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| ???org.dspace.app.webui.jsptag.ItemTag.dcfield??? | Value | Language |
|---|---|---|
| dc.contributor.advisor | 沈雅敬(Ya-Ching Shen) | |
| dc.contributor.author | Meng-Ting Chang | en |
| dc.contributor.author | 張孟亭 | zh_TW |
| dc.date.accessioned | 2021-06-15T01:29:14Z | - |
| dc.date.available | 2010-09-15 | |
| dc.date.copyright | 2009-09-15 | |
| dc.date.issued | 2009 | |
| dc.date.submitted | 2009-07-21 | |
| dc.identifier.citation | 1. http://ngis.zo.ntu.edu.tw/plant/index.htm
2. Hancke, J. L.; Burgos, R. A.; Ahumada, F. Schisandra chinensis (Turcz.) Baill.Fitoterapia 1999, 70, 451-471. 3. Chen, D. F.; Zhang, S. X.; Xie, L.; Xie, J. X.; Chen, K.; Kashiwada, Y.; Zhou, B. N.;Wang, P.; Cosentino, L. M.; Lee, K. H. Anti-AIDS agents-XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and ofrelated synthetic analogues. Bioorganic & Medicinal Chemistry 1997, 5, 1715-1723. 4. Chiu, P. Y.; Leung, H. Y.; Ko, K. M. Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats. Biol. Pharm. Bull. 2008, 31, 602-605. 5. Min, H. Y.; Park, E. J.; Hong, J. Y.; Kang, Y. J.; Kim, S. J.; Chung, H. J.; Woo, E. R.; Hung, T. M.; Youn, U. J.; Kim, Y. S.; Kang, S. S.; Bae, K. H.; Lee, S. K. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorganic & Medicinal Chemistry Letters 2008, 18, 523-526. 6. Chen, Y. G.; Wu, Z. C.; Gui, S. H.; Lv, Y. P.; Liao, X. R.; Halaweish, F. Lignans from Schisandra hernyi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro. Fitoterapia 2005, 76, 370-373. 7. Ip, S. P.; Yiu, H. Y.; Ko, K. M. Differential effect of schisandrin B and dimethyl diphenyl bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. Molecular and Cellular Biochemistry 2000, 205, 111-114. 8. http://www.wretch.cc/blog/poin8888/10252348 9. Panossian, A.; Wikman, G. Pharmacology of Schisandra chinensis Baill: an overview of Russian research and uses in medicine. Journal of Ethnopharmacology 2008, 118, 183-212. 10. Taguchi, H.; Ikeya, Y. The constituents of Schizandra chinensis Baill. I. The structures of gomisin A, B and C. Chem. Pharm. Bull. 1975, 23, 3296-3298. 11. Ikeya, Y.; Taguchi, H. The constituents of Schizandra chinensis Baill. The structure of a new lignan, gomisin D. Tetrahedron Letters 1976, 17, 1359-1362. 12. Taguchi, H.; Ikeya, Y. The constituents of Schizandra chinensis Baill. The structures of two new lignans, gomisin F and G, and the absolute structures of gomisin A, B, and C. Chem. Pharm. Bull. 1977, 25, 364-366. 13. Ikeya, Y.; Taguchi, H.; Yosioka, I.; Kobayashi, H. The constituents of Schizandra chinensis Baill. The structures of two new lignans, gomisin N and tigloylgomisin P. Chem. Pharm. Bull. 1978, 26, 3257-3260. 14. Ikeya, Y.; Taguchi, H.; Yosioka, I. The constituents of Schizandra chinensis Baill. The cleavage of the methylenedioxy moiety with lead tetraacetate in benzene, and the structure of angeloylgomisin Q. Chem. Pharm. Bull. 1979, 27, 2536-2538. 