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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張正琪(Cheng-Chi Chang) | |
| dc.contributor.author | Pin-Hsien Wu | en |
| dc.contributor.author | 吳品嫻 | zh_TW |
| dc.date.accessioned | 2021-06-08T00:05:14Z | - |
| dc.date.copyright | 2013-09-24 | |
| dc.date.issued | 2013 | |
| dc.date.submitted | 2013-08-14 | |
| dc.identifier.citation | 1. Slots, J., Periodontology: past, present, perspectives. Periodontology 2000, 2013.
62: p. 7–19. 2. Shue, L., Z. Yufeng, and U. Mony, Biomaterials for periodontal regeneration: A review of ceramics and polymers. Biomatter, 2012. 2(4): p. 271-7. 3. Lisa J. A. Heitz-Mayfield, N.P.L., Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontology 2000, 2013. 62(1): p. 218-231. 4. Yang, K.C., et al., Fibrin glue mixed with platelet-rich fibrin as a scaffold seeded with dental bud cells for tooth regeneration. J Tissue Eng Regen Med, 2012. 6(10): p. 777-85. 5. Duan, X., et al., Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration. J Cell Physiol, 2011. 226(1): p. 150-7. 6. Lindroos, B., R. Suuronen, and S. Miettinen, The potential of adipose stem cells in regenerative medicine. Stem Cell Rev, 2011. 7(2): p. 269-91. 7. Lenoir, N., Europe confronts the embryonic stem cell research challenge. Science, 2000. 287(5457): p. 1425-7. 8. Takahashi, K. and S. Yamanaka, Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006. 126(4): p. 663-76. 9. Apostolou, E. and K. Hochedlinger, Stem cells: iPS cells under attack. Nature, 2011. 474(7350): p. 165-6. 10. Ben-David, U. and N. Benvenisty, The tumorigenicity of human embryonic and induced pluripotent stem cells. Nat Rev Cancer, 2011. 11(4): p. 268-77. 11. Mizuno, H., M. Tobita, and A.C. Uysal, Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells, 2012. 30(5): p. 804-10. 12. Meliga, E., et al., Adipose-derived cells. Cell Transplant, 2007. 16(9): p. 963-70. 13. Toda, A., et al., The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues. J Pharmacol Sci, 2007. 105(3): p. 215-28. 14. Kesting, M.R., et al., Amniotic membrane in oral and maxillofacial surgery. Oral Maxillofac Surg, 2012. 15. Riau, A.K., et al., Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction. Biomaterials, 2010. 31(2): p. 216-25. 16. Mamede, A.C., et al., Amniotic membrane: from structure and functions to clinical applications. Cell Tissue Res, 2012. 349(2): p. 447-58. 17. Baer, P.C., et al., Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness. Cytotherapy, 2010. 12(1): p. 96-106. 18. Requicha, J.F., et al., Effect of Anatomical Origin and Cell Passage Number on the Stemness and Osteogenic Differentiation Potential of Canine Adipose-Derived Stem Cells. Stem Cell Rev, 2012. 8(4): p. 1211-1222. 19. Torensma, R., et al., The impact of cell source, culture methodology, culture location and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells. Stem Cells Dev, 2012. 22(7): p. 1086-1096. 20. Patricia A. Zuk, P., M. Min Zhu, and M. Hiroshi Mizuno, Multilineage Cells from Human Adipose Tissue Implications for Cell-Based Therapies. Tissue Engineering, 2001. 7(2): p. 211-228. 21. Barzilay, R., E. Melamed, and D. Offen, Introducing transcription factors to multipotent mesenchymal stem cells: making transdifferentiation possible. Stem Cells, 2009. 27(10): p. 2509-15. 22. Boulland, J.L., et al., Epigenetic Regulation of Nestin Expression during Neurogenic Differentiation of Adipose Tissue Stem Cells. Stem Cells Dev, 2012. 22(7): p. 1042-1052. 23. Li, H., et al., Autologous platelet-rich plasma promotes neurogenic differentiation of human adipose derived stem cells in vitro. Int J Neurosci, 2012. 123(3): p. 184-190. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/17291 | - |
| dc.description.abstract | 牙周病是發生於牙周組織之慢性發炎疾病，嚴重的牙周病可能會造成牙齒缺損，影響日常生活飲食、發音等生理狀態甚鉅，然而臨床上仍無完全治癒之治療方式，目前研究期望運用組織工程與幹細胞療法在缺失部位協助牙周骨質新生。脂肪幹細胞於疾病治療的研究上已有許多成功的經驗，並證實其具有多能性分化能力，利用脂肪幹細胞合併羊膜片共同培養，希望利用羊膜具有抗發炎、抗血管新生、降低感染風險，且有豐富的生長因子之特性，將此共同培養系統運用於大鼠模式的牙周骨缺損組織上，研究結果顯示脂肪幹細胞合併羊膜片共同培養系統可促進牙周骨缺損修復之能力，成功建立牙周骨質缺損研究之動物模式，並提供脂肪幹細胞與羊膜片移植應用於牙周病臨床治療之參考。 | zh_TW |
| dc.description.abstract | Periodontal disease is a chronic inflammatory reaction of periodontal tissues that potentially leads to tooth loss. It can affect daily activity, such as chewing and speech. Unfortunately, there is no effective therapy for periodontal disease. Use of tissue engineering technologies and stem cell therapy on Periodontal bone regeneration is a very promising treatment. Adipose-derived stem cell has been proved to its multipotency and have significant outcome in many disorders. Amniotic membrane is anti-inflammation, anti-angiogenic, low immunogenicity, and enriched with growth factor. We create a co-culture system with adipose-derived stem cell and amniotic membrane in periodontal osseous defect of rat model. The result suggest that the co-culture system could enhance periodontal bone regeneration. We believed this study could provide the base of the co-culture system as stem cell therapy and amniotic membrane transplantation in clinical periodontology. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-08T00:05:14Z (GMT). No. of bitstreams: 1 ntu-102-R00450004-1.pdf: 2608357 bytes, checksum: 6fcbbce05fec4a98f7c5fe590e415cd0 (MD5) Previous issue date: 2013 | en |
| dc.description.tableofcontents | 口試委員會審定書....................................... i
中文摘要 ............................................. ii 英文摘要 .............................................. iii 目次 ................................................. iv 緒言 ................................................... 1 材料與方法 ............................................. 4 結果 ................................................... 7 討論 .................................................. 10 參考文獻 .............................................. 12 | |
| dc.language.iso | zh-TW | |
| dc.title | 脂肪幹細胞療法合併羊膜共同培養系統對牙周骨質再生之效益 | zh_TW |
| dc.title | The Effect of Adipose-derived Stem Cell and Amniotic Membrane Co-culture System in Periodontal Bone Regeneration | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 101-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭彥彬,張博鈞 | |
| dc.subject.keyword | 脂肪幹細胞,羊膜,牙周骨質再生,共同培養系統,動物模式, | zh_TW |
| dc.subject.keyword | adipose-derived stem cell,amniotic membrane,periodontal bone regeneration,co-culture system,animal model, | en |
| dc.relation.page | 22 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2013-08-14 | |
| dc.contributor.author-college | 牙醫專業學院 | zh_TW |
| dc.contributor.author-dept | 口腔生物科學研究所 | zh_TW |
| 顯示於系所單位： | 口腔生物科學研究所 | |
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| ntu-102-1.pdf 目前未授權公開取用 | 2.55 MB | Adobe PDF |
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