請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28821
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 呂廷璋 | |
dc.contributor.author | Hui-Ching Yu | en |
dc.contributor.author | 余惠菁 | zh_TW |
dc.date.accessioned | 2021-06-13T00:24:24Z | - |
dc.date.available | 2012-07-30 | |
dc.date.copyright | 2007-07-30 | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007-07-27 | |
dc.identifier.citation | 水野卓,川合正允,賴慶亮 譯。1997。菇類的化學 生化學。國立編譯館,臺灣。
吳寬澤,2005。巴西蘑菇。社團法人台灣食藥用菇菌類生技協會41-45。 林克融,2002。探討培養基之pH值與Xanthan gum的添加對巴西蘑菇多醣體生產之影響。國立中央大學化學工程研究所碩士論文,桃園,臺灣。 林念蓁,2005。巴西洋菇發酵物對BALB/c鼠之非特異性免疫調節及其免疫調節蛋白純化與生理活性之探討。臺灣大學食品科技研究所碩士論文,臺北,臺灣。 陳怡倩,2001。利用批式液態培養來探討檸檬酸對裂褶菌生長及其多醣體生成 影響之研究。國立中央大學碩士論文,桃園,臺灣。 陳宣諭,2004。巴西洋菇對人體白血病U937細胞生長抑制機制及對Balb/c鼠尾靜脈注射CT26細胞之腫瘤轉移抑制效果。臺灣大學食品科技研究所碩士論文,臺北,臺灣。 連大進,1995。談黑豆栽培與應用。臺南區農業專訊,12:2-5。 連大進,游添榮,吳昭慧。1998。黑豆新品種台南3號的育成與推廣。臺南區農業專訊。22: 2-4。 曾慶瀛,余哲仁,余哲禮,1993。烏豆脂氧化酵素之純化與特性之探討,中華生質能源學會會誌,12(3-4): 171-178。 黃鈴娟,2000。樟芝與姬松茸之抗氧化性質及多醣組成分析。國立中興大學食品科學研究所碩士論文,臺中,臺灣。 楊梅,林琳,張其昌,1997。姬松茸菌絲深層培養及胺基酸分析研究,中國食用菌, 16(3): 41-42。 楊俐穎,2004。巴西洋菇水溶性多醣之特徵。臺灣大學食品科技研究所碩士論文,臺北,臺灣。 楊雅嵐,2005。黑豆、黃耆、巴西洋菇子實體及以豆科植物為發酵基質之巴西 洋菇發酵產物對倉鼠血脂之影響。國立台灣大學食品科技研究所碩士論文,臺北,臺灣。 蔡惠利,2004。巴西蘑菇、茶樹菇、牛肝菌和雞腿菇之呈味與抗氧化物質。國立中興大學食品科學系碩士論文,臺中,臺灣。 劉廷英。1984。豆豉油及其抗氧化性。中國農業雜誌。22:240-256。 劉勝宇,2001。探討培養溫度對巴西蘑菇液態發酵之影響。國立中央大學化學工程研究所碩士論文,桃園,臺灣。 鄭萬禎,2002。利用批式發酵生產巴西洋菇菌絲體及胞外多醣之研究。國立中興大學食品科學研究所碩士論文,臺中,臺灣。 戴文禎,1997。黑豆萃取物之抗氧化效用。中國文化大學生活應用科學研究所碩士論文,臺北,臺灣。 蘇正德,1992。果實種子類中藥之抗氧化性及生育醇類之調查研究。食品科學。19: 12-14。 Angeli JPF, Ribeiro LR, Gonzaga MLC, Soares SD, Ricardo MPSN, Tsuboy MS, Stidl R, Knasmueller S, Linhares RE, Mantovani MS. 2006. Protective effects of beta-glucan extracted from Agaricus brasiliensis against chemically induced DNA damage in human lymphocytes. Cell Biol Toxicol 22(4):285-291. Barbisan LF, Miyamoto M, Scolastici C, Salvadori DMF, Ribeiro LR, Eira AF, de Camargo JLV. 2002. Influence of aqueous extract of Agaricus blazei on rat liver toxicity induced by different doses of diethylnitrosamine. J Ethnopharmacol 83(1-2):25-32. Bellini MF, Angeli JPF, Matuo R, Terezan AP, Ribeiro LR, Mantovani MS. 2006. Antigen otoxicity of Agaricus blazei mushroom organic and aqueous extracts in chromosomal aberration and cytokinesis block micronucleus assays in CHO-k1 and HTC cells. Toxicol Vitro 20(3):355-360. Bellini MF, Giacomini NL, Eira AF, Ribeiro LR, Mantovani MS. 2003. Anticlastogenic effect of aqueous extracts of Agaricus blazei on CHO-k1 cells, studying different developmental phases of the mushroom. Toxicol Vitro 17(4):465-469. Bernardshaw S, Hetland G, Ellertsen LK, Tryggestad AMA, Johnson E. 2005. An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro. Inflammation 29(4-6):147-153. Blaschek W, Kasbauer J, Kraus J, Franz G. 1992. Pythium-Aphanidermatum - Culture, Cell-Wall Composition, and Isolation and Structure of Antitumor Storage and Solubilized Cell-Wall (1 -> 3), (1 -> 6)-Beta-D-Glucans. Carbohydr Res 231:293-307. Blumenkr.N, Asboehan.G. 1973. New Method for Quantitative-Determination of Uronic Acids. Anal Biochem 54(2):484-489. Bohn JA, BeMiller JN. 1995. (1->3)-beta-D-glucans as biological response modifiers: A review of structure-functional activity relationships. Carbohydr Polym 28(1):3-14. Bradford MM, Williams WL. 1976. New, Rapid, Sensitive Method for Protein Determination. Fed Proc 35(3):274. Camelini CM, Maraschin M, de Mendonca MM, Zucco C, Ferreira AG, Tavares LA. 2005. Structural characterization of beta-glucans of Agaricus brasiliensis in different stages of fruiting body maturity and their use in nutraceutical products. Biotechnol Lett 27(17):1295-1299. Chen L, Shao HJ, Su YB. 2004. Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses. Int Immunopharmacol 4(3):403-409. Choudhary, G. and Horvath, Cs. 1996.“Ion-Exchange hromatography”.Methods in enzymology 270:47-63. Chun H, Shin DH, Hong BS, Cho HY, Yang HC. 2001. Purification and biological activity of acidic polysaccharide from leaves of Thymus vulgaris L. Biol Pharm Bull 24(8):941-946. Chung HY, Cho YJ, Kim T. 2005. Isolation and characterization of a water-soluble polysaccharide from the mycelia of solid cultured Agaricus blazei murill. Food Sci Biotechnol 14(2):259-262. Cui FJ, Tao WY, Xu ZH, Guo WJ, Xu HY, Ao ZH, Jin J, Wei YQ. 2007. Structural analysis of anti-tumor heteropolysaccharide GFPS1b from the cultured mycelia of Grifola frondosa GF9801. Bioresour Technol 98(2):395-401. de Oliveira JM, Jordao BQ, Ribeiro LR, da Eira AF, Mantovani MS. 2002. Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro. Food Chem Toxicol 40(12):1775-1780. Demleitner S, Kraus J, Franz G. 1992. Synthesis and Antitumor-Activity of Sulfoalkyl Derivatives of Curdlan and Lichenan. Carbohydr Res 226(2):247-252. Dong Q, Yao J, Yang XT, Fang JN. 2002. Structural characterization of a water-soluble beta-D-glucan from fruiting bodies of Agaricus blazei Murr. Carbohydr Res 337(15):1417-1421. Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F. 1956. Colorimetric Method for Determination of Sugars and Related Substances. Anal Chem 28(3):350-356. Ebina T, Fujimiya Y. 1998. Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 11(4):259-265. Eguchi F, Watanabe Y, Zhang J, Miyamoto K, Yoshimoto H, Fukuhara T, Higaki M. 1999. Inhibitory effects of hot water extract from Agaricu blazei fruiting bodies(CJ-01) on hypertension development in spontaneously hypertensive rats. J Transl Med. 16(5/6): 201-207. Estrada A, Yun CH, Van Kessel A, Li B, Hauta S, Laarveld B. 1997. Immunomodulatory activities of oat beta-glucan in vitro and in vivo. Microbiol Immunol 41(12):991-998. Freeman AEH. 1979a. Agaricus in North-America - Type Studies. Mycotaxon 8(1):1-49. Freeman AEH. 1979b. Agaricus in the Southeastern United-States. Mycotaxon 8(1):50-118. Fujimiya Y, Kobori H, Oshiman K, Soda R, Ebina T. 1998a. Tumoricidal activity of high molecular weight polysaccharides derived from Agaricus blazei via oral administration in the mouse tumor model. Nippon Shokuhin Kagaku Kogaku Kaishi 45(4):246-252. Fujimiya Y, Suzuki Y, Katakura R, Ebina T. 1999. Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill. Anticancer Res 19(1A):113-118. Fujimiya Y, Suzuki Y, Oshiman K, Kobori H, Moriguchi K, Nakashima H, Matumoto Y, Takahara S, Ebina T, Katakura R. 1998b. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 46(3):147-159. Gomaa K, Kraus J, Rosskopf F, Roper H, Franz G. 1992. Antitumor and Immunological Activity of a Beta-1->3,1->6 Glucan from Glomerella-Cingulata. J Cancer Res Clin Oncol 118(2):136-140. Guterres ZDR, Mantovani MS, da Eira AF, Ribeiro LR, Jordao BQ. 2005. Genotoxic and antigenotoxic effects of organic extracts of mushroom Agaricus blazei Murrill on V79 cells. Genet Mol Biol 28(3):458-463. Guterrez ZR, Mantovani MS, Eira AF, Ribeiro LR, Jordao BQ. 2004. Variation of the antimutagenicity effects of water extracts of Agaricus blazei Murrill in vitro. Toxicol Vitro 18(3):301-309. Han SB, Yoon YD, Ahn HJ, Lee HS, Lee CW, Yoon WK, Park SK, Kim HM. 2003. Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus. Int Immunopharmacol 3(9):1301-1312. Hashimoto T, Nonaka Y, Minato K, Kawakami S, Mizuno M, Fukuda I, Kanazawa K, Ashida H. 2002. Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice. Biosci Biotechnol Biochem 66(7):1610-1614. Huang SJ, Mau JL. 2006. Antioxidant properties of methanolic extracts from Agaricus blazei with various doses of gamma-irradiation. LWT-Food Sci Technol 39(7):707-716. Humfeld H. 1948. The Production of Mushroom Mycelium (Agaricus-Campestris) in Submerged Culture. Science 107(2780):373-373. Hwang JS, Chung HK, Bae EK, Lee AY, Ji HJ, Park DW, Jung HJ, Cho CW, Choi HJ, Lee DS, Lee KR, Youn HJ. 2003. The polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in culture. Arch Pharm Res 26(4):294-300. Ito H, Shimura K, Itoh H, Kawade M. 1997. Antitumor effects of a new polysaccharide- protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) 'Himematsutake' and its mechanisms in tumor-bearing mice. Anticancer Res 17(1A):277-284. Itoh H, Ito H, Amano H, Noda H. 1994. Inhibitory-Action of a (1->6)-Beta-D-Glucan-Protein Complex (F-III-2-B) Isolated from Agaricus Blazei Murill (Himematsutake) on Meth-a Fibrosarcoma-Bearing Mice and Its Antitumor Mechanism. Jpn J Pharmacol 66(2):265-271. Izawa S, Inoue Y. 2004. A screening system for antioxidants using thioredoxin-deficient yeast: discovery of thermostable antioxidant activity from Agaricus blazei Murill. Appl Microbiol Biotechnol 64(4):537-542. Jin CY, Choi YH, Moon DO, Park C, Park YM, Jeong SC, Heo MS, Lee TH, Lee JD, Kim GY. 2006. Induction of G2/M arrest and apoptosis in human gastric epithelial AGS cells by aqueous extract of Agaricus blazei. Oncol Rep 16(6):1349-1355. Jung K, Ha Y, Ha SK, Han DU, Kim DW, Moon WK, Chae C. 2004. Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide. J Vet Med B 51(2):72-76. Kawagishi H, Inagaki R, Kanao T, Mizuno T, Shimura K, Ito H, Hagiwara T, Nakamura T. 1989. Fractionation and Antitumor-Activity of the Water-Insoluble Residue of Agaricus-Blazei Fruiting Bodies. Carbohydr Res 186(2):267-273. Kawagishi H, Kanao T, Inagaki R, Mizuno T, Shimura K, Ito H, Hagiwara T, Nakamura T. 1990. Formolysis of a Potent Antitumor (1->6)-Beta-D-Glucan Protein Complex from Agaricus-Blazei Fruiting Bodies and Antitumor-Activity of the Resulting Products. Carbohydr Polym 12(4):393-403. Kawagishi H, Katsumi R, Sazawa T, Mizuno T, Hagiwara T, Nakamura T. 1988a. Cyto-Toxic Steroids from the Mushroom Agaricus-Blazei. Phytochemistry 27(9):2777-2779. Kawagishi H, Nomura A, Yumen T, Mizuno T, Hagiwara T, Nakamura T. 1988b. Isolation and Properties of a Lectin from the Fruiting Bodies of Agaricus-Blazei. Carbohydr Res 183(1):150-154. Kawamura M, Kasai H, He LM, Deng XW, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M. 2005. Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 114(3):397-409. Ker YB, Chen KC, Chyau CC, Chen CC, Guo JH, Hsieh CL, Wang HE, Peng CC, Chang CH, Peng RY. 2005. Antioxidant capability of polysaccharides fractionated from submerge-cultured Agaricus blazei mycelia. J Agric Food Chem 53(18):7052-7058. Kim GY, Lee MY, Lee HJ, Moon DO, Lee CM, Jin CY, Choi YH, Jeong YK, Chung KT, Lee JK, Choi IH, Park YM. 2005a. Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells. Int Immunopharmacol 5(10):1523-1532. Kim JE, Lee WS, Chung HY, Jang SJ, Kim JS, Lee JB, Song CS, Park SY. 2004. The selective antitumor activity of water-soluble extracts of the fruiting bodies and the cultivated mycelia of Agaricus blazei Murill. Food Sci Biotechnol 13(3):347-352. Kim WS, Ordija CM, Freeman MW. 2003. Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. Biochem Biophys Res Commun 310(2):542-549. Kim YW, Kim KH, Choi HJ, Lee DS. 2005b. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett 27(7):483-487. Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K. 2004. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: Its antitumor and antimetastatic actions. Cancer Sci 95(9):758-764. Kishida E, Sone Y, Misaki A. 1989. Purification of an Antitumor-Active, Branched (1->3)-Beta-D-Glucan from Volvariella-Volvacea, and Elucidation of Its Fine-Structure. Carbohydr Res 193:227-239. Kishida E, Sone Y, Misaki A. 1992. Effects of Branch Distribution and Chemical Modifications of Antitumor (1->3)-Beta-D-Glucans. Carbohydr Polym 17(2):89-95. Kitamura S, Hori T, Kurita K, Takeo K, Hara C, Itoh W, Tabata K, Elgsaeter A, Stokke BT. 1994. An Antitumor, Branched (1->3)-Beta-D-Glucan from a Water Extract of Fruiting Bodies of Cryptoporus-Volvatus. Carbohydr Res 263(1):111-121. Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K, Kondo T, Kurita N, Suzuki M, Kanayama N, Terao T. 2005. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol 131(8):527-538. Kojima T, Tabata K, Itoh W, Yanaki T. 1986. Molecular-Weight Dependence of the Antitumor-Activity of Schizophyllan. Agric Biol Chem 50(1):231-232. Kraus J, Blaschek W, Schutz M, Franz G. 1992. Antitumor-Activity of Cell-Wall Beta-1,3/1,6-Glucans from Phytophthora Species. Planta Med 58(1):39-42. Kuo YC, Huang YL, Chen CC, Lin YS, Chuang KA, Tsai WJ. 2002. Cell cycle progression and cytokine gene expression of human peripheral blood mononuclear cells modulated by Agaricus blazei. J Lab Clin Med 140(3):176-187. Kweon MH, Jang H, Lim WJ, Chang HI, Kim CW, Yang HC, Hwang HJ, Sung HC. 1999. Anti-complementary properties of polysaccharides isolated from fruit bodies of mushroom Pleurotus ostreatus. J Microb Biot 9(4):450-456. Lee HJ, Koh JB. 2003. Effects of liquid culture of Agaricus blazei Murill on lipid metabolism and enzyme activity in rats fed high fat diet. Korean Journal of Nutrition. 36(4): 352-358. Leung MYK, Liu C, Koon JCM, Fung KP. 2006. Polysaccharide biological response modifiers. Immunol Lett 105(2):101-114. Lim TS, Na K, Choi EM, Chung JY, Hwang JK. 2004. Immunomodulating activities of polysaccharides isolated from Panax ginseng. J Med Food 7(1):1-6. Linehan SA, Martinez-Pomares L, Stahl PD, Gordon S. 1999. Mannose receptor and its putative ligands in normal murine lymphoid and nonlymphoid organs: In situ expression of mannose receptor by selected macrophages, endothelial cells, perivascular microglia, and mesangial cells, but not dendritic cells. J Exp Med 189(12):1961-1972. Machado MP, Rodrigues E, Terezan AP, Ribeiro UR, Mantovani MS. 2005. Cytotoxicity, genotoxicity and antimutagenicity of hexane extracts of Agaricus blazei determined in vitro by the comet assay and CHO/HGPRT gene mutation assay. Toxicol Vitro 19(4):533-539. Maeda YY, Watanabe ST, Chihara C, Rokutanda M. 1988. Denaturation and Renaturation of a Beta-1,6-1,3-Glucan, Lentinan, Associated with Expression of T-Cell- Mediated Responses. Cancer Res 48(3):671-675. Matsuzaki K, Sato T, Enomoto K, Yamamoto I, Oshima R, Hatanaka KI, Uryu T, Kaku H, Sone Y, Misaki A. 1986. Synthesis of Water-Soluble Branched Polysaccharides and Their Antitumor-Activity .4. Synthesis of water-soluble, branched polysaccharides having d-mannopyranose, d-arabinofuranose, or oligo-d- arabinofuranose side-chains and their antitumor-activityi. Carbohydr