15. Ikeya, Y.; Taguchi, H.; Yosioka, I.; Kobayashi, H. The constituents of Schizandra chinensis Baill. III. The structures of four new lignans, gomisin H and its derivatives, angeloyl-, tigloyl- and benzoyl-gomisin H. Chem. Pharm. Bull. 1979, 27, 1576-1582. 16. Ikeya, Y.; Taguchi, H.; Yosioka, I.; Kobayashi, H. The constituents of Schizandra chinensis Baill. IV. The structures of two new lignans, pre-gomisin and gomisin J. Chem. Pharm. Bull. 1979, 27, 1583-1588. 17. Ikeya, Y.; Taguchi, H.; Yosioka, I. The constituents of Schizandra chinensis Baill. VII. The structures of three new lignans, (–)-gomisin K1 and (+)-gomisins K2 and K3. Chem. Pharm. Bull. 1980, 28, 2422-2427. 18. Ikeya, Y.; Taguchi, H.; Yosioka, I.; Kobayashi, H. The constituents of Schizandra chinensis Baill. VIII. The structures of two new lignans, tigloylgomisin P and angeloylgomisin P. Chem. Pharm. Bull. 1980, 28, 3357-3361. 19. Ookawa, N.; Ikeya, Y.; Taguchi, H.; Yosioka, I. The constituents of Kadsura japonica Dunal. I. The structures of three new lignans, acetyl-, angeloyl- and caproyl-binankadsurin A. Chem. Pharm. Bull. 1981, 29, 123-127. 20. Ikeya, Y.; Ookawa, N.; Taguchi, H.; Yosioka, I. The constituents of Schizandra chinensis Baill. XI. The structures of three new lignans, angeloylgomisin O, and angeloyl- and benzoylisogomisin O. Chem. Pharm. Bull. 1982, 30, 3202-3206. 21. Ikeya, Y.; Taguchi, H.; Yosioka, I. The constituents of Schizandra chinensis Baill. X. The structures of γ-schizandrin and four new lignans, (–)-gomisins L1 and L2, (±)-gomisin M1 and (+)-gomisin M2. Chem. Pharm. Bull. 1982, 30, 132-139. 22. Ikeya, Y.; Taguchi, H.; Yosioka, I. The constituents of Schizandra chinensis Baill. XII. Isolation and structure of a new lignan, gomisin R, the absolute structure of wuweizisu C and isolation of schisantherin D. Chem. Pharm. Bull. 1982, 30, 3207-3211. 23. Ikeya, Y.; Kanatani, H.; Hakozaki, M.; Taguchi, H.; Mitsuhashi, H. The constituents of Schizandra chinensis Baill. XV. Isolation and structure determination of two new lignans, gomisin S and gomisin T. Chem. Pharm. Bull. 1988, 36, 3974-3979. 24. Ikeya, Y.; Sugama, K.; Okada, M.; Mitsuhashi, H. Two lignans from Schisandra sphenanthera. Phytochemistry 1991, 30, 975-980. 25. Chen, D. F.; Xu, G. J.; Yang, X. W.; Hattori, M.; Tezuka, Y.; Kikuchi, T.; Namba, T. Dibenzocyclo-octadiene lignans from Kadsura heteroclita. Phytochemistry 1992, 31, 629-632. 26. Yang, X. W.; Miyashiro, H.; Hattori, M.; Namba, T.; Tezuka, Y.; Kikuchi, T.; Chen, D. F.; Xu, G. J.; Hori, T.; Extine, M.; Mizuno, H. Isolation of novel lignans, heteroclitins F and G, from the stems of Kadsura heteroclita, and anti-lipid peroxidative actions of heteroclitins A-G and related compounds in the in vitro rat liver homogenate system. Chem. Pharm. Bull. 1992, 40, 1510-1516. 27. Liu, J. S.; Li, L. Schisantherins L-O and acetylschisantherin L from Kadsura coccinea. Phytochemistry 1993, 32, 1293-1296. 28. Liu, J. S.; Li, L. Kadsulignans L-N, three dibenzocyclooctadiene lignans from Kadsura coccinea. Phytochemistry 1995, 38, 241-245. 29. Liu, J. S.; Li, L. Schisantherins P and Q, two lignans from Kadsura coccinea. Phytochemistry 1995, 38, 1009-1011. 