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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 何國榮 | |
| dc.contributor.author | Chia-Hao Chang | en |
| dc.contributor.author | 張家豪 | zh_TW |
| dc.date.accessioned | 2021-06-13T08:20:30Z | - |
| dc.date.available | 2005-07-20 | |
| dc.date.copyright | 2005-07-20 | |
| dc.date.issued | 2005 | |
| dc.date.submitted | 2005-07-19 | |
| dc.identifier.citation | 1-9:參考文獻
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/36876 | - |
| dc.description.abstract | 本研究第一部份是以毛細管電層析質譜分離八種三口井除草劑。首先以等位沖堤的方式,尋找最佳的實驗參數,其參數包含緩衝溶液酸鹼值,操作電壓及有機修飾劑在緩衝溶液中的比例。在最佳條件下只能分出7根層析峰。為了達到更好的分離效果,我們參考文獻上有關於梯度沖堤的方法,設計出一個簡單的裝置。在梯度沖堤下,藉由連續地改變動相組成,可將八個除草劑解析開來。
有鑑於擋板(frits)在填充式毛細管電層析質譜造成的影響,實驗的第二部份是在毛細管兩端以拉尖縮口的方式取代擋板的燒製,可減少毛細管在製作及操作上的困難。並以低流速鞘流介面為游離化介面,發展出免擋板(fritless)毛細管電層析/電灑法質譜儀。 | zh_TW |
| dc.description.abstract | The eight triazines were studied by capillary electrochro matography/Mass Spectrometry(CEC/MS).Under isocratic elution condition including pH of the buffer solution, separation voltage and the ratio of organic solvent in the buffer solution. However , the eight triazines can not be separated under the optimized condition. In order to get better resolution, a simple device which can produce gradient elution is designed. Under gradient elution, the eight triazines could be separated.
Frits have several drawbacks in packed-CEC/MS. The fabrication of frits by sintering the packing material in the two end of the packed-capillary is substituted by drawing out fine tapers. This approach eliminated the difficulties of the making frits and maked the operation of packed-CEC/MS easier than frit-CEC/MS. The performance of the fritless packed-CEC ESI (electrospray ionization)-MS was demostrated. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T08:20:30Z (GMT). No. of bitstreams: 1 ntu-94-R92223030-1.pdf: 3859553 bytes, checksum: 0bedf527ac82546250b118a22339fac3 (MD5) Previous issue date: 2005 | en |
| dc.description.tableofcontents | 總目錄
圖目錄 表目錄 中/英文摘要 第一章:毛細管電層析電灑法質譜儀簡介.............................1 1-1:研究動機....................................................1 1-2:毛細管電層析原理............................................3 1-2-1:電泳...................................................4 1-2-2:電滲透流...............................................5 1-2-3:毛細管電層析進樣方式...................................8 1-3:毛細管電層析與高效能液相層析及毛細管電泳的比較..............10 1-4:毛細管電層析分離管柱的種類..................................11 1-4-1:填充式毛細管...........................................11 1-4-2:開管式毛細管...........................................12 1-4-3:整體式毛細管...........................................13 1-5:電灑游離法..................................................14 1-6:毛細管電層析/電灑法質譜儀介面...............................16 1-6-1:無鞘流介面.............................................16 1-6-2:鞘流介面...............................................17 1-6-3:液體結合式介面.........................................18 1-6-4:低流速鞘流界面.........................................18 1-7:毛細管電層析/電灑法質譜儀之應用.............................20 1-8:質譜儀-四極式離子阱的簡介...................................21 1-9:參考文獻....................................................35 第二章:三口井 除草劑毛細管電層析質譜儀分析........................39 2-1:前言........................................................39 2-2:實驗部份....................................................41 2-2-1:藥品...................................................41 2-2-2:儀器及實驗裝置.........................................42 2-2-2-1:毛細管電層析-質譜儀裝置...........................42 2-2-2-2:填充式毛細管的製作................................42 2-2-2-3:擋板(frits)的製作.................................44 2-2-2-4:低流速鞘流介面的製作..............................45 2-2-2-5:低流速鞘流介面的設置..............................46 2-2-3:實驗過程...............................................47 2-2-3-1:實驗前處理........................................47 2-2-3-2:實驗條件..........................................47 2-3:結果與討論..................................................49 2-3-1:等位沖堤...............................................50 2-3-1-1:有機修飾劑比例對於三口井 除草劑在分離上的影響.......50 2-3-1-2:操作電壓對於三口井 除草劑在分離上的影響.............51 2-3-1-3:pH值對於三口井 除草劑在分離上的影響.................53 2-3-1-4:最佳化.............................................54 2-3-2:梯度沖堤................................................55 2-3-2-1:最佳化.............................................57 2-3-3:等位沖堤與梯度沖堤的比較................................58 2-4:結論.........................................................59 2-5:參考文獻.....................................................88 第三章:免擋板(fritless)毛細管電層析質譜儀介面之開發..............91 3-1:前言.........................................................91 3-2:實驗部份.....................................................94 3-2-1:藥品....................................................94 3-2-2:儀器及實驗裝置..........................................95 3-2-2-1:單邊拉尖-免擋板(fritless)填充式毛細管的製備........95 3-2-2-2:兩邊拉尖-免擋板(fritless)填充式毛細管的製備........95 3-2-2-3:低流速鞘流介面的設置...............................96 3-2-3:實驗過程................................................97 3-2-3-1:實驗前處理.........................................97 3-2-3-2:實驗條件...........................................97 3-3:結果與討論...................................................98 3-3-1:單邊拉尖-免擋板(fritless)毛細管電層析/電灑法質譜儀......98 3-3-2:雙邊拉尖-免擋板(fritless)毛細管電層析/電灑法質譜儀......100 3-4:結論.........................................................102 3-5:參考文獻.....................................................107 | |
| dc.language.iso | zh-TW | |
| dc.title | 三口井除草劑毛細管電層析質譜儀分析與免擋板毛細管電層析質譜儀介面之開發 | zh_TW |
| dc.type | Thesis | |
| dc.date.schoolyear | 93-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 傅明仁,林萬寅 | |
| dc.subject.keyword | 毛細管電層析,質譜儀,免擋板, | zh_TW |
| dc.subject.keyword | CEC,MS,fritless, | en |
| dc.relation.page | 108 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2005-07-19 | |
| dc.contributor.author-college | 理學院 | zh_TW |
| dc.contributor.author-dept | 化學研究所 | zh_TW |
| 顯示於系所單位： | 化學系 | |
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