請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31934
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 江文章 | |
dc.contributor.author | Cheng-Pei Chung | en |
dc.contributor.author | 鍾成沛 | zh_TW |
dc.date.accessioned | 2021-06-13T03:25:02Z | - |
dc.date.available | 2006-07-31 | |
dc.date.copyright | 2006-07-31 | |
dc.date.issued | 2006 | |
dc.date.submitted | 2006-07-27 | |
dc.identifier.citation | 徐松蘭。2003。台灣五葉松對倉鼠降血脂作用的影響。國立屏東科技
大學食品科學系。屏東。 徐德瑞。2001。台灣五葉松抗氧化及對血癌細胞U937存活之研究。國立屏東科技大學食品科學系。屏東。 島崎弘幸。1990。生體內過酸化脂質測定。過酸化脂質實驗法(今田 尚志、值田伸夫編著),p.81,醫藥齒科出版社。東京。 許弘昇。2004。不同膽固醇添加量的倉鼠脂質代謝之影響。國立台灣 海洋大學食品科學系。基隆。 黃詠凱。2002。不同產地的糙薏仁對倉鼠脂質代謝的影響。國立台灣 大學食品科技研究所。台北。 傅茂組。1986。血脂質的新陳代謝及血管硬化。國防醫誌。2(1): 45-9 盧信芳。2002。台灣五葉松松針免疫活性之探討。國立屏東科技大學食品科學系。屏東。 Abe I, Seki T, Noguchi H, Kashiwada Y. 2000a. Galloyl ester from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis. Planta Med. 66: 753-756. Abe I, Seki T, Umehara K, Miyase T, Noguchi H, Sakakibara J, Ono T. 2000b. Green tea polyphenols: Novel and potent inhibitors of squalene epoxidase. Biochem Biophys Res Commun. 268: 767-771. Adeli K, Taghibiglou C, Van Iderstine SC, Lewis GF. 2001. Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Trends Cardiovasc Med. 11(5): 170-176. Alber JJ, Tollefson JH, Cheng CH, Steinmetz A. 1984. Isolation and characterization of human plasma transfer proteins. Arteriosclerosis. 4: 49-58. Arbeeny CM, Meyers DS, Bergquist KE, Gregg RE. 1992. Inhibition of fatty acid synthesis decreases very low density lipoprotein secretion in the hamster. J Lipid Res. 33: 843-851. Axelson M, Sjovall J. 1990. Potential bile acid precursors in plasma- possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acid in man. J Steroid Biochem. 36: 631-640. Baker VA, Hepburn SJ, Kennedy PA, Jones LJ, Lea JP, Sumpter PA, Ashby J. 1999. Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. Food Chem Toxic. 37: 13-22. Batta AK, Xu G, Honda A, Miyazaki T, Salen G. 2006. Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat. Metab Clin Exp. 55: 292-299. Benthsath A, Rusznyak S, Szent-Gyorgyi A. 1936. Vitamin nature of flavons. Nature. 138: 798. Bishop RW. 1992. Structure of the hamster LDL receptor gene. J Lipid Res. 33: 549-557. Blazso G, Gaspar R, Gabor M, Ruve HJ, Rohdewald P. 1996. ACE inhibition and hypotensive effect of a procyanidins containing extract from the bark of Pinus pinaster. Sol Pharm Pharmacol Lett. 6: 8-11. Boberg KM, Akerlund J, Bjorkhem I. 1989. Effect of sitosterol on the rat-limiting enzymes in cholesterol synthesis and degradation. Lipids. 24(1): 9-12. Bonaome A, Grundy SM. 1988. Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med. 318: 1244-1248. Brown MS, Goldstein JL. 1975. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47. Bruce C, Roland A, Chouinard J, Alan RT. 1998. Plasma lipid transfer proteins, high density lipoprotein, and reverse cholesterol transport. Ann Rev Nutr. 18: 297-330. Chandler FR, Freeman L, Hooper SN. 1979. Herbal remedies of the maritime Indians. J Ethnopharmacol. 1: 49-68. Chang JJ, Chen TH, Chan P, Chen YJ, Hsu FL, Lo MY, Lin JY. 2001. The in vitro inhibitory effect of tannin derivatives on 3-hydroxyl-3- methylglutaryl-coenzyme A reductase on Vero cells. Pharmacology. 62: 224-228. Chang TY, Chang CCY, Cheng D. 1997. Acyl-coenzyme A: cholesterol acyltransferase. Annu Rev Biochem. 66: 613-638. Chen MF, Hsu HC, Lee YT. 1995. Fish oil supplementation attenuates myointimal proliferation of the abdominal aorta after ballon injury in diet-induced hypercholesterolemic rabbits. Prostaglandins. 49: 295-310. Cheynier V, Souquet JM, Le Roux E, Guyrot S,Rigaud J. 1998. Size separation of condensed tannins by normal phase high performance liquid chromatography. Method Enzymol. 