippi, A.; Piancone, G.; Laia, R. C.; Balla, S.; Tibaldi, G. P., High -performance liquid-chromatography with UV detection and diod array UV conformation of isonicotinic-acid hydrazide in cattle milk. Journal of Chromatography B 1994, 656 (2), 466-471. 81. Kubo, H.; Kinoshita, T.; Matsumoto, K.; Nishikawa, T., Fluorometric-determination of isoniazid and its metabolites in urine by high-performance liquid chromatography. Chromatographia 1990, 30 (1-2), 69-72. 82. Kohno, H.; Kubo, H.; Furukawa, K.; Yoshino, N.; Nishikawa, T., Fluorometric-determination of isoniazid and its metabolites in urine by high-performance liquid-chromatography using in-line derivatization. Therapeutic Drug Monitoring 1991, 13 (5), 428-432. 83. Khuhawar, M. Y.; Zardari, L. A.; Laghari, A. J., Capillary gas chromatographic determination of isoniazid in pharmaceutical preparation by pre-column derivatization with acetylacetone. Asian Journal of Chemistry 2008, 20 (8), 5997-6006. 84. Khuhawart, M. Y.; Zardari, L. A., Ethyl chloroformate as a derivatizing reagent for the gas chromatographic determination of isoniazid and hydrazine in pharmaceutical preparations. Analytical Sciences 2008, 24 (11), 1493-1496. 85. Timbrell, J. A.; Wright, J. M.; Smith, C. M., Determination of hydrazine metabolites of isoniazid in human urine by gas-chromatography. Journal of Chromatography 1977, 138 (1), 165-172. 86. Huang, L. S.; Marzan, F.; Jayewardene, A. L.; Lizak, P. S.; Li, X. H.; Aweeka, F. T., Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasma. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2009, 877 (3), 285-290. 87. Song, S. H.; Jun, S. H.; Park, K. U.; Yoon, Y.; Lee, J. H.; Kim, J. Q.; Song, J., Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2007, 21 (7), 1331-1338. 88. Chen, X. Y.; Song, B.; Jiang, H. J.; Yu, K.; Zhong, D. F., A liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of isoniazid and ethambutol in human plasma. Rapid Communications in Mass Spectrometry 2005, 19 (18), 2591-2596. 89. Elbrashy, A. M.; Elashry, S. M., Colorimetric and titrimetric assay of isoniazid. Journal of Pharmaceutical and Biomedical Analysis 1992, 10 (6), 421-426. 90. Alapont, A. G.; Gimenez, E. A.; Zamora, L. L.; Calatayud, J. M., Inhibition of the system luminol-H2O2-Fe(CN)(6)(3-) chemiluminescence by the Mn(II) indirect determination of isoniazid in a pharmaceutical formulation. Journal of Bioluminescence and Chemiluminescence 1998, 13 (3), 131-137. 91. Koupparis, M. A.; Hadjiioannou, T. P., Indirect potentiometric determination of hydrazine, isoniazid, sulfide and thiosulfate with a chloramine-T ion-selective electrode. Talanta 1978, 25 (8), 477-480. 92. Liu, J.; Zhou, W. H.; You, T. Y.; Li, F. L.; Wang, E. K.; Dong, S. J., Detection of hydrazine, methylhydrazine, and isoniazid by capillary electrophoresis with a palladium modified microdisk array electrode. Analytical Chemistry 1996, 68 (19), 3350-3353. 93. Wang, E. K.; Zhou, W. H., Determination of isoniazid and hydrazine by capillary electrophoresis with amperometric detection at a Pt-particle modified carbon fiber microelectrode. Chinese Journal of Chemistry 1996, 14 (2), 131-137. 94. Faria, A. F.; de Souza, M. V. N.; Bruns, R. E.; de Oliveira, M. A. L., Simultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection. Talanta 2010, 82 (1), 333-339. 95. Nemutlu, E.; Celebier, M.; Uyar, B.; Altinoz, S., Validation of a rapid micellar electrokinetic capillary chromatographic method for the simultaneous determination of isoniazid and pyridoxine hydrochloride in pharmaceutical formulation. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2007, 854 (1-2), 35-42. 96. Lin, C. H.; Kaneta, T., On-line sample concentration techniques in capillary electrophoresis: Velocity gradient techniques and sample concentration techniques for biomolecules. Electrophoresis 2004, 25 (23-24), 4058-4073. 