Res 157:171-182. Menoli RCRN, Mantovani MS, Ribeiro LR, Speit G, Jordao BQ. 2001. Antimutagenic effects of the mushroom Agaricus blazei Murrill extracts on V79 cells. Mutat Res-Gen Tox En 496(1-2):5-13. Misaki A, Kakuta M, Sasaki T, Tanaka M, Miyaji H. 1981. Studies on Interrelation of Structure and Anti-Tumor Effects of Polysaccharides - Anti-Tumor Action of Periodate-Modified, Branched (1->3)-Beta-D-Glucan of Auricularia-Auricula- Judae, and Other Polysaccharides Containing (1->3)-Glycosidic Linkages. Carbohydr Res 92(1):115-129. Misaki A, Kawaguchi K, Miyaji H, Nagae H, Hokkoku S, Kakuta M, Sasaki T. 1984. Structure of Pestalotan, a Highly Branched (1->3)-Beta-D-Glucan Elaborated by Pestalotia Sp-815, and the Enhancement of Its Antitumor-Activity by Polyol Modification of the Side-Chains. Carbohydr Res 129(JUL):209-227. Miyamoto K, Watanabe Y, Iizuka N, Sakaguchi E, Okita K. 2002. Effects of hot water extract from Agaricu blazei fruiting bodies(CJ-01) on the intracellular cytokines level in a patient with bronchitis. J Transl Med. 19: 142-147. Miyazaki T, Nishijima M. 1982. Studies on Fungal Polysaccharides .32. Structural Examination of an Alkali-Extracted, Water-Soluble Heteroglycan of the Fungus Ganoderma-Lucidum. Carbohydr Res 109(Nov):290-294. Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. 1999. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochem Mol Biol Int 47(4):707-714. Mizuno M, Morimoto M, Minato K, Tsuchida H. 1998. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 62(3):434-437. Mizuno M, Shiomi Y, Minato K, Kawakami S, Ashida H, Tsuchida H. 2000. Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-alpha and nitric oxide from murine macrophages. Immunopharmacol 46(2):113-121. Mizuno T. 1989a. Development and Utilization of Bioactive Substances from Mushroom Fungi - Introduction.Japan Soc Biosci Biotechn Agrochem 63(4):861-862. Mizuno T. 1989b. Immunostimulative and Cyto-Toxic Antitumor Substances from Mushroom Fungi. Japan Soc Biosci Biotechn Agrochem 63(4):862-865. Mizuno T. 1995. Bioactive Biomolecules of Mushrooms - Food, Function and Medicinal Effect of Mushroom Fungi. Food Rev Int 11(1):7-21. Mizuno T. 2002. Medicinal properties and clinical effects of culinary-medicinal mushroom Agaricus blazei Murrill (Agaricomycetideae) (review). Int J Med Mushrooms 4(4):299-312. Mizuno T, Hagiwara T, Nakamura T, Ito H, Shimura K, Sumiya T, Asakura A. 1990a. Studies on the Host-Mediated Antitumor Polysaccharides .13. Antitumor-Activity and Some Properties of Water-Soluble Polysaccharides from Himematsutake, the Fruiting Body of Agaricus-Blazei Murill. Agric Biol Chem 54(11):2889-2896. Mizuno T, Inagaki R, Kanao T, Hagiwara T, Nakamura T, Ito H, Shimura K, Sumiya T, Asakura A. 1990b. Studies on the Host-Mediated Antitumor Polysaccharides .14. Antitumor-Activity and Some Properties of Water-Insoluble Hetero-Glycans from Himematsutake, the Fruiting Body of Agaricus-Blazei Murill. Agric Biol Chem 54(11):2897-2905. Mizuno T, Yeohlui P, Kinoshita T, Zhuang C, Ito H, Mayuzumi Y. 1996. Antitumor activity and chemical modification of polysaccharides from niohshimeji mushroom, Tricholma giganteum. Biosci Biotechnol Biochem 60(1):30-33. Nakajima A, Ishida T, Koga M, Takeuchi T, Mazda O, Takeuchi M. 2002. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice. Inter Immunopharmacol 2(8):1205-1211. Ohno N, Akanuma AM, Miura NN, Adachi Y, Motoi M. 2001a. (1fwdarw3)-beta-D-glucan in the fruit bodies of Agaricus blazei. Pharmaceut and Pharmacol Let 11(2):87-90. Ohno N, Furukawa M, Miura NN, Adachi Y, Motoi M, Yadomae T. 2001b. Antitumor beta-glucan from the cultured fruit body of Agaricus blazei. Biol Pharm Bull 24(7):820-828. Okura A, Arakawa H, Oka H, Yoshinari T, Monden Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [Val->2]Ha-Ras-Transformed Nih-3t3 Cells. Biochem Biophys Res Commun 157(1):183-189. Osaki Y, Kato T, Yamamoto K, Okubo J, Miyazaki T. 1994. Antimutagenic and Bactericidal Substances in the Fruit Body of a Basidiomycete Agaricus-Blazei, Jun-17. Yakugaku Zasshi 114(5):342-350. Oscarsson S, Karsnas P. 1998. Salt-promoted adsorption of proteins onto amphiphilic agarose-based adsorbents - II. Effects of salt and salt concentration. J Chromatogr A 803(1-2):83-93. Oshiman K, Fujimiya Y, Ebina T, Suzuki I, Noji M. 2002. Orally administered beta-1,6-D-polyglucose extracted from Agaricus blazei results in tumor regression in tumor-bearing mice. Planta Med 68(7):610-614. Peiser L, Mukhopadhyay S, Gordon S. 2002. Scavenger receptors in innate immunity. Curr Opin Immunol 14(1):123-128. Peng YF, Zhang L, Zeng FB, Xu YX. 2003. Structure and antitumor activity of extracellular polysaccharides from mycelium. Carbohydr Polym 54(3):297-303. Pinheiro F, Faria RR, de Camargo JLV, Spinardi-Barbisan ALT, de Eira AF, Barbisan LF. 2003. Chemoprevention of preneoplastic liver foci development by dietary mushroom Agaricus blazei Murrill in the rat. Food Chem Toxicol 41(11):1543-1550. Sakurai T, Ohno N, Suzuki I, Yadomae T. 1995. Effect of Soluble Fungal (1-]3)-Beta-D-Glucan Obtained from Sclerotinia-Sclerotiorum on Alveolar Macrophage Activation. Immunopharmacol 30(2):157-166. Sasaki T, Takasuka N, Chihara G, Maeda YY. 1976. Antitumor Activity of Degraded Products of Lentinan - Its Correlation with Molecular-Weight. Gann 67(2):191-195. Shimizu S, Kitada H, Yokota H, Yamakawa J, Murayama T, Sugiyama K, Izumi H, Yamaguchi N. 2002. Activation of the alternative complement pathway by Agaricus blazei Murill. Phytomedicine 9(6):536-545. Shimura K, Ito H, Hibasami H. 1983. Screening of Host-Mediated Anti-Tumor Polysaccharides by Crossed Immunoelectrophoresis Using Fresh Human-Serum. Jpn J Pharmacol 33(2):403-408. Shu CH, Wen BJ, Lin KJ. 2003. Monitoring the polysaccharide quality of Agaricus blazei in submerged culture by examining molecular weight distribution and TNF-alpha release capability of macrophage cell line RAW 264.7. Biotechnol Lett 25(24):2061-2064. Small,H,1990. Ion Exchange in ion Chromatography.In: Ion Chromatography. Small,H.(Ed.),Plenun Press,New York,pp.57-90 Sorimachi K, Akimoto K, Ikehara Y, Inafuku K, Okubo A, Yamazaki S. 2001a. Secretion of TNF-alpha, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro. Cell Struct Funct 26(2):103-108. Sorimachi K, Ikehara Y, Maezato G, Okubo A, Yamazaki S, Akimoto K, Niwa A. 2001b. Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. Biosci Biotechnol Biochem 65(7):1645-1647. Surenjav U, Zhang L, Xu XJ, Zhang XF, Zeng FB. 2006. Effects of molecular structure on antitumor activities of (1 -> 3)-beta-D-glucans from different Lentinus Edodes. Carbohydr Polym 63(1):97-104. Surenjav U, Zhang LN, Xu XJ, Zhang M, Cheung PCK, Zeng FB. 2005. Structure, molecular weight and bioactivities of (1 -> 3)-beta-D-glucans and its sulfated derivatives from four kinds of Lentinus edodes. Chinese J Polym Sci 23(3):327-336. Takaku T, Kimura Y, Okuda H. 2001. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 131(5):1409-1413. Takimoto F, Wakita D, Kawaguchi K, Kumazawa Y. 2004. Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull 27(3):404-406. Talorete TPN, Isoda H, Maekawa T. 2002. Agaricus blazei (class basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells. J Agric Food Chem 50(18):5162-5166. Tao YZ, Zhang L, Cheung PCK. 2006. Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides. Carbohydr Res 341(13):2261-2269. Ukawa Y, Ito H, Hisamatsu M. 2000. Antitumor effects of (1 -> 3)-beta-D-glucan and (1 -> 6)-beta-D-glucan purified from newly cultivated mushroom, Hatakeshimeji (Lyophyllum decastes Sing.). J of Biosc Bioeng 90(1):98-104. Unursaikhan S, Xu XJ, Zeng FB, Zhang LN. 2006. Antitumor activities of O-sulfonated derivatives of (1 -> 3)-alpha-D-glucan from different Lentinus edodes. Biosci Biotechnol Biochem 70(1):38-46. Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH. 2002. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: Functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem 10(4):1057-1062. Wasser SP. 2002. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Appl Microbiol Biotechnol 60(3):258-274. Watanabe T, Kawashita A, Ishi S, Mazumder TK, Nagai S, Tsuji K, Dan T. 2003. Antihypertensive effect of gamma-aminobutyric acid-enriched Agaricus blazei on mild hypertensive human subjects. Japan Soc Food Sci Technol 50(4):167-173. Watanabe T, Yamada T, Tanaka H, Jiang S, Mazumder TK, Nagai S, Tsuji K. 2002. Antihypertensive effect of gamma-aminobutyric acid-enriched Agaricus blazei on spontaneously hypertensive rats.Japan Soc Food Sci Technol 49(3):166-173. Wei HC, Bowen R, Cai QY, Barnes S, Wang Y. 1995. Antioxidant and Antipromotional Effects of the Soybean Isoflavone Genistein. Proc Soc Exp Biol Med 208(1):124-130. Williams DL. 1997. Overview of (1 -> 3)-beta-D-glucan immunobiology. Mediators Inflamm 6(4):247-250. Xia Y, Vetvicka V, Yan J, Hanikyrova M, Mayadas T, Ross GD. 1999. The beta-glucan- binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. J Immunol 162(4):2281-2290. Yanaki T, Itoh W, Tabata K. 1986. Correlation between the Antitumor-Activity of Schizophyllan and Its Triple Helix. Agric Biol Chem 50(9):2415-2416. Zou X. 2006. Fed-batch fermentation for hyperproduction of polysaccharide and ergosterol by medicinal mushroom Agaricus brasiliensis. Process Biochem 41(4):970-974. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/28821 | - |
dc.description.abstract | 巴西洋菇(Agaricus blazei Murill)是一種食藥兼用的菌菇,其子實體與菌絲發酵物之多醣區分已被證實具有免疫調節和抗腫瘤之生理活性。本研究目的在針對巴西洋菇菌絲發酵物中之水溶性多醣進行劃分純化,單離出具代表性之活性多醣,並對其特性做探討。結果顯示,巴西洋菇菌絲發酵物之水溶性粗多醣依電荷的差異,以陰離子交換樹脂(DEAE)劃分為五種區分,包括中性多醣(CP-FⅠ)、低蛋白含量多醣(CP-FⅡ)與高蛋白含量酸性多醣(CP-FⅢ),及多醣蛋白複合體(CP-FⅣ,CP-FⅤ),其中CP-FⅢ、CP-FⅣ和CP-FⅤ區分具有顯著刺激小鼠巨噬細胞株RAW 264.7產生TNF-α之活性。若以蛋白分解酵素和trichloroacetic acid (TCA) 處理水溶性粗多醣,則粗多醣中分別有63.5% 和88.5% 蛋白質會被除去,但CP-FⅢ、FⅣ 和FⅤ之蛋白質仍無法完全去除。活性區分CP-FⅢ之單糖組成以甘露糖和半乳糖為主,並含有葡萄糖、阿拉伯糖和岩藻糖以及另外含3.5% 醛醣酸與3.1%蛋白質;分子量398.8 kDa,分子量分散度為3.6,因此依據分子量分成CP-FⅢ-A (442.1 kDa)、CP-FⅢ-B (154 kDa) 和CP-FⅢ-C (27.4 kDa) 三區分,CP-FⅢ-A區分糖組成以半乳糖、阿拉伯糖和甘露糖為主,並且含有顯著的活性特徵糖岩藻糖7%;CP-FⅢ-B區分以甘露糖、半乳糖和阿拉伯糖為主;CP-FⅢ-C區分以甘露糖、半乳糖和葡萄糖為主。因此由以上結果推論,巴西洋菇發酵產物中具免疫活性之多醣為一具有顯著岩藻糖之特徵與兩種多醣蛋白複合體。 | zh_TW |