299:178-184. Chiang JYL. 1998. Regulation of bile acid synthesis. Front Biosci. 3: 176-193. Child P, Kuksis AJ. 1983. Uptake of 7-dehydro derivative of cholesterol, campesterol, and β-sitosterol by rat erythrocytes, jejunal villus cells, and brush border membranes. Lipid Res. 24: 552-565. Choi YS, Cho SH, Kim HJ, Lee HJ, Choi YS, Goto S, Ikeda I, Sugano M. 1989. Interaction of dietary protein, cholesterol and age in lipid metabolism of the rats. Brit J Nutr. 61: 31-43. Christensen NJ, Rubin CE, Cheung MC. 1983. Ultrastructural immunolocalization of apolipoprotein B within human jejunal absorptive cells. J Lipid Res. 24: 1229-1242. Cianflone K, Yasruel Z, Rodriguez MA, Vas D, Sniderman AD. 1990. Regulation of apoB secretion from HepG2 cell: evidence for a critical roll for cholesterol ester synthesis in the response to a fatty acid challenge. J Lipid Res. 31: 2045-2055. Conner WE, Witcak DT, Stone B, Armstrong M. 1969. Cholesterol balance and bile acid excretion in man fed dietary fats of different fatty acid composition. J Clin Invest. 48: 1363-1375. Davis RA, McNeal MM, Moses RL. 1982. Intrahepatic assembly of very low density lipoprotein. J Biol Chem. 257: 2634-2640. Desager JP, Horsmans Y. 1996. Clinical pharmacokinetics of 3-Hydroxy-3-methylblutaryl-coenzyme A reductase inhibitors. Clin Pharmacokinet. 31: 348-371. Ding YA, Chang WK, Chen ML. 1992. Changes in nutritional supply and atherosclerotic disease from 1945 to 1989 in Taiwan. J Clin Biochem Nutr. 13: 137-146. Dragendorff G. 1898. Die Heilpfanzen der verschiedenen Volker und Zeiten. Ihre Anwendung, wesentlichen Bestandteile und Geschichet. Duerden JM, Gibbons GF. 1988. Secretion and storage of newly synthesized hepatic triacylglycerol fatty acid in vivo in different nutritional states and in diabetes. Biochem J. 255: 929-935. Durackova Z, Trebaticky B, Novotny V, Zitnanova I, Breza J. 2003. Lipid metabolism and erectile function improvement by Pcnogenol®, extract from the bark of Pinus pinaster in patients suffering from erectile dysfunction-a pilot study. Nutr Res (Los Angel). 23: 1189-1198. Fang JM, Chang JF, Cheng YS. 1987. Flavonoids from Pinus Morrisonicola. Phytochemistry. 26: 2559-2561. Field FJ, Kam NTP, Mathur SN. 1990. Regulation of cholesterol metabolism in the intestine. Gastroenterology. 99: 539-551. Fielder M. 1975. Plant Medicine and folklore. New York: Winchester press: 55 Fielding CJ, Fielding PE. 1996. Dynamics of lipoprotein transport in the human circulatory system. Biochemistry of Lipid, Lipoproteins and Membranes. 23: 495-516. Fielding CJ, Reaven GM, Liu G, Fielding PE. 1984. Increased free cholesterol in plasma low and very-low density lipoproteins in non- insulin-dependent diabetes mellitus: Its role in the inhibition of cholesteryl ester transfer. Proc Natl Acad Sci. USA81: 2512-2516. Foger B, Chase M, Amar MJ, Vaisman BL. 1999. Cholesteryl ester transfer protein corrects dysfunctional HDL and reduces atherosclerosis in lecithin: cholesterol acyltransferase (LCAT) – transgenic mice. J Biol Chem. 274: 36912-36920. Folch J, Less M, Sloane-Stanely GM. 1957. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 226: 497-509. Fungwe TV, Cagen LM, Wilcox HG, Heigerg M. 1992. Regulation of hepatic secretion of very low density lipoprotein by dietary cholesterol. J Lipid Res. 33: 179-191. Fungwe TV, Cagen LM, Wilcox HG, Heigerg M. 1994. Effects of dietary cholesterol on hepatic metabolism of free fatty acid and secretion of VLDL in the hamster. Biochem Biophys Res Commun. 