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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江文章 | |
dc.contributor.author | Ai-Chen Hsieh | en |
dc.contributor.author | 謝艾臻 | zh_TW |
dc.date.accessioned | 2021-06-15T02:40:06Z | - |
dc.date.available | 2014-08-19 | |
dc.date.copyright | 2009-08-19 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-08-11 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44104 | - |
dc.description.abstract | 糖尿病是指體內胰島素分泌或作用異常,因而造成血糖過高的現象,並可能引起許多併發症的發生。衛生署最新公佈的民國97年台灣地區的十大死亡原因中,糖尿病為第五位,顯示糖尿病是現今台灣社會所極需關心的健康問題。本實驗選擇一些已知為低升糖指數(glycemic index, GI)或是已經實驗證實具有調節血糖功效的穀物,如:糙米、米麩皮、糙薏仁、薏仁麩皮作為產品原料,以雙軸擠壓機製造成膨發性穀類擠壓產品。而本實驗的主要目的是要評估穀類擠壓產品對STZ(streptozotocin)誘導之糖尿病大白鼠生理代謝的影響。結果顯示,攝取穀類擠壓產品無論有無添加膳食纖維,對STZ誘導之糖尿病大白鼠的醣類及脂質代謝皆無任何影響。但攝取穀類擠壓產品能顯著降低STZ誘導之糖尿病大白鼠的血漿TBARS濃度(p<0.05)。 | zh_TW |
dc.description.abstract | Diabetes mellitus(DM)is the disease in which the body dose not produce enough insulin or can’t use its own insulin as well as it should. It causes sugar to accumulate in the blood(hyperglycemia), and leading to various complication. The Department of Health in Taiwan reported that diabetes was the 5th leading cause of death in Taiwan in 2008. It represents that diabetes is coming to a serious health problem that we have to concern. In present study, I used some cereals that have been concerned with hypoglycemic effect as material to produce expansible extruded cereal products. The contents of the formula are brown rice, rice bran, dehulled adlay and adlay bran. And the objective of this study was to evaluate the effect of extruded cereal product on physiological metabolism in STZ induced diabetic rats. The results of this study demonstrated that the extruded cereal product with or whithout resistance maltodextrin wouldn’t affect the carbohydrate and lipid metabolism of STZ induced diabetic rats. But taking the extruded cereal product could reduce plasma TBARS of STZ induced diabetic rats. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T02:40:06Z (GMT). No. of bitstreams: 1 ntu-98-R96641031-1.pdf: 876230 bytes, checksum: ce5926c2ae62cd2caec7556db8aaa72e (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 中文摘要…………………………………I
