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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 沈雅敬(Ya-Ching Shen) | |
dc.contributor.author | Yuan-Wei Liu | en |
dc.contributor.author | 劉苑瑋 | zh_TW |
dc.date.accessioned | 2021-06-15T01:17:20Z | - |
dc.date.available | 2016-10-07 | |
dc.date.copyright | 2011-10-07 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-16 | |
dc.identifier.citation | 1. 江蘇新醫學院,「中藥大辭典」,上海科學技術出版社出版(1999)。
2. Jones, W.P.; A.D. Kinghorn. “Biologically Active Natural Products of The Genus Callicarpa.” Curr. Bioact. Compd. 2008, 4(1), 15-32. 3. Dan, Y.; Qian, Z.Z.; Liu, Y.Z.; Zhou, G. P.; Peng, Y.; Xiao, P. G. “New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 I. Callicarpa Linn. and Related Items.” Chin. Herb. Med. 2010, 2(4), 272-288. 4. Anaya, A.L.; Mata, R.; Sims, J.J.; González-Coloma, A.; Cruz-Ortega, R.; Guadaño, A.; Hernández-Bautista, B.E.; Midland, S.L.; Ríos, G.; Gómez-Pompa, A. “Allelochemical potential of Callicarpa acuminata.” J. Chem. Ecol. 2003, 29, 2761-2776. 5. Van den Berghe, D.A.; Ieven, M.; Mertens, F.; Vlietinck, A.J.; Lammens, E. “Screening of higher plants for biological activities. II Antiviral activity.” Lloydia 1978, 41, 463-471. 6. Tingle, F.C.; Mitchell, E.R. “Aqueous extracts from indigenous plants as oviposition deterrents forHeliothis virescens (F.).” J. Chem. Ecol. 1984, 10, 101-113. 7. Tellez, M.R.; Dayan, F.E.; Schrader, K.K.; Wedge, D.E.; Duke, S.O. “Composition and some biologicalactivities of the essential oil of Callicarpa americana (L.).” J. Agric Food Chem. 2000, 48, 3008-3012. 8. Cantrell, C. L.; Klun, J. A.; Bryson, C. T.; Kobaisy, M.; Duke, S. O. “Isolation and Identification of Mosquito Bite Deterrent Terpenoids from Leaves of American (Callicarpa americana) and Japanese (Callicarpa japonica) Beautyberry.” J. Agric. Food Chem. 2005, 53, 5948-5953. 9. Jones, W.P.; Tatiana, L.E.; Qiuwen, M.; Chai, H. B.; Soejarto, D.D.; Cordell, G. A.; Swanson, S. M.; A.D. Kinghorn. “Cytotoxic Constituents from the Fruiting Branches of Callicarpa americana Collected in Southern Florida.” J. Nat. Prod. 2007, 70, 372-377. 10. Cantino, P.D. “Evidence for a polyphyletic origin of the Lamiaceae.” Ann. Missouri Bot. Gard. 1992, 79, 361-379. 11. Spies, J.R. “The toxicity of certain plant extracts to goldfish. II.” J. Econ. Entomol 1933, 26, 285-288. 12. Chung, P.Y.; Chung, L.Y.; Ngeow, Y.F.; Goh, S.H.; Imiyabir, Z. “Antimicrobial activities of Malaysian plant species.” Pharm. Biol. 2004, 42, 292-300 13. Vigneron, J.P. “Substances antiappétantes d’origine naturelle.” Ann. Zool. Ecol. Anim. 1978, 10, 663-694. 14. Kuo, Y.C.; Ou, J.C.; Tsai, W.J.; Wu, C.L. “Sun CM. Evaluation of Chinese herbs that affect the cell-mediated immunity (II).” J. Chin. Med. 1996, 7, 119-131. 15. Kuo, Y.C.; Sun, C.M.; Tsai, W.J.; Ou, J.C.; Chen, W.P.; Lin, C.Y. “Blocking of cell proliferation, cytokines production and genes expression following administration of Chinese herbs in the human mesangial cells.” Life Sci. 1999, 64, 2089-2099. 