200: 1505-1511. Ginsberg HN, Zhang YL, Hernandez AA. 2005. Regulation of plasma triglycerides in insulin resistance and diabetes. Diabetic microvascular complications today. March/April: 20-26. Gokkusu C, Mostafazadeh T. 2003. Changes in oxidative stress in various tissues by long-term administration of vitamin E in hypercholestarolemic rats. Clinca Chemica Acta. 328: 155-161. Goldberg AC, Schonfeld G. 1985. Effects of diet on lipoprotein metabolism. Ann Rev Nutr. 5: 195-212. Grag ML, Snowwell AM, Sabine JR. 1985. Dietary cholesterol modifies both cholesterol content and fatty acid profiles of hepatic microsomal membrane. Nutr Rep Int. 32: 17-26. Grassmann J, Hippeli S, Vollmann R, Elstner EF. 2003. Antioxidative properties of the essential oil from Pinus mugo. J Agric Food Chem. 51: 7576-7582. Grundy SM. 1987. Cholesterol and coronary heart disease. Arch Intern Med. 157: 1177-1184. Grundy SM, Denke MA. 1990. Dietary influences on serum lipids and lipoproteins. J Lipid Res. 31(7): 1149-1172. Gulcin I, Buyukokuroglu ME, Oktay M, Kufrevioglu OI. 2003. Antioxidant and analgesic activities of turpentine of Pinus nigra Arn. Subsp. Pallsiana ( Lamb.) Holmboe. J. Ethnopharmacol. 86: 51-58. Haenen GRMM, Paquay JBG, Kothouwer REM, Bast A. 1997. Peroxynitrite scavenging of flavonoids. Biochem Biophys Res Commun. 236: 591–593. Halliwell B, Gutteridge JMC. 1998. Oxford University Press, New York. Free Radic Biol Med. 548-549. Han YC, Ryu KO, Lee KY, Chang SO, Youn KS. 1987. Research report of the Korean Institute of Forest Genetics. Seoul, Korea. Harris WS, Connror WE, Alam N, Illingworth DR. 1988. Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. J Lipid Res. 29: 1451-1457. Hasegawa N. 2000. Inhibition of lipogenesis by Pycnogenol. Phytother Res. 14: 472-473. Havel RJ, Hamilton RL. 1988. Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism. Hepatology. 8: 1689-1695. Heinecke JW. 1998. Oxidants and antioxidants in the pathogenesis of atherosclerosis: Implication for the oxidized low density lipoprotein hypothesis. Atherosclerosis. 141: 1-15. Hesler CB, Miline RW, Swenson TL, Weeth PK, Marcel YL, Tall AR. 1988. Monoclonal antibodies to the Mr. 74,000 cholesteryl ester transfer protein neutralize all of the cholesteryl ester and triglyceride transfer activities in human plasma. J Biol Chem. 263: 5020-5028. Hitunen TP, Luoma JS, Nikkari T, Yla-Herttuala S. 1998. Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions. Circulation. 97: 1079-1086. Hoppe B. 1969. Das Krauterbuch des Hieromimyus Boch. Wissenschafts- istorische Undersuchung. Stuttgart : Anton Hiesimann, 377-378. Ikeda I, Tanaka K, Sugano M, Vahouny GV, Gallo LL. 1988. Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res. 29: 1573-1582. Janisch K, Hippeli S, Dornisch K, Kern S, Elstner EF. 2002. Determination of the antioxidative potential of human plasma after supplementation with pycnogenol and whey. Food Res Int. 35: 257-266. Jansen MD, Haymond MW, Gerich JE, Cryer PE, Miles JM. 1987. Lipolysis during fasting. J Clin Invest. 79: 207-213. Johnson FL, Clair RW St., Rudel LL. 1983. Studies on the production of low density lipoproteins by perfuse livers from nonhuman primates. Effect of dietary choelesterol. J Clin Invest. 72: 221-236. Jonas A. 1998. Regulation of lecithin cholesterol acyltransferase activity. Prog Lipid Res. 37: 209-234. Kleinveld HA, Hak-Lemmers HLM, Stalenhoef AFH, Demacker PNM. 1992. Improved measurement of low-density-lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density-lipoprotein. Clin Chem. 38: 2066-2072. Koch R. 2002. Comparative study of Venostatin® and Pycnogenol® in chronic venous insufficiency. Phytother Res. 16: S1-S5. Kollesch J, Nickel D. 1994. Antike Heilkunst. Ausgewahlte Texte aus den medizinischen Schruften der Griechen und Romer. Stuttgart: Reclam. Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M. 1997. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 387: 414-417. Kostner K. 2002. Beyond LDL-cholesterol: New treatment raising HDL-cholesterol or enhancing reverse cholesterol transport. J Kardiol. 