英文摘要…………………………………II 詞彙縮寫表………………………………III 目錄………………………………………IV 表目錄……………………………………IX 圖目錄……………………………………XII 第一章 前言……………………………1 第二章 文獻整理………………………3 2.1 糖尿病………………………………3 2.1.1 糖尿病的現況 …………………3 2.1.2 糖尿病的定義及分類 …………3 2.1.3 糖尿病的診斷標準 ……………4 2.1.4 糖尿病相關併發症 ……………6 2.1.5 升糖指數(Glycemic index, GI)………8 2.1.6 糖尿病動物模式 …………………10 2.2 食品擠壓技術 ………………………12 2.2.1 擠壓技術簡介 ……………………12 2.2.2 影響擠壓產品的操作因子 ………12 2.3 薏仁 ………………………………15 2.3.1 薏仁簡介 ………………………15 2.3.2 薏仁的生理功效 ………………16 2.3.3 薏仁調節血糖的功效 …………17 2.4 米麩皮 ……………………………20 2.4.1 米麩皮簡介 ……………………20 2.4.2 米麩的有效成分及生理功效 …21 2.4.3 米麩調節血糖的功效 …………23 第三章 研究目的與架構 ……………26 3.1 研究目的 …………………………26 3.2 實驗架構 …………………………27 第四章 材料與方法 …………………28 4.1 實驗材料 …………………………28 4.2 實驗藥品 …………………………28 4.2.1 動物飼料配方 …………………28 4.2.2 一般藥品 ………………………28 4.2.3 商業試劑套組 …………………29 4.3 儀器設備 …………………………29 4.4 實驗方法 …………………………30 4.4.1 擠壓產品之特性分析……………30 4.4.1.1 膨發率(Expansion ratio, ER)…………30 4.4.1.2 縱向膨發率(Longitudinal expansion ratio, Long. ER)...30 4.4.1.3 比容積(Specific volume, SV)…………30 4.4.1.4 水溶性指標(Water solubility index, WSI)和吸水性指標(Water absorption index, WAI)...........…30 4.4.1.5 一般成分分析………………………........31 4.4.2 短期動物實驗……………………………………32 4.4.2.1 動物的誘導、分組與飼養……………………32 4.4.2.2 血漿分析……………………………………..33 4.4.2.2.1 血漿葡萄糖分析 …………………………33 4.4.3 長期動物實驗…………………………………...34 4.4.3.1 動物的誘導、分組與飼養…………………34 4.4.3.2 血漿分析…………………………………35 4.4.3.2.1 葡萄糖分析………………………35 4.4.3.2.2 胰島素分析……………………………35 4.4.3.2.3 三酸甘油酯分析………………………35 4.4.3.2.4 總膽固醇分析……………………35 4.4.3.2.5 高密度脂蛋白膽固醇分析…………………36 4.4.3.2.6 低密度脂蛋白膽固醇分析…………………36 4.4.3.2.7 果糖胺分析……………………………36 4.4.3.2.8 尿素氮分析(BUN)………………………37 4.4.3.2.9 Aspartate aminotransferase, AST (Glutamic oxaloacetic transaminase, GOT)分析 …………………37 4.4.3.2.10 Alanine aminotransferase, ALT (Glutamic pyruvic transaminase, GPT)分析 ……………37 4.4.3.2.11 Thiobarbituric acid reactive substances, TBARS分析.........38 4.4.3.3 肝臟分析……………………38 4.4.3.3.1 肝臟脂質萃取及分析………………………38 4.4.3.3.2 TBARS分析 ………………………39 4.4.3.4 糞便分析 ……………………………39 4.4.3.4.1 糞便的前處理……………………39 4.4.3.4.2 脂質分析…………………………39 4.4.4 統計分析……………………………………40 第五章 結果…………………………………41 5.1 穀類擠壓產品的製造……………………41 5.2 穀類擠壓產品原料配方之選擇 ………42 5.2.1 擠壓產品之特性分析 ………………42 5.2.2 短期動物實驗……………………….42 5.2.2.1 體重、攝食量及攝食效率(Food efficiency) ……42 5.2.2.2 口服葡萄糖耐受性試驗結果 ………………43 5.2.2.3 血脂的變化 …………………………43 5.3 穀類擠壓產品對STZ誘導之糖尿病大白鼠生理代謝影響之評估44 5.3.1 長期動物實驗 …………………………44 5.3.1.1 口服葡萄糖耐受性試驗結果 ………44 5.3.1.2 體重及攝食量的變化 ……………………46 5.3.1.3 臟器及組織重量 …………………………46 5.3.1.4 血液生化指標 ………………………………47 5.3.1.5 肝臟生化指標 ………………………………49 5.3.1.6 糞便生化指標 ………………………………50 第六章 討論 …………………………………………51 6.1 穀類擠壓產品原料配方之選擇 ………………51 6.1.1 擠壓產品特性評比 …………………………51 6.1.2 短期動物實驗 ………………………………53 6.2 穀類擠壓產品對STZ誘導之糖尿病大白鼠生理代謝影響之評估 55 6.2.1 新舊動物模式評比 ……………………55 6.2.2 擠壓產品對STZ誘導之糖尿病大白鼠體重及組織臟器的影響.60 6.2.3 擠壓產品對STZ誘導之糖尿病大白鼠醣類代謝的影響………61 6.2.4 擠壓產品對STZ誘導之糖尿病大白鼠脂質代謝的影響………63 6.2.5 擠壓產品對STZ誘導之糖尿病大白鼠體內氧化壓力的影響…63 