1.先生的飲酒行為是產後婦女生活品質的危險因子 2.應用極致液相層析/串聯式質譜儀分析人體血漿中之全氟碳化合物 – 初步研究

Abstract

1. ABTRACT Purpose: The objective of this study is to investigate the association between husbands’ alcohol drinking and wives’ HRQOL in the postpartum period. Methods: We used multistage stratified systematic sampling to recruit 24,200 pairs, postpartum women and newborns, from the Taiwan national birth register in 2005. A structured questionnaire was successfully administered to 87.8% of the sampled population. Subjects undertook a home interview 6 months after their deliveries between June 2005 and July 2006. The Medical Outcomes Study 36-item Short-Form (SF-36) was used to measure the quality of life of the women with their husbands’ alcohol drinking behavior. Results: After controlling for the potential confounders, there were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning along with the increase in frequency of husbands’ alcohol drinking. There were significantly gradual decreases in wives’ scores of SF-36 scales other than physical functioning and role-physical along with the increase in frequency of husbands’ alcohol drinking either in primiparous or multiparous women Conclusions: Our study adds evidence supporting the adverse effect of husbands’ alcohol drinking on women’s health as measured by the SF-36 HRQOL.

2. ABTRACT Purpose: The aim of this study was to develop a sensitive, convenient and accurate method by using UPLC-MS/MS for a broad range of PFCs for studies involving large sample series. Methods: We analyze the perfluorinated compounds by using ultra performance liquid chromatography－tandem mass spectrometry with protein precipitation and matrix-matched calibration method. And seven samples of plasma from TBPS were analyzed to investigate the applicability of this validated method. Results: Perfluorinated compounds were detected in all seven plasma samples. The average concentration of PFOS and PFOA were 31.25 ng/mL and 3.52 ng/mL. Moreover, UPLC provides significantly reduced analysis time and improved chromatographic behavior for PFCs compared with traditional LC. Conclusions: The low sample volume needed, the limited time consuming and the broad range of analytes which are included, make this method advantageous for large-scale epidemiological studies. Besides, this sample preparation technique and matrix-matched calibration method can easily be set up on standard LC-MS/MS instruments and is thus available to a wide range of laboratories.