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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31521
標題: | 臉部情緒感知對於大腦有效性聯結的改變 Changes in Effective Connectivity during Perception of Facial Expression: A Dynamic Causal Modeling Study |
作者: | Mu-Fang Lee 李睦方 |
指導教授: | 陳中明 |
關鍵字: | 功能性核磁共振影像,DCM,有效性聯結,情緒,精神分裂症, fMRI,DCM,effective connectivity,emotion,schizophrenia, |
出版年 : | 2006 |
學位: | 碩士 |
摘要: | 功能性核磁共振影像讓我們得以看到當大腦在感知人臉情緒時,腦部何處產生活動的改變。過去許多相關文獻指出,amygdala (AMY)、anterior cingulate cortex (ACC)、orbital-frontal cortex (OFC)與人類處理和感知情緒有關。至於這些大腦區域之間是如何相互影響,其中的機轉還不是很明朗。本論文在研究由這四個大腦區域組成的情緒網路,探討兩組受試者之中,健康個體與患者之間,情緒網路的有效聯結架構有何共通性和差異性. 11位健康個體和8位精神分裂症患者參與受試,對特定目標臉部情緒進行辨識的同時,進行功能性核磁共振影像掃描. Dynamic causal modeling (DCM)結合貝氏因子則是用於產生、推論、比較數個可能的情緒網路模型。而這些模型被指定不同的調節性聯結,內在聯結以及感覺輸入起源。 群組分析結果顯示,影像資料較支持以FFG為感覺輸入起源, 缺少從AMY, ACC和OFC到FFC等返回路徑的模型。此外,調節性聯結的作用呈現明顯的個體差異性。我們發現,調節性作用所造成大腦有效性聯結的改變,隨處理情緒物質的不同而有差別,健康受試者與患者之間也有差距。 The present work studied the connectivity architecture in emotional network comprising four brain areas: amygdala (AMY), anterior cingulate cortex (ACC), orbital-frontal cortex (OFC) and fusiform gyrus (FFG). 11 healthy controls and 8 schizophrenic patients underwent block-design fMRI analysis, while making judgment of a particular target facial emotion. Dynamic causal modeling (DCM) in conjunction with Bayes factors was used to compare models with different modulatory connectivity, intrinsic connectivity patterns and input regions in this emotional network. Comparison of group level showed superiority of the model in which the fusiform gyrus (FFG) serving as input region to receive external input. Moreover, models without backward connections from AMY, ACC and OFC to FFG were superior to models with fully connected structure. Furthermore, modulatory connectivity showed significant individual difference among control subjects. Our findings also illustrated differential brain connectivity due to the influence of modulatory effect (e.g. cognitive context, attention and learning), between healthy controls and schizophrenic patients, and between different types of emotional material. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/31521 |
全文授權: | 有償授權 |
顯示於系所單位: | 醫學工程學研究所 |
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