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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 陳家揚(Chia-Yang Chen) | |
dc.contributor.author | Ze-Ying Chen | en |
dc.contributor.author | 陳則穎 | zh_TW |
dc.date.accessioned | 2021-05-13T06:49:18Z | - |
dc.date.available | 2019-08-23 | |
dc.date.available | 2021-05-13T06:49:18Z | - |
dc.date.copyright | 2017-08-23 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-08-17 | |
dc.identifier.citation | 1. Y.C. Chang, W.L. Chen, F.Y. Bai, P.C. Chen, G.S. Wang, and C.Y. Chen, Determination of perfluorinated chemicals in food and drinking water using high-flow solid-phase extraction and ultra-high performance liquid chromatography/tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2012. 402(3): p. 1315-1325.
2. R. Loos, G. Locoro, T. Huber, J. Wollgast, E.H. Christoph, A. de Jager, B. Manfred Gawlik, G. Hanke, G. Umlauf, and J.M. Zaldivar, Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy. Chemosphere, 2008. 71(2): p. 306-313. 3. Y.Y. Pan, Y.L. Shi, and Y.Q. Cai, Determination of perfluorinated compounds in human blood samples by high performance liquid chromatography-electrospray tandem mass spectrometry. Fenxi Huaxue/ Chinese Journal of Analytical Chemistry, 2008. 36(10): p. 1321-1326. 4. M. Zhang, F.L. Tang, Y.Y. Yu, J.F. Xu, H. Li, M.H. Wu, W. Zhang, and J.Y. Pan, Residue concentration and distribution characteristics of perfluorinated compounds in surface water from Qiantang River in Hangzhou section. Huanjing Kexue/Environmental Science, 2015. 36(12): p. 4471-4478. 5. J.S. Boone, B. Guan, C. Vigo, T. Boone, C. Byrne, and J. Ferrario, A method for the analysis of perfluorinated compounds in environmental and drinking waters and the determination of their lowest concentration minimal reporting levels. Journal of Chromatography A, 2014. 1345: p. 68-77. 6. C. Lau, J.L. Butenhoff, and J.M. Rogers, The developmental toxicity of perfluoroalkyl acids and their derivatives. Toxicology and Applied Pharmacology, 2004. 198(2): p. 231-241. 7. S.T. Wolf and W.K. Reagen, Method for the determination of perfluorinated compounds (PFCs) in water by solid-phase extraction and liquid chromatography/tandem mass spectrometry (LC/MS/MS). Analytical Methods, 2011. 3(7): p. 1485. 8. V. Cruciani, C. Iovine, J.P. Thome, and C. Joaquim-Justo, Impact of three phthalate esters on the sexual reproduction of the Monogonont rotifer, Brachionus calyciflorus. Ecotoxicology, 2016. 25(1): p. 192-200. 9. K.M. Gani and A.A. Kazmi, Phthalate contamination in aquatic environment: A critical review of the process factors that influence their removal in conventional and advanced wastewater treatment. Critical Reviews in Environmental Science and Technology, 2016. 46(17): p. 1402-1439. 10. D.W. Gao and Z.D. Wen, Phthalate esters in the environment: A critical review of their occurrence, biodegradation, and removal during wastewater treatment processes. Science of the Total Environment, 2016. 541: p. 986-1001. 11. W. Li and J. Duan, Detection ofphthalates in water using ultra performance liquid chromatography-electrospray ionizationtandem mass spectrometry MRM mode– ‘ghost peaks’ and measurement methodology. Analytical Methods, 2011. 3(2): p. 314-321. 12. Z.P. Lin, M.G. Ikonomou, H. Jing, C. Mackintosh, and F.A.P.C. Gobas, Determination of phthalate ester congeners and mixtures by LC/ESI-MS in sediments and biota of an urbanized marine inlet. Environmental Science and Technology, 2003. 37(10): p. 2100-2108. 