97. Tsai, C. H.; Huang, H. M.; Lin, C. H., Violet light emitting diode-induced fluorescence detection combined with on-line sample concentration techniques for use in capillary electrophoresis. Electrophoresis 2003, 24 (17), 3083-3088. 98. Huang, H. Y.; Hsieh, S. H., Analyses of tobacco alkaloids by cation-selective exhaustive injection sweeping microemulsion electrokinetic chromatography. Journal of Chromatography A 2007, 1164, 313-319. 99. Lin, Y. H.; Lee, M. R.; Lee, R. J.; Ko, W. K.; Wu, S. M., Hair analysis for methamphetamine, ketamine, morphine and codeine by cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography. Journal of Chromatography A 2007, 1145 (1-2), 234-240. 100. Lin, Y. H.; Chiang, J. F.; Lee, M. R.; Lee, R. J.; Ko, W. K.; Wu, S. M., Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for analysis of morphine and its four metabolites in human urine. Electrophoresis 2008, 29 (11), 2340-2347. 101. Su, H. L.; Hsieh, Y. Z., Using cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography to determine selective serotonin reuptake inhibitors. Journal of Chromatography A 2008, 1209 (1-2), 253-259. 102. Fang, C.; Liu, J. T.; Lin, C. H., Optimization of the separation of lysergic acid diethylamide in urine by a sweeping technique using micellar electrokinetic chromatography. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2002, 775 (1), 37-47. 103. Quirino, J. P.; Iwai, Y.; Otsuka, K.; Terabe, S., Determination of environmentally relevant aromatic amines in the ppt levels by cation selective exhaustive injection-sweeping-micellar electrokinetic chromatography. Electrophoresis 2000, 21 (14), 2899-2903. 104. Isoo, K.; Terabe, S., Analysis of metal ions by sweeping via dynamic complexation and cation-selective exhaustive injection in capillary electrophoresis. Analytical Chemistry 2003, 75 (24), 6789-6798. 105. Li, X.; Hu, J.; Han, H., Determination of cypromazine and its metabolite melamine in milk by cation-selective exhaustive injection and sweeping-capillary micellar electrokinetic chromatography. Journal of Separation Science 2011, 34 (3), 323-330. 106. Yang, Y.; Nie, H.; Li, C.; Bai, Y.; Li, N.; Liao, J.; Liu, H., On-line concentration and determination of tobacco - specific N-nitrosamines by cation - selective exhaustive injection-sweeping-micellar electrokinetic chromatography. Talanta 2010, 82 (5), 1797-1801. 107. Shihabi, Z. K., Organic solvent high-field amplified stacking for basic compounds in capillary electrophoresis. Journal of Chromatography A 2005, 1066 (1-2), 205-210. 108. Hsu, M.-C.; Chen, D.; Liu, R. H., Detection of abused drugs in urine by GC-MS. Journal of Food and Drug Analysis 2009, 17 (4), 233-245. 109. Nakashima, K., High-performance liquid chromatographic analysis of drugs of abuse in biologic samples. Journal of Health Science 2005, 51 (3), 272-277. 110. Shannon, M.; Cox, M. N.; Baum, C. R., Toxicology reviews: Immunoassay in detecting drugs of abuse. Pediatric Emergency Care 1998, 14 (5), 372-375. 111. Kolmonen, M.; Leinonen, A.; Pelander, A.; Ojanpera, I., A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry. Analytica Chimica Acta 2007, 585 (1), 94-102. 112. Lee, H. K.; Ho, C. S.; Iu, Y. P. H.; Lai, P. S. J.; Shek, C. C.; Lo, Y.-C.; Klinke, H. B.; Wood, M., Development of a broad toxicological screening technique for urine using ultra-performance liquid chromatography and time-of-flight mass spectrometry. Analytica Chimica Acta 2009, 649 (1), 80-90. 113. Quintela, O.; Cruz, A.; de Castro, A.; Concheiro, M.; Lopez-Rivadulla, M., Liquid chromatography-electrospray ionisation mass spectrometry for the determination of nine selected benzodiazepines in human plasma and oral fluid. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2005, 825 (1), 63-71. 114. Musshoff, F.; Trafkowski, J.; Kuepper, U.; Madea, B., An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. Journal of Mass Spectrometry 2006, 41 (5), 633-640. 115. Laloup, M.; Fernandez, M. D. R.; De Boeck, G.; Wood, M.; Maes, V.; Samyn, N., Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. Journal of Analytical Toxicology 2005, 29 (7), 616-626. 116. Cheng, W. C.; Yau, T. S.; Wong, M. K.; Chan, L. P.; Mok, V. K. K., A high-throughput urinalysis of abused drugs based on a SPE-LC-MS/MS method coupled with an in-house developed post-analysis data treatment system. Forensic Science International 2006, 162 (1-3), 95-107. 117. Wu, T. Y.; Fuh, M. R., Determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4- methylenedioxymethamphetamine in urine by online solid-phase extraction and ion-pairing liquid chromatography with detection by electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2005, 19 (6), 775-780. 118. Maurer, H. H., Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Analytical and Bioanalytical Chemistry 2007, 388 (7), 1315-1325. 119. Pelander, A.; Ojanpera, I.; Laks, S.; Rasanen, I.; Vuori, E., Toxicological screening with formula-based metabolite identification by liquid chromatography/time-of-flight mass spectrometry. Analytical Chemistry 2003, 75 (21), 5710-5718. 120. Polettini, A.; Gottardo, R.; Pascali, J. P.; Tagliaro, F., Implementation and performance evaluation of a database of chemical formulas for the screening of pharmaco/toxicologically relevant compounds in biological samples using electrospray ionization-time-of-flight mass spectrometry. Analytical Chemistry 2008, 80 (8), 3050-3057. 121. Moriya, F., Urine levels of drugs for which Triage DOA screening was positive. Legal Medicine 2009, 11 (Supplement 1), S434-S436. 122. Freye, E., Types of urine drug testing, in: Pharmacology and abuse cocaine, amphetamines, ecstasy and related designer drugs. Springer Netherlands: 2009; pp. 253-260. 123. Jimenez, C.; Ventura, R.; Segura, J., Validation of qualitative chromatographic methods: strategy in antidoping control laboratories. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2002, 767 (2), 341-351. 124. Quintela, O.; Sauvage, F.-L.; Charvier, F.; Gaulier, J.-M.; Lachatre, G.; Marquet, P., Liquid chromatography-tandem mass spectrometry for detection of low concentrations of 21 benzodiazepines, metabolites, and analogs in urine: Method with forensic applications. Clinical Chemistry 2006, 52 (7), 1346-1355. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44142 | - |
dc.description.abstract | 第一部分: 開發毛細管電泳法於藥物及三聚氰胺之分析
分析的方法追求正確、靈敏、快速、環保。本研究第一部分開發快速、簡單、節省樣品及溶媒的毛細管電泳法分析生物檢品中的藥物以及奶粉中的不法添加物。Teicoplanin是一種能夠有效治療methicillin-resistant Staphylococcus aureus (MRSA)的抗生素,安全且有效的治療MRSA感染需要監控治療藥物血中濃度在理論範圍(therapeutic range)內。此部分開發了快速且具經濟效益的膠束電動層析法(micellar electrokinetic chromatography, MEKC)並結合固相萃取樣品處理技術達到分析物線下(off-line)濃縮10倍以上,可定量病人血清中之teicoplanin濃度。最低偵測極限(S/N=3)小於0.06 μg mL-1。為了提升毛細管電泳的偵測靈敏度,線上濃縮技術包括sweeping和stacking皆大幅改善偵測極限。於奶粉中違法添加三聚氰胺(melamine)近幾年來一直是重要的社會議題,利用所開發的sweeping-MEKC方法可快速、靈敏地篩檢奶粉中的三聚氰胺含量,最低偵測極限(S/N=3)可達10.9 ng mL-1,和傳統區帶電泳相比濃縮效率提升70倍。而利用所開發的cation selective exhaustive injection-sweeping-MEKC (CSEI-Sweep-MEKC)方法,合併場放大樣品堆積和掃集法兩種線上濃縮原理分析病人血中抗肺結核藥物isoniazid的濃度,其偵測極限可達9 ng mL-1,和膠束電動層析法相比濃縮效率提升85倍。本研究所開發的方法皆成功應用於分析實際樣品,顯示毛細管電泳配合線下及線上濃縮,可有效應用在生物檢品及奶粉中添加物的分析,為一靈敏、快速、簡單、環保的分析平台。 第二部分: 開發液相層析-飛行式質譜儀方法快速篩檢尿液中之 濫用藥物 藥物濫用能導致謀殺、自殺、性侵害和許多社會問題。此部分研究首先開發高效液相層析-飛行式質譜儀(HPLC-TOF MS)方法並進一步開發超高效液相層析-四極柱-飛行式質譜儀(UHPLC-QTOF MS)法快速篩檢尿液中之濫用藥物。具有高度濫用率的藥物包括amphetamines,opioids,benzodiazepines,barbiturates,ketamine,lysergic acid diethylamide (LSD),cannabis。