30. Ookawa, N.; Ikeya, Y.; Sugama, K.; Taguchi, H.; Maruno, M. Dibenzocyclooctadiene lignans from Kadsura japonica. Phytochemistry 1995, 39, 1187-1191. 31. Chen, D. F.; Zhang, S. X.; Chen, K.; Zhou, B. N.; Wang, P.; Cosentino, L. M.; Lee, K. H. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J. Nat. Prod. 1996, 59, 1066-1068. 32. Kuo, Y. H.; Yang Kuo, L. M.; Chen, C. F. Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis. J. Org. Chem. 1997, 62, 3242-3245. 33. Chen, Y. G.; Wang, P.; Lin, Z. W.; Sun, H. D.; Qin, G. W.; Xie, Y. Y. Dibenzocyclooctadiene lignans from Kadsura angustifolia. Phytochemistry 1998, 48, 1059-1062. 34. Kuo, Y. H.; Huang, H. C.; Yang Kuo, L. M.; Chen, C. F. Novel C19 homolignans, taiwanschirin A, B, and cytotoxic taiwanschirin C, and a new C18 lignan, schizanrin A, from Schizandra arisanensis. J. Org. Chem. 1999, 64, 7023-7027. 35. Kuo, Y. H.; Li, S. Y.; Wu, M. D.; Huang, R. L.; Yang Kuo, L. M.; Chen, C. F. A new anti-HBeAg lignan, kadsumarin A, from Kadsura matsudai and Schizandra arisanensis. Chem. Pharm. Bull. 1999, 47, 1047-1048. 36. Chen, Y. G.; Xie, Y. Y.; Cheng, K. F.; Cheung, K. K.; Qin, G. W. Compounds from Kadsura ananosma. Phytochemistry 2001, 58, 1277-1280. 37. Kuo, Y. H.; Li, S. Y.; Huang, R. L.; Wu, M. D.; Huang, H. C.; Lee, K. H. Schizarin B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities. J. Nat. Prod. 2001, 64, 487-490. 38. Chen, D. F.; Zhang, S. X.; Kozuka, M.; Sun, Q. Z.; Feng, J.; Wang, Q.; Mukainaka, T.; Nobukuni, Y.; Tokuda, H.; Nishino, H.; Wang, H. K.; Morris-Natschke, S. L.; Lee, K. H. Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. J. Nat. Prod. 2002, 65, 1242-1245. 39. Wu, M. D.; Huang, R. L.; Yang Kuo, L. M.; Hung, C. C.; Ong, C. W.; Kuo, Y. H. The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis. Chem. Pharm. Bull. 2003, 51, 1233-1236. 40. Chen, M.; Liao, Z.; Chen, D. F. Four new dibenzocyclooctadiene lignans from Kadsura renchangiana. Helvetica Chimica Acta 2004, 87, 1368-1376. 41. Li, L.; Ren, H. Y.; Yang, X. D.; Zhao, J. F.; Li, G. P.; Zhang, H. B. Rubriflorin A and B, two novel partially saturated dibenzocyclooctadiene lignans from Schisandra rubriflora. Helvetica Chimica Acta 2004, 87, 2943-2947. 42. Jia, Z. W.; Liao, Z.; Chen, D. F. Two new dibenzocyclooctadiene lignans from the water extract of Kadsura spp. Helvetica Chimica Acta 2005, 88, 2288-2293. 43. Kuo, Y. H.; Wu, M. D.; Huang, R. L.; Kuo, L. M.; Hsu, Y. W.; Liaw, C. C.; Hung, C. C.; Shen, Y. C.; Ong, C. W. Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica. Planta Med 2005, 71, 646-653. 44. Shen, Y. C.; Lin, Y. C.; Cheng, Y. B.; Kuo, Y. H.; Liaw, C. C. Taiwankadsurins A, B, and C, three new C19 homolignans from Kadsura philippinensis. Org. Lett. 2005, 7, 5297-5300. 45. Wang, W.; Liu, J.; Liu, R.; Xu, Z.; Yang, M.; Wang, W.; Liu, P.; Sabia, G.; Wang, X.; Guo, D. Four new lignans from the stems of Kadsura heteroclita. Planta Med 2006, 72, 284-288. 46. Sun, Q. Z.; Chen, D. F.; Ding, P. L.; Ma, C. M.; Kakuda, H.; Nakamura, N.; Hattori, M. Three new lignans, longipedunins A-C, from Kasura longipedunculata and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull. 2006, 54, 129-132. 