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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林中梧 | |
dc.contributor.author | Yi-Chun Lin | en |
dc.contributor.author | 林宜君 | zh_TW |
dc.date.accessioned | 2021-06-08T05:00:28Z | - |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-08-17 | |
dc.identifier.citation | Chapter 1
1. Cheung, M. M., Chan, J. K., Lau, W. H., Ngan, R. K. & Foo, W. W. Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality. Int J Radiat Oncol Biol Phys 54, 182-190, (2002). 2. Greer, J. P., Kinney, M. C. & Loughran, T. P., Jr. T cell and NK cell lymphoproliferative disorders. Hematology Am Soc Hematol Educ Program, 259-281 (2001). 3. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297, (2004). 4. Beilharz, T. H. et al. microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells. PLoS One 4, e6783, (2009). 5. Blenkiron, C. & Miska, E. A. miRNAs in cancer: approaches, aetiology, diagnostics and therapy. Hum Mol Genet 16 Spec No 1, R106-113, (2007). 6. Corcoran, D. L. et al. Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS One 4, e5279, (2009). 7. Fukuda, Y., Kawasaki, H. & Taira, K. Construction of microRNA-containing vectors for expression in mammalian cells. Methods Mol Biol 338, 167-173, (2006). 8. Garzon, R., Fabbri, M., Cimmino, A., Calin, G. A. & Croce, C. M. MicroRNA expression and function in cancer. Trends Mol Med 12, 580-587, (2006). 9. Landgraf, P. et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129, 1401-1414, (2007). 10. Lee, Y. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415-419, (2003). 11. Pfeffer, S. et al. Identification of virus-encoded microRNAs. Science 304, 734-736, (2004). 12. Zhang, B., Pan, X., Cobb, G. P. & Anderson, T. A. microRNAs as oncogenes and tumor suppressors. Dev Biol 302, 1-12, (2007). 13. Cai, X. et al. Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2, e23, (2006). 14. Cullen, B. R. Transcription and processing of human microRNA precursors. Mol Cell 16, 861-865, (2004). 15. Godshalk, S. E., Bhaduri-McIntosh, S. & Slack, F. J. Epstein-Barr virus-mediated dysregulation of human microRNA expression. Cell Cycle 7, 3595-3600, (2008). 16. Cosmopoulos, K. et al. Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma. J Virol 83, 2357-2367, (2009). 17. Zhu, J. Y. et al. Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas. J Virol 83, 3333-3341, (2009). 18. Edwards, R. H., Marquitz, A. R. & Raab-Traub, N. Epstein-Barr virus BART microRNAs are produced from a large intron prior to splicing. J Virol 82, 9094-9106, (2008). 19. Mathew, L. K. & Simon, M. C. mir-210: a sensor for hypoxic stress during tumorigenesis. Mol Cell 35, 737-738, (2009). 20. Schaar, D. G., Medina, D. J., Moore, D. F., Strair, R. K. & Ting, Y. miR-320 targets transferrin receptor 1 (CD71) and inhibits cell proliferation. Exp Hematol 37, 245-255, (2009). chapter 2 1. Suarez F, Lortholary O, Hermine O, et al. Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood 2006;107: 3034-3044. 2. Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342:575-577. 3. Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, et al. Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet 2001;357:39-40. 4. Yeh KH, Kuo SH, Chen LT, et al. Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosaassociated lymphoid tissue lymphomas with or without t(11;18)(q21;q21). Blood 2005;106:1037-1041. 5. Swerdlow SH, Campo E, Harris NL, et al. Tumours of Haematopoietic and Lymphoid Tissues, WHO Classification of Tumours. Lyon: IARC Press. 2008. 6. Torlakovic EE, Aamot HV, Heim S. A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma. J Pathol 2006;209:258-264. 7. Jourdan F, Molina TJ, Le Tourneau A, et al. Florid marginal zone differentiation in follicular lymphoma mimicking marginal zone lymphoma of MALT type in the lung. Histopathology 2006;49:426-429. 8. Roulland S, Suarez F, Hermine O, et al. Pathophysiological aspects of memory B-cell development. Trends Immunol 2008;29:25-33. 9. Toellner KM, Jenkinson WE, Taylor DR, et al. Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J Exp Med 2002;195:383-389. 10. Quong MW, Martensson A, Langerak AW, et al. Receptor editing and marginal zone B cell developent are regulated by the helix-loop-helix protein, E2A. J Exp Med 2004;199:1101-1112. 