本研究採用正、負離子模式分析,使所有的測試標準品皆可得到最佳的偵測靈敏度;分析管柱與移動相條件也經過最佳化來獲得良好的專一性與靈敏度;HPLC-TOF MS部分使用Atlantis dC18作為分析管柱,5 mM ammonium acetate / 0.1 % formic acid水溶液 (pH=3)與ACN作為鹼性分析物分析時的移動相。酸性分析物則使用pH值較高的10 mM ammonium acetate水溶液(pH=7)與ACN作為移動相。HPLC-TOF MS平台可準確篩檢尿液中的濫用藥物,但是偽陽性結果的問題無法直接解決。UHPLC-QTOF MS最佳化的條件為利用Poroshell EC C18做為分析管柱,0.1 % acetic acid 水溶液與methanol作為移動相組成,可在20分鐘內完成正、負離子模式分析;由於UHPLC-QTOF MS配合Jet stream離子源具有高靈敏度,尿液樣本可直接在簡單稀釋5倍後進行分析。兩種分析平台分別經過專一性、再現性、萃取回收率、基質效應與靈敏度的方法驗證,峰面積再現性在10倍法規閾值濃度與1倍法規閾值濃度的相對標準差皆小於25 %。UHPLC-QTOF MS並能進行二級質譜分析,確認篩檢結果的正確性。所開發分析方法不因篩檢品項增加而降低靈敏度,於資料處理軟體中建立不限品項數且欲篩檢之分析物分子式資訊,軟體即能自動比對精確質量與同位素模式(isotopic pattern),進行分析資料篩檢,縮減尿液中所含未知濫用藥物的種類範圍及品項,進一步可利用同一平台針對可疑化合物進行二級質譜確認,高效率的分析平台。為驗證方法的效力,我們將所開發的方法應用於分析12個尿液檢體。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-15T02:41:49Z (GMT). No. of bitstreams: 1 ntu-100-F95423009-1.pdf: 6833018 bytes, checksum: 72f19f7084a6b5b093f728cb53fa84ae (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 目錄
中文摘要---------------------------------------------------------------------------------------------I 英文摘要-------------------------------------------------------------------------------------------IV 內文目錄------------------------------------------------------------------------------------------VII 內文目錄一 第一部分:開發毛細管電泳法於藥物及三聚氰胺之分析 第一章:序論 壹、毛細管電泳分析法---------------------------------------------------------------------------1 貳、研究動機---------------------------------------------------------------------------------------2 第二章:開發固相萃取與膠束電動層析法分析病人血清中之teicoplanin 壹、引言---------------------------------------------------------------------------------------------3 貳、研究目的---------------------------------------------------------------------------------------4 参、實驗部分---------------------------------------------------------------------------------------5 3.1 儀器 -------------------------------------------------------------------------------------5 3.2 藥品與試劑 ----------------------------------------------------------------------------5 3.3 貯備液與工作溶液製備--------------------------------------------------------------6 3.4 空白血清製備--------------------------------------------------------------------------6 3.5 檢品溶液製備--------------------------------------------------------------------------6 3.6 毛細管電泳系統-----------------------------------------------------------------------7 3.7 分析方法確效--------------------------------------------------------------------------8 肆、結果與討論-----------------------------------------------------------------------------------10 4.1樣品前處理法條件最佳化-----------------------------------------------------------10 4.2 分析方法條件最佳化----------------------------------------------------------------11 4.3 最佳分析條件-------------------------------------------------------------------------13 4.4 分析方法確效-------------------------------------------------------------------------13 4.5分析病人血清中之teicoplanin濃度-----------------------------------------------14 伍、結論-------------------------------------------------------------------------------------------15 第三章 : 開發掃集式線上濃縮-膠束電動層析法快速篩檢嬰兒奶粉中之三聚氰胺 壹、引言-------------------------------------------------------------------------------------------16 貳、研究目的-------------------------------------------------------------------------------------18 参、實驗部分--------------------------------------------------------------------------------------18 3.1 儀器-------------------------------------------------------------------------------------18 3.2 藥品與試劑----------------------------------------------------------------------------19 3.3 貯備液與工作溶液製備-------------------------------------------------------------19 3.4 檢品溶液製備-------------------------------------------------------------------------19 3.5 毛細管電泳系統----------------------------------------------------------------------21 3.6 分析方法確效-------------------------------------------------------------------------22 