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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林俊彬(Chun-Pin Lin) | |
| dc.contributor.author | Yu-De Li | en |
| dc.contributor.author | 李昱德 | zh_TW |
| dc.date.accessioned | 2021-06-08T04:24:22Z | - |
| dc.date.copyright | 2010-06-30 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-06-22 | |
| dc.identifier.citation | 1. Priya, S.G., et al., Skin Tissue Engineering for Tissue Repair and Regeneration. Tissue Engineering Part B: Reviews, 2008. 14(1): p. 105-118.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/22678 | - |
| dc.description.abstract | 幾丁聚醣(chitosan)為極具發展潛力的生醫材料，近年來已被廣泛應用於骨骼組織修復、藥物釋放系統以及創傷敷料等方面。幾丁聚醣其具有良好的生物性質，例如生物相容性、生物降解性以及抗菌性，且幾丁聚醣對於血液有促進凝結止血的效果。然而幾丁聚醣的低機械性質和快降解速率均限制其應用範圍，特別在具有溶菌 | zh_TW |
| dc.description.abstract | Chitosan is a potential material for biomedical applications. Recently, it is widely applied in bone tissue regeneration, drug delivery systems and wound dressings. Chitosan has outstanding biological properties, including biocompatible, biodegradable and antibacterial ability. Moreover, chitosan has hemostatic ability for promoting blood to coagulate together. However, the applications of chitosan are limited for its low mechanical properties and rapid degradation trend, especially in the environment containing lysozyme. Chitosan existing in acid environment becomes a cationic polyelectrolyte due to its amine group, it can easily form polyelectrolyte complexes with other anionic polyelectrolytes and growth factors, or form crosslink structure with carboxylic group by composing amide bond. Through this strategy, the properties of chitosan can be modified and enhanced.
In this research, in order to enhance the mechanical properties and to ease the biodegradation rate, the glutamic acid, succinic acid and succinic anhydride are applied to form crosslink structure with chitosan separately, with the repeating unit ratio of 80:20 to 50:50. Besides, this study investigates physicochemical characterization and biological properties of the crosslinked hydrogels. Via the implant study, animal test was conducted to evaluate the possibility that crosslinked hydrogels could be a potential wound dressing material. Results of wound closure and histological tissue observation showed that chitosan/diacid crosslinked hydrogels could accelerate the process of wound healing and tissue regeneration. The study reveals chitosan could suppress the infiltration of inflammatory cells and accelerate fibroblast proliferation while the diaicds could enhance epithelial migration. Thus, chitosan/diacid crosslinked hydrogels could be potential materials for wound dressing applications. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T04:24:22Z (GMT). No. of bitstreams: 1 ntu-99-R97549025-1.pdf: 3350275 bytes, checksum: 3656d9234e2908a6636aa63f717226eb (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 中文摘要 I
Abstract Ⅱ 目錄 Ⅳ 表索引 VII 圖索引 VIII 第1章 簡介 1 第2章 文獻回顧 2 2-1 幾丁質之簡介 2 2-2 幾丁質之應用 3 2-3 幾丁聚醣之簡介 5 2-4 幾丁聚醣之應用 6 2-4-1 幾丁聚醣於廢水處理之應用 7 2-4-2 幾丁聚醣於藥物釋放之應用 8 2-4-3 幾丁聚醣於組織工程之應用 11 2-4-4 幾丁聚醣於創傷敷料之應用 14 2-4-5 幾丁聚醣於其他方面之應用 16 2-5 幾丁聚醣交聯系統之簡介 17 2-5-1 EDC / NHS 交聯系統之簡介 19 2-6 雙官能基酸之簡介 20 2-6-1 麩胺酸之簡介 20 2-6-2 琥珀酸之簡介 22 2-6-3 琥珀酸酐之簡介 22 2-7 皮膚構造之簡介 22 2-8 傷口癒合過程機制 23 第3章 實驗藥品與實驗儀器 26 3-1 實驗藥品 26 3-2 實驗儀器 29 第4章 實驗方法 32 實驗流程圖 32 4-1 幾丁聚醣/雙官能基酸交聯水膠製備方法 33 4-2 材料性質測試 34 4-2-1 傅立葉轉換紅外線光譜儀 34 4-2-2 膨潤比 34 4-2-3 壓縮模數 34 4-2-4 接觸角儀 34 4-2-5 熱重分析儀 35 4-2-6 微差掃瞄卡計儀 35 4-2-7 X-ray繞射儀 35 4-3 生物性質測試 35 4-3-1 生物降解性測試 35 4-3-2 細胞活性測試 36 4-3-3 抗菌測試 36 4-4 動物實驗 37 4-4-1 切傷實驗 37 4-4-2 燙傷實驗 37 4-4-3 病理組織切片觀察 38 第5章 結果與討論 39 5-1 材料性質測試 39 5-1-1 傅立葉轉換紅外線光譜分析 39 5-1-2 膨潤比分析 39 5-1-3 壓縮模數分析 40 5-1-4 接觸角分析 40 5-1-5 熱性質分析 40 5-1-5-1 熱重分析 40 5-1-5-2 微差掃瞄卡計分析 41 5-1-6 X-ray繞射分析 42 5-2 生物性質測試 42 5-2-1 生物降解性測試分析 42 5-2-2 細胞活性測試分析 42 5-2-3 抗菌測試分析 43 5-3 動物實驗 43 5-3-1 切傷動物實驗 43 5-3-1-1 正常皮膚病理組織切片觀察 44 5-3-1-2 切傷實驗病理組織切片觀察 44 5-3-2 燙傷動物實驗 46 5-3-2-1 燙傷傷口癒合情形觀察 47 5-3-2-2 燙傷實驗病理組織切片觀察 47 第6章 結論 49 參考文獻 50 | |
| dc.language.iso | zh-TW | |
| dc.subject | 創傷敷料 | zh_TW |
| dc.subject | 幾丁聚醣 | zh_TW |
| dc.subject | 雙官能基酸 | zh_TW |
| dc.subject | 交聯 | zh_TW |
| dc.subject | 水膠 | zh_TW |
| dc.subject | chitosan | en |
| dc.subject | wound dressing | en |
| dc.subject | hydrogel | en |
| dc.subject | crosslinked | en |
| dc.subject | diacid | en |
| dc.title | 幾丁聚醣/雙官能基酸交聯水膠於皮膚創傷敷料 | zh_TW |
| dc.title | Chitosan/Diacid Crosslinked Hydrogels for Skin Wound Dressing | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 謝國煌(Kuo-Huang Hsieh),吳銘芳(Ming-Fang Wu) | |
| dc.subject.keyword | 幾丁聚醣,雙官能基酸,交聯,水膠,創傷敷料, | zh_TW |
| dc.subject.keyword | chitosan,diacid,crosslinked,hydrogel,wound dressing, | en |
| dc.relation.page | 84 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2010-06-22 | |
| dc.contributor.author-college | 工學院 | zh_TW |
| dc.contributor.author-dept | 高分子科學與工程學研究所 | zh_TW |
| 顯示於系所單位： | 高分子科學與工程學研究所 | |
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