13. L. Wang, X. Gao, J. Guo, and P. Ye. Determination of four phthalate esters in surface water by solid-phase extraction and simplified mobile phase HPLC. in 5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011. 2011. 14. W.L. Wang, Q.Y. Wu, C. Wang, T. He, and H.Y. Hu, Health risk assessment of phthalate esters (PAEs) in drinking water sources of China. Environmental Science and Pollution Research, 2015. 22(5): p. 3620-3630. 15. X. Wang, X. Lou, N. Zhang, G. Ding, Z. Chen, P. Xu, L. Wu, J. Cai, J. Han, and X. Qiu, Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks. Environmental Toxicology and Chemistry, 2015. 34(10): p. 2205-2212. 16. R. Yang, Y. Liu, X. Yan, and S. Liu, Simultaneous extraction and determination of phthalate esters in aqueous solution by yolk-shell magnetic mesoporous carbon-molecularly imprinted composites based on solid-phase extraction coupled with gas chromatography-mass spectrometry. Talanta, 2016. 161: p. 114-121. 17. R.Z. Zhou, J. Jiang, T. Mao, Y.S. Zhao, and Y. Lu, Multiresidue analysis of environmental pollutants in edible vegetable oils by gas chromatography-tandem mass spectrometry. Food Chemistry, 2016. 207: p. 43-50. 18. W.L. Chen, J.C. Gwo, G.S. Wang, and C.Y. Chen, Distribution of feminizing compounds in the aquatic environment and bioaccumulation in wild tilapia tissues. Environmental Science and Pollution Research International, 2014. 21(19): p. 11349-11360. 19. R. Jeannot, H. Sabik, E. Sauvard, T. Dagnac, and K. Dohrendorf, Determination of endocrine-disrupting compounds in environmental samples using gas and liquid chromatography with mass spectrometry. Journal of Chromatography A, 2002. 974(1-2): p. 143-159. 20. X. Jing, S. Bing, W. Xiaoyan, S. Xiaojie, and W. Yongning, A study on bisphenol A, nonylphenol, and octylphenol in human urine amples detected by SPE-UPLC-MS. Biomedical and Environmental Sciences, 2011. 24(1): p. 40-46. 21. N. Salgueiro-González, M.J. López de Alda, S. Muniategui-Lorenzo, D. Prada-Rodríguez, and D. Barceló, Analysis and occurrence of endocrine-disrupting chemicals in airborne particles. TrAC - Trends in Analytical Chemistry, 2015. 66: p. 45-52. 22. H.W. Chen, C.H. Liang, Z.M. Wu, E.E. Chang, T.F. Lin, P.C. Chiang, and G.S. Wang, Occurrence and assessment of treatment efficiency of nonylphenol, octylphenol and bisphenol-A in drinking water in Taiwan. Science of the Total Environment, 2013. 449: p. 20-28. 23. P.A. Lara-Martin, E. Gonzalez-Mazo, and B.J. Brownawell, Environmental analysis of alcohol ethoxylates and nonylphenol ethoxylate metabolites by ultra-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 2012. 402(7): p. 2359-2368. 24. A.G. Asimakopoulos and N.S. Thomaidis, Bisphenol A, 4-t-octylphenol, and 4-nonylphenol determination in serum by Hybrid Solid Phase Extraction-Precipitation Technology technique tailored to liquid chromatography-tandem mass spectrometry. Journal of Chromatography. B: Analytical Technologies in the Biomedical and Life Sciences, 2015. 986-987: p. 85-93. 25. W.L. Chen, G.S. Wang, J.C. Gwo, and C.Y. Chen, Ultra-high performance liquid chromatography/tandem mass spectrometry determination of feminizing chemicals in river water, sediment and tissue pretreated using disk-type solid-phase extraction and matrix solid-phase dispersion. Talanta, 2012. 89: p. 237-245. 26. X. Hu, X. Wu, F. Yang, Q. Wang, C. He, and S. Liu, Novel surface dummy molecularly imprinted silica as sorbent for solid-phase extraction of bisphenol A from water samples. Talanta, 2016. 148: p. 29-36. 