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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張建成 | |
| dc.contributor.author | Sung Chen | en |
| dc.contributor.author | 陳松 | zh_TW |
| dc.date.accessioned | 2021-05-13T06:42:34Z | - |
| dc.date.available | 2021-01-04 | |
| dc.date.available | 2021-05-13T06:42:34Z | - |
| dc.date.copyright | 2018-01-04 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-10-16 | |
| dc.identifier.citation | 1. Azzazy, H.M. and M.M. Mansour, In vitro diagnostic prospects of nanoparticles. Clin Chim Acta, 2009. 403(1-2): p. 1-8.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/2586 | - |
| dc.description.abstract | 本研究最終目標為製造一個具有可攜帶式快速檢測功能之平台。平台採用微流體晶片，且具有合成檢測物質金奈米粒子、檢測過程與呈色顯示檢測結果之功能。本論文將以第一部分合成檢測物質金奈米粒子為主。利用微流體系統控制奈米材料製作時溶液的混合過程，達到控制奈米材料形狀。金奈米顆粒以還原法製作時，將會經過成核、成長與穩定三個階段。利用微流體系統控制各階段的溶液混合效果，達到均勻的混合與反應，得到穩定且快速製造金奈米顆粒。以傳統批次系統製造金奈米粒子，其混合效果依靠溶液分子的擴散，具有高分散性結果且反應時間較長。本研究利用微流體系統進行合成，控制反應溶液的流量以得到13至200奈米的金奈米粒子，並僅需數秒鐘即可完成反應。微流體晶片使用熱塑性塑膠Cyclic olefin polymers (COP)製成，微流道表面將呈現疏水性與帶負電的狀態，避免金奈米顆粒的附著。微流體晶片內部擁有微型混合器控制溶液的混合過程，增加其反應速率。 | zh_TW |
| dc.description.abstract | The use of microfluidic systems to control the synthesis of nanomaterials when the reaction reagents are mixed to achieve control of the nanomaterial size and morphology. Among those synthetic approaches, gold nanoparticles produced by the reduction method in solutions is through the nucleation, growth and stability of the three stages. The use of microfluidic system to control the various stages of the solution mixing effect can result in uniform mixing and reaction for stable and repeatable manufacture of gold nanoparticles. The traditional batch system for the gold nanoparticles synthesis, the mixing effect only depends on the diffusion of the solution molecules, so the dispersibility and reaction time can be issues. In this study, the microfluidic system was used to synthesize and control the flow of the reaction solution to obtain gold nanoparticles diameter ranging from 13 to 200 nanometers and the reaction was completed in just a few minutes. The microfluidic chap is made of thermoplastic elastomer Cyclic olefin polymers (COP), and the surface of the microchannel will exhibit hydrophobic and electronegativity charged conditions to avoid attachment of gold nanoparticles. In addition, micromixers are embedded to boost the reaction rate of the gold nanoparticles synthesis. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-13T06:42:34Z (GMT). No. of bitstreams: 1 ntu-106-R04543041-1.pdf: 5971911 bytes, checksum: c1155890c87ee85e12bf18ea0e2541f9 (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 iii ABSTRACT iv 目錄 v 圖目錄 viii 第1章 前言 1 1.1 研究動機 1 1.2 研究回顧 2 1.2.1 奈米粒子 2 1.2.2 金奈米粒子 9 1.2.3 金奈米粒子合成方法 11 1.2.4 微流體晶片系統 17 1.2.5 微流體晶片製程材料 18 1.2.6 微流體晶片接合方式 22 1.2.7 微型混合器 26 1.2.8 金奈米在微流體的製備 32 1.3 研究原理與方法 34 1.3.1 微流體晶片溶劑接合方式 34 1.3.2 金奈米粒子光學性質 34 1.3.3 以微流體系統的合成特性 40 第2章 實驗方法與材料 42 2.1 實驗藥品與材料 42 2.2 儀器設備 42 2.3 溶液配置 43 2.4 反應晶片製備 44 2.4.1 晶片製作 44 2.4.2 流道晶片 44 2.4.3 上蓋晶片 45 2.4.4 溶劑接合 45 2.4.5 微型混合器 46 2.5 比爾定律與紫外光可見光分光光譜分析原理 50 第3章 實驗結果與討論 53 3.1 微晶片製程 53 3.1.1 溶劑接合 53 3.1.2 針型介面裝置 53 3.1.3 微流道的切削製造 54 3.2 反應物濃度對金奈米之影響 56 3.2.1 四氯金酸濃度之影響 57 3.2.2 檸檬酸三鈉濃度之影響 59 3.3 流量對金奈米之影響 63 3.3.1 總體流量變化之影響 63 3.3.2 檸檬酸三鈉試劑流量之影響 66 3.3.3 四氯金酸試劑流量之影響 70 3.4 反應溫度對金奈米之影響 75 3.4.1 批次反應下之溫度影響 75 3.4.2 在微流道反應下之溫度影響 79 3.5 批次反應器與微流體反應器之比較 85 3.5.1 反應速率 85 3.5.2 產率 92 3.5.3 吸收波分布 98 第4章 結論 101 第5章 參考文獻 103 | |
| dc.language.iso | zh-TW | |
| dc.subject | 微流體 | zh_TW |
| dc.subject | 流體控制 | zh_TW |
| dc.subject | 奈米材料合成 | zh_TW |
| dc.subject | 金奈米粒子 | zh_TW |
| dc.subject | gold nanoparticles | en |
| dc.subject | nanomaterials synthesis | en |
| dc.subject | Fluidic control | en |
| dc.subject | microfluidics | en |
| dc.title | 微型化流體控制系統中進行金奈米合成 | zh_TW |
| dc.title | Synthesis of Gold Nanoparticles in a Microfluidic System | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳建甫 | |
| dc.contributor.oralexamcommittee | 朱錦洲,林真真,蘇正瑜,宮春斐 | |
| dc.subject.keyword | 流體控制,微流體,奈米材料合成,金奈米粒子, | zh_TW |
| dc.subject.keyword | Fluidic control,microfluidics,nanomaterials synthesis,gold nanoparticles, | en |
| dc.relation.page | 109 | |
| dc.identifier.doi | 10.6342/NTU201704290 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2017-10-16 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-106-1.pdf | 5.83 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。