9: 328-331. Kowala MC, Nunnari JJ, Durham SK, Nicolosi RJ. 1991. Doxazosin and cholestyramine similarly decrease fatty streak formation in the aortic arch of hyperlipidemic hamsters. Atherosclerosis. 91: 35-49. Kris-Etherton PM, Krummel D, Russell ME, Dreon D, Mackey S, Borchers J, Wood PD. 1988. National cholesterol education programe: The effect of diet on plasma lipids, lipoproteins and coronary heart disease. J Am Diet Assoc. 83: 1373-1440. Kris-Etherton PM, Dietschy J. 1997. Design criteria for studies examing individual fatty acid effects on cardiovascular disease risk factors: Human and animal studies. Am J Clin Nutr. 65(suppl): 1590S-1596S. Krone W, Greten H. 1984. Evidence for post-transcriptional regulation by insulin of 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol synthesis in human mononuclear leucocytes. Diabetologia. 26: 366-359. Kuo PC, Rudd MA, Nicolosi R, Loscalzo J. 1989. Effet of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of cebus monkeys. Arteriosclerosis. 9: 919-927. Kushwaha RS, Reardon CA, Lewis DS, Qi Y, Rice KS, Getz GS, Carey KD, Mcgill HC. 1994. Effect of dietary lipids on plasma activity and hepatic mRNA levels of cholesterol ester transfer protein in high- and low- responding baboons (Papio species). Metabolism. 43: 1006-1012. Lagrost L, Gambert P, Dangremont V, Athias A, Lallemant C. 1990. Role of cholesteryl ester transfer protein ( CETP ) in the HDL conversion process as evidenced by using anti-CETP monoclonal antibodies. J Lipid Res. 31: 1569-1575. Laparra J, Michaud J, Masquelier J. 1977. Etude pharmacocinetique des oligomers flavonoliques [A pharmacokinetic study on olicomeric flavonoids]. Plant Med Phytother. 11: 1331-1342. Leikin AI, Brenner RR. 1987. Cholesterol-induced microsomal changes modulate desaturase activities. Biochem Biophys Acta. 922 : 294-303. Le Tacon F, Bonneau M, Gelpe J, Boisseau T, Baradat P. 1962-1963. Dieback of maritime pine in the Landes of Gasconge following the introduction of seed from Iberian peninsula and the excessive cold weather. Revue Forestiere Francaise. 46: 474-484. Lee JW, Lee KW, Lee SW, Kim IH, Rhee C. 2004. Selective increase in pinolenic acid ( all-cis-5, 9, 12-18:3) in Korean pine nut oil by crystallization and its effect on LDL-receptor activity. Lipids. 39: 383-387. Linder MC. 1985. Nutritional Biochemistry and Metabolism with Clinical Application. pp28-31. Elsevier, New York. Ling WH, Jones PJH. 1995. Dietary phytosterols: A review of metabolism, benefits and side effects. Life Sci. 57: 195-206. Liu CH, Huang MT, Huang PC. 1995. Sources of triacylglycerol accumulation in livers of rats fed a cholesterol-supplemented diet. Lipids. 30: 527-531. Lu YF, Chiang CF. 2001. Effect of dietary cholesterol and fat levels on lipid peroxidation and th activities of antioxidant enzymes in rats. Int J Vitam Nutr Res. 71(6): 339-346. McNamara DJ. 1987. Effect of fat-modified diets on cholesterol and lipoprotein metabolism. Ann Rev Nutr. 7: 273-290. McNamara DJ. 1995. Dietary cholesterol and the optimal diet for reducing risk of atherosclerosis. Can J Cardiol. 11: 123G-126G. Maitra A, La Voie HA, Day Rn, Garmey JC, Veldhuis JD. 1995. Regulation of porcine granulose cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin and insulin like growth factor: synergism with follicle-stimulating hormone kinase A agonist. Endocrinology. 136: 5111-5117. Malstrom R, Packard CJ, Watson TDG, Rannikko S. 1997. Metabolic basis of hypotriglyceridemic effedts of insulin in normal men. Arterioscler Thromb Vasc Biol. 17: 1454-1464. Masquelier J, Michaud J, Laparra J, Dumon MC. 1979. Flavonoids and pycnogenols. Intern J Vit Nutr Res. 49: 307-311. Masquelier J, Triaud J. 1965. Fractionnement des leucoanthocyanes du vin [Fractionation of wine leucoanthocyanidins]. Soc Pharm Bordeaux. 