16. Woo, E.R.; Yoon, S.H.; Kwak, J.H.; Kim, H.J.; Park, H. “Inhibition of gp 120-CD4 interaction by various plant extracts.” Phytomedicine 1997, 4, 53-58 17. Kobaisy, M.; Tellez, M.R.; Dayan, F.E.; Duke, S.O. “Phytotoxicity and volatile constituents from leaves of Callicarpa japonica Thunb.” Phytochemistry 2002, 61, 37-40. 18. Dhar, M.L.; Dhar, M.N.; Dhawan, B.N.; Mehrotra, B.N.; Srimal, R.C.; Tandon, J.S. “Screening of Indian plants for biological activity. Part IV.” Indian J. Exp. Biol. 1973, 11, 43-54. 19. Singh, A.K.; Bhattachaary, A.K.; Prasad, G.; Sharma, V.D.; Gupta, K.C. “The essential oil of Callicarpa macrophylla Vahl. and its antimicrobial activity.” Ind. J. Microbiol 1982, 22, 286-288. 20. Suffness, M; Abbott, B.J.; Statz, D.; Wonilowicz, E.; Spjut, R. “The utility of P388 leukemia compared to B16 melanoma and colon carcinoma 38 for in vivo screening of plant extracts.” Phytother Res. 1988, 2, 89-97. 21 Crellin, J.K.; Philpott, J. A Reference Guide to Medicinal Plants: Herbal Medicine Past and Present. Durham, NC: Duke University Press 1997. 22. Rafinesque, C.S. Medical Flora; or Manual of the Medical Botany of the United States of North America. Vol. 2. Philadelphia: Atkinson and Alexander 1830. 23. Hartwell, J.L. Plants Used Against Cancer. A Survey. Lawrence, MA: Quarterman 1982. 24. Taylor, L.A. Plants Used as Curatives by Certain Southeastern Tribes. Cambridge, MA: Botanical Museum, Harvard University 1940. 25. Moerman, D.E. A Reference Dictionary. New York: Garland Publishing 1977. 26. Sen, M.; Pal, B.C. “Chemical investigation of the bark of Callicarpa arborea (Verbenaceae).” J. Indian Chem. Soc. 1974, 51, 903. 27. Manandhar, N.P. “An inventory of some vegetable drug resources of Makawanpur district Nepal.” Fitoterapia 1995, 66, 231-238. 28. Manandhar, N.P. “Herbal remedies of Surkhet district, Nepal.” Fitoterapia 1993, 64, 266-272. 29. Mi, H.M.; Zhang, C.H.; Su, Z.W.; Li, C.G. “A SEM observation on the leaves of the genus Callicarpa of 16 Chinese species.” Acta Pharm Sin (Yao Xue Xue Bao) 1984, 19, 381-386. 30. Womersley, J.S. Botanical validation in medicinal plant investigations. Noumea, New Caledonia: South Pacific Commission 1973. 31. McChesney, J.D.; Kabra, P.M.; Fraher, P. “Simple analogs of the toxin calliterpenone.” J. Pharm. Sci. 1979, 68, 1116-1120. 32. Goh, S.H.; Soepadmo, E.; Chang, P.; Barnerjee, U.; Chan, K.C.; Deverre, J.R.; Hadi, H.; Loke, S.E.; Nasrulhawq, A.; Oo, S.L.; Taylor, C.E.; Wong, W.H.; Zakaria, M. “Asian Symposium on Medicinal Plants and Spices.” Seoul; Korea: 1984. Studies on Malaysian medicinal plants: preliminary results. 33. Madulid, D.A.; Gaerlan, F.J.M.; Romero, E.M.; Agoo, E.M.G. “Ethnopharmacological study of the Ati tribe in Nagpana, Barotac Viejo, Iloilo.” Acta. Manilana 1989, 38, 25-40. 34. Lin, C.C.; Kan, W.S. “Medicinal plants used for the treatment of hepatitis in Taiwan.” Amer. J. Chinese Med. 1990, 18, 35-43. 35. Chen, R. S.; Lai, J. S.; Wu, T. S. “Studies on the Constituents of Callicarpa formosana Rolfe.” J. Chin. Chem. Soc. 1986, 33, 329-334. 36. Hosozawa, S.; Kato, N.; Munakata, K. “5,6,7-Trimethoxyflavone from Callicarpa japonica.” Phytochemistry 1972, 11, 2362. 