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標題: | 阿里山五味子果實新穎三萜類成分之研究 Studies on the Novel Triterpenoids from Fruits of Schisandra arisanensis Hayata |
作者: | Tzu-Ching Liao 廖梓晴 |
指導教授: | 沈雅敬(Ya-Ching Shen) |
關鍵字: | 阿里山五味子,降三萜,類,wuweiziartane-type,pre-schisanartane-type,schisanartane-type, Schisandra arisanensis Hayata,nortriterpenoid,wuweiziartane-type,pre-schisanartane-type,schisanartane-type, |
出版年 : | 2009 |
學位: | 碩士 |
摘要: | 本論文主要研究台灣產阿里山五味子 (Schisandra arisanensis Hayata) 果實之丙酮萃取物,並分析鑑定所含的降三萜類成分,共分離得到十個降三萜類化合物。其中包括了六個新化合物,分別命名為arisanlactones A-F (1-6),以及四個已知化合物,分別是schindilactone D (7)、schindilactone E (8)、pre-schisanartanin A (9)和pre-schisanartanin B (10)。
新化合物1-6為降三萜類,其中化合物1為一新骨架具有5/5/7/9/5-fused pentacyclic環系統,化合物2為wuweiziartane-type骨架,包含一新的合環結構;而化合物3-5為pre-schisanartane-type 骨架,化合物6和7為schisanartane-type骨架。以上所有化合物結構鑑定主要是利用一維及二維核磁共振圖譜 (包括1H-NMR、13C-NMR、DEPT90與DEPT135、1H-1H COSY、HMQC、HMBC、NOESY等實驗),再加上質譜與各種光譜數據,包括紅外光、紫外光、旋光儀,並且比對過去文獻相關化合物的數據而得。在立體結構解析方面,則是利用NOESY圖譜、分子模型以及X-ray單晶繞射來建立。同時,對化合物1-10的生合成路徑做了推測與討論。 This research focuses on nortriterpenoids isolated from the fruits of Taiwanese medicinal plant Schisandra arisanensis Hayata. Fractionatin of acetone extract by extensive chromatographic analysis afforded six new nortriterpenoids, arisanlactones A-F (1-6), together with four known compounds, schindilactone D (7), schindilactone E (8), pre-schisanartanin A (9) and pre-schisanartanin B (10). Compound 1 belongs to an unprecedented skeleton possessing a 5/5/7/9/5-fused pentacyclic ring system. Compound 2, a wuweiziartane-type skeleton, also contains a new class of fused ring system. Compounds 3-5 are categorized as a pre-schisanartane-type, and compound 6 is a schisanartane-type nortriterpenoid. All the structures of the above compounds were elucidated by 1D, 2D-NMR and Mass, in addition to several physical methods including IR, UV, and single crystal X-ray diffraction analysis, and comparing the spectroscopic data with those in the published papers. The relative configuration of compounds 1-6 was established by NOESY spectra and single crystal X-ray diffraction analysis. Plausible biosynthesis pathway of compounds 1-10 were also discussed. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/42566 |
全文授權: | 有償授權 |
顯示於系所單位: | 藥學系 |
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