104 : 81-85. Mayes PA. 1988. Harper’s Biochemistry. 21th eds. pp.241-52, 226-240. Lange Medical Publication, California. Mazier MJP, Jones PJH. 1991. Dietary fat quality and circulating cholesterol level in human: A review of action and metabolisms. Prog Food Nutr Sci. 15: 21-41. Mehlum A, Staels B, Duverger N, Tailleux A. 1995. Teffue-specific expression of the human gene for lecithin-cholesterol acyltansferase in transgenic mice alters blood lipid, lipoproteins and lipases towards a less atherogenic profile. Eur J Biochem. 230: 567-575. Mertens A, Holvoet P. 2001. Oxidized LDL and HDL: antagonists in atherothrombosis. FASEB J. 15: 2073-2084. Miettinen TA, Vuoristo M, Nissinen M, Jarvinen HJ, Gylling H. 2000. Sreum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and duing consumption of stanol ester margarine. Am J Clin Nutr. 71: 1095-1102. Miller AB. 1990. Diet and cancer: a review. Rev. Oncol. 3: 87–95. Minner H. 1479. Theraurus Medicamimum. Miwa S, Watada H, Omura C, Takayanagi N, Nishiyama K, Tanaka Y, Onuma T, Kawamori R. 2005. Anti-oxidative effect of fluvastatin in hyperlipidemic type 2 diabetic patients. Endocr J. 52(2): 259-264. Moreau RA, Norton RA, Hicks KB. 1999. Phytosterols and phytostanols lower cholesterol. Inform. 10: 572-577. Murakami S, Kondo Y, Toda Y, Kitajima H, Kameo K. 2002. Effect of taurine on cholesterol metabolism in hamster: up-regelation of low density lipoprotein (LDL) receptor by taurine. Life Sci. 70(20): 2355-2366. Murray RK, Granner DK, Mayes PA, Rodwell VW. 1996. Happers Biochemistry. 24eds pp.153-4, 198, 260-2, 588-93. Lange Medical Publication, Caligornia. Murry RK, Granner DK, Mayes PA, Rodwell VW. 1993. Happers Biochemistry. 23eds. pp.226-278. Lange Medical Publication, California. National Cholesterol Education Program (NCEP). 2002. Guildlines on the Detection, Evaluation and Treatment of Elevated Cholesterol in Adult: Adult Treatment III (ATP III). ACC Curr J. 11: 37-45. Newnham HH, Barter PJ. 1992. Changes in particle size of high density lipoproteins during incubation with very low density lipoproteins, cholesteryl ester transferase protein and lipoprotein lipase. Biochem Biophys Acta. 1125: 294-304. Nikkari ST, Solakivi T, Jaakkola O. 1991. The Hyperlipidemic hamster as an atherosclerosis model. Artery. 18: 285-290. Nistor A, Bulla A, Filip DA, Radu A. 1987. The Hyperlipidemic hamsters as a model of experimental atherosclerosis. Atherosclerosis. 68: 159-173. Nguyen LB, Shefer S, Tasjinen MR, Tikkamen MR. 2001. Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effect of cholesterol, sitosterol and lovastatin. J Lipid Res. 42: 195-200. Nicolosi RJ, Wilson LJ, Krause BR. 1998. The ACAT inhibitor, CI-1011 is effective in the prevention and regression of aortic fatty streak area in hamsters. Atherosclerosis. 137: 77-85. Owen MR, Corstorphine CC, Zammit VA. 1997. Overt and latent activities of diacylglycerol acyltransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion. Biochem J. 323: 17-21. Packer L, Rimbach G, Virgili F. 1999. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol. Free Rad Biol Med. 27: 704-724. Puhl H, Waeg G, Esterbauer H. 1994. Methods to determine oxidation of low-density lipoproteins. Methods Enzymol. 233: 425-41. Quintao ECR, Sperotto G. 1987. The role of dietary cholesterol in the regulation of human body cholesterol metabolism. Lipid Res. 22: 173-188. Raal FJ, Areias AJ, Waisberg R, Von AM. 1995. Susceptibility of low-density-lipoprotein to oxidation in familial hypercholesterolemia. Atherosclerosis. 