37. Bhandary, M.J.; Chandrashedar, K.R.; Kaveriappa, K.M. “Medical ethnobotany of the Siddis of Uttara Kannada district, Karnataka, India.” J. Ethnopharmacol 1995, 47, 149-158. 38. Alam, M.K. “Medical ethnobotany of the Marma tribe of Bangladesh.” Econ. Bot. 1992, 46, 330-335. 39. Manandhar, N.P. “A survey of medicinal plants of Jajarkot district, Nepal.” J. Ethnopharmacol 1995, 48, 1-6. 40. Tiwari, K.C.; Majumder, R.; Bhattacharjee, S. “Folklore medicines from Assam and Arunchal Pradesh (District Tirap).” Int. J. Crude Drug Res. 1979, 17, 61-67. 41. Lama ,S.; Santra, S.C. “Development of Tibetan plant medicine.” Sci. Cult. 1979, 45, 262-265. 42. Jain, S.P.; Puri, H.S. “Ethnomedicinal plants of Jaunsar-Bawar Hills, Uttar Pradesh, India.” J. Ethnopharmacol 1984, 12, 213-222. 43. Manandhar, N.P. “Some less known medicinal plants of Rasuwa district (Nepal).” Quart J. Crude Drug Res. 1980, 18, 147-151. 44. Manandhar, N.P. “An ethnobotanical survey of herbal drugs of Kaski district, Nepal.” Fitoterapian 1994, 65, 7-13. 45. Kuo, Y.C.; Sun, C.M.; Tsai, W.J.; Ou, J.C.; Chen, W.P.; Lin, C.Y. “Blocking of cell proliferation, cytokines production and genes expression following administration of Chinese herbs in the human mesangial cells.” Life Sci. 1999, 64, 2089-2099. 46. Lama, S.; Santra, S.C. “Development of Tibetan plant medicine.” Sci. Cult 1979, 45, 262-265. 47. David; S.S. “Role of Lipids in Plant Resistance to Insects.” Amer. Chem. Soc. 1983, 303-327. 48. Liu, H. Y.; He, H. P.; Gao, S.; Chen, C. X.; Shen, Y. M.; Hao, X.J. “Two New Diterpenoids from Callicarpa pedunculata.” Helv. Chim. Acta 2006, 89, 1017-1022. 49. Hu, Y.M.; Shen, Y.M.; Gu, Q.X.; Zuo, G.Y.; Hao, X.J. “Studies on chemical constituents of Callicarpa pedunculata.” Chin. Tradit. Herb. Drugs 2001, 32, 1063-1065. 50. Singh, A.K.; Agrawal, P.K. “16α,17-Isopropylideno-3-oxo-phyllocladane, a diterpenoid from Callicarpa macrophylla.” Phytochemistry 1994, 37, 587-588. 51. Zhou, B.T.; Li, X.Z.; Xu, P.S.; Ouyang, J.D.; Zhang, Y. “Chemical constituents from the upground of Callicarpa kwangtungensis Chun (II).” J. Tradit. Chin. Med. Univ. Hunan 2005, 25, 20-22. 52. Wang, Z.N.; Han, Z.; Cui, H.B.; Dai, H.F. “Chemical constituents from Callicarpa nudiflora.” J. Trop. Subtrop. Bot. 2007, 21, 359-362. 53. Subramanian, S.S.; Nair, A.G.R.; Vedantham, T.N.C. “Terpenoids and flavones of Callicarpa macrophylla and C. longifolia.” Phytochemistry 1974, 13, 306-307. 54. Shao, Y.; Hu, L. H.; Sim, K. Y.; Goh, S. H. “Lignanoids and Diterpenoids from Callicarpa furfuraceae.” Helv. Chim. Acta 2006, 89, 64-72. 55. Ono, M.; Chikuba, T.; Mishima, K.; Yamasaki, T.; Ikeda, T.; Yoshimitsu, H.; Nohara, T. “A New Diterpenoid and a New Triterpenoid Glucosyl Ester from the Leaves of Callicarpa japonica Thunb. var. luxurians Rehd.” J. Nat. Med. 2009, 63, 318-322. 56. Chen, J. J.; Wu, H. M.; Peng, C. F.; Chen, I. S.; Chu, S. D. “seco-Abietane Diterpenoids, a Phenylethanoid Derivative, and Antitubercular Constituents from Callicarpa pilosissima.” J. Nat. Prod. 2009, 72, 223-228. 