微型化流體控制系統中進行金奈米合成

Abstract

本研究最終目標為製造一個具有可攜帶式快速檢測功能之平台。平台採用微流體晶片，且具有合成檢測物質金奈米粒子、檢測過程與呈色顯示檢測結果之功能。本論文將以第一部分合成檢測物質金奈米粒子為主。利用微流體系統控制奈米材料製作時溶液的混合過程，達到控制奈米材料形狀。金奈米顆粒以還原法製作時，將會經過成核、成長與穩定三個階段。利用微流體系統控制各階段的溶液混合效果，達到均勻的混合與反應，得到穩定且快速製造金奈米顆粒。以傳統批次系統製造金奈米粒子，其混合效果依靠溶液分子的擴散，具有高分散性結果且反應時間較長。本研究利用微流體系統進行合成，控制反應溶液的流量以得到13至200奈米的金奈米粒子，並僅需數秒鐘即可完成反應。微流體晶片使用熱塑性塑膠Cyclic olefin polymers (COP)製成，微流道表面將呈現疏水性與帶負電的狀態，避免金奈米顆粒的附著。微流體晶片內部擁有微型混合器控制溶液的混合過程，增加其反應速率。

The use of microfluidic systems to control the synthesis of nanomaterials when the reaction reagents are mixed to achieve control of the nanomaterial size and morphology. Among those synthetic approaches, gold nanoparticles produced by the reduction method in solutions is through the nucleation, growth and stability of the three stages. The use of microfluidic system to control the various stages of the solution mixing effect can result in uniform mixing and reaction for stable and repeatable manufacture of gold nanoparticles. The traditional batch system for the gold nanoparticles synthesis, the mixing effect only depends on the diffusion of the solution molecules, so the dispersibility and reaction time can be issues. In this study, the microfluidic system was used to synthesize and control the flow of the reaction solution to obtain gold nanoparticles diameter ranging from 13 to 200 nanometers and the reaction was completed in just a few minutes. The microfluidic chap is made of thermoplastic elastomer Cyclic olefin polymers (COP), and the surface of the microchannel will exhibit hydrophobic and electronegativity charged conditions to avoid attachment of gold nanoparticles. In addition, micromixers are embedded to boost the reaction rate of the gold nanoparticles synthesis.