肆、結果與討論----------------------------------------------------------------------------------24 4.1線上濃縮條件最佳化-----------------------------------------------------------------24 4.2場放大樣品堆積法與掃集法之比較-----------------------------------------------27 4.3 掃集-膠束電動層析法方法確效---------------------------------------------------28 伍、結論-------------------------------------------------------------------------------------------30 第四章 : 開發陽離子選擇性完全注射-掃集-膠束電動層析法定量生物檢品中之 isoniazid 壹、 引言------------------------------------------------------------------------------------------31 貳、研究目的-------------------------------------------------------------------------------------33 参、實驗部分-------------------------------------------------------------------------------------33 3.1 儀器-------------------------------------------------------------------------------------33 3.2 藥品與試劑----------------------------------------------------------------------------34 3.3 貯備液與工作溶液製備-------------------------------------------------------------34 3.4 空白血漿製備-------------------------------------------------------------------------34 3.5 檢品溶液製備-------------------------------------------------------------------------34 3.6 毛細管電泳系統----------------------------------------------------------------------36 3.7 分析方法確效-------------------------------------------------------------------------37 肆、結果與討論----------------------------------------------------------------------------------39 4.1 MEKC分離參數最佳化--------------------------------------------------------------40 4.2 CSEI-Sweep線上濃縮參數最佳化-------------------------------------------------40 4.3 樣品前處理方開發-------------------------------------------------------------------42 4.4方法確效與應用-----------------------------------------------------------------------43 4.5 CSEI-Sweep-MEKC與其他分析平台比較---------------------------------------44 伍、結論--------------------------------------------------------------------------------------------44 第五章 : 第一部分總結------------------------------------------------------------------------45 第一部分附圖 Figure I-1 Chemical structures of the six major components of teicoplanin and the internal standard, theophylline--------------------------------------------------47 Figure I-2 Influence of ACN on separation of teicoplanin components---------------48 Figure I-3 Influence of pH on separation of teicoplanin components------------------49 Figure I-4 Influence of buffer concentration on separation of teicoplanin components -------------------------------------------------------------------------------------50 Figure I-5 Influence of SDS concentration on separation of teicoplanin components --------------------------------------------------------------------------------------51 Figure I-6 Electropherogram of serum sample from a patient undergoing teicoplanin treatment--------------------------------------------------------------------------52 Figure I-7 Correlation of teicoplanin concentration measured by MEKC and FPIA -------------------------------------------------------------------------------------53 Figure I-8 Structure of melamine-----------------------------------------------------------54 Figure I-9 Electropherograms of melamine obtained under conventional CZE, LVSS -CZE and FASS-CZE conditions----------------------------------------------55 Figure I-10 Effect of (A) injection time and (B) SDS concentration on peak intensity and migration time of melamine in sweeping-MEKC system--------------56 Figure I-11 Electropherograms of melamine obtained under optimized FASS-CZE and sweeping-MEKC conditions----------------------------------------------------57 Figure I-12 Sweeping - MEKC electropherograms of melamine - contaminated milk provided by the Joint research centre of the European