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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25302完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 邵耀華 | |
| dc.contributor.author | Szu-Han Lee | en |
| dc.contributor.author | 李思翰 | zh_TW |
| dc.date.accessioned | 2021-06-08T06:08:20Z | - |
| dc.date.copyright | 2007-07-31 | |
| dc.date.issued | 2007 | |
| dc.date.submitted | 2007-07-18 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/25302 | - |
| dc.description.abstract | 頸動脈內膜中層厚度（Carotid Intima-Media Thickness, CIMT）的量測結果，在近十年來已被視為診斷心血管疾病的重要危險因子之一，並且也常被用來當作患者接受治療的療效評估指標。但是過去的量測都只關心CIMT的厚度上的變化，往往因為量測技術上的限制，無法進一步的研究頸動脈管壁本身材質的變化，只從外觀的改變來當作臨床指標，很可能會遺漏一些重要生理資訊的表現。因此本實驗的研究目的在於利用現有的臨床檢測技術上，能否改進量測與計算的定義，在可靠的力學根據下，提供更為精確的臨床診療應用。
根據橡皮管的體外實驗結果，利用超音波以及影像分析所得到的橡皮管尺寸，與實際尺寸間的誤差只有3%，而使用超音波B-mode量測頸動脈的實驗結果顯示，在把頸動脈當作完全彈性體的假設下，所得到的CIMT硬度指標，於十位平均年齡為23.6歲的年輕健康男性中， 結果與過去文獻中常使用的Peterson’s elastic modulus相比較 ，結果顯示 容易受到不同受試者間，不同的生理狀態（血壓、舒張壓時管徑）之影響，而 在考慮受試者的IMT變化情況下，比 能夠反映更多的受試者頸動脈材料性質，因此得到了較為穩定的實驗結果。 由實驗結果顯示，本實驗所提出的頸動脈硬度指標，為一個有效且能反映更多生理資訊的指標，並且利用現有的超音波儀器，只要經過後端的影像處理分析，便能克服以往在量測上的限制，在將來經過更多的實驗驗證後，以期可以降低臨床診斷以及評估治療成效的難度，並提高其準確性。 | zh_TW |
| dc.description.abstract | Aims Measurement of change in carotid intima-media thickness (CIMT) has been proposed as an alternative for the occurrence of cardiovascular events in the assessment of therapeutic interventions. This study attempted to use the current technique of the clinical examination to improve diagnosis not only by the evolving technology but also by the mathematical progressing.
Methods and results We assume the carotid arterial wall is the elastic material so we can use the Hooke's law to analyze it. The experiment is based on the use of ultrasound B-mode imaging technique and the off-line image analysis. Elastic tube phantom experiments demonstrated the validity of the technique, providing the size of the tube within 3% of the actual values. The system was also tested in the common carotid arteries of 10 healthy males (age 23.6 y). According to the experimental result, it shows that our index is less variant than Peterson’s elastic modulus. The results of and are and respectively. Conclusion The new index shows the ability to reveal more physiological information and is more adaptable to be a risk factor of the cardiovascular events, but it needs more evidence to verify the observation. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T06:08:20Z (GMT). No. of bitstreams: 1 ntu-96-R94543030-1.pdf: 4592949 bytes, checksum: 6f051bf0d90da05289923c7780cd3e0f (MD5) Previous issue date: 2007 | en |
| dc.description.tableofcontents | 致 謝 I
中文摘要 II Abstract III 表目錄 VI 圖目錄 VII 第一章 序論 1 1-1 前言 1 1-2 研究動機與目的 3 1-3 文獻回顧 5 第二章 研究原理 8 2-1 動脈管組織結構特性 8 2-2 超音波影像原理 17 2-3 頸動脈在臨床檢測的角色 20 第三章 實驗方法 27 3-1 實驗方法 28 3-2 彈性力學模型 30 3-3 實驗設備 37 3-4 實驗步驟 40 3-5 IMT影像分析原理 42 第四章 結果與討論 46 4-1橡皮管實驗結果 46 4-2 頸動脈管壁量測與硬度評估 50 4-3 硬度指標差異討論 56 4-4 實驗結果討論 59 第五章 結論與未來工作 63 參考文獻 65 | |
| dc.language.iso | zh-TW | |
| dc.subject | 超音波B-mode | zh_TW |
| dc.subject | 頸動脈 | zh_TW |
| dc.subject | 內膜中層厚度 | zh_TW |
| dc.subject | 機械特性 | zh_TW |
| dc.subject | 危險因子 | zh_TW |
| dc.subject | Mechanical property | en |
| dc.subject | CCA | en |
| dc.subject | Cardiovascular events | en |
| dc.subject | Risk factor | en |
| dc.subject | Echo tracking | en |
| dc.subject | B-mode ultrasound | en |
| dc.subject | IMT | en |
| dc.title | 頸動脈內膜中層厚度變化之非侵入性動態測量 | zh_TW |
| dc.title | Noninvasive Dynamic Measurements of Carotid Intima-Media Thickness and Stiffness | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 95-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張家歐,王崇禮,許智欽 | |
| dc.subject.keyword | 頸動脈,內膜中層厚度,超音波B-mode,機械特性,危險因子, | zh_TW |
| dc.subject.keyword | CCA,IMT,B-mode ultrasound,Echo tracking,Mechanical property,Risk factor,Cardiovascular events, | en |
| dc.relation.page | 68 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2007-07-18 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 應用力學研究所 | zh_TW |
| 顯示於系所單位： | 應用力學研究所 | |
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