11. Schoetz U, Cervelli M, Wang YD, et al. E2A expression stimulates Ig hypermutation. J Immunol 2006;177:395-400. 12. Hauser J, Verma-Gaur J, Wallenius A, et al. Initiation of antigen receptordependent differentiation into plasma cells by calmodulin inhibition of E2A. J Immunol 2009;183:1179-87. 13. Ranuncolo SM, Polo JM, Dierov J, et al. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat Immunol 2007;8:705-714. 14. Greeve J, Philipsen A, Krause K, et al. Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas. Blood 2003;101: 3574-3580. 15. Pasqualucci L, Guglielmino R, Houldsworth J, et al. Expression of the AID protein in normal and neoplastic B cells. Blood 2004;104:3318-3325. 16. Said JW, Hoyer KK, French SW, et al. TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma. Lab Invest 2001;81:555-564. 17. Herling M, Patel KA, Hsi ED, et al. TCL1 in B-cell tumors retains its normal b-cell pattern of regulation and is a marker of differentiation stage. Am J Surg Pathol 2007;31:1123-1129. 18. Dunn-Walters D, Thiede C, Alpen B. Somatic hyp ermutation and B-cell lymphoma. Philos Trans R Soc Lond B Biol Sci 2001;356:73-82. 19. Qin Y, Greiner A, Hallas C, et al. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest 1997;76:477-485. 20. Nardini E, Rizzi S, Ménard S, et al. Molecular phenotype distinguishes two subsets of gastric low-grade mucosa-associated lymphoid tissue lymphomas. Lab Invest 2002;82: 535-541. 21. Malumbres R, Sarosiek KA, Cubedo E, et al. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood 2009;113:3754-3764. 22. Zhang J, Jima DD, Jacobs C, et al. Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 2009;113:4586-4594. 23. Hummel M, Oeschger S, Barth TF, et al. Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis. Gut 2006;55:782-787. 24. Aubin J, Davi F, Nguyen-Salomon F, et al. Description of a novel FR1 IgH PCRstrategy and its comparison with three other strategies for the detection of clonality in B cell malignancies. Leukemia 1995;9:471-479. 25. Giudicelli V, Chaume D, Lefranc MP. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis.Nucleic Acids Res. 2004;32:W435-440. 26. Chang B, Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994;15:367-373. 27. Bose B, Sinha S. Problems in using statistical analysis of replacement and silent mutations in antibody genes for determining antigen-driven affinity selection. Immunology 2005;116:172-183. 28. Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005;33:e179. 29. Bende RJ, Aarts WM, Riedl RG, et al. Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity. J Exp Med 2005;201:1229-1241. 30. Aarts WM, Bende RJ, Steenbergen EJ, et al. Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load. Blood 2000;95:2922-2929. 31. Stum A, Quackenbush J, Tranjanoski A. Genesis: cluster analysis of microarray data. Bioinformatics 2002;18:207-208. 32. Yao X, Teruya-Feldstein J, Raffeld M, et al. Peripheral T-cell lymphoma with aberrant expression of CD79a and CD20: a diagnostic pitfall. Mod Pathol 2001;14:105-110. 33. Kaleem Z, White G, Zutter MM. Aberrant expression of T-cell-associated antigens on B-cell non-Hodgkin lymphomas. Am J Clin Pathol 2001;115:396-403. 34. Sagaert X, Sprangers B, De Wolf-Peeters C. The dynamics of the B follicle: understanding the normal counterpart of B-cell-derived malignancies. Leukemia 2007;21:1378-1386. 35. Camacho FI, García JF, Cigudosa JC, et al. Aberrant Bcl6 protein expression in mantle cell lymphoma. Am J Surg Pathol 2004;8:1051-1056. 36. Zanetto U, Dong H, Huang Y, et al. Mantle cell lymphoma with aberrant expression of CD10. Histopathology 2008;53:20-29. 37. Mansoor A, Akbari M, Auer I, et al. Cyclin D1 and t(11;14)-positive B-cell neoplasms resembling marginal zone B-cell lymphoma: a morphological variant of mantle cell lymphoma. Hum Pathol 2007;38:797-802. 38. Wenzel C, Dieckmann K, Fiebiger W, et al. CD5 expression in a lymphoma of the mucosa-associated lymphoid tissue (MALT)-type as a marker for early dissemination and aggressive clinical behaviour. Leuk Lymphoma 2001;42:823-829. 39. Kwon K, Hutter C, Sun Q, et al. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 2008;28:751-762. 40. Basso K, Sumazin P, Morozov P, et al. Identification of the human mature B cell miRNome. Immunity 2009;30:744-752. 