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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39341
Title: | 感染引發之發炎與致癌機轉之探討 Regulatory mechanisms of infection-induced inflammation and carcinogenesis |
Authors: | Ya-Jen Chang 張雅貞 |
Advisor: | 陳青周 |
Keyword: | 急性呼吸道徵候群,癌症,感染,訊息傳遞,發炎,幽門桿菌, inflammation,cancer,infection,SARS,Helicobacter pylori,signal transduction, |
Publication Year : | 2005 |
Degree: | 博士 |
Abstract: | 本論文探討急性呼吸道徵候群冠狀病毒(SARS-CoV)感染肺細胞,或幽門螺旋桿菌(Helicobactor pylori)感染胃上皮細胞,引發發炎或致癌基因包括ICAM-1、IL-8、COX-2或cyclin D1表現之訊息傳遞路徑。
IFN-γ在肺上皮細胞NCI-H292磷酸化STAT1的Y701,受PKC和Src kinase 之調控,IFN-γ和TPA均可活化c-Src而磷酸化STAT1之Y701,且增加這兩者之交互作用。IFN-γ可磷酸化JAK1/2和PLC-γ 之tyrosine,後者之作用受AG490 (JAK 抑制劑)抑制,IFN-γ並增加JAK1/2 和PLCγ之交互作用,表示JAK1/2 可調控PLC-γ的活化,此結果結合先前之發現,證實IFN-γ經由JAK1/2活化PLC-γ、PKC、c-Src 和STAT1;AG490可抑制IFN-γ所引發之JAK1/2 和STAT1之交互作用,但是對TPA之此項作用無影響,因此IFN-γ可經由兩種路徑引發ICAM-1之表現,一為JAK1/2 /PLCγ/PKC/c Src/STAT1,另一為JAK1/2直接活化STAT1。 SARS-CoV 棘蛋白可引發肺細胞釋放IL-8。轉殖SARS-CoV 棘蛋白可活化 IL-8 promoter與AP1,對NF- The mechanism of SARS-CoV or Helicobactor pylori infection-induced inflammation or carcinogenesis was investigated in this study. Several novel signaling pathways were explored in the regulation of ICAM-1, IL-8, COX-2, or cyclin D1 gene expression. In lung epithelial NCI-H292 cells, the signaling pathway for IFN- |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39341 |
Fulltext Rights: | 有償授權 |
Appears in Collections: | 藥理學科所 |
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ntu-94-1.pdf Restricted Access | 33.45 MB | Adobe PDF |
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