115: 9-15. Regnstron J, Nilsson J. 1994. Lipid oxidation and inflammation-induced intimal fibrosis in coronary heart disease. J Lab Clin Med. 124(2): 162-168. Ressell DW, Setchell KDR. 1992. Bile acid synthesis. Biochemistry. 31: 4737-4749. Rice-Evans CA, Packer L. 1998. Flavonoids in heath and disease. Marcel Dekker, Inc. From Nuvanta. Rigotti A, Trigatti BL, Panman M, Rayburn H, Herz J, Krieger M. 1997. A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci (USA). 94: 12610-12615. Ross R. 1999. Atherosclerosis- An inflammatory disease. N Engl J Med. 340: 115-126. Roth BD. 1998. ACAT inhibitor: evolution from cholesterol-absoption inhibitors to antiatherosclerotic agent. DDT. 3(1): 19-25. Sanders TAB, Hochland MC. 1983. A comparision of the influence on plasma lipids and platelet function of supplements of n-3 and n-6 polyunsaturated fatty acids. Br J Nutr. 50: 521-529. Schneider WJ. 1996. Removal of lipoproteins from plasma. Biochemistry of lipid, lipoproteins and membranes. Plenum, New York, pp.517-541. Scientific Consultative Committee of Ntional Defence. On the possibility of relaying on wild plants and animals as a source of nutrition. Part 4, OSA, Helsinki. 1979. Senthilmohan ST, Zhang J, Stanley RA. 2003. Effect of flavonoids extract Enzogenol with vitamin C on protein and DNA damage in older human subject. Nutr. Res. 23: 1199-1210. Sessions VA, Martin A, Gomez-Munoz A, Brindly DN, Salter AM. Cholesterol feeding induces hypertriglyceridemia in hamster and increase the activity of the Mg2+-dependent phosphatidate phosphohydrolase in the liver. Biochem Biophys Acta. 1166: 238-248. Shand B, Strey C, Scott R, Morrison Z, Gieseg S. 2003. Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoids extract of pine bark and vitamin C. Phytother Res. 17: 490-494. Smith DR. 1998. Animal models: Nutrition and lipoprotein metabolism. Curr Opin Lipidol. 9(1): 3-6. Spaker SD, Fabris M, Ferrari V, Carbonare MD, Leon A. 1997. Quercetin protects cutaneous tissue-associated cell types including sensory neurous from oxidative stress induced by glutathione deleption: cooperative effects of ascorbic acid. Free Radic Biol Med. 22: 669-678 Stalenhoef AFH, Malloy MJ, Kane JP. 1984. Metabolism of apolipoprotein B-48 and B-100 of triglyceride-rich lipoproteins in normal and lipoprotein lipase-deficient humans. Proc Natl Acad Sci. USA81: 1839-1843. Stocker R, Keaney JF. 2003. Role of oxidative modification in atherosclerosis. Physiol Rev. 84: 1381-1478. Sucking KE, Strange EF. 1985. Role of avyl-CoA: acyltransferase on cellular cholesterol metabolism. J Lipid Res. 26: 641-671. Sugiyama Y, Odaka S, Itokawa S, Itokawa E. 1995. TMP-153, a nevel ACAT inhibitor, lowers plasma cholesterol throuth its hepatic action in Golden hamster. Atherosclerosis. 118(1): 145-153. Swift LL, Manowitz NR, Dun GD, Le Quire VS. 1979. Cholesterol and saturated fat diet induces hepatic synthesis of cholesterol-rich lipoprotein. Clin Res. 27: 378-185. Tall AR. 1993. Plasma cholesterol ester transfer protein. J Lipid Res. 34: 1255-1274. Theriault A, Wang Q, Iderstine SCV, Chen B, Franke AA, Adeli K. 2000. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J Lipid Res. 41: 1969-1979. Thomas MJ, Thornbrog T, Manning J, Hooper K, Rudel LL. 1994. Fatty acid composition of low-density lipoprotein influences its susceptibility to auto-oxidation. Biochemistry. 33: 1828-1834. Thomas MK, Narang D, Lakshmy R, Gupta R, Naik N, Maulik SK. 2006. Correlation between inflammation and oxidative stress in normacholesterolemic coronary artery disease patients ‘on’ and ‘off’ atorvastatin for short time intervals. Cardiovasc Drugs Ther. Thompson GR. 1989. A handbook of hyperlipidemia. Current Science. London. Vanhanen HT, Blomqvist S, Ehnholm C, Hyvonen M, Jauhiainen M, Torstila I, Miettinen TA. 1993. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE henotypes during dietary sitostanol ester treatment. J Lipid Res. 34: 1535-1544. Vaya J, Mahmood S, Goldblum A, Aviram M, Volkova N, Shaalan A, Musa R, Tamir, S. 2003. Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy. Phytochemistry. 62: 89-99. Virgili F, Kobuchi H, Packer L. 1998. Procyanidins extracted from Pinus maritima (Pycnogenolt): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW 264.7 macrophages. Free Radic Biol Med. 24: 1120–1129. Weinmann. 1745. Phytanthoza iconographia. Westerate JA, Meijer GW. 1998. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolemic and mildly hypercholesterolemic subjects. Eur J Clin Nutri. 52: 334-343. Wikinson J, Higgins JA, Fitzsimmons C, Bowyer DE. 1998. Dietary fish oils modify the assembly of VLDL and expression of the LDL receptor in rabbit liver. Arterioscler Thromb Vasc Biol. 18: 1490-1497. Wiseman H. 1996. Dietary influences on membrance function: Importance in protection against oxidative damage and disease. Nutr Biochem. 7: 2-15. Witztum JL, Steinberg D. 1991. Role of oxidized low density lipoprotein in atherosclerosis. J Clin Invest. 88: 1785-1792. Wood JE, Senthilmohan ST, Peskin AV. 2002. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chemistry. 77: 155-161. Yamada K, Noda Y, Nakayama S, Komori Y, Sugihara H, Yamada K, Noda Y, Nakayama S, Komori Y, Sugihara H, Haegawa T, Nabeshima T. 1995. Role of Nitric oxide in learning and memory in monoamine metabolismin the rat brain. Brit J Pharmacol. 115: 852–858. Yang CS, Wang ZY. 1993. Tea and cancer. J. Natl. Cancer Inst. 85: 1038-1049. Youngken HW. 1924. The drugs of the North American Indian II. Am J Pharmacol. 97: 257-271. Zhao SE, Zhang JX. 1990. Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects. Am J Clin Nutr. 56: 99-105. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31934 | - |
dc.description.abstract | 法國海濱松( Pinus maritima)樹皮萃取物,商品名為Pycnogenol®(PYC),已有很多文獻指出具有多項生理療效,唯其脂質代謝部份較為缺乏。本研究之目的在於探討富含法國海濱松樹皮萃取物產品對於倉鼠脂質代謝之影響,並藉此推測其降血脂的機制。本實驗以AIN-93M飼料為基本飼料組成,配製高脂高膽固醇飼料(額外添加豬油5%與膽固醇添加0.2%),正對照物質則使用β-穀固醇(β-sitosterol,添加量為4%),處理組則分別額外添加0.2%、0.4%、0.8%三個劑量的富含松樹皮萃取物產品粉末。實驗動物48隻倉鼠以體重隨機分組,分別為正常組、高脂組、正對照組,以及三個處理組(分別為低、中、高劑量)共六組,餵食標準AIN-93M飼料馴養2週,之後除正常組之外,餵食修飾AIN-93M高脂高膽固醇飼料8週誘發高血脂症(hyperlipidemia)。實驗期間結束後倉鼠禁食12小時,犧牲取血,肝臟、副腎脂、副睪脂則秤重後冷凍保存。結果顯示,三個處理組與高脂組相比,在血清TC(total cholesterol)均有顯著下降的效果,但三者之間並無顯著差異;血清TG(triglyceride)方面,處理組之中隨產品添加濃度增加有線性下降的效果,但在低劑量組並無顯著差異;血清中LDL膽固醇(low-density lipoprotein cholesterol)的濃度隨產品添加量的升高呈線性降低;但血清中HDL膽固醇(high-density lipoprotein cholesterol)方面,處理組與高脂組均無顯著差異。肝臟脂質方面,處理組肝中TC在高劑量組與高脂組相比有顯著下降的現象,肝中TG則以低劑量組降低的效果最好,而試驗物質對於肝臟脂肪酸的影響並不明顯。在排除脂質的影響方面,糞便中TC、TG、膽汁酸含量均隨添加劑量上升而降低。而在抗氧化能力方面,血清TBARS值在低、中劑量組均顯著低於高脂組,但高劑量組TBARS值顯著高於高脂組,三個處理組隨產品添加比例提高,其血清TBARS值呈劑量關係上升;肝臟TBARS則隨添加松樹皮萃取物增多呈線性下降的趨勢,在高劑量組與高脂組相比有顯著的降低;且三個處理組其血清LDL氧化的遲滯時間(lag time)均較高脂組要長,高劑量組在氧化測定時間之內均尚未完全氧化。 | zh_TW |
dc.description.abstract | The trade name of French marine pine bark extract is Pycnogenol ®(PYC), and many researches have referred that PYC possesses some physiological activities, but that is poor on hypolipidemic. The aim of this study is to investigate the effect of French marine pine ( Pinus maritima ) bark extract on lipid metabolism, and from above to presume the mechanism of the hypolipidemic activity. In this experiment, 48 hamsters were divided into 6 groups according to their weight, and gave them the modified diet according to AIN-93M. The high-fat diet contained 5% lard and 0.2% cholesterol additionally, whereas the positive-control contained 4% β-sitosterol. The three experimental groups contained 0.2%, 0.4%, 0.8% ( low, medium, and high dose ) product powder rich of PYC, additionally. In