27. Y. Sun, M. Wada, N. Kuroda, K. Hirayama, H. Nakazawa, and K. Nakashima, Simultaneous Determination of Phenolic Xenoestrogens by Solid-Phase Extraction and High-Performance Liquid Chromatography with Fluorescence Detection. Analytical Sciences, 2001. 17(6): p. 697-702. 28. Y.Y. Gou, S. Lin, D.E. Que, L.L. Tayo, D.Y. Lin, K.C. Chen, F.A. Chen, P.C. Chiang, G.S. Wang, Y.C. Hsu, K.P. Chuang, C.Y. Chuang, T.C. Tsou, and H.R. Chao, Estrogenic effects in the influents and effluents of the drinking water treatment plants. Environmental Science and Pollution Research International, 2016. 29. A.F. Toro-Velez, C.A. Madera-Parra, M.R. Pena-Varon, W.Y. Lee, J.C. Bezares-Cruz, W.S. Walker, H. Cardenas-Henao, S. Quesada-Calderon, H. Garcia-Hernandez, and P.N. Lens, BPA and NP removal from municipal wastewater by tropical horizontal subsurface constructed wetlands. Science of the Total Environment, 2016. 542(Pt A): p. 93-101. 30. X. Yang, H. Zhang, Y. Liu, J. Wang, Y.C. Zhang, A.J. Dong, H.T. Zhao, C.H. Sun, and J. Cui, Multiresidue method for determination of 88 pesticides in berry fruits using solid-phase extraction and gas chromatography-mass spectrometry: Determination of 88 pesticides in berries using SPE and GC-MS. Food Chemistry, 2011. 127(2): p. 855-865. 31. A. Azzouz and E. Ballesteros, Trace analysis of endocrine disrupting compounds in environmental water samples by use of solid-phase extraction and gas chromatography with mass spectrometry detection. Journal of Chromatography A, 2014. 1360: p. 248-257. 32. W.R. Barrionuevo and F.M. Lancas, Comparison of liquid-liquid extraction (LLE), solid-phase extraction (SPE), and solid-phase microextraction (SPME) for pyrethroid pesticides analysis from enriched river water. Bulletin of Environmental Contamination and Toxicology, 2002. 69(1): p. 123-128. 33. R.C. Duca, G. Salquebre, E. Hardy, and B.M. Appenzeller, Comparison of solid phase- and liquid/liquid-extraction for the purification of hair extract prior to multi-class pesticides analysis. Journal of Chromatography. B: Analytical Technologies in the Biomedical and Life Sciences, 2014. 955-956: p. 98-107. 34. M. Pelajic, G. Pecek, D. Mutavdzic Pavlovic, and D. Vitali Cepo, Novel multiresidue method for determination of pesticides in red wine using gas chromatography-mass spectrometry and solid phase extraction. Food Chemistry, 2016. 200: p. 98-106. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/2761 | - |
dc.description.abstract | 全氟碳化合物、鄰苯二甲酸酯、壬基酚與雙酚A普遍存在於環境中,這些物質被廣泛的使用於日常消費性產品,如防水衣物塗料、油漆、塑膠產品、清潔劑及食品容器。許多研究指出,這些物質具有肝毒性、發展毒性與生殖毒性。除此之外,這些物質也都屬於內分泌干擾物質,具有影響人體賀爾蒙系統的性質。此四類物質主要藉由水在環境中傳播,因此就有需要監測此四類物質於環境水體中的濃度。本研究將探討10種全氟碳化合物 (PFBA, PFPeA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFHxS, and PFOS)、6種鄰苯二甲酸酯 (DEP, BBP, DEHP, DNOP, DINP and DIDP)、壬基酚、雙酚A於水中的濃度。此研究將以極致液相層析搭配串聯式質譜儀進行分析,並以固相萃取做為樣本前處理方法。水樣在分析前會先以30 μL 88%甲酸酸化至pH 3。固相萃取吸附劑在操作前依序以5 mL異丙醇、甲醇及Milli-Q水進行活化,以5 mL/min通過100 mL水樣後,以0.6 mL 10%甲醇/90% Milli-Q水清洗吸附劑兩次,之後氮氣吹淨45秒。最後依序使用2 mL甲醇、2 mL異丙醇,以流速1 mL/min各沖提兩次,並全部收集。萃取溶液濃縮至1.0 mL後以0.22 μm尼龍過濾器過濾,並再次濃縮至近乾,最後以100 μL甲醇回溶並上機分析。實驗結果顯示,6種鄰苯二甲酸酯的基質效應介於88%到116%之間。全氟碳化物方面,PFBA, PFNA, PFDA, PFUnDA, PFDoDA的基質效應介於77%到85%之間,PFPeA, PFHxA, PFOA, PFHxS, PFOS的基質效應分別為64%、33%、55%、60%、10%。壬基酚與雙酚A的基質效應則為79%與93%。 | zh_TW |