Commission, and the Bureau of food and drug analysis in Taiwan-----------------------------58 Figure I-13 Structures of isoniazid and the internal standard-----------------------------59 Figure I-14 Electropherogram of human plasma spiked with 1 μg mL-1 isoniazid under sweeping-MEKC and CSEI-Sweep-MEKC conditions---------------------60 Figure I-15 Electropherograms of human plasma spiked with 2 μg mL-1 isoniazid with different percentages of ACN in buffer---------------------------------------61 Figure I-16 Electropherograms of human plasma spiked with 2 μg mL-1 INH. (A) CB with different phosphoric acid concentrations. (B) HCB with different injection time length-------------------------------------------------------------62 Figure I-17 Electropherograms of human plasma spiked with 2 μg mL-1 INH with different concentrations of SDS in buffer-------------------------------------63 Figure I-18 Electropherograms of INH with sample solution comprised of (A) 50 % MeOH with 30 mM of phosphoric acid. (B) 50% MeOH without phosphoric acid-------------------------------------------------------------------64 Figure I-19 Relationship between the phosphoric acid concentrations in the sample matrix and the peak height of isoniazid--------------------------------------65 Figure I-20 Effect of sample injection time length on the peak intensity of isoniazid ----------------------------------------------------------------------------------66 Figure I-21 Electropherograms of (A) human plasma spiked with 0.1 μg mL-1 INH compared with blank sample and (B) plasma samples from patients treated with isoniazid---------------------------------------------------------------------67 第一部分附表 Table I-1 Analytical precision and accuracy of teicoplanin components--------------68 Table I-2 Linear range, limit of detection (LOD), and limit of quantitation (LOQ) of the teicoplanin components------------------------------------------------------68 Table I-3 Limit of detections (LOD), enhancement factor (EF) of melamine in different sample matrix effect of the FASS-CZE and sweeping-MEKC system---------------------------------------------------------------------------69 Table I-4 Comparison of performance of analytical methods in determination of isoniazid in human plasma--------------------------------------------------------69 內文目錄二 第二部分 : 開發液相層析-飛行式質譜儀方法快速篩檢尿液中之濫用藥物 第一章 : 序論 壹、濫用藥物篩檢與飛行式質譜儀之優勢-------------------------------------------------71 貳、研究動機-------------------------------------------------------------------------------------73 第二章 : 開發HPLC-TOF MS方法快速篩檢尿液中的濫用藥物 壹、研究目的--------------------------------------------------------------------------------------74 貳、實驗部分-------------------------------------------------------------------------------------74 2.1儀器條件及材料----------------------------------------------------------------------74 2.2試劑與檢品-----------------------------------------------------------------------------74 2.3標準品配製-----------------------------------------------------------------------------75 2.4固相萃取步驟--------------------------------------------------------------------------76 2.5 HPLC-TOF MS分析條件------------------------------------------------------------78 2.6定性分析方法確效--------------------------------------------------------------------79 2.7 應用-------------------------------------------------------------------------------------79 参、結果與討論---------------------------------------------------------------------------------79 3.1樣品萃取方法的開發---------------------------------------------------------------79 3.2 HPLC-ESI-TOF MS分析條件的開發---------------------------------------------81 3.3分析方法確效------------------------------------------------------------------------82 3.4 應用-------------------------------------------------------------------------------------83 