the results, serum-TC ( total cholesterol ) was significantly decreased compared with high-fat group, but there were no differences between the three experimental groups, and serum-TG ( triglyceride ) was decreased in linear manner, but not significant in low dose group. The serum-LDL ( low density lipoprotein cholesterol ) was also significantly decreased in linear manner, but PYC did not influence the concentration of serum-HDL ( high density lipoprotein cholesterol ). In liver lipid, liver-TC was significantly decreased in high dose group, whereas liver-TG was decreased most significantly in low dose group, but the consistence percentage of liver-fatty acid was not influenced. On the effect of excreting lipid, feces-TC, feces-TG, and feces-bile acid were all decreased in dose dependent fit. Serum-TBARS was decreased significantly compared with high-fat group in low and medium dose group, but increased significantly in high dose group, and the serum-TBARS in three experimental groups were increasing in linear manner. Liver-TBARS in experimental groups decreased, and significant in high dose group. Also, the lag time of LDL-C oxidation was prolonged in experimental groups significantly, and the LDL-C was not completely oxidized in high dose group during detection time. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T03:25:02Z (GMT). No. of bitstreams: 1 ntu-95-R93641024-1.pdf: 2034324 bytes, checksum: 0ba3ef5edad477c7d99e78ca7a4db8e9 (MD5) Previous issue date: 2006 | en |
dc.description.tableofcontents | 中文摘要……………………………………………………………....1
英文摘要…………………………………………………………………3 詞彙縮寫表………………………………………………………………5 目錄…………………………………………………………………....6 圖次………………………………………………………………………8 表次……………………………………………………………………..10 壹、 前言…………………………………………………………11 貳、 文獻整理……………………………………………………15 1. 法國海濱松與其他松樹的比較…………………………..15 1.1 松的簡介及法國海濱松………………………………...15 1.2 法國海濱松的樹皮萃取物……………………………...17 1.3 松樹的相關生理活性研究……………………………...18 2. 脂質代謝…………………………………………………..21 2.1 膽固醇……………………………………………………...21 2.2 脂蛋白……………………………………………………...22 2.3 脂蛋白的氧化修飾………………………………………...29 2.4 肝臟脂質…………………………………………………...30 2.5 與膽固醇酯化相關的酵素及蛋白質……………………...32 2.6 糞便脂質…………………………………………………...35 2.7 高脂飲食與心血管疾病…………………………………...37 3. 植物固醇…………………………………………………..39 4. 動物模式…………………………………………………..42 參、 實驗流程……………………………………………………43 肆、 材料與方法…………………………………………………44 1. 實驗動物…………………………………………………..44 2. 實驗材料…………………………………………………..44 3. 飼料配製…………………………………………………..44 4. 實驗方法…………………………………………………..45 4.1 動物分組…………………………………………………...45 4.2 動物飼養及樣本採集……………………………………...45 4.3 血清分析…………………………………………………...46 4.4 肝臟分析…………………………………………………...49 4.5 糞便分析…………………………………………………...51 5. 統計分析…………………………………………………..52 伍、 實驗結果……………………………………………………56 1. 攝食量、體重以及組織臟器重量變化…………………..56 2. 血清脂質變化……………………………………………..57 3. 肝臟脂質變化……………………………………………..59 4. 糞便脂質變化……………………………………………..60 5. 動物體內抗氧化能力之變化……………………………..61 陸、 討論…………………………………………………………62 1. 體重與組織臟器重量的變化……………………………..62 2. 血清脂質的變化…………………………………………..63 3. 血清中脂蛋白組成及肝臟脂質含量變化………………..64 4. 體內抗氧化能力…………………………………………..68 5. 糞便脂質…………………………………………………..71 柒、 結論…………………………………………………………83 捌、 參考文獻……………………………………………………84 玖、 附錄……………………………………………………..101 | |
dc.language.iso | zh-TW | |
dc.title | 含松樹皮萃取物製品對於倉鼠脂質代謝的影響 | zh_TW |
dc.title | Effect of Product containing Pine Bark Extract on Lipid Metabolism in Hamsters | en |
dc.type | Thesis | |
dc.date.schoolyear | 94-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 謝明哲,潘子明,孫璐西,江孟燦 | |
dc.subject.keyword | 脂質代謝,Pycnogenol&reg,倉鼠,高血脂症, | zh_TW |
dc.subject.keyword | lipid metabolism,Pycnogenol&reg,hyperlipidemia,hamsters, | en |
dc.relation.page | 109 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2006-07-29 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-95-1.pdf 目前未授權公開取用 | 1.99 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。