57. Talapatra, S.K.; Polley, M.; Talapatra, B. “Terpenoids and related compounds. Part 32 Calliphyllin, a new diterpene from the leaves of Callicarpa macrophylla.” J. Indian Chem. Soc. 1994, 71, 527-532. 58. Wang, Y. M.; Xiao, H.; Liu, J. K.; Wang, F. “New Iridoid Glycosides from the Twigs and Leaves of Callicarpa formosana var. formosana.” J. Asian Nat. Prod. Res. 2010, 12, 220-226. 59. Xu, J.; Harrison, L.J.; Vittal, J. J.; Xu, Y. J.; Goh, S.H. “Four New Clerodane Diterpenoids from Callicarpa pentandra” J. Nat. Prod. 2000, 63, 1062-1065 60. Pan, P.; Sun, Q.S. “Chemical constituents of Callicarpa macrophylla Vahl.” J. Shenyang Pharm. Univ. 2006, 23, 565-567. 61. Ren, F.Z.; Luan, X.H.; Zhao, Y.M.; Qu, H. “Studies on flavonoids from leaves of Callicarpa bodinieri Levl.” China J. Chin. Mater Med. 2001, 26, 841-844. 62. Ahmad, S.A.; Siddiqui, S.A.; Zaman, A. “Chemical examination of Callicarpa macrophylla, Lagerstromea lanceolata, Ficus palmata, and Taxodium mucronatum.” J. Indian Chem. Soc. 1976, 53, 1165-1166. 63. Zhou, B.T.; Li, X.Z.; Xu, P.S. “Chemical composition from Callicarpa cathayana H. T. Chang.” J. Guangdong Coll. Pharm. 2005, 21, 695-696. 64. Dong, L.; Liu, M.S.; Wang, J.H. “Lipophilic compounds of Callicarpa nudiflora Hook. Et Arn.” Chin. J. Med. Chem. 2009, 19, 371-374. 65. Pan, P.; Jia, L.Y.; Sun, Q.S. “RP-HPLC determination of betulinic acid in Callicarpa macrophylla.” China J. Chin. Mater Med. 2008, 33, 753-755. 66. Chen, R. S.; Lai, J. S.; Wu, T. S. “Studies on the Constituents of Callicarpa formosana Rolfe.” J. Chin. Chem. Soc. 1986, 33, 329-334. 67. Gao, F.P.; Wang, H.; Ye, W.C.; Zhao, S.X. “Chemical constituents from the leaves of Callicarpa nudiflora.” J. China Pharm. Univ. 2010, 41,120-123. 68. Chung, I.M.; Ali, M.; Upadhayay, K.; Ahmad, A. “Isolation and cytotoxic activity of acyclic triterpene callicarpenol from Callicarpa macrophylla.” Asian J. Chem. 2005, 17, 1907-1914. 69. Mei, W. L.; Han, Z.; Cui, H. B.; Zhao, Y. X.; Deng, Y. Y..; Dai, H. F. “A new Cytotoxic Iridoid from Callicarpa nudiflora.” Nat. Prod. Res. 2010, 24, 899-904. 70. Dong, L.; Liu, M.S.; Wang, J.H. “Lipophilic compounds of Callicarpa nudiflora Hook. Et Arn.” Chin. J. Med. Chem. 2009, 19, 371-374. 71. Lu, C.H.; Shen, Y.M. “Water-soluble constituents from Callicarpa pedunculata.” Chin. J. Nat. Med. 2008, 6, 176-178. 72. Zou, G.D.; Cheng, Y.Y.; Fang, T.Z.; Xie, E.L.; Tang, X.B.; Yuan, G.P.; Hu, S.R.; Zhou, G.P.; Hou, H.C. “HPLC determination of verbascoside in Folium Callicarpae Pedunculatae.” Chin. J. Pharm. Anal. 2010, 30, 160-162. 73. Pharmacopeia Committee of P. R. China, 2010. Pharmacopoeia of People’s Republic of China. Beijing: China Medical Science and Technology Press. 74. Lin, C.Z.; Chai, L.; Cai, Z.X.; Zhao, Z.X.; Zhang, C.X.; Zhu, C.C. “Component analysis of phenylethanoid glycosides from Callicarpa kochiana Makino.” Trad. Chin. Drug Res. Clin. Pharm. 2010, 276-284. 75. Ono, M.; Mishima, K.; Yamasaki, T.; Masuoka, C.; Okawa, M.; Kinjo, J.; Ikeda, T.; Nohara, T. “A new Lignan Glucoside from the Stems of Callicarpa japonica Thunb. var. luxurians Rehd.” J. Nat. Med. 2008, 63, 86-90. 