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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 沈立言 | |
dc.contributor.author | Hsiang-Ling Huang | en |
dc.contributor.author | 黃湘玲 | zh_TW |
dc.date.accessioned | 2021-06-08T07:18:49Z | - |
dc.date.copyright | 2008-08-06 | |
dc.date.issued | 2008 | |
dc.date.submitted | 2008-07-24 | |
dc.identifier.citation | 行政院衛生署國民健康局。91年台灣地區國民健康促進知識、態度與行為調查。2008。
行政院衛生署民健康局。擺脫壓力、快樂過生活—認識憂鬱症。2008。 朱英龍。2005。解憂─憂鬱症百問。董氏基金會。台灣。 李明濱。1999。精神醫學新知。台灣醫學會。台北。 李文瑞、李秋貴。2000。金匱要略湯證論治。中國科學技術出版社。北京。p 831-836。 林金盾。2004。生理心理學─神經與行為。藝軒圖書出版社。台北。 柯存財。1996。甘麥大棗湯對於內源性憂鬱症動物模式療效之研究。中國醫學研究所博士論文。台中。 馬榮、姚海燕、庫寶善、錢瑞琴、藏孝廉、郭建功。2005。解鬱丸及其拆方對憂鬱模型小鼠的抗憂鬱作用差異比較。中國臨床康復。 夏翔、施杞。2006。中國食療大全。上海科學科技出版社。上海。 張琦、楊靜、劉雨星、劉友平、周奇志。2006。百地甘棗湯對憂鬱模型大鼠腦內神經遞質的影響。成都中醫藥大學學報。 陳正宗、賴德仁。2008。憂鬱症是可以治療的疾病、過早中斷治療容易復發。台灣憂鬱症防治協會。 曾文星、徐靜。1994。現代精神醫學。水牛出版社。台北。 黃隆正、李明濱。2003。憂鬱症與自殺。台灣醫學7(6): 929-934。 楊淑娥。1998。甘麥大棗湯對齧齒動物抗焦慮作用之研究。台灣台中。 蔡述信。2003。以台灣全民健保承保抽樣歸人檔案分析憂鬱症病患的醫療利用。中國醫藥學院醫務管理研究所。台中。 賴孟泉、林育茹。2005。梅約憂鬱症小百科。天下生活出版股份有限公司。台北。 裴美玲。2007。系統性文獻回顧與整合分析:催眠治療在「憂鬱症」與「憂鬱情緒」上之應用。南華大學自然醫學研究所。嘉義。 鄭漢臣。2003。中國食用本草•植物卷。上海辭書出版社。上海。 劉德麟、楊威。1995。從單胺類遞質看甘麥大棗湯治療婦人臟躁症的機理。中國中醫基礎醫學雜誌。1(2):55-56。 Anderson IM,Tomenson BM. 1995. Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis. BMJ 310(6992):1433-1438. Ashton AK. 2004. Reversal of fluoxetine-induced sexual dysfunction by switching to escitalopram. J Sex Marital Ther 30(1):1-2. Brambilla P, Cipriani A, Hotopf M,Barbui C. 2005. Side-effect profile of fluoxetine in comparison with other SSRIs, tricyclic and newer antidepressants: a meta-analysis of clinical trial data. Pharmacopsychiatry 38(2):69-77. Chan AL, Yang TC, Chen JX, Yu LH,Leung HW. 2006. Cost of depression of adults in Taiwan. Int J Psychiatry Med 36(1):131-135. Chen PJ, Hsieh CL, Su KP, Hou YC, Chiang HM, Lin IH,Sheen LY. 2008. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am J Chin Med 36(1):95-106. Cheng FC, Kuo JS, Shih Y, Lai JS, Ni DR,Chia LG. 1993. Simultaneous measurement of serotonin, catecholamines and their metabolites in mouse brain homogenates by high-performance liquid chromatography with a microbore column and dual electrochemical detection. J Chromatogr 615(2):225-236. Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H,Doerr HW. 2003. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 361(9374):2045-2046. Clayton AH, Zajecka J, Ferguson JM, Filipiak-Reisner JK, Brown MT,Schwartz GE. 2003. Lack of sexual dysfunction with the selective noradrenaline reuptake inhibitor reboxetine during treatment for major depressive disorder. Int Clin Psychopharmacol 18(3):151-156. Dhigra D,Sharma A. 2005. Evaluation of antidepressant-like activity of glycyrrhizin in mice. Indian J Pharmacol 37(6):390-394. Dhingra D,Sharma A. 2006. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Prog Neuropsychopharmacol Biol Psychiatry 30(3):449-454. Fernstrom JD. 1981. Dietary precursors and brain neurotransmitter formation. Annu Rev Med 32:413-425. Fernstrom JD,Wurtman RJ. 1972. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178(59):414-416. Fountoulakis KN, Samolis S, Iacovides A,St Kaprinis G. 2007. Ecchymoses as an adverse effect of fluoxetine treatment. Psychiatry Res 152(1):91-92. Glowinski J,Iversen LL. 1966. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 13(8):655-669. Halford JC, Harrold JA, Lawton CL,Blundell JE. 2005. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr Drug Targets 6(2):201-213. Heo HJ, Park YJ, Suh YM, Choi SJ, Kim MJ, Cho HY, Chang YJ, Hong B, Kim HK, Kim E, Kim CJ, Kim BG,Shin DH. 2003. Effects of oleamide on choline acetyltransferase and cognitive activities. Biosci Biotechnol Biochem 67(6):1284-1291. Huang SC, Tsai SJ,Chang JC. 2004. Fluoxetine-induced memory impairment in four family members. Int J Psychiatry Med 34(2):197-200. Huang X, Kojima-Yuasa A, Norikura T, Kennedy DO, Hasuma T,Matsui-Yuasa I. 2007. Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. Am J Chin Med 35(3):517-532. Huang YL, Yen GC, Sheu F,Chau CF. 2008. Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices. J Agric Food Chem 56(5):1734-1739. Inskip HM, Harris EC,Barraclough B. 1998. Lifetime risk of suicide for affective disorder, alcoholism and schizophrenia. Br J Psychiatry 172:35-37. James AN, Ryan JP,Parkman HP. 2005. Effects of the selective serotonin reuptake inhibitor, fluoxetine, on regional gastric contractility. Neurogastroenterol Motil 17(1):76-82. Jiang JG, Huang XJ, Chen J,Lin QS. 2007. Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Nat Prod Res 21(4):310-320. Kanazawa M, Satomi Y, Mizutani Y, Ukimura O, Kawauchi A, Sakai T, Baba M, Okuyama T, Nishino H,Miki T. 2003. Isoliquiritigenin inhibits the growth of prostate cancer. Eur Urol 43(5):580-586. Koch M. 2006. Animal model of depression. Animal models of neuropsychiatric diseases London: Imperial College Press. Lee SM, Min BS, Lee CG, Kim KS,Kho YH. 2003. Cytotoxic triterpenoids from the fruits of Zizyphus jujuba. Planta Med 69(11):1051-1054. Lee SM, Park JG, Lee YH, Lee CG, Min BS, Kim JH,Lee HK. 2004. Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. Biol Pharm Bull 27(11):1883-1886. Luper S. 1999. A review of plants used in the treatment of liver disease: part two. Altern Med Rev 4(3):178-188. Menegazzi M, Di Paola R, Mazzon E, Genovese T, Crisafulli C, Dal Bosco M, Zou Z, Suzuki H,Cuzzocrea S. 2008. Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice. Pharmacol Res. Meyers S. 2000. Use of neurotransmitter precursors for treatment of depression. Altern Med Rev 5(1):64-71. Mirsal H, Kalyoncu A,Pektas O. 2002. [Ecchymosis associated with the use of fluoxetine: case report]. Turk Psikiyatri Derg 13(4):320-324. Moon A,Kim SH. 1997. Effect of Glycyrrhiza glabra roots and glycyrrhizin on the glucuronidation in rats. Planta Med 63(2):115-119. Murray CJ,Lopez AD. 1997. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 349(9064):1498-1504. Park JH, Lee HJ, Koh SB, Ban JY,Seong YH. 2004. Protection of NMDA-induced neuronal cell damage by methanol extract of zizyphi spinosi semen in cultured rat cerebellar granule cells. J Ethnopharmacol 95(1):39-45. Parle M, Dhingra D,Kulkarni SK. 2004. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. J Med Food 7(4):462-466. Peng WH, Hsieh MT, Lee YS, Lin YC,Liao J. 2000. Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety. J Ethnopharmacol 72(3):435-441. Porsolt RD, Anton G, Blavet N,Jalfre M. 1978. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 47(4):379-391. Porsolt RD, Bertin A,Jalfre M. 1977a. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther 229(2):327-336. Porsolt RD, Le Pichon M,Jalfre M. 1977b. Depression: a new animal model sensitive to antidepressant treatments. Nature 266(5604):730-732. Rackova L, Jancinova V, Petrikova M, Drabikova K, Nosal R, Stefek M, Kostalova D, Pronayova N,Kovacova M. 2007. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. Nat Prod Res 21(14):1234-1241. Seligman ME,Beagley G. 1975. Learned helplessness in the rat. J Comp Physiol Psychol 88(2):534-541. Shin YW, Bae EA, Lee B, Lee SH, Kim JA, Kim YS,Kim DH. 2007. In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. Planta Med 73(3):257-261. Shishkina GT, Dygalo NN, Yudina AM, Kalinina TS, Tolstikova TG, Sorokina IV, Kovalenko IL,Anikina LV. 2006. The effects of fluoxetine and its complexes with glycerrhizic acid on behavior in rats and brain monoamine levels. Neurosci Behav Physiol 36(4):329-333. Shou C, Feng Z, Wang J,Zheng X. 2002. The inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitro. Planta Med 68(9):799-803. Shou CH, Wang J, Zheng XX,Guo DW. 2001. Inhibitory effect of jujuboside A on penicillin sodium induced hyperactivity in rat hippocampal CA1 area in vitro. Acta Pharmacol Sin 22(11):986-990. Sommi RW, Crismon ML,Bowden CL. 1987. Fluoxetine: a serotonin-specific, second-generation antidepressant. Pharmacotherapy 7(1):1-15. Takei M, Kobayashi M, Li XD, Pollard RB,Suzuki F. 2005. Glycyrrhizin inhibits R5 HIV replication in peripheral blood monocytes treated with 1-methyladenosine. Pathobiology 72(3):117-123. Terra JL. 2008. [Suicide risk and depression]. Rev Prat 58(4):385-388. Thase ME. 2005. Mood disorders: neurobiology. In: Sadock, B. J.,Sadock, V. A., editors. Comprehensive textbook of psychiarty (8th ed.). Philadelphia: Lippincott Williams & Wikins. p. 1559-1717. Wang W,Chen WW. 1991. [Antioxidative activity studies on the meaning of same original of herbal drug and food]. Zhong Xi Yi Jie He Za Zhi 11(3):159-161, 134. Wasserman D. 2006. Depression: the facts. New York: Oxford university press. Wojcikowski K, Stevenson L, Leach D, Wohlmuth H,Gobe G. 2007. Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process. J Altern Complement Med 13(1):103-109. Yu XQ, Xue CC, Zhou ZW, Li CG, Du YM, Liang J,Zhou SF. 2008. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 82(1-2):68-78. Zhan C,Yang J. 2006. Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. Pharmacol Res 53(3):303-309. Zhang M, Ning G, Shou C, Lu Y, Hong D,Zheng X. 2003. Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med 69(8):692-695. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/26642 | - |
dc.description.abstract | 憂鬱症於全球之罹患率約為10%,但目前臨床之治療方法卻易造成副作用,如體重下降、食慾不振等。因此尋求副作用較少的替代性療法具有極大的意義。甘麥大棗湯由甘草 (Glycyrrhiza uralensis Fisch.) 、小麥 (Triticum aestivum L.) 及大棗 (Zizyphus jujuba Mill.) 所組成,具有和中緩急,補中益氣之能,有助於養心安神、亦補脾氣,在中醫上被用於治療臟躁,而臟躁之臨床病症與憂鬱症頗為相似。強迫游泳試驗 (forced swim test) 為利用常見用於評估臨床抗憂鬱劑之動物模式,因此本研究欲以此模式來探討甘麥大棗湯及其單方組成材料之抗憂鬱效果。實驗採用八週齡Nerl: Wistar公鼠隨機分為六組,分別為C組 (dd H2O 10 mL/kg bw) 、L組 (甘草萃取物0.4 g/kg bw) ,W組 (小麥萃取物1.6 g/kg bw) 、J組 (大棗萃取物0.5 g/kg bw) 、LWJ (甘麥大棗湯萃取物2.5 g/kg bw,甘草、小麥及大棗比例為5:20:6) 以及P組 (百憂解Prozac 18 mg/kg bw) ,在胃管灌注21天樣品後,進行強迫游泳試驗,試驗完成後立即犧牲,取其腦部分析單胺類化合物 (monoamine) 之含量。實驗結果顯示,P組大鼠體重及食慾明顯降低 (p<0.05) ,而其餘組別與控制組相比皆無顯著性之差異。給予LWJ及百憂解顯著降低(p<0.05)大鼠在強迫游泳試驗中之不活動時間,而其他單方組別與控制組相較之下無明顯差異。在5-hydroxytrypatamine (5-HT) 方面,LWJ組及P組可以顯著增加 (p<0.05) 大鼠腦部皮質前區之5-HT含量;而在皮質前區與杏仁核中的5-hydroxyindoleacetic acid (5-HIAA) 與控制組相比無顯著差異。LWJ組及P組可顯著提升紋狀體中dopamine (DA) 之含量,並可降低3,4-dihydroxyphenylacetic acid (DOPAC) 及DOPAC/DA的代謝率。綜合以上結果顯示,甘麥大棗湯對強迫游泳試驗所誘導的憂鬱症具有改善之效果,並且不會有體重下降及食慾減低之副作用。 | zh_TW |