肆、結論------------------------------------------------------------------------------------------84 第三章 : 開發UHPLC-QTOF MS方法快速篩檢尿液中的濫用藥物 壹、研究目的-------------------------------------------------------------------------------------85 貳、材料與方法----------------------------------------------------------------------------------85 2.1儀器條件及材料----------------------------------------------------------------------85 2.2試劑與檢品---------------------------------------------------------------------------85 2.3標準品配製----------------------------------------------------------------------87 2.4樣品前處理----------------------------------------------------------------------87 2.5儀器條件及材料----------------------------------------------------------------------87 2.6定性分析方法確效-------------------------------------------------------------------88 2.7 應用-------------------------------------------------------------------------------------89 参、結果與討論-----------------------------------------------------------------------------89 3.1樣品處理方法開發--------------------------------------------------------------------89 3.2 UHPLC-ESI-QTOF MS分析條件的開發----------------------------------------89 3.3分析方法確效--------------------------------------------------------------------------91 3.4 標準品相關資料建立----------------------------------------------------------------91 3.5尿液檢品分析----------------------------------------------------------------------91 肆、結論----------------------------------------------------------------------------------------92 第四章 : 第二部分總結------------------------------------------------------------------------93 第二部分附圖 Figure II-1 Extraction ion chromatogram of 35 basic compounds-----------------------94 Figure II-2 Extraction ion chromatogram of 6 acidic compounds-----------------------94 Figure II-3 Peak intensities of 6 basic compounds in six different mobile phase compositions-------------------------------------------------------------------95 Figure II-4 Peak intensities of 5 acidic compounds in different mobile phases--------96 Figure II-5 Peak area of buprenorphine in different mass detector conditions---------97 Figure II-6 Peak area of THC-COOH in different mass detector conditions-----------98 Figure II-7 Screen results of urine sample No.17------------------------------------------99 第二部分附表 Table II-1 Validation results of 41 forensic drugs---------------------------------------102 Table II-2 Screening report of sample A11 and sample A26--------------------------103 Table II-3 Validation results of 62 forensic drugs and metabolites-------------------105 Table II-4 Accurate mass and structure of 62 forensic compounds and metabolites -------------------------------------------------------------------------------------108 Table II-5 Screen results of 12 suspect urine samples from TOF MS, QTOF MS, and Immunoassay------------------------------------------------------------------119 參考文獻--------------------------------------------------------------------------------------121 | |
dc.language.iso | zh-TW | |
dc.title | 毛細管電泳與液相層析-飛行式質譜儀於藥物與毒化物之分析研究 | zh_TW |
dc.title | Studies on Using Capillary Electrophoresis and Liquid Chromatography Time-of-Flight Mass Spectrometry to Analyze Drugs and Toxicological Compounds | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 吳信隆,張煥宗,麥富德,陳家揚 | |
dc.subject.keyword | teicoplanin,三聚氰胺,isoniazid,毛細管電泳,濫用藥物,液相層析-飛行式質譜儀, | zh_TW |
dc.subject.keyword | teicoplanin,melamine,isoniazid,capillary electrophoresis,drug of abuse,liquid chromatography time - of - flight mass spectrometry, | en |
dc.relation.page | 187 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-17 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥學研究所 | zh_TW |
顯示於系所單位: | 藥學系 |
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