47. Li, H. R.; Feng, Y. L.; Yang, Z. G.; Wang J.; Daikonya, A.; Kitanaka, S.; Xu, L. Z.; Yang, S. L. New lignans from Kadsura coccinea and their nitric oxide inhibitory activities. Chem. Pharm. Bull. 2006, 54, 1022-1025. 48. Xu, L. J.; Huang, F.; Chen, S. B.; Zhang, Q. X.; Li, L. N.; Chen, S. L.; Xiao, P. G. New lignans and cytotoxic constituents from Schisandra propinqua. Planta Med 2006, 72, 169-174. 49. Xu, L. J.; Huang, F.; Chen, S. B.; Chen, S. L.; Xiao, P. G. A new triterpene and dibenzocyclooctadiene lignans from Schisandra propinqua (Wall.) Baill. Chem. Pharm. Bull. 2006, 54, 542-545. 50. Choi, Y. W.; Takamatsu, S.; Khan, S. I.; Srinivas, P. V.; Ferreira, D.; Zhao, J.; Khan, I. A. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J. Nat. Prod. 2006, 69, 356-359. 51. Shen, Y. C.; Liaw, C. C.; Cheng, Y. B.; Ahmed, A. F.; Lai, M. C.; Liou, S. S.; Wu, T. S.; Kuo, Y. H.; Lin, Y. C. C18 dibenzocyclooctadiene lignans from Kadsura philippinensis. J. Nat. Prod. 2006, 69, 963-966. 52. Chen, M.; Kilgore, N.; Lee, K. H.; Chen, D. F. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J. Nat. Prod. 2006, 69, 1697-1701. 53. Shen, Y. C.; Lin, Y. C.; Ahmed, A. F.; Cheng, Y. B.; Liaw, C. C.; Kuo, Y. H. Four new nonaoxygenated C18 dibenzocyclooctadiene lignans from Kadsura philippinensis. Chem. Pharm. Bull. 2007, 55, 280-283. 54. Shen, Y. C.; Cheng, Y. B.; Lan, T. W.; Liaw, C. C.; Liou, S. S.; Kuo, Y. H.; Khalil, A. T. Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis. J. Nat. Prod. 2007, 70, 1139-1145. 55. Lei, C.; Huang, S. X.; Chen, J. J.; Pu, J. X.; Yang, L. B.; Zhao, Y.; Liu, J. P.; Gao, X. M.; Xiao, W. L.; Sun, H. D. Lignans from Schisandra propinqua var. propinqua. Chem. Pharm. Bull. 2007, 55, 1281-1283. 56. Ma, W. H.; Ma, X. L.; Huang, H.; Zhou, P.; Chen, D. F. Dibenzocyclooctadiene lignans from the stems of Kadsura induta and their antiviral effect on hepatitis B virus. Chemistry & Biodiversity 2007, 4, 966-972. 57. Li, H. R.; Wang, L. Y.; Yang, Z. G.; Kitanaka, S. Kadsuralignans H-K from Kadsura coccinea and their nitric oxide production inhibitory effects. J. Nat. Prod. 2007, 70, 1999-2002. 58. Shen, Y. C.; Lin, Y. C.; Cheng, Y. B.; Chang, C. J.; Lan, T. W.; Liou, S. S.; Chien, C. T.; Liaw, C. C.; Khalil, A. T. New oxygenated lignans from Kadsura philippinensis. Helvetica Chimica Acta 2008, 91, 483-494. 59. Pu, J. X.; Yang, L. M.; Xiao, W. L.; Li, R. T.; Lei, C.; Gao, X. M.; Huang, S. X.; Li, S. H.; Zheng, Y. T.; Huang, H.; Sun, H. D. Compounds from Kadsura heteroclita and related anti-HIV activity. Phytochemistry 2008, 69, 1266-1272. 60. Gao, X. M.; Pu, J. X.; Huang, S. X.; Yang, L. M.; Huang, H.; Xiao, W. L.; Zheng, Y. T.; Sun, H. D. Lignans from Kadsura angustifolia. J. Nat. Prod. 2008, 71, 558-563. 61. Lu, Y.; Chen, D. F. Kadsutherin D, a new dibenzocyclooctadiene lignan from Kadsura species. Natural Product Research 2008, 22, 1344-1349. 62. Chen, M.; Xu, X. M.; Liao, Z. H.; Dong, L.; Li, L.; Huang, C. Z. Neglschisandrins A-B: two new dibenzocyclooctadiene lignans from Schisandra neglecta. Molecules 2008, 13, 548-555. 