6.2.6 擠壓產品對STZ誘導之糖尿病大白鼠肝、腎功能的影響……64 6.2.7 長期動物實驗中各組生化指標的標準差過大的原因 ……64 第七章 結論 ……………………………66 參考文獻 ………………………………67 表 目 錄 表一、 世界衛生組織於2006年公佈之糖尿病診斷標準 ………5 表二、 臨床上用於診斷糖尿病急性併發症的標準 ………7 表三、 常見食物的升糖指數……….9 表四、 自發性第1型糖尿病動物模式 …………………10 表五、 自發性第2型糖尿病動物模式…………………10 表六、 常用於誘導動物糖尿病的化學藥劑 …………11 表七、 Clextral BC-45型雙軸擠壓機之螺旋配置………14 表八、 薏仁籽實及其不同部位之ㄧ般成分組成…………15 表九、 米麩的ㄧ般組成………………………………21 表十、 米麩中具調節血糖效果的有效成分…………24 表十一、 穀類擠壓產品的原料配方…………………77 表十二、 穀類擠壓產品的物化特性…………………78 表十三、 穀類擠壓產品樣品四的一般成分組成 ……79 表十四、 短期動物實驗各組的飼料組成 ………80 表十五、 短期動物實驗期間各組的體重、攝食量及攝食效率 ……81 表十六、 短期動物實驗開始時各組OGTT血漿葡萄糖濃度、血漿三酸甘油酯濃度及血漿膽固醇濃度 .........82 表十七、 短期動物實驗結束時各組OGTT血漿葡萄糖濃度、血漿三酸甘油酯濃度及血漿膽固醇濃度 ………………83 表十八、 長期動物實驗各組的飼料組成 ……………84 表十九、 長期動物實驗期間十八週齡大白鼠各組體重的變化 …85 表二十、 長期動物實驗期間九週齡大白鼠各組體重的變化 ……86 表二十一、 長期動物實驗期間十八週齡大白鼠各組攝食量的變化.87 表二十二、 長期動物實驗期間九週齡大白鼠各組攝食量的變化 …88 表二十三、 長期動物實驗開始時十八週齡大白鼠各組OGTT血漿葡萄糖濃度、血漿三酸甘油酯濃度及血漿膽固醇濃度…………………89 表二十四、 長期動物實驗開始時九週齡大白鼠各組OGTT血漿葡萄糖濃度、血漿三酸甘油酯濃度及血漿膽固醇濃度…………90 表二十五、 餵食十八週齡大白鼠不同的實驗飼料六週後各組OGTT血漿葡萄糖濃度 …………………………………91 表二十六、 餵食九週齡大白鼠不同的實驗飼料六週後各組OGTT血漿葡萄糖濃度 ……………………………………………92 表二十七、 餵食十八週齡大白鼠不同的實驗飼料六週後各組心臟、脾臟及腎 臟重量…..……………………………………93 表二十八、 餵食十八週齡大白鼠不同的實驗飼料六週後各組肝臟、肺臟、腹 腎脂肪及附睪脂肪重量………………………94 表二十九、 餵食九週齡大白鼠不同的實驗飼料六週後各組心臟、脾臟及腎臟 重量.……………………………………95 表三十、 餵食九週齡大白鼠不同的實驗飼料六週後各組肝臟、肺臟、腹腎 脂肪及附睪脂肪重量……………………………96 表三十一、 餵食十八週齡大白鼠不同的實驗飼料六週後各組血液生化指標數 值.……………………………………………97 表三十二、 餵食九週齡大白鼠不同的實驗飼料六週後各組血液生化指標數值......98 表三十三、 餵食十八週齡大白鼠不同的實驗飼料六週後各組肝臟脂質濃度及含量………………………………………99 表三十四、 餵食九週齡大白鼠不同的實驗飼料六週後各組肝臟脂質濃度及含量………………………………100 表三十五、 餵食十八週齡大白鼠不同的實驗飼料六週後各組糞便脂質濃度及含量……………………………101 表三十六、 餵食九週齡大白鼠不同的實驗飼料六週後各組糞便脂質濃度及含量………............102 表三十七、 餵食九週齡及十八週齡大白鼠不同的實驗飼料六週後血漿及肝臟TBARS濃度..………………………………103 圖 目 錄 圖一、 穀類擠壓產品……………………………104 圖二、 短期動物實驗開始及結束時各組大白鼠OGTT血漿葡萄糖曲線....105 圖三、 長期動物實驗開始時各組大白鼠OGTT血漿葡萄糖曲線…106 圖四、 長期動物實驗結束時各組大白鼠OGTT血漿葡萄糖曲線……107 圖五、 長期動物實驗期間各組大白鼠禁食血糖值的變化……108 圖六、 長期動物實驗期間各組大白鼠血漿總膽固醇濃度的變化..109 圖七、 長期動物實驗期間各組大白鼠血漿三酸甘油酯濃度的變化110 | |
dc.language.iso | zh-TW | |
dc.title | 穀類擠壓產品對糖尿病大白鼠生理代謝之影響 | zh_TW |
dc.title | Effect of cereal extruded products on physiological metabolism in diabetic rats. | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 江孟燦 | |
dc.contributor.oralexamcommittee | 鄭心嫻,蔡震壽,龔瑞林 | |
dc.subject.keyword | 薏仁,米麩皮,糖尿病,STZ,TBARS, | zh_TW |
dc.subject.keyword | adlay,rice bran,diabetes,STZ,TBARS, | en |
dc.relation.page | 110 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-08-12 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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