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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李水盛(Shoei-Sheng Lee) | |
| dc.contributor.author | Hsin-Yi Chen | en |
| dc.contributor.author | 陳欣苢 | zh_TW |
| dc.date.accessioned | 2021-06-13T01:14:03Z | - |
| dc.date.available | 2021-08-03 | |
| dc.date.copyright | 2011-10-07 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-03 | |
| dc.identifier.citation | 1. Li, H. L.; Yang, T. Y. Sapotaceae in Flora of Taiwan, 2nd ed.; Editorial committee of the Flora of Taiwan: Taipei, 1996; Vol. IV, p. 86-87.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/29663 | - |
| dc.description.abstract | 山欖科(Sapotaceae)大約有107個屬，超過1000個種，但至今仍只有少數山欖屬(Planchonella)植物之成分有被研究。本論文為持續本研究室先前對山欖葉部之成分探討，針對其山欖葉部乙醇萃取物之極性化割的正丁醇及甲醇可溶層做進一步成分分離，利用離心式分配層析儀、SP 700樹脂、凝膠管柱層析、矽膠管柱層析和逆向管柱層析等方式進行，共計得到15個化合物，包括六個黃酮醇成分：isorhamnetin 3-O-robinobioside (1)、3-O-rutinoside (2)、3-O-neohesperidoside (11) and 3-O-(2,6-di-O-α-rhamnosyl)-β-galactopyranoside (14)、quercetin 3-O-rutinoside (12) 及typhaneoside (13)；一個三萜成分：ursolic acid (3)；和八個三萜類皂苷即Mi-saponins A-C (15、6和4)、3'-O-β-apiofuranosylarganin F (5)、3-O-glucopyranosyl- protobassic acid (7)、isoarganin F (8)、3'-O-de-β-D-apiofuranosylisoarganin F (9)和arganin F (10)。其結構解析係藉由一維TOCSY與二維NMR技術之光譜分析而確認，其中化合物5、8和9為新的三萜類配醣體。 | zh_TW |
| dc.description.abstract | The Sapotaceae family contains about 107 genera and more than 1000 species. Up to now, only a few species of the Planchonella genus have been investigated phytochemically. In a continuation of our recent study on the EtOH extract of Planchonella obovata leaf, this thesis focused on chemical investigation of the n-BuOH and MeOH soluble fractions. Repeated chromatography through centrifugal partition chromatography, SP 700 resin, Sephadex LH-20, silica gel, and reversed-phase C-18 column (Lobar and semi-preparative HPLC) yielded fifteen compounds (1~15). They are six flavonols, i.e., isorhamnetin 3-O-robinobioside (1), 3-O-rutinoside (2), 3-O-neohesperidoside (11), 3-O-(2,6-di-O-α-rhamnosyl)-β-galactopyranoside (14), quercetin 3-O-rutinoside (12) and typhaneoside (13); one triterpene, i.e. ursolic acid (3); and eight triterpenoid saponins, i.e. Mi-saponins A-C (15, 6 and 4), 3'-O-β- apiofuranosylarganin F (5), 3-O-glucopyranosylprotobassic acid (7), isoarganin F (8), 3'-O-de-β-D-apiofuranosylisoarganin F (9) and arganin F (10). The structures of these compounds were elucidated based on elaborate spectroscopic analysis, especially using 1D-TOCSY and 2D-NMR. Among them, compounds 5, 8 and 9 are found to be new saponins. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-13T01:14:03Z (GMT). No. of bitstreams: 1 ntu-100-R98423003-1.pdf: 9694006 bytes, checksum: 5cb53ed70b546c0d9acf5976a89aa635 (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | 口詴委員會審定書 ..........................................i
誌謝 ................................................... ii 中文摘要 ...................................... I 英文摘要(Abstract) ............................. II 總目錄 ........................ III 表目錄 ........................ IV 圖目錄 ................... V 流程圖目錄 ............................. VIII 詞彙縮寫(Glossary of Abbreviations).......... IX 第一章 緒論 ............................................. 1 1.1 研究目的 ................. 1 1.2 植物簡介 ................... 1 1.3 Planchonella屬植物成分之相關研究 ................ 3 第二章 實驗結果與討論.............................. 6 2.1 黃酮類成分及三萜類成分之結構解析 ............... 6 2.1.1 Flavan-3-ol成分1, 2, 11-14之結構解析 ......... 8 2.1.1.1 Isorhamnetin 3-O-robinobioside (1)之結構解析 ..... 8 2.1.1.2 Isorhamnetin 3-O-rutinoside (2)之結構解析 .. 10 2.1.1.3 Isorhamnetin 3-O-neohesperidoside (11)之結構解析 . 12 2.1.1.4 Quercetin 3-O-rutinoside (12)之結構解析 ..... 14 2.1.1.5 Typhaneoside (13)之結構解析 .......... 16 2.1.1.6 Isorhamnetin 3-O-(2,6-di-O-α-rhamnosyl)-β-galactopyranoside (14)之結構解析 ...................... 18 2.1.2 Ursolic acid (3)之結構解析 ...................... 20 2.1.3 Protobassic acid glycosides 4-10, 15及衍生物4a之結構解析 .......... 22 2.1.3.1 Mi-saponin C (4)及Mi-saponin C peracetate (4a)之結構解析 ........ 23 2.1.3.2 3'-O-β-Apiofuranosylarganin F (5)之結構解析 .. 27 2.1.3.3 Mi-saponin B (6)之結構解析 ........ 31 2.1.3.4 3-O-β-D-Glucopyranosylprotobassic acid (7)之結構解析 ................ 35 2.1.3.5 Isoarganin F (8)之結構解析 ......... 37 2.1.3.6 3'-O-De-β-D-apiofuranosylisoarganin F (9)之結構解析 ................. 41 2.1.3.7 Arganin F (10)之結構解析 .............. 45 2.1.3.8 Mi-saponin A (15)之結構解析 ............. 49 2.2 結論 .................................................... 53 第三章 實驗部分 ......................................... 54 3.1 儀器與器材 ...................................... 54 3.1.1 理化性質測定儀器 ............... 54 3.1.2 成分分離之儀器與器材 ........ 54 3.1.3 詴藥及溶劑 ............................. 55 3.1.4 薄層層析展開系統 ................ 56 3.2 山欖葉部成分萃取與分離 ....................... 56 3.2.1 甲醇可溶層之成分分離 (A) ............. 59 3.2.2 甲醇可溶層之成分分離 (B)............ 60 3.2.3 正丁醇層之成分分離 .......... 61 3.3 各化合物之物理數據 ....................... 63 參考文獻 .................................. 69 | |
| dc.language.iso | zh-TW | |
| dc.title | 山欖葉部之成份研究 (II) | zh_TW |
| dc.title | Chemical investigation of the leaves of Planchonella obovata (R. Br.) Pierre (II) | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳繼明,陳春雄(Chung-Hsiung Chen),林雲蓮(Yun-Lian Lin) | |
| dc.subject.keyword | 山欖科,山欖,三萜,類皂苷, | zh_TW |
| dc.subject.keyword | Sapotaceae,Planchonella obovata,triterpenoid saponins, | en |
| dc.relation.page | 162 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2011-08-03 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥學研究所 | zh_TW |
| 顯示於系所單位： | 藥學系 | |
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