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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 謝淑貞(Shu-Chen Hsieh) | |
dc.contributor.author | Ting-Yu Chao | en |
dc.contributor.author | 趙庭郁 | zh_TW |
dc.date.accessioned | 2021-06-08T01:09:49Z | - |
dc.date.copyright | 2014-09-03 | |
dc.date.issued | 2014 | |
dc.date.submitted | 2014-08-18 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/18525 | - |
dc.description.abstract | 國內外很高比例的停經後婦女都患有骨質疏鬆症,帶來很多危害健康的風險,例如骨折的產生。其主要病因為雌激素缺乏。臨床上常用的賀爾蒙治療法即是給予雌激素,可減少骨折風險但是卻會引起不良副作用,例如增加罹患乳癌與心血管疾病的風險。大豆異黃酮(genistein)是一種植物性雌激素,因其結構與人體雌激素類似,可與體內雌激素受體結合並有類雌激素的效果。已有研究顯示genistein可用於減緩部分女性更年期症狀,且對於骨質疏鬆的延緩甚至預防較賀爾蒙給予有效用佳卻幾乎沒有副作用的優勢。但是身為親油性的物質,它的水溶性並不好。為了提升生物利用率,我們藉由化學修飾改變其結構與增加其水溶性,也在體外試驗看到更佳的吸收率。因此本研究利用停經後骨質疏鬆的小鼠模式探討genistein與modified genistein (genistein 7-O-phosphate)兩者保護骨頭的作用。研究結果顯示modified genistein比genistein更能維持骨頭微結構的完整,因此推測modified genistein具有更佳的抗骨鬆效用。 | zh_TW |
dc.description.abstract | Increase in bone turnover associated with ovarian hormone deficiency after menopause facilitates the development of postmenopausal osteoporosis. Conventional treatment for postmenopausal osteoporosis is hormone replacement therapy (HRT) which is a prescription of exogenous estrogen. However, several undesirable side effects are associated with HRT, including elevated risk of breast cancer and cardiovascular events. On the other hand, genistein is an estrogenic isoflavone found mainly in soybeans and soy products; long-term clinical studies indicate that genistein appears to be one of the most effective and safe isoflavone in preserving bone health. Nevertheless, its poor aqueous solubility contributes to low bioavailability. An isoflavone derivative, genistein 7-O-phosphate, has been obtained by microbial bioconversion and found to be more rapidly absorbed into the intestine than the parent drug in Caco-2 absorption study. Evaluation of micro-computed tomography analysis of bone microarchitecture shows that treatment with genistein 7-O-phosphate results in more complete preservation of bone tissue integrity than genistein. Given this finding, the modified genistein seems to have greater potential in preserving bone health than genistein. | en |
dc.description.provenance | Made available in DSpace on 2021-06-08T01:09:49Z (GMT). No. of bitstreams: 1 ntu-103-R01641039-1.pdf: 3106089 bytes, checksum: 4766279d8dbf0cec0113a8e13b5dcb61 (MD5) Previous issue date: 2014 | en |
dc.description.tableofcontents | Table of Contents
口試委員會審定書 ii Acknowledgement iii 中文摘要 iv Abstract v Chapter 1. Introduction 1 1.1 Overview 1 1.2 Literature Review 2 1.2.1 Bone Biology 2 1.2.2 Osteoporosis 3 Definition and Pathophysiology 3 Diagnosis 5 Risk Factors 7 Prevention and Treatment 8 1.2.3 Estrogen and Postmenopausal Osteoporosis 15 1.2.4 Genistein 16 Structure and Estrogenic Activity 16 Effects on Bone 20 Absorption Study 22 1.2.5 Genistein 7-O-Phosphate 23 1.2.6 Rodent Models of Osteoporosis 24 Chapter 2. Aims 27 2.1 Research Motivation 27 2.2 Hypothesis 28 2.3 Experimental Framework 29 Chapter 3. Materials and Methods 30 3.1 Materials 30 3.1.1 Study Samples 30 3.1.2 Chemicals 30 3.1.3 Instruments 31 3.1.4 Kits 32 3.2 Methods 32 3.2.1 Animals 32 3.2.2 Measurement of Blood Concentration of Genistein 34 3.2.3 Measurement of Bone Densitometry and Bone Microarchitecture 35 3.2.4 Histopathology of Bone Tissue 36 3.2.5 Measurement of Serum Bone Turnover Markers 37 3.2.6 Statistical Analysis 37 Chapter 4. Results 38 4.1 Anthropometric Analysis 38 4.2 Plasma Concentration of Genistein 44 4.3 Bone Mineral Density and Bone Microarchitecture 45 4.4 Histopathology of Bone Tissue 51 4.5 Serum Bone Turnover Markers 58 4.5.1 Bone Formation Marker 58 4.5.2 Bone Resorption Markers 59 Chapter 5. Discussion 61 Chapter 6. Conclusion 68 Chapter 7. Appendix 70 Chapter 8. References 71 | |
dc.language.iso | en | |
dc.title | 化學修飾之大豆異黃酮延緩卵巢摘除小鼠之骨質疏鬆的功效 | zh_TW |
dc.title | Anti-osteoporotic Effects of Modified Genistein in Ovariectomized Mice | en |
dc.type | Thesis | |
dc.date.schoolyear | 102-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 蘇南維(Nan-Wei Su),潘敏雄(Ming-Hsiung Pan) | |
dc.subject.keyword | 大豆異黃酮 (genistein、genistein 7-O-phosphate),雌激素缺乏,骨質疏鬆症, | zh_TW |
dc.subject.keyword | postmenopausal osteoporosis,estrogen deficiency,genistein 7-O-phosphate,genistein, | en |
dc.relation.page | 88 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2014-08-18 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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