dc.description.abstract | Perfluoroalkyl substances (PFASs), phthalate esters (PAEs), nonylphenol (NP), and bisphenol A (BPA) are ubiquitous in the environment. These chemicals are widely used in consumer products, such as protective coatings for textiles, paint, plastic products, detergents, and food containers. Many studies show that these compounds have hepatotoxicity, reproductive toxicity, and developmental toxicity, and they are endocrine-disrupting compounds, which means they can alter the function of our hormone system. Water is the primary way for these chemicals to spread in the environment. Thus, it is necessary to monitor these compounds in the water. This study will determine 10 PFASs (PFBA, PFPeA, PFHxA, PFOA, PFNA, PFDA, PFUnDA, PFDoDA, PFHxS, and PFOS), 6 PAEs (DEP, BBP, DEHP, DNOP, DINP, and DIDP), nonylphenol, and bisphenol A in river water with ultra-high performance liquid chromatography/tandem mass spectrometry. Solid-phase extraction (SPE) with HLB cartridges will be chosen as sample preparation method. Water samples were acidified to pH 3 by adding 30 μL of 88% formic acid before SPE. In SPE procedures, the cartridgess were conditioned with 5 mL of isopropyl alcohol, 5 mL of methanol and 5 mL Milli-Q water sequentially. After loading 100 mL water samples at the flow rate of 5 mL/min, the cartridges were washed with 0.6 mL of MeOH/Milli-Q water (1:9, v/v) twice, then dried with nitrogen gas (N2) for 45 seconds. Elution was conducted by 2 mL of methanol followed by 2 mL of isopropyl alcohol, each solvent eluted at flow rate of 1 mL/min twice, and was collected together. The extracts were concentrated to 1.0 mL, and were filtrated through 0.22 μm nylon filters. The filtered extracts were concentrated to barely dried, and then were reconstituted with 100 μL of methanol prior to instrumental analysis. The results showed that the matrix effect factors of six PAEs were 88%-116%. In PFASs, the matrix effect factors of PFBA, PFNA, PFDA, PFUnDA and PFDoDA were 77%-85%, and PFPeA, PFHxA, PFOA, PFHxS and PFOS were 64%, 33%, 55%, 60% and 10%, respectively. Matrix effects of nonylphenol and BPA were 79% and 93%, respectively. | en |
dc.description.provenance | Made available in DSpace on 2021-05-13T06:49:18Z (GMT). No. of bitstreams: 1 ntu-106-R04844007-1.pdf: 1287300 bytes, checksum: 69ea6c923b550a46fadf8d7bbec85bb8 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 中文摘要 I
Abstract II Contents IV List of Figures VI List of Tables VII Chapter 1. Introduction 1 1.1 Perfluoroalkyl substances 1 1.2 Phthalate esters 2 1.3 Nonylphenol and bisphenol A 3 1.4 Analytical Methods 5 1.5 Objectives 5 Chapter 2. Methods 7 2.1 Standards and Reagents 7 2.2 Sample preparation 8 2.3 Instrumental analysis 9 2.4 Quality assurance and quality control 12 Chapter 3. Results and discussion 13 3.1 Optimization of solid-phase extraction 13 3.2 Identification and quantification 18 3.3 Matrix effect 19 Chapter 4. Conclusion 21 References 22 Figures 26 Tables 29 | |
dc.language.iso | en | |
dc.title | 以固相萃取搭配極致液相層析/串聯式質譜儀分析水中全氟碳化合物、鄰苯二甲酸酯、壬基酚與雙酚A | zh_TW |
dc.title | Determination of Perfluoroalkyl Substances, Phthalate Esters, Nonylphenol, and Bisphenol A in Water by Solid-Phase Extraction and UPLC-MS/MS | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 郭錦樺(Ching-Hua Kuo),陳鑫昌(Hsin-Chang Chen) | |
dc.subject.keyword | 全氟碳化物,鄰苯二甲酸酯,壬基酚,雙酚A,固相萃取,極致液相層析/串聯式質譜儀, | zh_TW |
dc.subject.keyword | Perfluoroalkyl substances,phthalate esters,nonylphenol,bisphenol A,solid-phase extraction,UPLC-MS/MS, | en |
dc.relation.page | 43 | |
dc.identifier.doi | 10.6342/NTU201703938 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2017-08-18 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 環境衛生研究所 | zh_TW |
顯示於系所單位: | 環境衛生研究所 |
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