dc.description.abstract | Agaricus blazei Murill, is an edible and medicinal mushroom. Literatures have shown that polysaccharides isolated from A. blazei contributed its immunomodulating and antitumor activities. In this thesis, the features of active polysaccharides from A. blazei mycelia fermentation products were studied. Using DEAE-Toyopearl 650M, we separated water-soluble crude polysaccharides from A. blazei Murill mycelia fermentation products into five fractions: neutral polysaccharides (CP-FI), low protein containing polysaccharides (CP-FⅡ), rich protein containing acid polysaccharides (CP-FⅢ), and two polysaccharide-protein complexes (CP-FⅣ and CP-FV). In vitro study, three fractions (CP-FⅢ, CP-FIV, and CP-FV) can significantly stimulate mouse macrophage RAW 264.7 to release TNF-a. The chemical characteristics of CP-FIII were as follows: monosaccharide composition, mannose: glucose: galatose: arabinose: fucose (45:10:30:12:3); uronic acid content, 3.5%; protein content, 3.1%; weight-average molecular weight (Mw), 398.8 kDa; polydispersity, 3.6. According to their molecular weight, FIII was further divided into three fractions: CP-FⅢ-A (442.1 kDa), CP-FⅢ-B (154 kDa) and CP-FⅢ-C (27.4 kDa). Fraction CP-FⅢ-A mainly consisted of galactose, arabinose, mannose and fucose; fraction CP-FⅢ-B mainly consisted of mannose, galactose and arabinose: fraction CP-FⅢ-C mainly consisted of mannose, glucose and galactose. The results indicated that the polysaccharides had bioactivity of TNF-a stimulation on RAW 264.7, a rodent macrophage cell line, were a fucose containing polysaccharide with high molecular weight, and two other protein-glycan complexes. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T00:24:24Z (GMT). No. of bitstreams: 1 ntu-96-R94641027-1.pdf: 1107095 bytes, checksum: f2e6260b84eb87c6e2c06d0a6dc4519f (MD5) Previous issue date: 2007 | en |
dc.description.tableofcontents | 總目錄
中文摘要 I 英文摘要 II 總目錄 III 圖目錄 VI 表目錄 VII 壹、前言 1 貳、文獻整理 1 ㄧ、巴西洋菇 1 (一)巴西洋菇的分類與型態特徵 1 (二)巴西洋菇的化學組成 2 (三)巴西洋菇的生理活性 2 1.抗腫瘤作用 7 2.免疫調節作用 8 3.抗氧化 9 4.其他 10 (四)巴西洋菇活性多醣之化學特性 10 1.( 1,4 ; 1,6 )-α-D-glucan 14 2.( 1,3 ; 1,6 )–β-D-glucans 14 3.Glucomannan 16 4.醣-蛋白質複合物 16 5.其他活性物質與特性 17 (五)利用離子交換層析分離巴西洋菇多醣與蛋白質 17 1.離子交換原理與膠體種類 17 2.離子交換層析之影響因子與應用 18 (六)巴西洋菇的生產方式 19 1.栽培方式簡介 19 2.豆科發酵基質-黑豆的簡介 20 二、菇類多醣之免疫調節活性及影響因子 21 (一)多醣之免疫調節活性 21 (二)影響多醣活性因子 23 1、骨幹結構 23 2、分子量 24 3、分支度 25 4、構形 26 5、化學修飾 26 參、 材料與方法 28 ㄧ、實驗流程 28 二、實驗材料 29 三、實驗藥品與試劑 29 (一)化學試劑 29 (二)標準品 29 (三)酵素 30 四、樣品製備方式 30 (一)熱水萃取液樣品的製備 30 (二)粗多醣樣品的製備 30 (三)粗多糖經蛋白質酵素水解處理樣品 30 (四)粗多醣經TCA (trichloroacetic acid) 去除蛋白質處理樣品 31 (五)陰離子交換樹脂(DEAE-650M)區分多醣 31 (六)膠體過濾層析區分多醣 31 五、分析方法 32 (ㄧ)粗多醣收率分析 32 (二)醣含量測定 - Phenol-sulfuric acid assay 32 (三)蛋白質含量測定-Modified Bradford 33 (四)醛醣酸urobic acid含量測定-(m-hydroxydiphenyl method) 33 (五)單醣組成測定 33 (六)分子量測定 34 六、TNF一以刺激活性試驗34 肆、結果與討論36 一、分離純化巴西洋聽菌絲發酵產物之水溶性多醣36 (一)巴西洋聽發酵產物萃出多醣產率與組成36 (二)粗多醣經蛋白質酵素與三氣醋酸(TCA)作用其組成變化37(三)CP、CP一P和CP一TCA以陰離子交換樹脂區分39 二、多醣對RAW2647巨噬細胞株分泌TNF一a的影響45 三、多醣區分與其組成特性47 (一)多醣之糖組成47 (二)多醣之分子量分佈49 (三)活性多醣(CP一Flll)之分子量與糖組成52 伍、結論56 陸、參考文獻57 染、附錄68 附表一、各種聽類對具有sarcoma180肉瘤天竺鼠的抗腫瘤測試結果68 附圖一、巴西洋聽菌絲發酵物粗多醣及各區分(Fl?FV)刺激小鼠巨噬細胞RAW 2647分泌TNF一a之效果69 | |
dc.language.iso | zh-TW | |
dc.title | 巴西洋菇菌絲水溶性多醣之劃分與理化特性 | zh_TW |
dc.title | Fractionation and characterization of water-soluble polysaccharides from Agaricus blazei Murill mycelia | en |
dc.type | Thesis | |
dc.date.schoolyear | 95-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 盧訓,張永和,徐敬衡,邵貽沅 | |
dc.subject.keyword | 巴西洋菇,多醣,多醣蛋白複合體,免疫調節,菌絲發酵物, | zh_TW |
dc.subject.keyword | Agaricus blazei Murill,polysaccharides,polysaccharides-protein complex,immunomodulating,mycelia fermentation products, | en |
dc.relation.page | 69 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2007-07-27 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-96-1.pdf 目前未授權公開取用 | 1.08 MB | Adobe PDF |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。