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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 葉力森 | |
| dc.contributor.author | Tzann-Huey Chou | en |
| dc.contributor.author | 周贊慧 | zh_TW |
| dc.date.accessioned | 2021-06-15T02:36:46Z | - |
| dc.date.available | 2009-08-18 | |
| dc.date.copyright | 2009-08-18 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-08-13 | |
| dc.identifier.citation | 1.Hendrick, M.J. and M.H. Goldschmidt, Do injection site reactions induce fibrosarcomas in cats? J Am Vet Med Assoc, 1991. 199(8): p. 968.
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Forrest, Four fraction palliative radiotherapy for osteosarcoma in 24 dogs. J Am Anim Hosp Assoc, 2002. 38(5): p. 445-51. 104.Ramirez, O., 3rd, et al., Palliative radiotherapy of appendicular osteosarcoma in 95 dogs. Vet Radiol Ultrasound, 1999. 40(5): p. 517-22. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/44025 | - |
| dc.description.abstract | 貓疫苗注射相關疫苗(Vaccine-associated sarcoma；VAS)，又名注射部位肉瘤(Injection site sarcoma; ISS)，為一惡性程度高且難以治癒的腫瘤。本研究目的為整理針對國內貓疫苗相關肉瘤之發生情形、特性及預後，同時提出台灣首2例以放射線輔助治療之病例報告。本研究收集2002至2009年，經台灣大學獸醫學系病理部及竹南動物科技研究所動物醫學組，診斷為貓疫苗注射相關肉瘤的病例共57例，進行分析。其中1例為生檢病例，其餘56例皆接受一次或一次以上之手術切除，2例則另合併放射線治療。幾乎所有病例皆接受過多次疫苗注射，但大多數飼主未曾聽過此疾病。56例中，腫瘤最大直徑中位數為5公分；47例(84%)為首次手術，9例(16%)則為復發後再次切除；僅14例(25%)接受大範圍切除、1例(2%)截肢，29例(52%)為非大範圍切除，12例(21%)無法得知。首次接受手術者之中位數無病時間(disease free interval)為150日，存活時間 (overall survival time) 為216.5日，13例尚未復發，其中5例之無病與存活時間達1年以上，中位數大於900日；接受第二次以上手術者之中位數無病時間為64日，存活時間為180日。首次切除者中，36例之腫塊最大直徑大於2公分，其中12例接受大範圍切除，中位數無病時間210日、存活時間216.5日；24例接受非大範圍切除，中位數無病時間90日、存活時間210日。此外，研究結果顯示波斯血統貓所佔比例達35%，雖與研究母體比較未發現顯著差異，但較過去文獻中所提之1-3%，明顯高出許多；術後傷口癒合不良為主要併發症(15例，26%)，但不必然與預後有關；4例病患於末期發生後軀癱瘓之現象，其中2例並分別以電腦斷層及屍解證實與腫瘤相關，此為首篇提出貓疫苗相關肉瘤可能導致癱瘓的較大型研究。整體而言，中位數無病時間為120日，中位數存活時間則為210日，且至研究終了已有49%之病例死於腫瘤相關原因。 | zh_TW |
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| dc.description.tableofcontents | 目次
圖次………………………………………………………………………Ⅲ 表次………………………………………………………………………Ⅳ 中文摘要…………………………………………………………………Ⅴ 英文摘要…………………………………………………………………Ⅵ 第一章 序言……………………………………………………………1 第二章 文獻探討………………………………………………………3 第一節 貓疫苗注射相關肉瘤之流行病學……………………………3 第二節 病因學…………………………………………………………5 第三節 臨床呈相及診斷………………………………………………13 第四節 組織病理學……………………………………………………18 第五節 治療……………………………………………………………20 第六節 預後……………………………………………………………28 第七節 關於Vaccine-Associated Feline Sarcoma Task Force 31 第八節 飼主教育………………………………………………………32 第九節 建議之疫苗注射計畫與預防貓疫苗相關肉瘤………………33 第三章 材料及方法……………………………………………………37 第一節 病例收集………………………………………………………37 第二節 病歷紀錄回顧…………………………………………………37 第三節 統計分析………………………………………………………39 第四章 結果……………………………………………………………40 第一節 病畜特徵………………………………………………………40 第二節 注射史…………………………………………………………40 第三節 臨床特徵………………………………………………………41 第四節 治療……………………………………………………………42 第五節 組織病理學發現………………………………………………43 第六節 後續追蹤………………………………………………………44 第七節 品種好發………………………………………………………47 第五章 討論與結論……………………………………………………48 第六章 病例報告………………………………………………………56 第七章 參考文獻………………………………………………………66 附錄………………………………………………………………………74 圖次 頁次 圖2-1 建議貓疫苗施打之部位………………………………………35 圖6-1 手術前計畫切除範圍(病例一) ………………………………61 圖6-2 切除腫塊及其下肌肉後暴露之健康組織(病例一) …………61 圖6-3 左肩皮膚於放療後變深褐色(病例一)………………………61 圖6-4 病畜肩胛間之巨大腫塊(病例二) ……………………………62 圖6-5 術前(病例二) …………………………………………………63 表次 頁次 表2-1 貓疫苗注射肉瘤之臨床分期…………………………………18 表2-2 不同治療方式結果之比較……………………………………27 表2-3 預後因子分析…………………………………………………31 表4-1 臨床分期分布…………………………………………………41 表4-2 免疫組織化學染色之結果……………………………………44 表4-3 無病時間大於一年者…………………………………………45 表4-4 比較不同腫塊大小與切除範圍之預後………………………46 表4-5 後軀癱瘓病例…………………………………………………47 表6-1 放療對正常組織之副作用……………………………………59 | |
| dc.language.iso | zh-TW | |
| dc.subject | 貓 | zh_TW |
| dc.subject | 台灣地區 | zh_TW |
| dc.subject | 疫苗相關肉瘤 | zh_TW |
| dc.subject | vaccine-associated sarcoma | en |
| dc.subject | Feline | en |
| dc.subject | Taiwan | en |
| dc.title | 台灣地區貓疫苗相關肉瘤回溯性研究：57例 (2002-2009) | zh_TW |
| dc.title | Retrospective Survey of Feline Vaccine-Associated Sarcoma in Taiwan: 57 cases (2002-2009) | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 龐飛,李繼忠 | |
| dc.subject.keyword | 貓,疫苗相關肉瘤,台灣地區, | zh_TW |
| dc.subject.keyword | Feline,vaccine-associated sarcoma,Taiwan, | en |
| dc.relation.page | 75 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-08-13 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 獸醫學研究所 | zh_TW |
| 顯示於系所單位： | 獸醫學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-98-1.pdf 未授權公開取用 | 603.79 kB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。