41. Tan LP, Wang M, Robertus JL, et al. miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes. Lab Invest 2009;89:708-716. 42. Mraz M, Pospisilova S, Malinova K, et al. MicroRNAs in chronic lymphocyticleukemia pathogenesis and disease subtypes. Leuk Lymphoma 2009;50:506-509. 43. Navarro A, Beà S, Fernández V, et al. MicroRNA expression, chromosomal alterations, and immunoglobulin variable heavy chain hypermutations in Mantle cell lymphomas. Cancer Res 2009;69:7071-7078. 44. Roehle A, Hoefig KP, Repsilber D, et al. MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. Br J Haematol 2008;142:732-744. 45. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007;129:1401-1414. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/23396 | - |
dc.description.abstract | 鼻咽自然殺手/T細胞淋巴癌是一種特殊類型的結節外淋巴瘤,與EB病毒有很強的關連性。MicroRNAs(miRNAs)會影響到多種癌症的發生及生物學上功能,然而,鼻咽自然殺手/T細胞淋巴癌上miRNAs的分布及表現量還是未知數。因此我們在鼻咽自然殺手/T細胞淋巴癌病人檢體中篩選55隻人類miRNAs及39隻EB病毒miRNAs的表現模式。我們由46個鼻咽自然殺手/T細胞淋巴癌病人的組織石蠟包埋蠟塊中純化出total RNA,以即時定量聚合酶連鎖反應來分析定量人類及EB病毒 miRNAs的表現情況。我們分別使用三種統計方法來作分析,由T Test結果可知,EBV-miR BART13*和Has miR-155、miR-210及miR-320的表現於早期和晚期的鼻咽自然殺手/T細胞淋巴癌中有顯著性差異,和第二次重複的結果相同,兩次結果都可分析出有顯著性差異。由集群分析結果可知,我們無法利用miRNAs的表現模式區分出鼻咽自然殺手/T細胞淋巴癌早期和晚期階段。 | zh_TW |
dc.description.abstract | Nasal Natural Killer/T-Cell Lymphoma (NNKTL) is a distinctive type of extranodal lymphoma with a strong association with Epstein-Barr virus (EBV). MicroRNAs have been implicated in the development and biological behaviors of a variety of cancers. However, expression patterns of miRNAs in NNKTLs are still unknown. We screened the expression patterns of 39 EBV-encoded and 55 human microRNAs in NNKTL. Total RNAs were isolated from paraffin-embedded tissues of NNKTLs. Real-time quantitative PCR was used to analyze the expression levels of EBV and human microRNAs. We used three statistical methods to analyze our QPCR results. From the T Test results, we can know that EBV-miR BART13 * and Hsa miR-155, miR-210 and miR320 have significant difference between the early and late stage in NNKTL and from the repeated data also have same result. From the Cluster analysis results, we could not separate the early and late stage in NNKTL clearly base on miRNAs expression patterns. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T05:00:28Z (GMT). No. of bitstreams: 1 ntu-99-R97444002-1.pdf: 10014581 bytes, checksum: 0c39190f449bfabde2ca9de08dd042f8 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 口試委員會審定書…………………………………………………………………..i
誌謝…………………………………………………………………………………..ii 中文摘要……………………………………………………………………………..iii Abstract…………………………………………………………………………….. iv Chapter 1 Expression of human and Epstein-Barr virus-encoded microRNAs in Nasal Natural Killer/T-Cell Lymphoma Introduction………………………………………………………………….. ..1 Materials & Methods…………………………………………………………..6 Results………………………………………………………………………. ...11 Discussion……………………………………………………………………. .18 References……………………………………………………………………...21 Tables………………………………………………………………………… .24 Figure Legends………………………………………………………………...31 Figures………………………………………………………………………….35 Chapter 2 E2A-positive Gastric MALT lymphoma has weaker plasma cell differentiation and stronger expression of the memory B-cell associated miR-223 Introduction………………………………………………………………….. .45 Materials & Methods………………………………………………………….48 Results………………………………………………………………………….53 Discussion……………………………………………………………………....58 References……………………………………………………………………. .61 Tables………………………………………………………………………….. 68 Figure Legends………………………………………………………………... 70 Figures………………………………………………………………………….73 Appendix……………………………………………………………………………..77 | |
dc.language.iso | en | |
dc.title | 探討由人類及Epstein-Barr病毒所譯成的microRNAs於鼻咽自然殺手/T細胞淋巴癌中之表現模式 | zh_TW |
dc.title | Expression of human and Epstein-Barr virus-encoded microRNAs in Nasal Natural Killer/T-Cell Lymphoma | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 田蕙芬,葉秀慧,謝建興 | |
dc.subject.keyword | 鼻咽自然殺手/T細胞淋巴癌,EB病毒,EB病毒microRNAs,人類microRNAs,即時定量聚合酶,連鎖反應,集群分析, | zh_TW |
dc.subject.keyword | Nasal Natural Killer/T-Cell Lymphoma,Epstein-Barr virus,EBV microRNAs,Human microRNAs,Real-time quantitative PCR,Cluster analysis, | en |
dc.relation.page | 86 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2010-08-17 | |
dc.contributor.author-college | 醫學院 | zh_TW |
dc.contributor.author-dept | 病理學研究所 | zh_TW |
顯示於系所單位: | 病理學科所 |
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