76. Yamasaki, T.; Masuoka, C.; Nohara, T.; Ono, M. “A New Phenylethanoid Glycoside from the Fruits of Callicarpa japonica Thunb. var. luxurians Rehd.” J. Nat. Med. 2007, 61, 318-322. 77. Xie, E. L.; Zhou, G. P.; Ji, T. F.; Wu, J.; Yuan, G. P. “A novel phenylpropanoid glycoside from Callicarpa kwangtungensis Chun.” Chin. Chem. Lett. 2009, 20, 827-829. 78. Chung, I.M.; Upadhyaya, K.; Ahmad, A. “Isolation of fatty acids and other constituents from Callicarpa macrophylla fruits.” Asian. J. Chem. 2006, 18, 1751-1758. 79. Dong, L.; Wang, J.H.; Liu, M.S. „Phenilic acid constituents of leaves from Callicarpa nudiflora Hook. Et Arn.” J. Shenyang Pharm. Univ. 2010, 27, 290-319. 80. 台灣植物誌第二版編輯委員會,「台灣植物誌第二版第六冊」台灣植物誌第二版編輯委員會出版,台北(2003)。 81. 台灣植物誌第二版編輯委員會,「台灣植物誌第二版第四冊」台灣植物誌第二版編輯委員會出版,台北(1998)。 82. 彭鏡毅(1996-12-03)。[中文種名:細葉紫珠(紅面將軍)]。《數位典藏與數位學習聯合目錄》。http://catalog.digitalarchives.tw/Exhibition/Detail.jsp?OID= 133193(2011/07/26瀏覽)。 83. Mendes, E.; Marco, J. L.; Rodrigues, B.; Jimeno, M. L.; Lobo, A. M.; Prabhakar, S. “Diterpenoids from Salvia candelabrum.” Phytochemistry 1989, 28, 1685-1690. 84. Zinkel, D. F.; Magee, T. V. “Diterpene Resin Acids from the Needle Oleoresin of Pinus strobus.” Phytochemistry 1987, 26, 769-774. 85. Carman, R. M.; Duffield, A. R. “The Optical Rotation of Some C 15- Oxygenated Labda-8(17), 13-dienes.” Aust. J. Chem. 1995, 48, 1357-1366. 86. Toshima, H.; Oikawa, H.; Toyomasu, T.; Sassa T. “Total Synthesis of Both Enantiomers of Copalol via Optical Resolution of a General Synthetic Intermediate for Drimane Sesquiterpenes and Labdane Diterpenes.” Tetrahedron 2000, 56, 8443-8450. 87. Tkachev, A. V.; Denisov, A. Y.; Gatilov, Y. V.; Bagryanskaya, I. Y.; Shevtsov, S. A.; Rybalova, T. V. “Stereochemistry of Hydrogen Peroxide - Acetic Acid Oxidation of Ursolic Acid and Related Compounds.” Tetrahedron 1994, 50, 11459-11488. 88. Braun, S. “Strukturaufklarung Einer Neuen Diterpensaure Aus Metasequoia Glyptostroboides Mit Hilfe Der 13C- NMR- Spektroskopie. ”Tetrahedron 1977, 33, 145-150. 89. Konishi, T.; Konoshima, T.; Fujiwara, Y.; Kiyosawa, S.; Miyahara, K.; Nishi M. “Stereostructures of New Labdane-Type Diterpenes, Excoecarins F, G1, and G2 from the Wood of Excoecaria agallocha.” Chem. Pharm. Bull. 1999, 47, 456-458. 90. Zdero, C.; Bohlmann, F.; King, R.M. “Ent-Labdanes, Manoyloxide and Helipterol Derivatives from Chysocephalum ambiguum.”Phytochemistry 1992, 31, 1631-1638. 91. Lopes, L. M. X.; Bolzani, V. da S. “Lignans and Diterpenes of Three Aristolochia Species.” Phytochemistry 1988, 27, 2265-2268. 92. Sachdev, K.; Kulshreshtha, D. K. “Flavonoids from Dodonaea viscosa.” Phytochemistry 1983, 22, 1253-1256. 93. Ahmad, V. U.; Khan, M. A.; Baqai, F. T.; Tareen R. B. “Santoflavone, A 5-Deoxyflavonoid from Achillea santolina” Phytochemistry 1995, 38, 1305-1307. 94. Paul, M.D. Medicinal Natural Products. School of pharmaceutical Sciences University of Nottingham, UK 2002. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42598 | - |
dc.description.abstract | 本論文主要在研究細葉紫珠 (Callicarpa pilosissima) 含有之萜類化合物,將其枝葉部份用酒精萃取,使用各種的管柱色層分析方法進行分離鑑定所含之化學組成成份。實驗結果共分離了九個化合物,其中包括了四個新的萜類化合物。