63. Chen, M.; Liao, Z. H.; Xu, X. M.; Wen, Y.; Sun, M.; Zhang, H. X.; Ma, W. H. Neglschisandrins C-D: two new dibenzocyclooctadiene lignans from Schisandra neglecta. Molecules 2008, 13, 1148-1155. 64. Xu, L. J.; Liu, H. T.; Peng, Y.; Chen, S. B.; Chen, S. L.; Xiao, P. G. Heteroclitins N-Q, new compounds from stems of Kadsura heteroclita (Roxb.) Craib. Helvetica Chimica Acta 2008, 91, 220-226. 65. Liu, H. T.; Xu, L. J.; Peng, Y.; Yang, J. S.; Yang, X. W.; Xiao, P. G. Complete assignments of 1H and 13C NMR data for new dibenzocyclooctadiene lignans from Kadsura oblongifolia. Magn. Reson. Chem. 2009, DOI: 10.1002/mrc.2430 66. Li, X. N.; Pu, J. X.; Du, X.; Yang, L. M.; An, H. M.; Lei, C.; He, F.; Luo, X.; Zheng, Y. T.; Lu, Y.; Xiao, W. L.; Sun, H. D. Lignans with anti-HIV activity from Schisandra propinqua var. sinensis. J. Nat. Prod. 2009, 72, 1133-1141. 67. Shen, Y. C.; Lin, Y. C.; Cheng, Y. B.; Chiang, M. Y.; Liou, S. S.; Khalil, A. T. Dibenzocyclooctadiene lignans from Kadsura philippinensis. Phytochemistry 2009, 70, 114-120. 68. http://tw.myblog.yahoo.com/jwxMgna1OeGRndKTNNpo1YW9Iw/article?mid=3978 69. Silva, T. D.; Lopes, L. M. X. Aryltetralol and aryltetralone lignans from Holostylis reniformis. Phytochemistry 2006, 67, 929-937. 70. Chang, J. B.; Reiner, J.; Xie, J. G. Progress on the chemistry of dibenzocyclooctadiene lignans. Chem. Rev. 2005, 105, 4581-4609. 71. Ferris, J. P.; Boyce, C. B.; Briner, R. C.; Weiss, U.; Qureshi, I. H.; Sharpless, N. E. Lythraceae alkaloids. X. Assignment of absolute stereochemistries on the basis of chiraloptical effects. J. Am. Chem. Soc. 1971, 93, 2963-2968. 72. Gottlieb, H. E.; Mervič, M.; Ghera, E.; Frolow, F. Conformational study of dibenzocyclo-octadiene systems related to the schizandrin-type lignans. J. Chem. Soc. Perkin Trans. I 1982, 2353-2354. 73. Dewick, P. M. Medicinal natural products: a biosynthetic approach, 2nd ed. Medicinal Natural Products. 2002, p 130-135 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42929 | - |
| dc.description.abstract | 本論文主要研究臺灣產阿里山五味子(Schisandra arisanensis Hayata)果實部位的丙酮萃取物，進行分離並分析鑑定所含的木酚素成分，實驗結果共分得十七個木酚素化合物。其中包括了四個新的aryltetralone-type lignans，命名為arisantetralones A-D (1-4)，以及七個新的C18-dibenzocyclooctadiene lignans，命名為arisanschinins F-L (5-11)。
以上化合物的結構是利用各種物理數據，包括比旋光度、紅外線、紫外線、CD 光譜、質譜以及配合1D、2D 核磁共振圖譜，並參考相關文獻而建立。化合物1是一柱狀結晶物質，透過X-ray 偵測更能確定其骨架與相對立體結構。 最後，將所分得的十七個化合物進行生物活性檢測。在人類周邊血液單核球(PBMC)免疫調節功能評估試驗中，化合物4 在細胞毒性較小的情況下，對PBMC增生有明顯抑制作用，具有進一步研究的價值。另外，在癌細胞毒殺測試中發現化合物5 對癌細胞株HEp-2、Daoy、MCF-7 和WiDr 具有不錯的細胞毒殺活性，其ED50 值分別為4.12、6.23、4.09 和6.08 μg/ml。 | zh_TW |
| dc.description.abstract | Investigation of an acetone-soluble extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis Hayata has resulted in the isolation of eleven new oxygenated lignans and six known compounds. Four of the new lignans, arisantetralones A-D (1-4), possess an aryltetralone skeleton, while the other seven new compounds, arisanschinins F-L (5-11), belong to the polyoxygenated C18-dibenzocyclooctadiene lignans.
