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標題: | 可分解磁性生醫玻璃於腫瘤熱治療之研究 The Study of Magnetic Biodegradable Bioglass for Tumor Hyperthermia |
作者: | Wei-Ren Wang 王尉任 |
指導教授: | 林?輝 |
關鍵字: | 溶膠-凝膠法,生醫玻璃,生物可分解性,磁滯損失,癌症熱治療, sol-gel method,bioglass,biodegradable,hysteresis loss,hyperthermia, |
出版年 : | 2005 |
學位: | 碩士 |
摘要: | 惡性腫瘤(癌症)是一種相當常見的疾病,尤其在我們所存在的環境當中,隨處都有各種不同的致癌因子,若不能夠有效的預防,則定期的健康檢查可以幫助早期發現並治療以避免其擴大的可能。在癌症治療方面,已有相當長時間的發展,最普遍的如外科手術、放射線治療及化學藥物等,皆為最常使用且有效的方式;除此之外,隨著生物資訊與醫療儀器在近幾年有突破性的發展,也有一些新的方法可以治療癌症,例如免疫療法與溫熱(高體溫)療法等,都是目前針對癌症治療最熱門的研究題目。
本研究是以溫熱療法為主題,利用本實驗室所開發的可分解性生醫玻璃作為基本材料,以溶膠-凝膠(sol-gel)技術合成出具有磁性的粉末,再以磁滯曲線分析其磁性質。當我們提供交流電感應磁場時,材料因磁滯損失而產生熱能,使材料的溫度上升,經測試後可知其有相當好的生物相容性,若將它表面改質後再經靜脈注射入人體內,則可以達到殺死癌細胞的目的,藉此提供溫熱療法更有效且無害人體的新選擇。 The malignant tumor (cancer) is a common disease, because there are many carcinogens existing in the surrounding environment. Many therapeutic methods have been developed for cancer treatment which included surgery, radiotherapy, and chemical medicine. But none among those was matched to clinical satisfaction. In recent years, due to well-developed medical instruments and biotechnologies, some new methods have been developed for cancer treatment. For example, immunotherapy, hyperthermia, etc., all turned out to be the most popular research topics for cancer therapy. This research is aimed to develop a biodegradable bioglass on cancer hyperthermia. We choose bioglass as the basic material and in cooperate the magnetic powder into the bioglass by sol-gel method. The hysteresis loop will be used to analyze the magnetic and thermal-induced property. After exposure to an alternating magnetic field, we can find out that the temperature of the material increased due to hysteresis loss. The results of cytotoxicity tests showed no harmful to the cell adhesion, proliferation and differentiation. If the bioglass with surface modification injected into human body in the future, it can be a new choice for hyperthermia to kill tumor cell more efficiently and without doing harm to the human body. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/38111 |
全文授權: | 有償授權 |
顯示於系所單位: | 醫學工程學研究所 |
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