分離得到的化合物中,共有三個屬於 3,4-seco-abietane 骨架的雙萜類新化合物 Callipilosins A~C (1~3)、一個 labdenoic-type 的雙萜類新化合物 Callipilosin D (4)、以及五個已知化合物 ursolic acid (5)、3-oxoanticopalic acid (6)、(E)-6β- hydroxylabda-8(17),13-dien-15-oic acid (7)、5-hydroxy-3,6,7,4'- tetramethoxyflavone (8)、artemetin (9)。 以上化合物的結構是利用核磁共振圖譜 1D NMR (1H-NMR、13C-NMR) 及 2D NMR (COSY、HMQC、HMBC、NOESY) 加上各種物理數據分析,包括旋光度、紅外線、紫外線、CD 光譜及高解析電灑式質譜儀,並參考相關文獻而確認。另外化合物1為結晶物質,其結構與相對立體結構更經由 X-ray 單晶繞射解析做更進一步的證明。此外,化合物4利用與文獻比對旋光數值定立其絕對立體結構。 最後將所分得的化合物進行抗癌、抗發炎等生物活性檢測。 | zh_TW |
dc.description.abstract | This research is a chemical investigation of the terpenoid constituents from Callicarpa pilosissima. The ethanol extracts of the twigs and leaves of C. pilosissima were separated by extensive column chromatography to give nine compounds, including four new terpenoids.
Callipilosins A~C (1~3) belong to new diterpenes of 3,4-seco-abietane-type while callipilosin D is a new analog of labdenoic-type diterpene. In addition, five known compounds were isolated including a triterpene, ursolic acid (5), two labdenoic-type diterpenes, 3-oxoanticopalic acid (6) and (E)-6β-hydroxylabda- 8(17),13-dien-15-oic acid (7), and two flavons, 5-hydroxy-3,6,7,4'-tetramethoxy- flavone (8) and artemetin (9). The structures of these compounds were determined on the basis of spectroscopic analyses, such as 1D-NMR (1H and 13C-NMR) and 2D-NMR (COSY, HMQC, HMBC, NOESY) techniques, physical methods including optical rotation, IR, UV, CD, HRESIMS, as well as by comparison with the published data. Moreover, compound 1 was further confirmed by X-ray crystallographic analysis. The absolute stereochemistry of compound 4 was determined by optical rotation data. All the isolated components were tested biological activities including anti-tumor and anti-inflammatory effects. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T01:17:20Z (GMT). No. of bitstreams: 1 ntu-100-R98423020-1.pdf: 8073005 bytes, checksum: 8d0885241e020d70934639d66624d2de (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | 第一章 序論 1
第一節 前言 1 第二節 相關化合物之文獻回顧 7 第二章 材料及方法 25 第一節 材料介紹 25 第二節 分離流程 28 第三節 實驗儀器 33 第四節 實驗溶劑及矽膠 35 第五節 化合物結構測定之方法 36 第三章 實驗結果 37 第一節 化合物1 (Callipilosin A) 之結構解析 37 第二節 化合物2 (Callipilosin B) 之結構解析 49 第三節 化合物3 (Callipilosin C) 之結構解析 61 第四節 化合物4 (Callipilosin D) 之結構解析 72 第五節 化合物5之結構 83 第六節 化合物6之結構 84 第七節 化合物7之結構 85 第八節 化合物8之結構 86 第九節 化合物9之結構 87 第十節 抗癌活性 88 第十一節 抗發炎活性 89 第四章 結論 90 第五章 參考文獻與附錄 93 第一節 參考文獻 93 第二節 附錄:X-ray 數據 102 | |
dc.language.iso | zh-TW | |
dc.title | 細葉紫珠枝葉之萜類成分研究 | zh_TW |
dc.title | Studies on the terpenoids from the twigs and leaves of
Callicarpa pilosissima | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 周宏農,李慶國 | |
dc.subject.keyword | 細葉紫珠,3,4-seco-abietane,labdenoic-type,雙萜,類,flavone, | zh_TW |
dc.subject.keyword | Callicarpa pilosissima,3,4-seco-abietane,labdenoic-type,diterpene,flavone, | en |
dc.relation.page | 105 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-16 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 藥學研究所 | zh_TW |
顯示於系所單位: | 藥學系 |
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