dc.description.abstract | Depression is a kind of psychiatric disorders that affects more than 10% of the general population. The clinical treatments used nowadays always cause several side-effects such as losing body weight and reducing appetite. Therefore, we expect to look for the alternative treatment simultaneous with antidepressant effect and less side-effect. Gan-Mai-Dazao-Tang is a traditional decoction used to treat depression and anxiety. The ingredients of Gan-Mai-Dazao-Tang include Glycyrrhiza uralensis Fisch. (licorice), Triticum aestivum L. (wheat) and Zizyphus jujuba Mill. (jujube). It can nourish the heart, tranquilize the mind, invigorate the spleen and replenish qi (氣) in the traditional Chinese medicine. The objective of this study is to investigate the antidepressant effects of Gan-Mai-Dazao-Tang and its ingredients in rats on the forced-swim test (FST) – an animal model for predicting the clinical efficacy of antidepressants. Eight-week-old male Nerl: Wistar rats were randomized to C (10 mL/kg bw dd H2O), L (0.4 g/kg bw licorice extract), W (1.6 g/kg bw wheat extract), J (0.5 g/kg bw jujube extract), LWJ [2.5 g/kg bw of complex extract (licorice: wheat: jujube = 5:20:6)] and P (18 mg/kg bw Prozac) groups. Samples were administered by gavage for 21 days. After FST, the animals were sacrificed and their brains were collected for monoamines analysis. The results have shown that the body weight and the appetite of rats were significantly lowered in P group (p<0.05), while the other groups were not significantly different with each other. The immobility time in FST was significantly decreased in LWJ and P group compared with control (p<0.05), but the ingredients of Gan-Mai-Dazao-Tang showed no significantly antidepressant effect in FST. The concentration of serotonin (5-HT) in frontal cortex were significantly higher in LWJ and P group compared with control (p<0.05), although 5-hydroxyindoleacetic acid in frontal cortex and amygdale were not significantly different between LWJ and the control group. However, administration of LWJ and P significantly increased the dopamine (DA) concentration (p<0.05) and decreased the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) (p<0.05) and DOPAC/DA turnover (p<0.05) in striatum compared to the control. The results indicate that Gan-Mai-Dazao-Tang may have the potential antidepressant effect and less side-effect in rats. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T07:18:49Z (GMT). No. of bitstreams: 1 ntu-97-R95641003-1.pdf: 966728 bytes, checksum: e0e05c9981662ce995fa1b03e40b5369 (MD5) Previous issue date: 2008 | en |
dc.description.tableofcontents | 中文摘要 I
英文摘要 II 目錄 IV 圖次 VI 表次 VII 第一章、前言 1 第二章、憂鬱症 3 第一節、憂鬱症之介紹 3 第二節、憂鬱症的重要性 4 第三節、憂鬱症之成因 7 第四節、神經傳導 8 第五節、單胺類神經傳導物質 9 第六節、憂鬱症之治療 11 第七節、憂鬱症之動物模式 14 第三章、本實驗之實驗材料介紹 21 第一節、甘麥大棗湯 (Gan-Mai-Dazao-Tang) 21 第二節、甘草 (Glycyrrhiza uralensis Fisch.) 25 第三節、小麥 (Triticum aestivum L.) 31 第四節、大棗 (Zizyphus jujuba Mill.) 33 第四章、實驗架構 38 第一節、樣品萃取 38 第二節、動物實驗 39 第五章、材料與方法 39 第一節、實驗材料 39 第二節、實驗方法 44 第六章、實驗結果 48 第七章、結果與討論 51 第八章、結論 65 第九章、參考文獻 66 附錄 74 | |
dc.language.iso | zh-TW | |
dc.title | 甘麥大棗湯及其材料於抗憂鬱效果之探討 | zh_TW |
dc.title | Antidepressant effect of Gan-Mai-Dazao-Tang and its ingredients | en |
dc.type | Thesis | |
dc.date.schoolyear | 96-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 侯鈺琪,謝慶良,江文章 | |
dc.subject.keyword | 甘麥大棗湯,強迫游泳試驗,抗憂鬱,單胺化合物,單胺類代謝物, | zh_TW |
dc.subject.keyword | Gan-Mai-Dazao-Tang,antidepressant effect,forced swim test,monoamines,monoamine metabolite, | en |
dc.relation.page | 93 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2008-07-27 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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