The structural elucidation of these metabolites was determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. And the above-mentioned results were also compared with the published data. The structure of compound 1 was confirmed by X-ray crystallographic analysis. The biological activities of these compounds were also tested and evaluated. The immunomodulatory effect of compound 4 on human peripheral blood mononuclear cells (PBMC) proliferation was better than the others. In addition, compound 5 exhibited cytotoxicity against HEp-2, Daoy, MCF-7, and WiDr tumor cell lines with ED50 values of 4.12, 6.23, 4.09, and 6.08 μg/ml, respectively. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T01:29:14Z (GMT). No. of bitstreams: 1 ntu-98-R96423023-1.pdf: 5366513 bytes, checksum: 06d2103956d612d39e437de7f994ab6f (MD5) Previous issue date: 2009 | en |
| dc.description.tableofcontents | 目錄
中文摘要...................................i 英文摘要..................................ii 第一章 序論.......................................1 第一節 前言................................1 第二節 相關化合物之文獻回顧................3 第二章 材料及方法.........................30 第一節 材料介紹...........................30 第二節 分離流程...........................31 第三節 實驗儀器...........................36 第四節 實驗溶劑及矽膠.....................38 第三章 實驗結果...........................39 第一節 化合物1 之結構解析.................40 第二節 化合物2 之結構解析.................44 第三節 化合物3 之結構解析.................47 第四節 化合物4 之結構解析.................50 第五節 化合物5 之結構解析.................53 第六節 化合物6 之結構解析.................58 第七節 化合物7 之結構解析.................61 第八節 化合物8 之結構解析.................65 第九節 化合物9 之結構解析.................69 第十節 化合物10 之結構解析................73 第十一節 化合物11 之結構解析..............78 第十二節 化合物12 之結構..................82 第十三節 化合物13 之結構..................83 第十四節 化合物14 之結構..................84 第十五節 化合物15 之結構..................85 第十六節 化合物16 之結構..................86 第十七節 化合物17 之結構..................87 第十八節 生物活性測試 (一)................88 第十九節 生物活性測試 (二)................90 第四章 結論......................................91 參考文獻..................................94 附錄一：NMR 圖譜.........................101 附錄二：IR、CD 光譜 MS 圖譜..............135 附錄三：X-ray 數據.......................158 附錄四：生物活性測試流程.................163 | |
| dc.language.iso | zh-TW | |
| dc.subject | 細胞毒殺 | zh_TW |
| dc.subject | 阿里山五味子 | zh_TW |
| dc.subject | 木酚素 | zh_TW |
| dc.subject | aryltetralone | zh_TW |
| dc.subject | dibenzocyclooctadiene | zh_TW |
| dc.subject | 免疫調節功能 | zh_TW |
| dc.subject | dibenzocyclooctadiene | en |
| dc.subject | cytotoxicity | en |
| dc.subject | immunomodulatory effect | en |
| dc.subject | Schisandra arisanensis Hayata | en |
| dc.subject | aryltetralone | en |
| dc.subject | lignan | en |
| dc.title | 阿里山五味子果實活性木酚素成分之研究 | zh_TW |
| dc.title | Studies on the Bioactive Lignans from Fruits of Schisandra arisanensis Hayata | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 97-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 周宏農,謝珮文 | |
| dc.subject.keyword | 阿里山五味子,木酚素,aryltetralone,dibenzocyclooctadiene,免疫調節功能,細胞毒殺, | zh_TW |
| dc.subject.keyword | Schisandra arisanensis Hayata,lignan,aryltetralone,dibenzocyclooctadiene,immunomodulatory effect,cytotoxicity, | en |
| dc.relation.page | 165 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2009-07-22 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥學研究所 | zh_TW |
| Appears in Collections: | 藥學系 | |
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| File | Size | Format | |
|---|---|---|---|
| ntu-98-1.pdf Restricted Access | 5.24 MB | Adobe PDF |
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